Clinical trials: Cocaine Addiction
Cocaine Dependence, Cocaine Addiction
A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction
Subjects will be randomly assigned to receive either one of the two potential dose combinations of the study medications or placebo over 6 weeks.
- Trial name
- NCT00567814
- Testing
- Metyrapone, Oxazepam
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Embera NeuroTherapeutics, Inc.
Asperger's Disorder, Asperger Disorder
QAIAx (AIhealth4U) - AI Smart Health Cities: Microcity Enclave Program (Quantum AI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum AI/AGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Cocaine Addiction
Efficacy of N-acetylcysteine on the Craving Symptoms of Abstinent Hospitalized Patients With Cocaine Addiction
Cocaine abuse is associated with serious physical, psychiatric and social problems. Addiction results in the compulsive use of a substance with loss of control and persistence despite the negative consequences.The act of…
- Trial name
- NCT03423667
- Testing
- N-acetylcysteine, Lactose powder
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- Salvatore Campanella
Cocaine Addiction, Opioid Addiction
sTMS for Substance Use-disordered Veterans
The purpose of this study is to determine if synchronized transcranial magnetic stimulation is safe and tolerable in individuals with cocaine, opioid, or alcohol use disorders.
- Conditions
- Cocaine Addiction, Opioid Addiction, Alcohol Addiction
- Trial name
- NCT04336293
- Testing
- sTMS
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Cocaine Dependence, Cocaine Addiction
Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study
The main purpose of this study is to determine if it is safe to use the study drug, clavulanic acid, in combination with cocaine.
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Cocaine-Related Disorders
- Trial name
- NCT02563769
- Testing
- Clavulanic acid, Intravenous cocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Temple University
Cocaine Addiction
A Study of the Relationship Between Disulfiram and Cocaine Self-administration.
The problem of cocaine dependence remains a major medical, social, and legal concern. Several studies have suggested that disulfiram may be beneficial for the treatment of cocaine dependence.
- Trial name
- NCT00729300
- Testing
- disulfiram
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Cocaine Addiction
Integrative Meditation (IM) for Cocaine Addiction
Cocaine addiction continues to be a major problem in the U.S. with no FDA-approved pharmaceutical therapy. Finding effective treatment for cocaine addiction has long been a challenge to scientists and clinicians.
- Trial name
- NCT01211418
- Testing
- Integrative Meditation, Supportive Counseling
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Maryland, Baltimore
Substance Use Disorders, Contingency Management
Effectiveness of Contingency Management in the Treatment of Crack Addiction in Brazil
Crack addiction has become a severe public health problem in Brazil. Crack users present elevated prevalence rates of psychiatric comorbidities, sexual transmitted infections and unemployment with high probability of living or…
- Conditions
- Substance Use Disorders, Contingency Management, Addiction, Cocaine
- Trial name
- NCT03345394
- Testing
- Contingency Management, Standard treatment
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- Federal University of São Paulo
Cocaine Addiction
Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving
We propose that the systemic administration of lidocaine following the induction of cue-induced craving, relative to saline plus cue-induced craving or lidocaine without cue-induced craving, will block the reconsolidation of cue…
- Trial name
- LIDO (NCT01929343)
- Testing
- lidocaine following cue-induced craving, lidocaine following neutral stimulus, saline
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Bryon Adinoff
Addiction, Cocaine
Attention Training for Opioid-maintained Cocaine Users
The purpose of this study is to determine the feasibility and preliminary efficacy of attention training using a portable electronic device for opioid-dependent cocaine-users stabilized on methadone.
- Conditions
- Addiction, Cocaine, Methadone, Opiates
- Trial name
- NCT01870882
- Testing
- Attentional retraining, Control condition
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Cocaine Addiction
Effects of tDCS on Craving, Relapse and Cognitive Functions Among Patients With Cocaine Use Disorder
Repetitive bilateral (left cathodal/ right anodal) transcranial Direct Current Stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) reduces craving and seems to decrease relapse risk in addiction.
- Trial name
- NCT03025321
- Testing
- transcranial Direct Current Stimulation (tDCS)
- Where
- Netherlands
- Volunteers
- 59 people
- Sponsor
- Erasmus Medical Center
Addiction, Cocaine-Related Disorders
Benefits of Therapy With Virtual Reality Exposure in the Treatment of Cocaine Use Disorders
Cocaine addiction is a multifactorial disease with important consequences: somatic, psychiatric... The number of applications for treatment for cocaine addiction is gradually increasing from year to year but no conventional…
- Trial name
- CORVI (NCT04280900)
- Testing
- Virtual Reality-Enhanced Cognitive Behavioral Therapy (VR-CBT), Treatment as usual
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cocaine Addiction
Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving
The investigators' recently completed study has provided the first evidence that administration of the medication propranolol, following exposure to cocaine cues, can alter drug-associated memories and reduce craving and other…
- Trial name
- NCT01822587
- Testing
- Propranolol, 40 mg, Propranolol, 80 mg
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Medical University of South Carolina
Hippocampal Neurogenesis in Cocaine Addiction
Hippocampal Neurogenesis in Human Subjects
This study is being done to measure the number of brain cells that grow in the brain throughout our lives while determining an effective way to complete this with an MRI (Magnetic Resonance Imaging) scanner.
- Trial name
- NG (NCT02028273)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Alcoholism, Cocaine Addiction
The Effects of Theta Burst Stimulation on the Brain Response to Drug and Alcohol Cues
High relapse rates among substance dependent individuals are likely due to a combination of factors that involve limbic circuits in the brain involved in craving, including vulnerability to salient cues.
- Conditions
- Alcoholism, Cocaine Addiction, Drug Addiction
- Trial name
- addictionTBS (NCT02939352)
- Testing
- Real continuous Theta Burst Stimulation
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Medical University of South Carolina
Cocaine Addiction, Opiate Addiction
Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study
Background: The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence.
- Trial name
- NCT00292136
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Substance Use Disorders
Transcranial Magnetic Stimulation for Cocaine Addiction
Background: Cocaine use disorders (CUD) is a complex brain disorder, involving several brain areas and neurocircuits. Effective treatments for CUD are still needed.
- Conditions
- Cocaine Dependence, Substance Use Disorders, Chemical Addiction, Mental Disorder
- Trial name
- BRAINSWITCH (NCT03333460)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Recovery Housing and Drug Abuse Treatment Outcome
Reinforcement-Based Therapy (RBT) is an intensive outpatient substance abuse treatment that includes relapse prevention skills training, goal setting, help with finding employment and abstinence-contingent rent payment for…
- Trial name
- NCT03278496
- Testing
- Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Johns Hopkins University
Cocaine Addiction, Cocaine Abuse
Psychology of Reward and Punishment: Functional and Molecular Brain Imaging and Monoaminergic Correlates
Background: Brain imaging studies, genetic research, and investigations of stress have provided more information about the role of dopamine in processing reward and punishment, and in vulnerability to substance dependence.
- Trial name
- NCT00865332
- Where
- 2 sites in United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Addiction
Dexamphetamine Sustained Release Pharmacokinetics and Clinical Validation of Dried Blood Spots
The pharmacokinetics of 10 to 12 individuals receiving 60 mg of sustained release dexamphetamine will be studied. These individuals have received this medication before in a previous trial where the pharmacodynamics were…
- Trial name
- NCT02768441
- Testing
- Dexamphetamine
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute