Clinical trials: Coats Disease
Thalassemia Major
Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients
This study compares the effects of Packed Red Blood Cells (PRBCs) prepared in two different ways on the transfusion indices in beta(ß)-Thalassemia transfusion-dependent patients.
- Trial name
- NCT03992001
- Testing
- Blood component A, Blood component B
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Università degli Studi di Ferrara
Cardiovascular Diseases, Heart Diseases
White Coat Hypertension and Antihypertensive Treatment Effect - SCOR in Hypertension
To investigate the mechanisms of white coat hypertension and study it further as a risk factor for heart damage.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005316
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coat's Disease
Treatment of Congenital Telangiectasia (Coat's Disease) With Open-label Anecortave Acetate (15mg.)
Congenital Telangiectasia or Coat's disease is an uncommon disorder that involves the growth of blood vessels of the macula. These blood vessels msy extend beneth the retina to produce an area of sub-retinal…
- Trial name
- NCT00211315
- Testing
- anecortave acetate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Manhattan Eye, Ear & Throat Hospital
White Coat Hypertension, Hypertension
Virtual Reality as a Tool to Lower Blood Pressure and Anxiety in Clinic Settings
This clinical trial aims to evaluate whether a calming virtual reality (VR) experience can reduce office blood pressure (OBP) and anxiety in adults undergoing ambulatory blood pressure monitoring (ABPM) at Mayo Clinic in Florida.
- Conditions
- White Coat Hypertension, Hypertension, Blood Pressure, Anxiety
- Trial name
- NCT06960057
- Testing
- Virtual Reality Exposure
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Mayo Clinic
Hypertension
Stopping Antihypertensive Treatment amOng Hypertensive Patients in Primary Care (STOP-Trial)
The STOP-Trial is a prospective multicenter nonrandomized open study on grade I hypertension, performed by General practitioners.
- Trial name
- NCT02268071
- Testing
- Antihypertensive treatment will be stopped for 1 year unless hypertension recurrence
- Where
- 24 sites in France
- Volunteers
- 403 people
- Sponsor
- Central Hospital, Nancy, France
Transient Hypertension
Effect of Midazolam on White-coat Hypertensive Dental Patients
Intravenous sedation was used for dealing with transient hypertension, so-called white-coat hypertension, before dental treatment.
- Trial name
- NCT01528371
- Testing
- Midazolam, Normal Saline Solution (NSS)
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Okayama University
Acute Bronchitis
A Phase 4 Clinical Trial to Evaluate the Efficacy and Safety of CANIUM Tab. in Acute Bronchitis Patients.
This study compared two oral medicines containing Pelargonium sidoides extract in patients aged 12 to 75 years with acute bronchitis.
- Trial name
- NCT07835620
- Testing
- DSP2505(Canium), Umckamin
- Where
- 12 sites in South Korea
- Volunteers
- 223 people
- Sponsor
- Dasan Pharmaceutical Co., Ltd.
Bacterial Infections, HIV Infections
Phase I Study of the Clinical Pharmacology of Azithromycin in Buffy Coat of HIV-Infected Subjects.
To compare the uptake of azithromycin in white cells relative to plasma concentrations in HIV-infected patients.
- Trial name
- NCT00002139
- Testing
- Azithromycin
- Where
- United States
- Sponsor
- Pfizer
Coats Disease
Evaluation of Retinal and Vascular Features in Coats Disease After Intravitreal Injections of Ranibizumab
This study evaluates the retinal and vascular features in patients affected by Coats disease under the effects of Ranibizumab intravitreal injections using optical coherence tomography and optical coherence tomography angiography
- Trial name
- NCT04310631
- Testing
- Ranibizumab Injection
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- Federico II University
Coats Disease
Coats Plus Syndrome and LCC Syndrome: Series of 10 Pediatric Cases. Review of Literature and Natural History
Coats plus syndrome is a very rare and serious disease, caused by premature telomere shortening. It is a pediatric, multi-systemic disease, the main features of which are retinal vasculopathy and neurological disorders…
- Trial name
- COATS+ (NCT04089995)
- Testing
- data collection
- Where
- 6 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Limoges
Thrombocytopenia
Pathogen Reduction Evaluation & Predictive Analytical Rating Score
The objective of this study is to determine if pooled buffy coat-derived pathogen reduced plasma-stored platelet concentrates are non-inferior compared to plasma-stored platelet concentrates in terms of WHO bleeding complications…
- Trial name
- PREPAReS (NCT02783313)
- Testing
- Pathogen reduced plasma-stored platelet concentrates, Plasma-stored platelet concentrates
- Where
- 10 sites in Canada, Netherlands and 1 more
- Volunteers
- 567 people
- Sponsor
- Sanquin Research & Blood Bank Divisions
Hypertension, Obesity
Renal Response to Lower Body Negative Pressure in Pre-hypertensive States
The purpose of this study is to determine whether in pre-hypertensive and hypertensive states such as white coat hypertension, obesity related hypertension or resistant hypertension, renal function is more sensitive to…
- Conditions
- Hypertension, Obesity, White Coat Hypertension, Resistant Hypertension
- Trial name
- NCT01734096
- Testing
- Lower body negative pressure (LBNP), Candesartan cilexetil
- Where
- 2 sites in Switzerland
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- PD Dr. Grégoire Wuerzner
Retinal Telangiectasis, Coats Disease
Interest of Intravitreal Injections of Anti-VEGF as Initial and Adjuvant Treatment in Coats Disease
Coats disease is a predominantly unilateral progressive retinal vascular disease, characterized by retinal telangiectasias with intra- or subretinal exudate deposits, which can lead to retinal detachment and one-sided blindness.
- Trial name
- COATS-VEGF (NCT03940690)
- Testing
- Anti-VEGF injections of bevacizumab, Laser
- Where
- 6 sites in France
- Volunteers
- 18 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Hypertension,Essential, White Coat Hypertension
Implementing Hypertension Screening Guidelines in Primary Care
The goal of this study is to use a cluster-randomized design (1:1 ratio) among 8 primary care clinics affiliated with New York-Presbyterian Hospital to test the effectiveness of a theory-informed multifaceted implementation…
- Trial name
- EMBRACE (NCT03480217)
- Testing
- Multifaceted Implementation Strategy, Usual care
- Where
- 2 sites in United States
- Volunteers
- 1,186 people
- Sponsor
- Columbia University
Hypertension, Uncontrolled Hypertension
Use of Automated Office Blood Pressure Monitoring
Blood pressure measurements by three methods Office Blood Pressure Measurement (OBPM), Automated Office Blood Pressure Measurement (AOBPM), and Home Blood Pressure Measurement (HBPM) were collected retrospectively across three…
- Conditions
- Hypertension, Uncontrolled Hypertension, Hypertension, White Coat, Hypertension, Resistant to Conventional Therapy
- Trial name
- NCT05395403
- Testing
- Blood pressure measurement device
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Alabama at Birmingham
NAFLD; Hypertension, White-coat Hypertension, Masked Hypertension
24-h-ambulatory Blood Pressure Monitoring and Pulse Wave Analysis in NAFLD Patients
Evaluation of the individual cardiovascular risk profile of patients with non-alcoholic fatty liver disease (NAFLD) using 24-hour ambulatory long-term blood pressure measurement and pulse wave analysis
- Trial name
- HyperNAFLD (NCT04543721)
- Testing
- 24-h-ABPM
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital of Cologne
Heroin Dependence, Amphetamine Dependence
Mirtazapine as a Treatment for Co-Occurring Opioid and ATS Dependence in Malaysia
The purpose of this study is to evaluate tolerability, acceptability and potential efficacy of 4 months of maintenance treatment with Mirtazapine as compared to placebo for patients with co-occurring amphetamine-type stimulant…
- Trial name
- NCT02541526
- Testing
- Mirtazapine
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Macular Edema Caused by Leber's Miliary Aneurysms
Treatment of Macular Edema Caused by Leber's Miliary Aneurysms Using Intravitreal Aflibercept and Peripheral Laser Photocoagulation
This study evaluates the effectiveness of intravitreal Aflibercept (IVA) injection therapy, combined with peripheral laser photocoagulation, in the treatment of macular edema caused by Leber's miliary aneurysm.
- Trial name
- NCT03908723
- Testing
- Panretinal photocoagulation
- Where
- Egypt
- Volunteers
- 6 people
- Sponsor
- Alexandria University
Coronary Artery Disease
Effect of Paroxetine on COAT-Platelet Production in Normal Volunteers and Patients With Cardiovascular Disease
COAT-platelets stands for collagen and thrombin stimulated platelets, which are two things in the body that make platelets stick together.
- Trial name
- NCT00229528
- Testing
- Paxil-CR
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma