Clinical trials: Closure Technique
Lung Disease, Pulmonary Lobectomy
PleuraSeal Post Market Study (Europe)
To further characterize the PleuraSeal Sealant System as compared to standard of care (sutures and staples only) in subjects undergoing an elective pulmonary lobectomy and segmentectomy via open thoractomy.
- Trial name
- NCT00704171
- Testing
- Standard Tissue Closure Techniques, PleuraSeal Lung Sealant System
- Where
- 9 sites in United States, Austria and 4 more
- Volunteers
- 121 people
- Sponsor
- Integra LifeSciences Corporation
Incisional Hernia After Midline Laparotomy, Quality of Life (QOL)
NoPro - Norwegian Hernia Prophylaxis Study
A multicenter randomized controlled trial comparing midline laparotomy closures using the small-bite suture technique alone to those using the small-bite suture technique with an additional onlay prophylactic polypropylene mesh.
- Conditions
- Incisional Hernia After Midline Laparotomy, Quality of Life (QOL), Burst Abdomen, Surgical Site Infections
- Trial name
- NoPro (NCT06858020)
- Testing
- Prophylactic polypropylene onlay mesh
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Sykehuset Innlandet HF
Ventral Hernia
Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia Repair
A ventral hernia happens when the muscles in the front of your belly become weak and let organs push through, causing a bulge. If it gets worse, intestines can slip into the bulge, leading to serious pain and health problems.
- Trial name
- NCT07226791
- Testing
- AGN-151607-DP
- Where
- 13 sites in United States
- Volunteers
- 200 people
- Sponsor
- AbbVie
Cesarean Section Complications
Knot Burial Technique for Rectus Sheath Closure
Caesarean section is one of the most commonly performed abdominal operations on women in most countries of the world. Its rate has increased markedly in recent years, and is about 20-25% of all child-births in most developed…
- Trial name
- NCT04156282
- Testing
- knot burial technique, classical closure
- Where
- Egypt
- Volunteers
- 358 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Macular Hole Surgery, ILM Peeling
Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologus Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study)
The aim of this study is to compare the functional visual outcomes, anatomical closure rate and macular perfusion changes assessed by OCT and OCTA after surgical repair of macular hole using Tenon capsule graft versus ILM flap.
- Conditions
- Macular Hole Surgery, ILM Peeling, Tenon Capsule, ILM Flap
- Trial name
- NCT07633457
- Testing
- vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)]
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Postoperative Pain
Double Lock Versus Continuous Non-locking Technique for Closure of Rectus Sheath in Cesarean Sections on Post-operative Pain
In this trial we compare the effect of 2 closure techniques of the rectus sheath during cesarean sections on postoperative pain.
- Trial name
- NCT02679365
- Testing
- lower segment cesarean section and double lock closure of rectus sheath, lower segment cesarean section and continuous non-locking closure of rectus sheath
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Pilonidal Sinus
Endoscopic Pilonidal Sinus Treatment (EPSIT) Versus Sinus Laser Closure (SiLaC) Versus Lay Open Technique
Aim of the work To compare Sinus Laser closure versus lay open technique versus Endoscopic pilonidal sinus treatment as regards recurrence rate, operative data, postoperative pain, intra and postoperative complications, healing…
- Trial name
- NCT04418336
- Testing
- Endoscopic Pilonidal sinus treatment (EPSIT) versus Sinus Laser Closure (SiLaC) versus lay open technique
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Incisional Hernia, Malignancy
Risk Factors for Development of Incisional Hernia in Transverse Incisions
RESEARCH PROJECT OBJECTIVES The aim of this planned study is to evaluate factors, with particular reference to surgical technique of abdominal closure, accumulation of advanced glycation end products, and collagen content in the…
- Trial name
- NCT03561727
- Testing
- Mass closure technique, Layered closure technique
- Where
- Poland
- Volunteers
- 392 people
- Sponsor
- Medical University of Warsaw
Wound Healing
Comparison of Two Methods of Securing Skin Grafts Using Negative Pressure Wound Therapy: Vacuum Assisted Closure (VAC) and Gauze Suction (GSUC)
The purpose of this study is to compare how well two methods (VAC and G-SUC) of securing skin grafts using negative pressure wound therapy work.
- Trial name
- NCT00952120
- Testing
- GSUC, VAC
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Cesarean Section Complications, Uterine Bleeding
Surgical Incision Closure Method to Prevent Niche Formation After Cesarean Section- Randomized Controlled Trial
In the last decade we have been exposed to the complication of a caesarean section called a "niche". A niche is an anaerobic defect in the location of the cesarean section, which represents the discontinuity of the endometrium…
- Trial name
- NCT04766073
- Testing
- Niche prevention suture
- Where
- Israel
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Total Hip Replacement, Wound Complication
Hip DAA Closure Techniques
This study aims to analyze the difference in rates of wound complications using two different closure techniques in Direct anterior approach for primary total hip replacement.
- Trial name
- NCT06006572
- Testing
- wound closure subcuticular running stitch using 3-0 monocryl suture without skin adhesive, wound closure subcuticular running stitch using 3-0 monocryl suture with two layers of skin adhesive
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Wound Closure Technique
A Comparison of Polyglactin 910 and Chromic Gut Suture in the Closure of Punch Biopsy Sites
Some Dermatologists prefer absorbable suture to non-absorbable suture in the closure of punch biopsy sites. The reason these are often preferred is because patients do not have to pay for another visit to get the suture material…
- Trial name
- NCT01722994
- Testing
- Polyglactin 910 sterile synthetic absorbable suture (Ethicon), Chromic Gut Sterile absorbable Suture (Ethicon)
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Mississippi Medical Center
Pterygium
Alcohol 20% for Separation of Pterygium and Comparison of Different Wound Closure Methods
Purpose of this study is to evaluate efficiency and safety of Alcohol 20% for peeling pterygium and to compare 3 different methods of operative wound closure: Bare sclera, Sliding flap, Amniotic membrane + biological glue
- Trial name
- NCT00704977
- Testing
- pterygium surgery using alcohol 20% for tissue separation and bare sclera as wound closure technique
- Where
- 2 sites in Israel
- Volunteers
- 150 people
- Sponsor
- Soroka University Medical Center
Surgical Site Infection, Colorectal Cancer
Comparison of Method for Skin Closure in Colorectal Cancer.
Compared to tissue adhesives and skin stapling devices, tissue adhesives are reported to have advantages in terms of wound infection and cost competitiveness.
- Trial name
- NCT06549803
- Testing
- skin bond, skin stapler
- Where
- South Korea
- Volunteers
- 304 people
- Sponsor
- Yoon Suk Lee
Oroantral Fistula, Double Layer
Double-Layer Closure Technique Using Buccal and Palatal Flaps for Oroantral Fistula
A prospective clinical case series was conducted involving twelve patients with oroantral fistulas ≥5 mm in diameter. Closure was performed using split-thickness buccal and palatal mucosal flaps with a subepithelial palatal…
- Trial name
- OAF-DLC (NCT07196566)
- Testing
- Closure was performed using split-thickness buccal and palatal mucosal flaps with a subepithelial palatal connective tissue graft
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Tanta University
Mitral Paravalvular Leaks (PVL)
A Novel Technique for Percutaneous Mitral Paravalvular Leak Closure: LBBAP Lead Assisted Ventricular Septal Way
The investigators will perform closure the mitral paravalvular leak in patient with mechanical aortic and mitral valve.
- Trial name
- NCT07129122
- Testing
- Transventricular access
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Bursa Postgraduate Hospital
Chorioamnionitis, Pregnancy Complications, Infectious
Closure of Skin in ChorioAmnionitis Research Pilot Study
The purpose of the CSCAR pilot study is to improve the design of a full-scale trial by determining the patient recruitment rate and participation rate.
- Conditions
- Chorioamnionitis, Pregnancy Complications, Infectious, Complications; Cesarean Section, Postoperative Complications
- Trial name
- CSCAR (NCT01988168)
- Testing
- Suture closure, Staples closure
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Child Delivery Using an Elective C- Section
Evaluation of the BioWeld1 System as a Method for Surgical Incision Closure
The purpose of this study is to assess the safety and performance of the BioWeld1 System procedure for surgical incision closure of the skin in women scheduled for elective C-section procedure.
- Trial name
- NCT01709240
- Testing
- BioWeld1 System
- Where
- Israel
- Sponsor
- IonMed Ltd
Left Atrail Appendage Closure: Peri-device Leaks
Multimodality Evaluation of LAA Leaks Arising After Incomplete LAAC: Insights From the LAA-Leak Registry
Closure of peri-device leaks (PDL) after incomplete LAAC have shown early feasibility, however no comparison study of all the leak closure modalities exists.
- Trial name
- NCT05131308
- Testing
- leak closure with either detachable embolization coils, vascular plugs/CSO, or RFA
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Total Laparoscopic Hysterectomy, Benign Conditions
Comparison of Two Methods of Vaginal Cuff Closure at Laparoscopic Hysterectomy
American Congress of Obstetricians and Gynecologists (ACOG) advises minimally invasive methods in gynecological surgery to ensure increased benefits to the patient and reduce potential hospitalization costs.
- Trial name
- NCT02293369
- Testing
- Cuff closure via vaginal route, Cuff closure via laparoscopic route
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Istanbul University