Clinical trials: Clinical High Risk for Psychosis
Psychosis
Mentalization Based Treatment (MBT) in Help Seeking Youths With a Clinical High-Risk Condition for Psychosis (CHR-P)
The primary objective of this study is to evaluate the efficacy of Mentalization-Based Treatment (MBT) combined with Need-Based Clinical Interventions (NBCI) compared to NBCI alone, on CHR-P diagnostic statuses and symptom…
- Trial name
- MBT-Psychosis (NCT07093671)
- Testing
- MBT + NBCI
- Where
- Switzerland
- Volunteers
- 212 people
- Sponsor
- Marco Armando
Clinical High-risk Syndrome of Psychosis
RTMS for CHR Based on Personalized Targets Using Magnetoencephalography
This study is an before-after study in the same subject, which enrolled 26 individuals with high-risk psychiatric syndrome (CHR). The target of subjects intervention relies on the results of magnetoencephalography localization.
- Trial name
- NCT06802952
- Testing
- rTMS
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Shanghai Mental Health Center
Clinical High Risk for Psychosis (CHR)
A Multimodal Imaging Study of Dopamine in Early Psychosis
The development of new treatments for psychosis, a psychiatric condition that is prevalent and highly disabling despite antipsychotic medications, has been limited, in part, by a lack of information from brain imaging studies…
- Trial name
- MISDEP (NCT06977308)
- Testing
- Methylphenidate (MPH), [11C]raclopride
- Volunteers
- 115 people
- Sponsor
- New York State Psychiatric Institute
Psychosis, Clinical High Risk for Psychosis
Smartphone Applications Youth With Early Psychosis in Community Outpatient Settings
The project aims to test the utility of implementing a mobile health application ("mhealth app") in early psychosis care in the community outpatient setting and in the university medical center setting.
- Trial name
- BHCOEMobi (NCT03286595)
- Testing
- Mobi mHealth app
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Clinical High Risk Syndrome for Psychosis
PRIME vs Usual Care for Clinical High Risk
The purpose of this study is to determine whether specialty care is superior to usual care in the treatment of patients at clinical high risk for psychosis.
- Trial name
- NCT02960451
- Testing
- PRIME care, Usual care
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Clinical High-risk
Develop a Psychosis Risk Calculator for Chinese Mental Health Servises
This project will use the collected clinical and biological information of high-risk groups, use embedded computer chips, and use big data background analysis system to comprehensively evaluate the risk of high-risk groups, and…
- Trial name
- NCT04509778
- Testing
- routine clinical treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Mental Health Center
Psychosis
Computer-Aided Learning for Managing Stress
The purpose of this study is to learn whether a new family therapy using computer games with biofeedback might help people at clinical high risk for psychosis and their family members learn to experience less stress and have…
- Trial name
- CALMS (NCT02531243)
- Testing
- CALMS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Beth Israel Deaconess Medical Center
Clinical High Risk for Psychosis
Gabapentin in Patients at Clinical Risk for Psychosis
The purpose of this study is to test the effects of the drug gabapentin on brain function thought to be important in the development of schizophrenia.
- Trial name
- NCT02557945
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- New York State Psychiatric Institute
Clinical High Risk for Psychosis (CHR)
Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis
This study aims to evaluate the feasibility and effectiveness of telehealth interventions for individuals at clinical high risk for psychosis (CHR).
- Trial name
- NCT05968560
- Testing
- CBT Skills Group for CHR Youth, Individual CBT sessions, CBT Skills Group for Families
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Psychosis
E-Detection Tool for Emerging Mental Disorders
Psychosis is a severe mental disorder that involves abnormal experiences and altered behaviour. Although the onset of psychosis occurs in young people, most cases will only be identified later in the course of illness.
- Trial name
- ENTER (NCT05127278)
- Where
- 2 sites in United Kingdom
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- King's College London
Mood Disorders, Prodromal Symptoms
MBCT and CBT for Youth at High Risk for Mood and Psychotic Disorders: a Randomized Controlled Trial
The present study is a randomized controlled trial comparing the efficacy and acceptability of CBT and MBCT group-based interventions adapted for young people at elevated risk for mood or psychotic disorder onset or relapse.
- Conditions
- Mood Disorders, Prodromal Symptoms, Bipolar Disorder, Parents
- Trial name
- NCT05070052
- Testing
- cognitive behavioral therapy, mindfulness-based cognitive therapy
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, Los Angeles
Ultra-high Risk for Psychosis, Clinical High Risk for Psychosis
Metacognitive Training in Ultra-high Risk
The aim of this pilot study is to examine whether metacognitive training can improve symptoms, wellbeing and functioning in individuals with attenuated psychotic symptoms.
- Conditions
- Ultra-high Risk for Psychosis, Clinical High Risk for Psychosis, At-risk Mental State
- Trial name
- NCT05827900
- Testing
- Metacognitive Training
- Where
- 2 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Psychosis, Suicide
Youth Nominated Support Team
This study aims to adapt the current Youth-Nominated Support Team (YST) manual used to treat suicide risk for people at clinical high risk for psychosis.
- Conditions
- Psychosis, Suicide, Health Care Utilization, Family Members
- Trial name
- YST (NCT05558332)
- Testing
- Youth-Nominated Support Teams for CHR
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, Irvine
Psychosis, Prodromal Schizophrenia
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk
This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability…
- Conditions
- Psychosis, Prodromal Schizophrenia, Prodromal Symptoms
- Trial name
- SCORES (NCT05131035)
- Testing
- SCORES (Specific COgnitive Remediation with Support)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
Clinical High Risk for Psychosis (CHR)
French Validation of Schizophrenia Proneness Instrument- Child Youth
The clinical concept of a at risk mental state of developing psychosis is based on the identification of attenuated psychotic symptoms during the prodromal phase of psychoses (Schmidt et al., 2015).
- Trial name
- SPI-CY-Fr (NCT06649552)
- Testing
- Psychiatric and psychological diagnostic tests
- Where
- 3 sites in France
- Volunteers
- 52 people
- Sponsor
- Centre Psychothérapique de Nancy
Clinical High Risk for Psychosis (CHR), Psychotic Disorders
Accelerated Neuromodulation Therapy and Neurocomputational Biomarkers in Individuals at Clinical High Risk for Psychosis
The goal of this study is to learn whether an accelerated form of neuromodulation therapy is safe, feasible, and well tolerated in young people at clinical high risk for psychosis (CHR-P), and whether it is associated with…
- Conditions
- Clinical High Risk for Psychosis (CHR), Psychotic Disorders, Prodromal Symptoms
- Trial name
- TMS-CHR (NCT07786714)
- Testing
- Active Intermittent Theta Burst Stimulation (BEAM-F3 Targeting)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Douglas Mental Health University Institute
Prodromal Schizophrenia
Neurofeedback Training for High Risk Psychosis
Young people who are at great risk for developing psychosis have cognitive deficits which are strongly related to functioning in the community.
- Trial name
- NCT03447548
- Testing
- Neurofeedback processing speed training, Active control
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Hartford Hospital
Clinical High Risk for Psychosis
The Predictive Role of Self-representation in Transition of Individuals at Clinical High Risk for Psychosis
Schizophrenia is one of the most consumptive diseases, which brings great loss to patients and their families, and even to the society.
- Trial name
- NCT04444180
- Testing
- Virtual hand illusion (VHI)
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Clinical High Risk for Psychosis (CHR)
Mobile Thinking Intervention: A Inital Test
This study will test the inital efficacy of a brief mobile intervention targeting biased thinking.
- Trial name
- NCT06909422
- Testing
- Mobile Intervention for Biased Thinking
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Clinical High Risk for Psychosis (CHR)
Digital Dialectical Behavioural Therapy (d-DBT) for Youth at Clinical High Risk (CHR) for Psychosis
This study examines the feasibility and acceptability of a digital dialectical behavior therapy (d-DBT) intervention for youth at clinical high risk (CHR) for psychosis.
- Trial name
- NCT06928935
- Testing
- d-DBT
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health