Clinical trials: Clinical High Risk
High Blood Pressure
Immediate Pressor Response to Oral Salt
The goal of this study is to establish a diagnostic accuracy of an immediate pressor response to oral salt (IPROS) to identify salt sensitivity of blood pressure (SSBP)
- Trial name
- IPROS (NCT06226636)
- Testing
- salt
- Where
- 2 sites in Zambia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mulungushi University
Caries, Dental, Risk Reduction
Using a Mouthwash Containing Propolis, Clove Oil and Chlorhexidine to Improve the Caries Risk of High Risk Patients
This study is conducted to determine if using a mouthwash containing propolis, clove oil and chlorhexidine will improve the caries risk of high risk patients in comparison to using a mouthwash containing chlorhexidine only.
- Trial name
- NCT03553628
- Testing
- Chlorhexidine, Propolis and Clove Oil mouthwash, Chlorhexidine mouthwash
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Moataz Gamal Ali Abdul-Maksoud Konsouh
Lung Cancer
Implementing Fragmentomics Into Real World Screening IntervenTions to Evaluate Clinical Utility Among Individuals With Elevated Risk for Lung Cancer
The purpose of this study is to determine whether availability of DNA Evaluation of Fragments for Early Interception (DELFI) Lung Cancer Screening Test, FirstLook™ to practicing physicians affects overall lung cancer screening…
- Trial name
- FIRSTLUNG (NCT06145750)
- Testing
- Ability to order FirstLook™, Continuing Medical Education for Lung Cancer
- Where
- 3 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Delfi Diagnostics Inc.
Suicide Risk Assessment
The Effectiveness of Interactive Discussion Group Intervention About Suicide Risk Identification and Assessment for Clinical Nurses
Suicide attempters or people with self-harm have a high percentage in seeking medical services before and after their suicidal or self-harm behaviour compared to general population.
- Trial name
- NCT02033915
- Testing
- Interactive discussion group
- Where
- Taiwan
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Anemia, Diabetes
A Comparative Clinical Trial of the TensorTip, a Novel Non Invasive Device for Measurement Blood Parameters
1. Aim: The aim of the clinical trial is to study the accuracy of the TensorTip device compared with registered (FDA-approved) invasive and non-invasive devices. 2.
- Conditions
- Anemia, Diabetes, Heart Disease, High Blood Pressure
- Trial name
- NCT01196533
- Testing
- Non invasive peripheral blood monitoring
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Cnoga Medical Ltd.
Medical Education
The Differential Impact of High-Stakes Versus Routine OSCE Stations on Nursing Students' Stress Levels and Clinical Competency: An Experimental Study
Abstract Background: Objective Structured Clinical Examinations (OSCEs) are vital for assessing nursing competence. However, the design of OSCE stations, particularly comparing critical (high-stakes) versus routine (low-stakes)…
- Trial name
- NCT07656506
- Testing
- High-Stake OSCE
- Where
- Iran
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Torbat Heydariyeh University of Medical Sciences
Dental Caries
Preventive Regimens With Herbal and Fluoride Toothpaste on Remineralization in High Caries Patients With Initial Lesions
This study will be conducted to assess the effect of different preventive regimens using herbal toothpaste versus fluoride toothpaste on the management of remineralization and caries risk in high caries risk patients.
- Trial name
- NCT04446390
- Testing
- Himalaya complete care toothpaste, colgate cavity protection
- Where
- 2 sites in Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breastfeeding, Patient Simulation
Comparison of Baby Dolls for Teaching Newborn Positioning and Attachment
In this baby doll comparison study, clinical lactation specialists will complete two back-to-back video-based simulations (telesimulations) focused on newborn positioning and attachment.
- Conditions
- Breastfeeding, Patient Simulation, High Fidelity Simulation Training
- Trial name
- NCT04715724
- Testing
- Positioning and Attachment video-based simulation (telesimulation)
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- LiquidGoldConcept
Venipuncture, Healthy Adult
Clinical Trial to Assess the Effectiveness of Applying Dry Local Heat and/ or High Tourniquet Pressure for Venipuncture.
Low level intervention health products clinical trial, fourth phase, non-commercial research. Dissertation of COMPLUTENSE UNIVERSITY of Madrid. Principal Investigator of this clinical trial: Ms.
- Trial name
- ECYPVEN-H/17 (NCT04027218)
- Testing
- Dry heat, High pressure, Combination of dry heat and high pressure
- Where
- Spain
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Alveolar Ridge Preservation, Tooth Extraction
A 14 Weeks Longitudinal Study to Investigate the Effect of Leukocyte- Platelet Rich Fibrin Plug on the Quality of the Newly Formed Bone in Ridge Preservation Procedure Following a Tooth Extraction. It is a Clinical, Radiographic and Histomorphometric Study.
This 14 weeks longitudinal study will be conducted from March 2018 to June 2020, with a 40 participants. No subjects has received placebo medication at any point in the research procedures.
- Trial name
- NCT03487718
- Testing
- Leukocyte platelet rich fibrin plug + d-PTFE membrane, d-PTFE membrane
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Firas Al Yafi
Cardiovascular Diseases
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of High-dose CKD-385 in Healthy Volunteers(Fed)
This study is a randomized, open-label, fed, single dose, crossover study to investigate the pharmacokinetic profiles and safety of high-dose CKD-385 in healthy volunteers under fed conditions.
- Trial name
- NCT04083846
- Testing
- Reference drug, Test drug 1, Test drug 2
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Viral Hepatitis B, Immunization; Infection
Hepatitis B Virus Vaccination in HIV-positive Patients and Individuals at High Risk for HIV Infection
The primary aim of this open-label, randomized control trial is to compare the immunogenicity at week 28 after 20µg HBV vaccine (at week 0, 4, 24) versus 40µg HBV vaccine (40-µg at week 0, 4, 24 week) among HIV-positive patients…
- Conditions
- Viral Hepatitis B, Immunization; Infection, HIV Infections
- Trial name
- NCT03854630
- Testing
- Engerix-B
- Where
- Taiwan
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
HIV Preexposure Prophylaxis
Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024)
The main purpose of the study is to evaluate the safety and tolerability of oral Islatravir (ISL) once monthly (QM) as Preexposure Prophylaxis (PrEP) in cisgender men who have sex with men (MSM) and transgender women (TGW) who…
- Trial name
- Impower-024 (NCT04652700)
- Testing
- ISL, FTC/TDF, FTC/TAF
- Where
- 25 sites in United States, Brazil and 5 more
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Osteoporosis
Artificial Intelligence-Guided Diagnosis for High-Risk Osteoporosis Populations: A Pragmatic Randomized Clinical Trial
Project Summary I. Project Objectives With the rapid advancement of medical technology, smart medical devices have become one of the key components of modern healthcare.
- Trial name
- NCT07620834
- Testing
- VeriOsteo OP
- Where
- 3 sites in Taiwan
- Volunteers
- 1,180 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Dental Implant Failed
Autogenous Particles Harvesting During Implant Surgery
The aim was to compare the osteoblast activity and osteogenic potential of autogenous bone particles harvested using three different techniques, determine the most advantageous method of collecting autogenous bone particles.
- Trial name
- NCT06240416
- Testing
- Low speed drilling without irrigation, High speed drilling with irrigation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Human Papilloma Virus Infection
Clinical Evaluation of the APTIMA® HPV Assay and Comparison With the HR HC2® Test Using LBC ThinPrep® Specimens
To assess and compare the performance of the HR HPV HC2® test (Qiagen/Digene) and the APTIMA® HPV Assay (Hologic) using LBC Specimens (ThinPrep® Pap Test) for the detection of HPV infection and high-grade CIN lesions in a…
- Trial name
- NCT02634190
- Testing
- Thinprep® LBC, APTIMA® HPV Assay, HR HC2® HPV DNA
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Hologic Deutschland GmbH
Colorectal Adenoma, Colorectal Polyp
To Compare Artificial Intelligence Software Aided Adenoma Detection in Screening Colonoscopies Versus Standard Colonoscopy Without Artificial Intelligence Software Assistance in Participants Between 45 and 75 Years of Age
The aim of this study is to assess the efficacy of Ultivision Artificial Intelligence (AI) Software in detecting adenomas in screening colonoscopy procedures. The safety of Ultivision AI Software will also be assessed.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colorectal Adenocarcinoma, Colorectal SSA
- Trial name
- AIDA (NCT04196088)
- Testing
- Ultivision Artificial Intelligence Software, No Artificial Intelligence Software enhancement
- Where
- 9 sites in United States
- Volunteers
- 978 people, healthy volunteers welcome
- Sponsor
- Docbot, Inc.
Psychosis, First Episode Psychosis
Feasibility of an Early Detection Program for Early Psychosis on a College Campus
The objective of the proposed study is to determine the feasibility of an Early Detection program that aims to: (i) identify college students at clinical high risk (CHR) of psychosis or with first episode psychosis (FEP), and…
- Conditions
- Psychosis, First Episode Psychosis, Clinical High Risk for Psychosis
- Trial name
- NCT03983421
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Atrial Fibrillation (AF)
Energy Dose and Cardioversion Outcomes in AF
This multicenter, randomized study will compare two electrical cardioversion energy strategies in adults with atrial fibrillation who are scheduled to undergo cardioversion during atrial fibrillation ablation or within 3 months…
- Trial name
- LE-HI-CV (NCT07884253)
- Testing
- Synchronized Electrical Cardioversion With Different Energy Strategies, Conventional Step-Up Energy Cardioversion
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
High Caries Risk Patients
Assessment of Inhibition of Biofilm Formation and Plaque Bacterial Count of Fluoride Varnish Containing Chlorhexidine and Cetylpyridinium Chloride Versus Conventional Fluoride Varnish
Two different Fluoride varnish systems(Fluoride varnish containing Chlorhexidine and Cetylpyridinium Chloride (CPC) and conventional fluoride) will be applied to high caries risk patients to assess their clinical effects on…
- Trial name
- NCT04254835
- Testing
- Cervitec F, Ivoclar Vivadent - Schaan Liechtenstein, Fluor Protector, Ivoclar Vivadent - Schaan Liechtenstein
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University