Clinical trials: Clinical Deterioration, open to volunteers
Sepsis, Deterioration, Clinical
Hospital-Onset Sepsis Systematic Detection and Structured Interventions
Sepsis is a life-threatening reaction to an infection. It can begin while a person is already in the hospital for some other reason. Sepsis that starts in the hospital is often recognized late, and treatment can be delayed.
- Conditions
- Sepsis, Deterioration, Clinical, Critical Illness, Early Warning Score
- Trial name
- CATCH SEPSIS (NCT07804251)
- Testing
- Algorithm-triggered sepsis alert with structured critical care team activation
- Where
- United States
- Volunteers
- 3,700 people
- Sponsor
- Patricks Lyons
Acute Ischemic Stroke, Cerebral Infarction
Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT)
Stroke is the second leading cause of death worldwide, and ischemic stroke is the most frequent type. Intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 hours of symptom onset is the most effective…
- Trial name
- TREND-IVT (NCT06548971)
- Testing
- Aspirin, Best medical management
- Where
- 119 sites in China
- Volunteers
- 1,184 people
- Sponsor
- Capital Medical University
Patient Deterioration, Patient Monitoring
Wireless Assessment of Respiratory and Circulatory Distress - Europe
Hospital patient monitoring in Europe is often intermittent, which can delay detection of clinical deterioration during hospitalization and after discharge.
- Conditions
- Patient Deterioration, Patient Monitoring, Clinical Deterioration
- Trial name
- WARD-EU (NCT07451249)
- Testing
- WARD-CSS (Wireless Assessment of Respiratory and Circulatory Distress - Clinical Support System)
- Where
- 5 sites in Denmark, Netherlands and 2 more
- Volunteers
- 1,240 people, healthy volunteers welcome
- Sponsor
- Eske Kvanner Aasvang
Deterioration, Clinical
The Orientation Intervention to Rapid Response Teams (ORIENT-RRT) Study: A Quasi-Experimental Study
This study will measure knowledge, confidence, and nursing practice outcomes related to the effectiveness and feasibility of a 12-hour educational clinical intervention for NGNs during orientation.
- Trial name
- The ORIENT-RRT (NCT07897851)
- Testing
- Orientation day with rapid response nurse
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Respiratory Monitoring
Respiratory OBservation Using Ultra-Sensitive nanoTechnology
The Problem - About one in three patients get even more sick while they are in hospital. This often happens because of chest infections, sepsis (very serious infection), or heart problems.
- Trial name
- ROBUST (NCT07650539)
- Testing
- Nanotechnology respiratory monitor
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- University College, London
Clinical Reasoning in Nursing Education, Virtual Simulation
MAGICS - Multi-Agent Generative AI in Clinical Simulation for Clinical Deterioration Training
This study compares the effectiveness of a Generative AI-integrated blended simulation programme and high-fidelity simulation alone on nursing students' clinical reasoning and learning experience during deterioration training
- Conditions
- Clinical Reasoning in Nursing Education, Virtual Simulation, Artificial Intelligence in Education, Deterioration, Clinical
- Trial name
- MAGICS (NCT07872735)
- Testing
- Generative AI-integrated Blended Simulation, High Fidelity Simulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Clinical Deterioration
Multicomponent Exercise to Prevent Hospitalization-Associated Disability
The study is a randomized controlled trial conducted in the Geriatrics Department of a tertiary hospital in Spain (Hospital Universitario de Navarra).
- Trial name
- FIS_Prevention (NCT07707310)
- Testing
- Behavioral: Exercise
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Aortic Valve Stenosis, Structural Valve Deterioration
Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication
The VIVALL-2 study is a randomized trial to compare the self-expandable supra-annular Allegra and the balloon-expandable intra-annular Edwards transcatheter valve systems in patients with degenerated biological aortic surgical…
- Trial name
- NCT06049654
- Testing
- NVT ALLEGRA TAVI System TF, EDWARDS SAPIEN 3 or SAPIEN ULTRA SYSTEM
- Where
- 12 sites in Italy, Spain and 1 more
- Volunteers
- 104 people
- Sponsor
- Fundación EPIC
Clinical Deterioration
Predicting ICU Transfers and Other Unforeseen Events (PICTURE)-Pediatric
The purpose of this study is to evaluate the effectiveness and user satisfaction of the study teams early warning system, called PICTURE, which utilizes artificial intelligence (AI) techniques and algorithms to identify patient…
- Trial name
- NCT07304050
- Testing
- PICTURE-Pediatric scores and alerts, Control Arm - Scores and alerts hidden
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- University of Michigan
Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute
Repeated Examinations for Typing Pulmonary Embolism
PURPOSE The two related purposes of the RE-TyPE study are: 1. To improve understanding of the early clinical course of intermediate-high risk pulmonary embolism and its association with outcome and 2.
- Conditions
- Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute, Pulmonary Embolism With Acute Cor Pulmonale, Pulmonary Embolism With Right Ventricle Enlargement
- Trial name
- RE-TyPE (NCT07491094)
- Where
- 3 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Sahlgrenska University Hospital
Pulmonary Embolism and Thrombosis, Deterioration, Clinical
Adverse Outcome of Acute Pulmonary Embolism by Artificial Intelligence System Based on CT Pulmonary Angiography
The investigators aim to build a predictive tool for Adverse Outcome of Acute Pulmonary Embolism by Artificial Intelligence System Based on CT Pulmonary Angiography.
- Conditions
- Pulmonary Embolism and Thrombosis, Deterioration, Clinical, Artificial Intelligence
- Trial name
- PEAICTPA (NCT05482269)
- Testing
- no intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shengjing Hospital
Branch Atheromatous Disease, Cognitive
Cognitive Outcomes in BAD-related Stroke
Branch atheromatous disease (BAD) is a distinct subtype of ischemic stroke that is particularly prevalent among Chinese and other Asian populations.
- Conditions
- Branch Atheromatous Disease, Cognitive, Deterioration, Clinical
- Trial name
- NCT07761182
- Testing
- END exposure
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Inpatient Facililty Diagnoses
Wireless Monitoring for Clinical Deterioration
The study evaluates whether implementing a wireless monitoring system for patients admitted to hospital wards reduces mortality and cardiopulmonary failure.
- Trial name
- i-PROTECT (NCT06644599)
- Testing
- wireless monitoring
- Where
- Saudi Arabia
- Volunteers
- 13,160 people
- Sponsor
- King Abdullah International Medical Research Center
Acute Ischemic Stroke
MRSI Evaluation for Minor Stroke With Large Vessel Occlusion
The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke (LVO-MIS) evolution using magnetic resonance spectroscopic imaging evaluation.
- Trial name
- MINORITY (NCT06457217)
- Testing
- Magnetic resonance spectroscopic imaging
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Shanghai 6th People's Hospital
Postoperative Care, Deterioration, Clinical
Optimized Novel Wireless Assessment of Respiratory and Circulatory Dirstress - Alarm Validation
The ONWARD study evaluates user experiences from continuous vital sign monitoring alarms sent to the clinical staff in case of deviating vital signs at the general hospital ward.
- Trial name
- ONWARD - AV (NCT07649642)
- Testing
- Continuous vital sign monitoring
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Eske Kvanner Aasvang
Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke
Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)
Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor…
- Conditions
- Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke, Acute Ischemic Stroke, Cardioembolic Stroke
- Trial name
- NCT07013396
- Testing
- Transcranial Doppler (TCD) examination
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Sepsis, Patient Deterioration
UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial
This study is designed to test two new risk scores - one designed to predict a patient's four-hour risk of developing sepsis and one designed to predict a patient's four-hour risk of deterioration (cardiac arrest, death…
- Trial name
- NCT06779617
- Testing
- SEPSys, RESCUE
- Where
- 8 sites in United States
- Volunteers
- 150,000 people
- Sponsor
- University of Maryland, Baltimore
Acute Disease, Disease Progression
Multimodal Digital Biomarker Prediction of Acute Clinical Deterioration
Rather than relying on a single abnormal vital sign, the study will examine how multiple physiologic signals change together over time and whether changes in the relationships among these signals provide useful information about…
- Conditions
- Acute Disease, Disease Progression, Critical Illness, Biomarkers
- Trial name
- FUSION-72 (NCT07817550)
- Testing
- Multimodal Digital Biomarker Monitoring
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Truway Health, Inc.
Nursing Homes Residents, Deterioration, Clinical
Clinical Assessment and Treatment in the Nursing Home as an Alternative to Hospital Admission
This multicenter, cluster-randomized, unblinded quality-improvement study evaluates whether home-based clinical assessment by municipal acute care teams can safely reduce hospital admissions among nursing home residents…
- Conditions
- Nursing Homes Residents, Deterioration, Clinical, Infection, Dehydration
- Trial name
- NCT07756554
- Testing
- Home-based Clinical Assessment and Treatment
- Where
- 4 sites in Denmark
- Volunteers
- 9,000 people
- Sponsor
- Copenhagen University Hospital at Herlev
Pulmonary Embolism and Thrombosis, Deterioration, Clinical
A Predictive Tool for Predicting Adverse Outcomes in Acute Pulmonary Embolism Patients Using CTPA.
This study collected clinical, laboratory, and CT parameters of acute patients with acute pulmonary embolism from admission to predict adverse outcomes within 30 days after admission into hospital.
- Trial name
- NCT05098769
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital