Clinical trials: Clinical Deterioration
Multiple Trauma, Polytrauma
Development and Internal Validation of a Multimodal Prediction Score for Early Hemodynamic Deterioration in Adult Polytrauma Patients
Severe traumatic injury involving multiple body regions (polytrauma) carries a high risk of rapid bleeding, tissue hypoperfusion, and circulatory collapse.
- Conditions
- Multiple Trauma, Polytrauma, Hemodynamic Instability, Traumatic Shock
- Trial name
- NCT07850427
- Volunteers
- 300 people
- Sponsor
- Assiut University
Early Clinical Deterioration
Early Warning Systems, Risk of Early Clinical Deterioration
Primary purpose of the study was to evaluate the relationship between "NEWS" and "VIEWS" scores of patients who were screened retrospectively, early clinical deterioration, return to intensive care and morbidity / mortality.
- Trial name
- NCT03912701
- Testing
- Vitalpac early warning score (VIEWS)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Erzincan University
Nursing Homes Residents, Deterioration, Clinical
Clinical Assessment and Treatment in the Nursing Home as an Alternative to Hospital Admission
This multicenter, cluster-randomized, unblinded quality-improvement study evaluates whether home-based clinical assessment by municipal acute care teams can safely reduce hospital admissions among nursing home residents…
- Conditions
- Nursing Homes Residents, Deterioration, Clinical, Infection, Dehydration
- Trial name
- NCT07756554
- Testing
- Home-based Clinical Assessment and Treatment
- Where
- 4 sites in Denmark
- Volunteers
- 9,000 people
- Sponsor
- Copenhagen University Hospital at Herlev
Sepsis, Deterioration, Clinical
Hospital-Onset Sepsis Systematic Detection and Structured Interventions
Sepsis is a life-threatening reaction to an infection. It can begin while a person is already in the hospital for some other reason. Sepsis that starts in the hospital is often recognized late, and treatment can be delayed.
- Conditions
- Sepsis, Deterioration, Clinical, Critical Illness, Early Warning Score
- Trial name
- CATCH SEPSIS (NCT07804251)
- Testing
- Algorithm-triggered sepsis alert with structured critical care team activation
- Where
- United States
- Volunteers
- 3,700 people
- Sponsor
- Patricks Lyons
Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke
Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)
Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor…
- Conditions
- Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke, Acute Ischemic Stroke, Cardioembolic Stroke
- Trial name
- NCT07013396
- Testing
- Transcranial Doppler (TCD) examination
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Emergency Medicine
Development and Evaluation of a Patient Safety Model
Despite systems for early detection of critical illness, 12% of patients in the emergency department develop clinical deterioration with an increased risk of death as a result.
- Trial name
- NCT03457272
- Testing
- New risk assessment
- Where
- 4 sites in Denmark
- Volunteers
- 34,556 people
- Sponsor
- University of Aarhus
Vital Signs, Clinical Deterioration
Image-based Remote Monitoring in Cardiac Surgery Patients
In this observational study, 100 patients admitted to the Cardiothoracic ward will be additionally monitored with video-cameras. The video-cameras will measure heart- and respiration rate continuously.
- Trial name
- FORSEE-3 (NCT06099327)
- Testing
- Image-based vital sign monitoring
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Postoperative Care, Deterioration, Clinical
Optimized Novel Wireless Assessment of Respiratory and Circulatory Dirstress - Alarm Validation
The ONWARD study evaluates user experiences from continuous vital sign monitoring alarms sent to the clinical staff in case of deviating vital signs at the general hospital ward.
- Trial name
- ONWARD - AV (NCT07649642)
- Testing
- Continuous vital sign monitoring
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Eske Kvanner Aasvang
Early Warning Score, Risk Stratification
Individual Early Warning Score (I-EWS)
Early Warning Score (EWS) is a clinical scoring system used in hospitals in Denmark and internationally to systematically observe admitted patients using a standardised response algorithm.
- Trial name
- NCT03690128
- Testing
- I-EWS with incorporated clinical assessment (Trigger Tool), Standard EWS - Control (Trigger Tool)
- Where
- 8 sites in Denmark
- Volunteers
- 150,000 people
- Sponsor
- Herlev Hospital
Alert Fatigue, Health Personnel, Deterioration, Clinical
Automated Alerts of Patient Deterioration vs. Routine Monitoring of High-risk Patients Admitted to Medical Wards
The primary aim of the current study is to assess the effect of continuous wireless vital signs monitoring with generation of real-time alerts compared to blinded monitoring without alerts on the cumulative duration of any…
- Trial name
- WARD (NCT04661748)
- Testing
- real time alarm of deviating vital signs
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Sepsis, Deterioration, Clinical
Outcomes of Digital Alerting Systems in Secondary Care
Why? The investigators are trying to find out if participants that suddenly deteriorate on the ward can be identified sooner by wearing a wearable sensor.
- Trial name
- NCT04638738
- Testing
- SensiumVitals wearable patch sensor
- Where
- United Kingdom
- Volunteers
- 650 people
- Sponsor
- Imperial College London
Clinical Deterioration, Hospital Medicine
Realtime Streaming Clinical Use Engine for Medical Escalation
The escalation of care for patients in a hospitalized setting between nurse practitioner managed services, teaching services, step-down units, and intensive care units is critical for appropriate care for any patient.
- Conditions
- Clinical Deterioration, Hospital Medicine, Monitoring, Physiologic
- Trial name
- ReSCUE-ME (NCT04026555)
- Testing
- MEWS++ Monitoring, Predictor Score
- Where
- United States
- Volunteers
- 2,780 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
COVID-19 Disease
A Phase II Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Exosomes Overexpressing CD24 to Prevent Clinical Deterioration in Patients With Moderate or Severe COVID-19 Infection
A Phase II Randomized, double-blind, Placebo-controlled Study to Evaluate the safety and efficacy of exosomes overexpressing CD24 to prevent clinical deterioration .The study population will include patients with moderate or…
- Trial name
- NCT04969172
- Testing
- Exosomes overexpressing CD24
- Where
- Israel
- Volunteers
- 155 people
- Sponsor
- Eli Sprecher, MD
Escalation of Care, Cardiopulmonary Arrest
Early Warning System for Clinical Deterioration on General Hospital Wards
The goal is to develop a two-tiered monitoring system to improve the care of patients at risk for clinical deterioration on general hospital wards (GHWs) at Barnes-Jewish Hospital (BJH).
- Conditions
- Escalation of Care, Cardiopulmonary Arrest, Respiratory Arrest, Severe Sepsis
- Trial name
- NCT01280942
- Testing
- EWS Nursing Alerts, Wireless Remote Sensor
- Where
- United States
- Volunteers
- 20,031 people
- Sponsor
- Washington University School of Medicine
In-hospital Deterioration, Intra Hospital Cardiac Arrest
Correlation Between Monitoring Frequency and Clinical Deterioration in Hospitalized Patients
Acute deterioration among hospitalised patient can result in serious adverse events like cardiac arrest, unexpected death or unanticipated intensive care unit (ICU) admission.
- Conditions
- In-hospital Deterioration, Intra Hospital Cardiac Arrest, Sudden Death
- Trial name
- NCT02180854
- Testing
- Control group, Increased monitoring frequency
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Bispebjerg Hospital
Simulation
Serious Game Versus Traditional Teaching to Improve Clinical Reasoning Skills
Detection of patient deterioration is a major healthcare problem. Indeed, acute clinical deterioration of the patient is often preceded by changes of several physiological parameters within 6 to 24h before the event occurs.
- Trial name
- NCT03428269
- Testing
- simulation by gaming (LabForGames Warning), traditional education
- Where
- 4 sites in France
- Volunteers
- 146 people
- Sponsor
- Université Paris-Sud
Mortality, Clinical Deterioration
EWSs and 28-Day Mortality in Geriatric ED Patients
This prospective observational cohort study evaluated the prognostic performance of commonly used early warning scores for predicting 28-day all-cause mortality among geriatric patients presenting to the emergency department with…
- Conditions
- Mortality, Clinical Deterioration, Geriatric Patients, Frailty
- Trial name
- EWSsGer (NCT07577349)
- Testing
- Demographic Characteristics, Comorbidities, Vital Signs
- Where
- Turkey (Türkiye)
- Volunteers
- 2,744 people
- Sponsor
- Haseki Training and Research Hospital
Early Warning Score, Monitoring
Observational Study Evaluating the viQtor for Early Detection of Clinical Deterioration in Post-ICU Patients on General Wards
Rationale Following ICU discharge, intermittent vital sign monitoring may delay timely recognition of clinical deterioration and lead to unnecessary readmissions.
- Conditions
- Early Warning Score, Monitoring, Telemedicine-Based Education, Readmission
- Trial name
- ViQtor (NCT06815718)
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Erasmus Medical Center
Respiratory Depression, Respiratory Failure
VitalThings Guardian Contactless Monitoring
This is a confirmatory study without any intervention. It is an uncontrolled, non-randomized and open-label study with measurements made with comparators, and it has a preset hypothesis for the primary endpoint.
- Conditions
- Respiratory Depression, Respiratory Failure, Deterioration, Clinical
- Trial name
- VINCENT (NCT06083272)
- Testing
- Vitalthings Guardian M10 fixed and M10 mobile
- Where
- Norway
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- VitalThings
Respiratory Monitoring
Respiratory OBservation Using Ultra-Sensitive nanoTechnology
The Problem - About one in three patients get even more sick while they are in hospital. This often happens because of chest infections, sepsis (very serious infection), or heart problems.
- Trial name
- ROBUST (NCT07650539)
- Testing
- Nanotechnology respiratory monitor
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- University College, London