Clinical trials: Clinical Classification
Sickle Cell Disorders
GenoMed4ALL: Improving SCD Classification and Prognosis by AI
GenoMed4All 'Genomics and Personalized Medicine for all though Artificial Intelligence in Haematological Diseases' aims to advance on individual SCD patients' disease characterisation and to improve the monitoring of patients'…
- Trial name
- GenoMed4ALL (NCT06019208)
- Where
- 5 sites in France, Italy and 2 more
- Volunteers
- 1,000 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Choledochal Cyst
Biliary Dilatation National Special Disease Cohort in China
This study is a multicenter, bidirectional cohort study aimed at continuously enrolling patients with biliary dilatation from 25 medical centers in China.
- Trial name
- NCT06881004
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Blood Cancer
Clinical Evaluation of the Scopio Cell Morphology Technology
Digital morphology is currently expanding and developing new applications based on artificial intelligence software. We recently published a study comparing screen validation and microscopic reading of bone marrow aspirates.
- Trial name
- Hemascopio (NCT06574308)
- Testing
- Blood cells classification
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Squamous Cell Carcinoma of the Cervix, Adenocarcinoma of the Cervix
Concurrent Treatment of Squamous Cell Carcinoma or Adenocarcinoma of the Cervix With CIGB-300 for Local Application
They include patients who are candidates to complete concurrent treatment with endocavitary brachytherapy External radiation therapy + more QT based weekly cisplatin.
- Trial name
- NCT01639625
- Testing
- CIGB300
- Where
- Argentina
- Volunteers
- 18 people
- Sponsor
- Laboratorio Elea Phoenix S.A.
Pneumonia; Pulmonary Infection
A Multicenter Randomized Trial of CT-Based AI Decision Support for Early Pneumonia Care
Adults hospitalized with pneumonia who need new or increased oxygen support or have defined immunocompromise will be assigned to usual care with or without access to a CT-based AI report.
- Trial name
- NCT07895290
- Testing
- CT-Based AI Decision Support for Pneumonia
- Where
- China
- Volunteers
- 4,800 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hypertension, Pulmonary
Evaluate the Efficacy, Safety and Pharmacokinetics of GSK1325760A in the Treatment of Pulmonary Arterial Hypertension
The primary objective of this study is to evaluate the effect of GSK1325760A on improvement in exercise capacity in subjects with pulmonary arterial hypertension (PAH).
- Trial name
- NCT00540436
- Testing
- GSK1325760A
- Where
- 15 sites in Japan
- Volunteers
- 25 people
- Sponsor
- GlaxoSmithKline
Asthma
Letters in Addition to Emailed Audit and Feedback in Refining Asthma Treatment in Primary Care
Public Health England have estimated that 36,000 excess deaths occur each year due to UK air pollution. Respiratory inhalers produce 3% of NHS greenhouse gas production.
- Trial name
- CLEARAIR (NCT05761873)
- Testing
- Provision of audit and feedback via email and paper, Provision of audit and feedback via paper only
- Where
- United Kingdom
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Low Back Pain
The Derivation of a Clinical Prediction Rule to Identify Those With Low Back Pain Who Will Respond Favorably to Intramuscular Dry-needling
The purpose of this study is to investigate specific clinical characteristics, amongst those with low back pain, that identify patient appropriateness for Intermuscular Dry-Needling (IMDN) and to develop a prediction tool that…
- Trial name
- NCT06204055
- Testing
- Intramuscular Dry-Needling
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Whitworth University
Oral Cancer, Oral Lichen Planus
Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis
This study aims to develop an AI program that can classify oral findings into Normal/variation of normal or an oral disease by clinical photos analysis, aiding in lowering the percentages of false positive and false negative…
- Conditions
- Oral Cancer, Oral Lichen Planus, Fordyce Granule, Leukoplakia
- Trial name
- NCT06325514
- Testing
- Artificial intelligence based program
- Where
- Egypt
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mechanical Ventilation, Patient-Ventilator Asynchrony
Patient-Ventilator Asynchrony: Occurence and Clinical Impact in Usual Care
The goal of this observational study is to unravel the occurence, impact and relations of Patient-Ventilator Aynchrony (PVA) in mechanically ventilated patients.
- Trial name
- PVA-detection (NCT07624786)
- Testing
- PVA classification software
- Where
- 3 sites in Netherlands
- Volunteers
- 110 people
- Sponsor
- Erasmus Medical Center
Rheumatoid Arthritis
Good EULAR Response In Patients With Early Rheumatoid Arthritis
This open-label, prospective, observational study will evaluate the clinical response to etanercept + methotrexate therapy in patients with moderate to severe rheumatoid arthritis, as prescribed by the rheumatologist in a normal…
- Trial name
- EARLY RA (NCT01558089)
- Testing
- etanercept, methotrexate
- Where
- 9 sites in Greece
- Volunteers
- 76 people
- Sponsor
- Pfizer
IgA Nephropathy
Oxford Classification and Clinical Remission After Initial Treatments in Patients With IgA Nephropathy
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis and one of the leading causes of end-stage renal disease in China.
- Trial name
- NCT05528991
- Where
- China
- Volunteers
- 474 people
- Sponsor
- Shenzhen Second People's Hospital
Systemic Sclerosis (SSc), Systemic Sclerosis
C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy, in Participants With Systemic Sclerosis (SSc) Refractory to Standard Therapy
This Phase 1b, multicenter, open-label study will evaluate the safety and efficacy of a single infusion of autologous anti-CD20/BCMA chimeric antigen receptor T cells (C-CAR168) following lymphodepleting chemotherapy in…
- Conditions
- Systemic Sclerosis (SSc), Systemic Sclerosis, Systemic Sclerosis (Scleroderma), Systemic Sclerosis - 2013 ACR/EULAR Classification Criteria
- Trial name
- NCT07854483
- Testing
- C-CAR168
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- AbelZeta Inc.
Colonic Polyps
Diagnostic Accuracy of NICE Classification to Predict Deep Submucosal Invasion
The purpose of this study is to evaluate the diagnostic accuracy of NICE classification to predict deep submucosal invasion of colonic polyps > 1 cm, considering histology as the gold standard, in a group of endoscopists who…
- Trial name
- NICE (NCT02328066)
- Testing
- NBI used by trained endoscopists
- Where
- Spain
- Volunteers
- 2,171 people
- Sponsor
- Asociación Española de Gastroenterología
Clinical Decision-Making, Decision Making, Computer-assisted
A Study to the Impact of Accuracy Problem Lists in Electronic Health Records on Correctness and Speed of Clinical Decision-making Performed by Dutch Healthcare Providers
The primary objective of this study is to determine whether patient records with complete, structured and up-to-date problem lists ('accurate problem lists'), result in better clinical decision-making, compared to patient records…
- Conditions
- Clinical Decision-Making, Decision Making, Computer-assisted, Medical Records, Problem-Oriented, Quality of Health Care
- Trial name
- ADAM's APPLE (NCT05657002)
- Testing
- patient A with accurate problem list, patient B with inaccurate problem list, patient A with inaccurate problem list
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Eva Klappe
Obesity (BMI > 35), Difficult Airway
Ultrasound vs Clinical Parameters for Difficult Airway Prediction in Obesity
Obesity is associated with anatomical changes in the upper airway that increase the risk of difficult laryngoscopy and difficult mask ventilation during anesthesia.
- Conditions
- Obesity (BMI > 35), Difficult Airway, Difficult Airway Intubation, Difficult Mask Ventilation
- Trial name
- NCT07528677
- Testing
- Airway Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Heart Failure, Heart Failure NYHA Class III
Clinical Study to Evaluate the Predictive Value of the Heart Failure Questionnaire (HF-Q) for the Occurrence of Μajor Αdverse Cardiovascular Events (MACE) in Patients With Symptomatic Heart Failure
Cardiac Heart Failure Questionnaire HF-Q) to assess the severity of the symptoms of Heart Failure. In this study, modified and translated, the "four-point" questionnaire by Severo and his associates - Heart Failure Questionnaire…
- Conditions
- Heart Failure, Heart Failure NYHA Class III, Heart Failure NYHA Class II, Heart Failure NYHA Class IV
- Trial name
- THETIS (NCT03947853)
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Congenital Cataract
Congenital Cataract Morphological Classifications
Photography is considered as one of the most important means to promote evidence-based medical practice in pediatric ophthalmology.This study is to investigate the feasibility of congenital cataract morphological classifications…
- Trial name
- NCT02748031
- Testing
- slit-lamp-adapted anterior segmental photography
- Where
- China
- Volunteers
- 1,050 people
- Sponsor
- Sun Yat-sen University
Ulcerative Colitis
The Diversity of the Fungal and Bacterial in Colon Mucosa of Patients With Different Degree of Inflammation of Ulcerative Colitis
We analyzed the diversity of the fungal and bacterial within colon mucosa between patients with different degree of inflammation of Ulcerative Colitis.
- Trial name
- NCT03151850
- Testing
- ulcerative colitis, Control
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Xiuli Zuo
Myelodysplastic Syndrome
5-Azacitidine in Low-risk Myelodysplastic Syndromes (MDSs)
Azacitidine will be given at a dose of 75 mg/sqm (s.c) daily for 5 consecutive days every 28 days (every month) for a total of 8 courses to low risk MDSs according to IPSS scoring system.
- Trial name
- MDSAZA0706 (NCT00897130)
- Testing
- Azacytidine
- Where
- 7 sites in Italy
- Volunteers
- 28 people
- Sponsor
- Università degli Studi di Brescia