Clinical trials: Cleft Palate, active
Cleft Palate, Cleft Lip and Palate
Book Sharing for Toddlers With Clefts
Children with clefts exhibit difficulty with language and literacy compared to children without clefts. However, little is known about interventions to address these difficulties in the cleft population.
- Trial name
- BOOST (NCT06338319)
- Testing
- Book-Sharing for Toddlers with Clefts (BOOST)
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Seattle Children's Hospital
Cleft Lip and Palate
Test-Retest Reliability, Responsiveness and Interpretability of CLEFT-Q
The goal of this observational study is to test the questionnaire CLEFT-Q in a population of patients with cleft lip and/or palate. The main questions it aims to answer are: 1. Are CLEFT-Q scores reliable over time? 2.
- Trial name
- CLEFT-QSwePsyc (NCT05775679)
- Where
- Sweden
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Department of Plastic and Reconstructive Surgery
Maxillary Deficiency, Cleft Lip and Palate
Evaluation of Maxillary Expansion Using Clear Aligners' Therapy in Patients With Cleft Lip and Palate at the Mixed Dentition Stage
The goal of this clinical trial is to learn if the aligners can expand upper dental arch in patients with cleft lip and palate at age of 6-8 years old to correct their collapsid archs.
- Trial name
- Pilot (NCT06994754)
- Testing
- clear aligners
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Cairo University
Cleft Lip and Palate, Speech Disorders in Children
High and Low Intensity Speech Intervention in Children With a Cleft Palate: Perceptions of Children, Their Caregivers and Speech-language Pathologists
A cleft (lip and) palate (CP±L) is the most common congenital abnormality of the face and skull with a significant social impact, affecting speech, hearing, feeding, oral behavior, dentition and satisfaction with appearance.
- Trial name
- NCT06895395
- Testing
- High intensive combined phonetic-phonological intervention, Low intensive combined phonetic-phonological intervention
- Where
- Belgium
- Volunteers
- 175 people
- Sponsor
- University Ghent
Cleft Palate, Unilateral Cleft Palate
Palatoplasty Techniques Using PRF and Gentamicin-Loaded PRF in Cleft Palate
This prospective, randomized controlled trial evaluates the clinical efficacy of autologous Platelet-Rich Fibrin (PRF) and Gentamicin-Loaded PRF as regenerative and antimicrobial biological adjuncts in primary palatoplasty.
- Conditions
- Cleft Palate, Unilateral Cleft Palate, Bilateral Cleft Palate, Complete Cleft Palat
- Trial name
- NCT07752849
- Testing
- Standard palatoplasty ( control), Platelet _ Rich Fibrin ( PRF), gentamicin_ loaded PRF
- Where
- Yemen
- Volunteers
- 90 people
- Sponsor
- Al-Thawra Modern General Hospital
Toothbrushing, Gingivitis
Effectiveness of Dual Light Electric Toothbrush vs. Manual Toothbrush in Orthodontic Patients Undergoing Oral Surgery
The study is a randomized clinical trial to compare the effectiveness of a dual light ultrasonic toothbrush on periodontal health in orthodontic patients undergoing surgery.
- Conditions
- Toothbrushing, Gingivitis, Cleft Lip and Palate
- Trial name
- NCT06122805
- Testing
- Toothbrush
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Cleft Lip, Cleft Palate
Effects of AlignBabyCleft (ABaCleft)
Since the appearance of presurgical infant orthopedic (PSIO) as a treatment for patients with cleft lip and palate ( CLP) , numerous techniques have been described with the aim of aligning the displaced alveolar segments and…
- Trial name
- (ABaCleft) (NCT05357092)
- Testing
- Appliance. Orthodontic appliance to carry out dentoalveolar movement
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Cleft Palate, Cleft Lip
Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring
Cleft lip and palate surgeries present unique anesthetic challenges due to shared airway access with the surgical field, frequent anatomical abnormalities, and a predominantly infant and toddler population.
- Conditions
- Cleft Palate, Cleft Lip, Laryngospasm, Bronchospasm
- Trial name
- NCT07651904
- Testing
- Standard General Anesthesia per Institutional Protocol
- Volunteers
- 150 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Cleft Palate, Pain
Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.
- Conditions
- Cleft Palate, Pain, Postoperative Care, Perioperative Care
- Trial name
- OPAL-Cleft (NCT06962306)
- Testing
- Methadone hydrochloride, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate
The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and/or palate.
- Conditions
- Kallmann Syndrome, Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea, Polycystic Ovarian Syndrome
- Trial name
- NCT01601171
- Where
- Switzerland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cleft Palate Children
Length of Hospital Stay and Postoperative Analgesic Requirements After Introduction of a Specific Maxillary Nerve Block in Children Undergoing Cleft Palate Surgery
Cleft lip and palate (CLP) is one of the most common congenital malformations and requires repeated surgical correction during childhood.
- Trial name
- NCT07279883
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cleft Lip and Palate
How Does Orthognathic Surgery Affect Jaw and Neck Motor Function?
In a prospective longitudinal study design, details in jaw-neck kinematics and electromyography (EMG) activity changes in patients (women and men) referred for surgical correction of basal relations between the maxilla and…
- Trial name
- NCT05876169
- Testing
- Orthognathic surgery
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Umeå University
Alveolar Cleft
Alveolar Cleft Reconstruction With Cortical-Shells
The main goal of the secondary alveolar bone grafting (SABG) for alveolar clefts is the rehabilitation of the disorganized maxilla, aiming to stabilize the maxillary foundation as a solid functional mass that would abort growth…
- Trial name
- NCT06585566
- Testing
- Cortical-shell graft
- Where
- 2 sites in Egypt
- Volunteers
- 7 people
- Sponsor
- Beni-Suef University
Cleft Lip and Palate
Ketorolac in Palatoplasty
The purpose of this study is to see if the addition of IV Ketorolac to usual care multi-modal pain therapy compared to usual care will improve oral intake post-operatively
- Trial name
- NCT04771156
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cleft Lip and Cleft Palate
The Financial and Emotional Impact of Cleft Palate
Cleft lip and/or palate (CL±P) is the most prevalent congenital craniofacial defect with a significant social impact, affecting speech, hearing, feeding, oral behavior, dentition and satisfaction with appearance.
- Trial name
- NCT06905678
- Testing
- Questionnaires, Semi-structured interviews
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- University Hospital, Ghent
Cleft Palate, Plasma Rich in Growth Factors
Role of Plasma Rich Growth Factor in Repair Primary Cleft Palate
Does the plasma-rich growth factor (PRGF) with primary cleft palate repair accelerate wound healing and prevent post-operative oronasal fistula occurrence?
- Trial name
- PRGF (NCT06889181)
- Testing
- Plasma Rich in Growth Factors (PRGF)
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cleft Palate
Furlow With Buccinator and Fistula Formation
Furlow with buccal myomucosal flap (group 1) Local anesthesia with a vasoconstrictor will be injected at the beginning of the surgery after Z- flap outline marking.
- Trial name
- NCT07840911
- Testing
- furlow with buccinator, two flap palatoplasty
- Volunteers
- 20 people
- Sponsor
- Fayoum University
Congenital Disorder, Cleft Lip Palate
Clinical Application of Artificial Intelligence in New Borns With Cleft Lip and Palate
The goal of this observational study is to evaluate whether passive plate therapy using automated AI-designed devices can reduce cleft size in newborns with cleft lip and palate.
- Trial name
- CLIP-AI (NCT06970158)
- Testing
- AI-Designed Passive Plate Therapy
- Where
- 2 sites in India
- Volunteers
- 70 people
- Sponsor
- University Hospital, Basel, Switzerland
Cleft Lip Palate
Quadratus Lumborum Block for Iliac Bone Harvest in Pediatric Cleft Alveolus Repair
This prospective, randomized, double-blinded controlled trial will investigate the effectiveness of a lateral quadratus lumborum (QL) block in 50 children aged 6-14 years undergoing iliac crest bone grafting for cleft alveolus…
- Trial name
- NCT07846761
- Testing
- Lateral quadratus lumborum block
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Otitis Media in Children, Cleft Palate Children
Respiratory Tract Microbiome and Probiotics in Children With Cleft Palate
Otitis media with effusion (OME) involves fluid accumulation in the middle ear without infection, sometimes causing discomfort and hearing loss in children.
- Trial name
- NCT06505330
- Testing
- Probactiol Baby
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp