Clinical trials: Classification
Early-stage Breast Cancer, HER2-positive Breast Cancer
Adjuvant Trastuzumab Plus Neratinib in Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer After Neoadjuvant Trastuzumab Plus Pertuzumab
Neratinib is an irreversible pan-HER tyrosine kinase inhibitor (TKI). Currently, no studies have investigated the use of macromolecular anti-HER2 agents combined with TKIs for the treatment of non-pCR HER2-positive breast cancer…
- Conditions
- Early-stage Breast Cancer, HER2-positive Breast Cancer, Adjuvant Treatment After Trastuzumab, RCB Classification 1-2
- Trial name
- NCT05760612
- Testing
- Trastuzumab and neratinib, Trastuzumab and Pertuzumab
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Stage 3 Age Related Macular Degeneration (AREDS Classification)
Microperimetry and Eye Progressing From Stage 3 to Stage 4 Age-related Macular Degeneration (AMD)
Age-related macular degeneration (AMD) is an acquired retinal pathology affecting the central region of the retina responsible for discrimination between high spatial frequencies (reading), colour vision and the central visual…
- Trial name
- PREVISION (NCT02395757)
- Testing
- MAIA™ (Centervue, Padova, Italy; distributed in France by EDC Lamy, Carvin, France)
- Where
- France
- Volunteers
- 182 people
- Sponsor
- Hospices Civils de Lyon
Cerebral Palsy (CP), Reliability and Validity
Dubousset Functional Test: An Investigation of Its Validity and Reliability in Children With GMFCS I-II Spastic Cerebral Palsy
the investigators hypothesize that over time, it may lead to loss of functional capacity in children with CP. In this context, our study aims to examine the validity and reliability of the four-component Dubousset Functional Test…
- Conditions
- Cerebral Palsy (CP), Reliability and Validity, Functional Test, Gross Motor Function Classification System (GMFCS) Level I,II
- Trial name
- NCT06831591
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Inonu University
Coccydynia, Sagittal Balance
Sagittal Spinopelvic and Coccygeal Alignment in Sitting and Standing Positions in Coccydynia
This observational cross-sectional study aims to investigate the differences in spinopelvic and coccygeal morphometric parameters in standing and sitting positions among patients diagnosed with coccydynia.
- Conditions
- Coccydynia, Sagittal Balance, Morphological Analysis and Classification
- Trial name
- Coccydynia (NCT07076927)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Generative Artificial Intelligence, Creative Thinking
The Effect of Artificial Intelligence Supported Morphological Analysis on Problem Solving and Creative Thinking Disposition
It will be conducted as a two-group, pretest-posttest, randomized controlled study to determine the effect of generative artificial intelligence-supported morphological analysis on nursing students' problem solving skills and…
- Conditions
- Generative Artificial Intelligence, Creative Thinking, Problem Solving, Morphological Analysis and Classification
- Trial name
- NCT07018973
- Testing
- GAISMA, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- Gazi University
ASA-PS Classification
ASA Prediction Using Health Data and Medication Use
The development of a machine learning algorithm that predicts American Society of Anesthesiologist-Physical Status (ASA-PS) based on preoperative variables would not only improve clinical decision-making in patient risk…
- Trial name
- NCT06629350
- Where
- Netherlands
- Volunteers
- 149,422 people
- Sponsor
- Erasmus Medical Center
Colorectal Liver Metastasis (CRLM), Histopathological Growth Patterns (HGPs)
Deep Learning-Based Analysis of Colorectal Cancer Pathology Images: An Innovative Approach for Predicting Colorectal Cancer Subtypes
Colorectal cancer (CRC) is a leading cause of mortality in China, with metastasis significantly contributing to poor outcomes. Histopathological growth patterns (HGPs) in colorectal liver metastasis (CRLM) provide vital…
- Conditions
- Colorectal Liver Metastasis (CRLM), Histopathological Growth Patterns (HGPs), Artificial Intelligence (AI) in Diagnosis, Vision Transformer (ViT)
- Trial name
- NCT06936098
- Testing
- CRLM surgery
- Where
- China
- Volunteers
- 431 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Systemic Sclerosis - 2013 ACR/EULAR Classification Criteria
Clinical Study of CD7 CAR-T Cells for Relapsed/refractory Autoimmune Diseases
The primary objective was to evaluate the safety of CD7 CAR-T cells for the treatment of subjects with relapsed/refractory AID. CD7 CAR-T cells were infused in a single infusion in subjects who were screened after signing an…
- Trial name
- NCT06871644
- Testing
- T cell injection targeting CD7 chimeric antigen receptor
- Where
- China
- Volunteers
- 18 people
- Sponsor
- PersonGen BioTherapeutics (Suzhou) Co., Ltd.
To Establish a Standardized Background Parenchimal Enhancement Classification System
From Variability to Standardization: The Impact of Breast Density on Background Parenchymal Enhancement in Contrast-Enhanced Mammography and the Need for a Structured Reporting System
This retrospective study includes 213 patients who underwent CEM, mammography (MG), and ultrasound (US) between May 2022 and June 2023 at the P.O. 'A. Perrino' Hospital, Brindisi.
- Trial name
- NCT06838117
- Where
- Italy
- Volunteers
- 213 people
- Sponsor
- Graziella di Grezia
Core Muscles, Endurance
Relationship Between Core Muscles Endurance and Saliba's Postural Classification System in Patients With Chronic Mechanical Low Back Pain
The aim of the study is to investigate the relationship between core muscles endurance and Saliba Postural Classification System in patients with chronic mechanical low back pain.
- Conditions
- Core Muscles, Endurance, Saliba's Postural Classification System, Low Back Pain, Mechanical
- Trial name
- NCT06660472
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Obesity, fMRI
Clinical Classification and Imaging Markers in Patients of Obesity
This is an observational study to explore the etiology and clinical classification in patients with obesity and to achieve personalized treatment.
- Conditions
- Obesity, fMRI, Clinical Classification
- Trial name
- NCT06649071
- Testing
- Naturalistic observation
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Both Bone Forearm Fracture, AO Classification 22D/2.1-5.2
Casting Versus Flexible Intramedullary Nailing in Displaced Pediatric Forearm Shaft Fractures
The forearm is the most common fracture location in children, with an increasing incidence. Displaced forearm shaft fractures have traditionally been treated with closed reduction and cast immobilization.
- Conditions
- Both Bone Forearm Fracture, AO Classification 22D/2.1-5.2, 7-12 Year Old
- Trial name
- NCT04664517
- Testing
- Flexible intramedullary nail (FIN), Reduction auder general anesthesia and long arm cast
- Where
- 5 sites in Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Multimoda Lultasound, Thyroid Cancer
Multimodality US Based on Angio Planewave Ultrasensitive Imaging and Shear Wave Elastography to Evaluate the Malignancy Risk Value of Thyroid Nodules
The goal of this clinical trial is to explore the value of a multimodal ultrasound model based on Angio Planewave Ultrasensitive Imaging, Shear Wave Elastography and grayscale ultrasound in the differential diagnosis of benign…
- Conditions
- Multimoda Lultasound, Thyroid Cancer, Microvascular Classification
- Trial name
- NCT06530771
- Testing
- ultrasound
- Where
- China
- Volunteers
- 720 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Sperm Classification
Sperm Video Recording Protocol
The purpose of this study is to obtain anonymous video clips of male semen at high magnification, to manually select out of the video spermatozoon images, and to manually classify their morphology by qualified embryologists based…
- Trial name
- NCT06150846
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- BAIBYS Fertility
Cervical Cancer Susceptible Population Classification
Cervical Cancer Susceptible Population Classification
Cervical cancer is the third most common lethal tumor globally, causing around a quarter million deaths annually, despite the availability of HPV vaccines.
- Trial name
- NCT06405945
- Testing
- PCR and sequence
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Being Between 40-80 Years Old, Being Diagnosed With Haemiplegia
The Relationship Between Lower Limb Functionality, Foot Joint Position Sensation and Balance in Haemiplegic Patients
Stroke is defined as a neurological disorder resulting from acute focal damage to the central nervous system caused by vascular factors, which may include cerebral infarction, intracerebral haemorrhage and subarachnoid…
- Conditions
- Being Between 40-80 Years Old, Being Diagnosed With Haemiplegia, Getting 20 Points or More in the Mini Mental Test, Volunteering to Participate in the Study
- Trial name
- NCT06043960
- Testing
- Humac Norm İsokinetic Machine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karabuk University
C-staged Hepatocellular Carcinoma in BCLC Classification
A Trial of Hepatic Arterial Infusion Combined With Apatinib and Camrelizumab for C-staged Hepatocellular Carcinoma in BCLC Classification
This study was designed to evaluate the effectiveness and safety of hepatic arterial infusion chemotherapy combined with Apatinib and Camrelizumab (Triplet-combined Therapy) for C-staged Hepatocellular Carcinoma in BCLC…
- Trial name
- TRIPLET (NCT04191889)
- Testing
- Hepatic Arterial Infusion combined with Apatinib and Camrelizumab
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Sun Yat-sen University
Clinical Decision-Making, Decision Making, Computer-assisted
A Study to the Impact of Accuracy Problem Lists in Electronic Health Records on Correctness and Speed of Clinical Decision-making Performed by Dutch Healthcare Providers
The primary objective of this study is to determine whether patient records with complete, structured and up-to-date problem lists ('accurate problem lists'), result in better clinical decision-making, compared to patient records…
- Conditions
- Clinical Decision-Making, Decision Making, Computer-assisted, Medical Records, Problem-Oriented, Quality of Health Care
- Trial name
- ADAM's APPLE (NCT05657002)
- Testing
- patient A with accurate problem list, patient B with inaccurate problem list, patient A with inaccurate problem list
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Eva Klappe
Endometrial Cancer, Adjuvant Radiotherapy
Study of Early Stage Endometrial Cancer Based on Molecular Classification and Traditional Risk Stratification to Guide Adjuvant Radiotherapy Decisions
The purpose of this study is to compare the efficacy and toxicity of early stage endometrial cancer based on molecular classification and conventional risk stratification adjuvant therapy decision-making, and to provide…
- Conditions
- Endometrial Cancer, Adjuvant Radiotherapy, Molecular Classification
- Trial name
- NCT05524389
- Testing
- Vaginal brachytherapy, Pelvic external beam radiotherapy, Observation
- Volunteers
- 624 people
- Sponsor
- Peking Union Medical College Hospital
AML According to WHO 2016 Classification (Except Acute Promyelocytic Leukemia) AND (Refractory to Induction Therapy OR Relapsed After First Line Treatment)
Quizartinib and High-dose Ara-C Plus Mitoxantrone in Relapsed/Refractory AML With FLT3-ITD
In this multicenter, upfront randomized phase II trial, all patients receive quizartinib in combination with HAM (high-dose cytarabine, mitoxantrone) during salvage therapy.
- Trial name
- Q-HAM (NCT03989713)
- Testing
- MRD-triggered arm, Prophylactic Arm
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Prof. Dr. Richard F Schlenk