Clinical trials: Chronic Venous Insufficiency
Chronic Venous Disease, Vein Disease
Randomized, Placebo-crontrolled Clinical Trial Evaluating the Efficacy and Safety of Heparan Sulfate 120 mg Prolonged-Release Tablets Compared With Placebo in Patients With Chronic Venous Disease
This multicenter, randomized, double-blind study is a phase III evaluates the safety and effectiveness of CLR prolonged-release tablets in patients with chronic venous insufficiency, has been shown to be effective in reducing the…
- Conditions
- Chronic Venous Disease, Vein Disease, Venous Insufficiency of Leg
- Trial name
- CLR-18 (NCT07684833)
- Testing
- CLR Tablets - Heparan Sulphate
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Barbara Maglione
Varicose Veins, Venous Reflux
High Intensity Focused Ultrasound in PAtients With Varicose Veins in Singapore
The aim of the study is to evaluate the efficacy of non-invasive echotherapy for the treatment of varicose veins, within local population, using the Sonovein® device.
- Conditions
- Varicose Veins, Venous Reflux, Chronic Venous Insufficiency
- Trial name
- VESPA (NCT04339088)
- Testing
- Questionnaires
- Where
- Singapore
- Volunteers
- 15 people
- Sponsor
- Singapore General Hospital
Edema, Chronic Venous Insufficiency
Validation of a New Method of Limb Volumetry
Volumetry is essential for the diagnosis and follow-up of patients with limb edema. The objective of this project is the validation of real-time reconstruction and calculation of limb volume using a 3D laser scanner.
- Conditions
- Edema, Chronic Venous Insufficiency, Lymphedema
- Trial name
- NCT01574911
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
End-Stage Kidney Disease (ESKD), Non-valvular Atrial Fibrillation (NVAF)
The Safety and Effectiveness of Warfarin Vs Apixaban in Patients With NVAF/ VTE and ESKD on Dialysis
This is a retrospective study of End-Stage Kidney Disease (ESKD) patients on dialysis receiving apixaban or warfarin at Tawam Hospital [a tertiary care hospital in Al Ain, UAE].
- Conditions
- End-Stage Kidney Disease (ESKD), Non-valvular Atrial Fibrillation (NVAF), Venous Thromboembolism (VTE)
- Trial name
- WARD (NCT06606275)
- Testing
- Apixaban, Warfarin
- Where
- United Arab Emirates
- Volunteers
- 67 people
- Sponsor
- Abu Dhabi Health Services Company
CCSVI, Chronic Cerebrospinal Venous Insufficiency
Multi-center Registry for CCSVI Testing and Treatment
Patients suspected of CCSVI (chronic cerebrospinal venous insufficiency) may be tested and if appropriate treated with catheter venoplasty by an interventional radiologist in their local community who has been credentialled…
- Conditions
- CCSVI, Chronic Cerebrospinal Venous Insufficiency, Venous Malformations of CNS Draining Veins
- Trial name
- CCSVI (NCT01205633)
- Testing
- venous angioplasty
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Hubbard Foundation
Chronic Venous Insufficiency
Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency
The purpose of this study is to evaluate the efficacy and safety of the fixed-dose combination of coumarin and troxerutin versus placebo in the symptomatic treatment of chronic venous insufficiency.
- Trial name
- NCT01848210
- Testing
- Coumarin/troxerutin
- Volunteers
- 829 people
- Sponsor
- Takeda
Venous Thromboembolic Disease, Kidney Failure, Chronic
Anticoagulation Strategies for Acute Venous Thromboembolism in Patients With End-Stage Renal Disease Using USRDS Data
Patients with end stage renal disease (ESRD) are at significantly increased risk of thrombosis and bleeding relative to those with normal renal function which makes anticoagulation particularly challenging.
- Trial name
- NCT04818151
- Testing
- Warfarin, Apixaban
- Where
- United States
- Volunteers
- 14,914 people
- Sponsor
- Johns Hopkins University
Vascular, DVT - Deep Vein Thrombosis
Outcomes of Iliac Vein Stenting With Dedicated Venous Stents in Treatment of Chronic Post-thrombotic Venous Ulcers
Outcomes of iliac vein stenting with dedicated venous stents in treatment of chronic post-thrombotic venous ulcers Deep vein thrombosis (DVT) affects 1 to 3 individuals per 1000 annually.
- Conditions
- Vascular, DVT - Deep Vein Thrombosis, Post Thrombotic Syndrome, Venous Ulcer of Leg
- Trial name
- NCT07762222
- Testing
- dedicated venous stenting, Dedicated venous stent / iliofemoral dedicated venous stenting
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Chronic Venous Insufficiency, Chronic Venous Thrombosis
Best Endovenous Treatment, Including STenting, Versus Non-endovenous Treatment in Chronic Proximal Deep Venous Disease
Chronic obstruction of the iliac veins or inferior vena cava can occur as a result of deep vein thrombosis (DVT), or due to extrinsic compression in non-thrombotic iliac vein lesions (NIVLs).
- Conditions
- Chronic Venous Insufficiency, Chronic Venous Thrombosis, Iliac Vein Stenosis, Iliac Vein Obstruction
- Trial name
- BEST (NCT05622500)
- Testing
- Deep venous stenting, Best medical therapy
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Chronic Venous Insufficiency
Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System
To evaluate the safety and effectiveness of the BlueLeaf System for the restoration of venous competence for the treatment of symptomatic chronic venous insufficiency (CVI).
- Trial name
- INFINITE-OUS (NCT03216005)
- Testing
- BlueLeaf System
- Where
- 5 sites in Australia, Canada and 1 more
- Volunteers
- 14 people
- Sponsor
- Intervene, Inc.
Chronic Venous Insufficiency
Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein
The aim of this study is to perform a randomized, prospective trial comparing the two current methods of treatment for chronic venous insufficiency, in an effort to evaluate complications and outcomes for each method, and…
- Trial name
- NCT02236338
- Testing
- Ablation of the Incompetent Greater Saphenous Vein, ClosureFAST radiofrequency catheter, EVLT 980nm diode laser system
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Virginia Commonwealth University
Chronic Venous Insufficiency
Assessment of the Effect of Spa Therapy on the Quality of Life of Patients with Chronic Venous Insufficiency (NEYRAC)
Evaluation of the effectiveness of a phlebology-oriented spa therapy at 6 months on the quality of life of patients suffering from chronic venous insufficiency of the lower limbs
- Trial name
- NEYRAC (NCT05449743)
- Testing
- Spa therapy
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Le Syndicat Intercommunal pour le Thermalisme et l'Environnement
Varicose Veins, Chronic Venous Insufficiency
Elastic Compression Stockings and Varicose Veins Recurrence
Hypothesis. Regular using of Class 1 below-knee graduated compression stockings (RAL GZ 387 standard) compared to the absence of elastic compression will reduce the risk of clinically significant varicose veins recurrence at 12…
- Trial name
- ECOS-VVR (NCT04231942)
- Testing
- Graduated Compression Stocking: continuous using, Graduated Compression Stocking: intermittent using
- Where
- 3 sites in Russia
- Volunteers
- 319 people
- Sponsor
- Pirogov Russian National Research Medical University
Multiple Sclerosis
Study To Evaluate Treating Chronic Cerebrospinal Venous Insufficiency (CCSVI) in Multiple Sclerosis Patients
This is a single center, multispecialty, randomized double blind placebo control feasibility clinical trial. The purpose is to evaluate the safety, feasibility and efficacy of percutaneous transluminal angioplasty in treating…
- Trial name
- NCT01089686
- Testing
- Venoplasty
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Manish Mehta, MD
Obstructive Sleep Apnea Syndrome, Chronic Venous Insufficiency
SPA Therapy in the Treatment of Sleep Apnea Syndrome
The purpose of this study is to determine whether 3-week of SPA therapy improves sleep apnea in patients with chronic venous insufficiency and concomitant Obstructive Sleep Apnea Syndrome (OSAS).
- Trial name
- THERMA-SAS (NCT02559427)
- Testing
- 3-week immediate SPA treatment, 3-week late SPA treatment
- Where
- 9 sites in France
- Sponsor
- Association Francaise pour la Recherche Thermale
End-stage Renal Disease (ESRD)
Creating a Buttonhole Tunnel Track by Repeated Needling of the AV Fistula on the Same Day in Patients on Hemodialysis.
BACKGROUND: The patients diagnosed with end stage renal disease require dialysis and for that they need to have a vascular access for hemodialysis (HD) placed.
- Trial name
- NCT03989141
- Testing
- Repeated cannulation Buttonhole., Single cannulation Buttonhole.
- Where
- 2 sites in Denmark
- Volunteers
- 43 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Chronic Cerebrospinal Venous Insufficiency
Doppler Sonography, MR Venography, Plethysmography for the Diagnosis of CCSVI
This study is aimed at evaluation of diagnostic value of Doppler sonography, MR venography and air-plethysmography for the assessment of abnormalities in the internal jugular veins, with catheter venography as the reference test.
- Trial name
- NCT01425554
- Testing
- Doppler sonography of internal jugular veins, Magnetic resonance venography of internal jugular veins, Air-plethysmography of the neck
- Where
- Poland
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Euromedic Specialist Clinics, Poland
Chronic Venous Insufficiency
Assessment of the Relationship Between Severity of Chronic Venous Obstruction and Venous Claudication
Assessment of the Relationship between Severity of Chronic Venous Obstruction and Venous Claudication
- Trial name
- TIRED (NCT05662761)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Venous Insufficiency
The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency
Chronic Venous Insufficiency (CVI) is impaired venous return which results in lower limbs symptoms that include pain, swelling and dermatologic changes.
- Trial name
- NCT02498327
- Testing
- Gelatine Capsule, Venavine Intensive®
- Where
- South Africa
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Johannesburg
Lower Extremity Edema, Congestive Heart Failure(CHF)
Pedal Pump Clinical Trial on Edema V1
Previous research on the osteopathic manual technique entitled "Pedal Pump" has shown health benefits, specifically increasing lymphatic flow, decreasing lower extremity edema, and decreasing serum lactic acid after maximal…
- Conditions
- Lower Extremity Edema, Congestive Heart Failure(CHF), Chronic Venous Insufficiency (CVI), Kidney Disease
- Trial name
- NCT07760363
- Testing
- Pedal Pump
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David McVay