Clinical trials: Chronic Stroke, open to volunteers
Chronic Stroke
Effects of Transcutaneous Electrical Nerve Stimulation on Cognitive Function and Upper Limb Motor Function in People With Chronic Stroke
Upper limb impairment is present in more than 85% of people with stroke, which greatly affect the quality of life, social participation, and performance of daily activities of people with stroke.
- Trial name
- NCT05615610
- Testing
- tSCS, tVNS, Control
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The Hong Kong Polytechnic University
Chronic Stroke
Psychometric Study of the Spanish Version of Two Upper Limb Assessment Scales in Chronic Stroke
The purpose of this cross-sectional study is to translate and cross-culturally adapt to Spanish the Motor Evaluation Scale for Upper Extremity in Stroke Patients (MESUPES) and the Stroke Upper Limb Capacity Scale (SULCS) and to…
- Trial name
- NCT05872191
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Valencia
Chronic Stroke
Transcranial Direct Current Stimulation Enhances Dual-task Performance in Stroke
Stroke often impairs lower limb control, resulting in gait abnormalities and difficulties in dual-task performance, such as walking while engaging in cognitive activities.
- Trial name
- NCT06818240
- Testing
- Active transcranial direct current stimulation
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Atherosclerosis Cardiovascular Disease, Chronic Kidney Disease
A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
The purpose of this study is to measure cardiovascular outcomes with orforglipron compared with placebo in participants with atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD).
- Trial name
- NCT07241390
- Testing
- Orforglipron
- Where
- 566 sites in Argentina, Australia and 36 more
- Volunteers
- 7,140 people
- Sponsor
- Eli Lilly and Company
Hemorrhagic Stroke, Ischemic Stroke
Changes in Hemodynamic Response Following Transcranial Electrical Stimulation in Sroke Individuals
The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and…
- Conditions
- Hemorrhagic Stroke, Ischemic Stroke, Subacute Stroke, Chronic Stroke Survivors
- Trial name
- NCT07433972
- Testing
- Transcranial direct current stimulation, transcranial alternating current stimulation, Rehabilitation program
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Type 2 Diabetes, Coronary Heart Disease
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
PREMAP invites residents of the Eloisa region (South Savo, Finland) turning 45, 50, or 55 years of age in 2026 to undergo a blood-based NMR metabolomics risk assessment for five interlinked cardio-renal-metabolic conditions (type…
- Conditions
- Type 2 Diabetes, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Disease
- Trial name
- PREMAP (NCT07820800)
- Testing
- Digital health interventions
- Where
- Finland
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Chronic Stroke Patient
Relationship Between Balance, Arm Function and Body Awareness in People With Stroke
Stroke is one of the leading causes of long-term disability worldwide and is frequently associated with impairments in balance, upper extremity function, and body awareness.
- Trial name
- NCT07652710
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Baskent University
Stroke, Chronic Phase of Disease
Rehabilitation Strategies for Social Participation in Chronic Stroke Survivors
The goal of this clinical trial is to test a new rehabilitation program, combining acceptance and commitment therapy with strategy training (ACES), to help people resume social participation after stroke and live in the…
- Trial name
- START2ACT (NCT06758505)
- Testing
- Strategy Training Only, Strategy Training embedded with Acceptance and Commitment Therapy Principles
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Pittsburgh
Stroke, Chronic Stroke Patients
kTMP-Enhanced Motor Rehabilitation for Chronic Stroke Recovery (KULMINATE) Pilot
kTMP, kilohertz transcutaneous magnetic perturbations, is a low intensity transcranial magnetic stimulation technique that will be used in this study to promote arm/hand rehabilitation in patients who have been disabled by stroke.
- Conditions
- Stroke, Chronic Stroke Patients, Arm Weakness as a Consequence of Stroke
- Trial name
- NCT07631078
- Testing
- kTMP
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Magnetic Tides
Stroke, Chronic Stroke
Personalized Transcranial Direct Current Stimulation in Stroke Recovery
The central objective of this application is to explore the neural substrate of personalized tDCS (ptDCS) and to determine whether the paradigm for each stroke patient can predict the amount of sustained clinical improvement…
- Conditions
- Stroke, Chronic Stroke, Hemorrhage Brain, Ischemic Stroke
- Trial name
- NCT06286800
- Testing
- Transcranial direct current stimulation (tDCS) with OT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Methodist Hospital Research Institute
Cardiovascular Diseases, Chronic Kidney Diseases
Improving the Collaborative Health of Adult Dyads
This study tests the efficacy of a dyadic intervention to mitigate the adverse health consequences of adults with pre-existing chronic health conditions and their informal carepartners (IC).
- Conditions
- Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus, Type 2, Chronic Disease
- Trial name
- NCT05370014
- Testing
- Integrating Community-based Intervention Under Nurse Guidance with Families (iCINGS FAM)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Acute Ischemic Stroke, Intracranial Arterial Stenosis
Post-Market Active Surveillance and Health Economic Evaluation of Cerebrovascular Diagnostic and Therapeutic Devices
The research focuses on "post-market active surveillance and health economic evaluation of non-pharmacological therapies and innovative cerebrovascular diagnostic and therapeutic devices".
- Conditions
- Acute Ischemic Stroke, Intracranial Arterial Stenosis, Extracranial Arterial Stenosis, Intracranial Aneurysms
- Trial name
- NCT07828379
- Testing
- Endovascular Treatment for Acute Ischemic Stroke
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Acute Stroke, Chronic Stroke Patient
Unimanual Versus Bimanual Motor Skill Learning in Acute and Chronic Stroke
To test the capacity of healthy individuals, chronic and acute stroke patients to learn and retain a complex unimanual or bimanual motor skill, trained on the neurorehabiliation robot REAplan® et the Dextrain® device.
- Conditions
- Acute Stroke, Chronic Stroke Patient, Healthy Individuals (Controls), Stroke (Subacute)
- Trial name
- MLAS6 (NCT07826832)
- Testing
- REAplan®, Dextrain® Manipulandum
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Dialysis, Chronic Kidney Disease (Stages 3b-5)
Left Atrial Appendage Occlusion in Dialysis Patients With Atrial Fibrillation: A Multicentre Pilot Study
Objectives: This pilot study aims to evaluate the safety and efficacy of left atrial appendage occlusion (LAAO) in dialysis patients and atrial fibrillation (AF) to establish a novel stroke prevention strategy and determine an…
- Conditions
- Dialysis, Chronic Kidney Disease (Stages 3b-5), Atrial Fibrillation, End Stage Kidney Failure
- Trial name
- LAAO-DAF (NCT07257614)
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Stroke, Acute, Stroke (Subacute)
Inter-Limb Transfer in Acute Stroke
This study aims to investigate whether the improvements achieved through motor skill learning (MSkL) with the ipsilesional upper limb (UL) are transferred to the contralesional UL during the (sub)acute stroke phase, and to…
- Conditions
- Stroke, Acute, Stroke (Subacute), Healthy Individuals (Controls), Chronic Stroke Patients
- Trial name
- MLAS5 (NCT07822633)
- Testing
- REAplan®, Dextrain Manipulandum®
- Where
- 2 sites in Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Stroke, Stroke, Chronic
Repetitive Transcranial Magnetic Stimulation, a Form of Non-invasive Brain Stimulation, as a Possible Treatment for Post-stroke Fatigue
This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for post-stroke fatigue in people who have had a stroke more than six months prior to enrolling.
- Conditions
- Stroke, Stroke, Chronic, Fatigue
- Trial name
- NCT05584124
- Testing
- High frequency repetitive transcranial magnetic stimulation
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Chronic Stroke, Balance
"Effects of a Combined Repetitive Transcranial Magnetic Stimulation and Physical Therapy Protocol on Motor Function, Balance, and Quality of Life in Chronic Post-Stroke Hemiplegia: A Case Series"
Chronic post-stroke hemiplegia frequently results in persistent motor deficits, impaired balance, and reduced quality of life. Conventional physical therapy is fundamental for functional recovery; however, motor improvement often…
- Trial name
- NCT07597746
- Testing
- rTMS, physical therapy
- Volunteers
- 20 people
- Sponsor
- Sierra Varona SL
Osteoarthritis Pain, Myocardial Infarction (MI)
Community Physical Exercise Program in Chronic Disease
This study focuses on promoting physical activity (PA) through the implementation of a Community Physical Exercise Program for Chronic Diseases (CPEP-CD), targeting individuals aged 50 years and older with at least two of the…
- Conditions
- Osteoarthritis Pain, Myocardial Infarction (MI), Hypertension, Dyslipidemia
- Trial name
- CPEPCD (NCT06771024)
- Testing
- Physical Exercise
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Associação para o Desenvolvimento do Centro Académico de Investigação e Formação Biomédica do Algarv
Chronic Stroke
Ankle Robotics for Error Augmentation After Stroke
The goal of this pilot clinical trial is to test whether training with a portable ankle robot improves ankle push-off and walking speed in adults with chronic stroke who have ankle weakness.
- Trial name
- NCT07804342
- Testing
- AMBLE
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Chronic Gastritis, Gastric Cancer (GC)
Validating a Medical AI Fine-Tuning Platform for Major Diseases
The goal of this observational study is to leverage the abundant patient resources and standardized medical records from Beijing Friendship Hospital, Xuanwu Hospital, and Beijing Anzhen Hospital, combined with the existing data…
- Conditions
- Chronic Gastritis, Gastric Cancer (GC), Coronary Artery Disease, Stroke
- Trial name
- NCT07795645
- Testing
- Smart Medical Big Data Dataset Construction, Large-Scale Medical Knowledge Graph Construction, Multi-Disease Medical Large Model Fine-Tuning Platform Construction and Fine-Tuning
- Where
- China
- Volunteers
- 96,000 people
- Sponsor
- Beijing Friendship Hospital