Clinical trials: Chronic Pulmonary Aspergillosis, active
Chronic Pulmonary Aspergillosis
Impact of Chronic Pulmonary Aspergillosis (CPA) on Health Status and Well-being
To develop and validate a novel disease-specific questionnaire for measuring HRQoL in patients with Chronic Pulmonary Aspergillosis (CPA-HAQ) for use in clinical research, including clinical trials.
- Trial name
- CAPSULE (NCT06885905)
- Where
- 3 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Chronic Pulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis
Oral Itraconazole Versus Combination of Systemic Glucorticoids and Oral Itraconazole in CPA-ABPA Overlap Syndrome
While ABPA and CPA represent two distinct manifestations of Aspergillus-related lung disease, there is an overlap of investigations that are currently used for the diagnosis of these entities.
- Trial name
- GLITZ (NCT05444946)
- Testing
- Prednisone tablet and Itraconazole, Oral itraconazole
- Where
- 2 sites in India
- Volunteers
- 104 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pulmonary Tuberculoses, Aspergillosis
Pulmonary Aspergillosis in Tuberculosis Patients
Pulmonary tuberculosis (PTB) is the most common cause of lung destruction, contributing to coinfections development, and Aspergillosis spp. is one of the most important.
- Conditions
- Pulmonary Tuberculoses, Aspergillosis, Old Tuberculosis, Active Tuberculosis
- Trial name
- NCT05045391
- Testing
- Aspergillus IgG detection
- Where
- Uzbekistan
- Volunteers
- 200 people
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Chronic Pulmonary Aspergillosis
Deposition of Inhaled Liposomal Amphotericin B in Chronic Pulmonary Aspergillosis (CPA)
This study evaluates and aims to optimize inhalation treatment with nebulized liposomal amphotericin B in patients with chronic pulmonary aspergillosis.
- Trial name
- NIMBUS (NCT07530263)
- Testing
- 12 mg of nebulised 99mTc-liposomal amphotericin B, 24 mg of nebulised 99mTc-liposomal amphotericin B, SPECT/CT scan
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Radboud University Medical Center
Chronic Pulmonary Aspergillosis
A Study of Itraconazole and Posaconazole for Chronic Pulmonary Aspergillosis
A prospective, randomized, open-label comparative study evaluating oral itraconazole and oral posaconazole in treatment-naïve patients with CPA, with treatment for 12 months is proposed.
- Trial name
- POSITRON (NCT07825259)
- Testing
- Posaconazole Delayed Release Oral Tablet, Itraconazole (ITZ)
- Where
- 2 sites in India
- Volunteers
- 220 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Pulmonary Aspergillosis, CPA
A Trial to Compare Nebulized Amphotericin B and Nebulized Normal Saline as Maintenance in Patients With Chronic Pulmonary Aspergillosis
The treatment of CPA is with oral itraconazole for 6-12 months. Oral itraconazole results in better clinical outcomes in CPA compared to supportive care.
- Conditions
- Chronic Pulmonary Aspergillosis, CPA, Aspergilloma
- Trial name
- NAB-CPA (NCT06447402)
- Testing
- Normal saline, Amphotericin B deoxycholate
- Where
- India
- Volunteers
- 196 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD)
Immune Status and Disease Control of Inflammatory Airway Diseases
The goal of this study is to learn how the body's immune system affects disease control in people with different airway inflammatory diseases.We want to understand: 1.Whether specific immune cell patterns in the blood are linked…
- Conditions
- Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis), Bronchiectasis
- Trial name
- ISDC-IAD (NCT07493629)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
Pulmonary Tuberculoses, Chronic Pulmonary Aspergillosis
Vitamin D and Immune Response in Pulmonary Tuberculosis With and Without Chronic Pulmonary Aspergillosis
The goal of the study is to determine whether vitamin D levels are associated with cytokine profiles in patients with pulmonary tuberculosis, including those with chronic pulmonary aspergillosis.
- Conditions
- Pulmonary Tuberculoses, Chronic Pulmonary Aspergillosis, Healthy Participants
- Trial name
- NCT07516158
- Where
- Uzbekistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Chronic Pulmonary Aspergillosis, Aspergillosis
Interferon-gamma as Adjunctive Therapy in Chronic Pulmonary Aspergillosis: a Randomised Feasibility Study
This study explores the role of treatment with interferon-gamma to improve outcomes in chronic pulmonary aspergillosis (CPA). CPA is a progressive infection caused by the fungus Aspergillus affecting patients with chronic lung…
- Trial name
- INCAS (NCT05653193)
- Testing
- Interferon Gamma-1B 0.1 MG Per 0.5 ML Injection PLUS antifungals as standard of care, Antifungals as standard of care
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Manchester University NHS Foundation Trust
Chronic Pulmonary Aspergillosis
Rezafungin for Treatment of Chronic Pulmonary Aspergillosis (CPA) in Adults With Limited Treatment Options
The goal of this clinical trial is to to evaluate the drug rezafungin in the treatment of Chronic Pulmonary Aspergillosis (CPA) in male and female patients aged 18 years and over with limited treatment options.
- Trial name
- NCT06794554
- Testing
- Rezafungin Acetate
- Where
- 37 sites in Austria, Belgium and 8 more
- Volunteers
- 60 people
- Sponsor
- Mundipharma Research Limited
Chronic Pulmonary Aspergillosis
Chronic Pulmonary Aspergillosis and Ambisome Aerosol with Itraconazole
This study compares the therapeutic (clinical and radiological) efficacy of a six-month treatment by itraconazole and nebulised Ambisome® (liposomal amphotericin B = LAmB) versus treatment by itraconazole alone, in non - or…
- Trial name
- NCT03656081
- Testing
- inhaled Ambisome®, Itraconazole
- Where
- France
- Volunteers
- 224 people
- Sponsor
- Poitiers University Hospital