Clinical trials: Chronic Pouchitis
Pouchitis
A Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis
The purpose of this study is to compare the efficacy of vedolizumab intravenous (IV) and placebo in terms of the percentage of participants with chronic or recurrent pouchitis achieving clinically relevant remission.
- Trial name
- EARNEST (NCT02790138)
- Testing
- Ciprofloxacin, Vedolizumab
- Where
- 34 sites in United States, Belgium and 7 more
- Volunteers
- 102 people
- Sponsor
- Takeda
Chronic Pouchitis, Pouchitis
Fecal Microbiota Transplant for Patients With Chronic Pouchitis
The purpose of this research study is to assess the safety and efficacy of fecal microbiota transplant (FMT) in the treatment of chronic pouchitis.
- Trial name
- NCT05829109
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Maia Kayal
Ulcerative Colitis, Colorectal Cancer
Objective Perfusion Rate Assessment by Near-infrared Fluorescence in Ileal Pouch Formation and Ileal-pouch-anal Anastomosis
In this prospective, non-randomized cohort study, real-time intraoperative visualization using near-infrared-fluorescence by indocyanine green injection (ICG-NIRF) is performed at three time points during ileal pouch…
- Conditions
- Ulcerative Colitis, Colorectal Cancer, Crohn Disease, Familial Adenomatous Polyposis
- Trial name
- NCT04695964
- Testing
- ICG-NIRF Imaging plus ingress and egress analysis
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Pouchitis
Study of the Safety and Efficacy of AMT-101 in Subjects With Pouchitis
Phase 2 Study Investigating the Efficacy of AMT-101 in Subjects with Chronic Antibiotic-resistant Pouchitis
- Trial name
- FILLMORE (NCT04741087)
- Testing
- AMT-101 (oral)-Dose A, AMT-101 (oral)-Dose B
- Where
- 34 sites in United States, Belgium and 8 more
- Volunteers
- 22 people
- Sponsor
- Applied Molecular Transport
Pouchitis, Ileal Pouchitis
Tofacitinib For Treatment Of Chronic Pouchitis
A phase 2 pilot study to evaluate the effectiveness of tofacitinib in subjects with chronic pouchitis
- Conditions
- Pouchitis, Ileal Pouchitis, Ileal Pouch
- Trial name
- NCT04580277
- Testing
- Tofacitinib 10 mg
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cedars-Sinai Medical Center
Pouchitis
CLF065 for Chronic Pouchitis
This clinical trial is to evaluate investigational compound CLF065 as a treatment for adult patients with chronic pouchitis. The goals are to establish the safety, feasibility and efficacy of weekly dosing of long acting CLF065…
- Trial name
- OPUS (NCT07226050)
- Testing
- CLF065
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Calibr, a division of Scripps Research
Inflammatory Bowel Diseases, Colitis, Ulcerative
A Study of Kynteles Injection (Vedolizumab) in Adults With Moderate to Severe Ulcerative Colitis or Crohn's Disease or Chronic Pouchitis
In this study, participants with ulcerative colitis or Crohn's disease or pouchitis will be treated with Kynteles injection (Vedolizumab) according to their clinic's standard practice.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT04799496
- Where
- 43 sites in South Korea
- Volunteers
- 688 people
- Sponsor
- Takeda
Pouchitis, Ulcerative Colitis
Fecal Microbiota Transplantation (FMT) in the Treatment of Pouchitis
The aim of our study is to investigate the efficacy and safety of fecal microbiota transplantation (FMT) in the treatment of antibiotic dependent chronic pouchitis. This is a double-blinded randomized placebo controlled study.
- Trial name
- NCT03378921
- Testing
- Fecal microbiota transplantation
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Helsinki University Central Hospital
Pouchitis, Irritable Pouch Syndrome
Efficacy of Liraglutide Therapy in Patients With IPAA
Patients with an ileal pouch-anal anastomosis(IPAA; pouch) due to refractory inflammatory bowel disease and increased bowel frequency in the absence of significant pouch inflammation will be randomized to liraglutide or placebo…
- Trial name
- NCT04763564
- Testing
- Liraglutide Pen Injector
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Pouchitis, Pouches, Ileoanal
Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch
The goal of this clinical trial is to learn if mirikizumab works to treat pouch disorders in adults. The main questions it aims to answer are: Does mirikizumab reduce symptoms of pouch disorders Participants will: Take…
- Conditions
- Pouchitis, Pouches, Ileoanal, Pouch, Ileal
- Trial name
- NCT06864403
- Testing
- Mirikizumab - Intravenous (IV), Mirikizumab - Subcutaneous (SC)
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Pouchitis
Efficacy of Alicaforsen in Pouchitis Patients Who Have Failed to Respond to at Least One Course of Antibiotics
A Phase III, multi-centre, double-blind randomised controlled trial in subjects with chronic antibiotic refractory pouchitis. Subjects will undertake a <2 week screening period to provide baseline data and be assessed for…
- Trial name
- NCT02525523
- Testing
- Alicaforsen
- Where
- 41 sites in United States, Belgium and 8 more
- Volunteers
- 138 people
- Sponsor
- Atlantic Pharmaceuticals Ltd
Pouchitis, Inflammatory Bowel Diseases
Faecal Microbiota Transplantation in the Treatment of Chronic Pouchitis
Patients with the chronic bowel disease pouchitis is disabled by bloody diarrhoea and abdominal pain often followed by fever. Pouchitis is an inflammation in a pouch, a reservoir formed by the small intestine in the management of…
- Conditions
- Pouchitis, Inflammatory Bowel Diseases, Ulcerative Colitis
- Trial name
- MicroPouch (NCT04100291)
- Testing
- Faecal microbiota transplantation
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
Pouchitis, Crohn's Disease
Stem Cells for the Treatment of Pouchitis
The purpose of this study is to determine the safety and feasibility of using allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat people with medically refractory Pouchitis.
- Conditions
- Pouchitis, Crohn's Disease, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases
- Trial name
- NCT05578508
- Testing
- Mesenchymal Stem Cells (MSCs)
- Where
- United States
- Sponsor
- The Cleveland Clinic
Pouchitis, Inflammatory Bowel Diseases
Faecal Microbiota Transplantation From Normal Pouch Function Donor in the Treatment of Chronic Pouchitis
Patients with chronic pouchitis is disabled by bloody diarrhoea and abdominal pain often followed by fever. Pouchitis is an inflammation in a pouch, a reservoir formed by the small intestine in the management of the chronic…
- Conditions
- Pouchitis, Inflammatory Bowel Diseases, Ulcerative Colitis
- Trial name
- NCT04820413
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 3 people
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
Ulcerative Colitis, Pouchitis
Adalimumab in the Treatment of Chronic Pouchitis
This study wants to investigate the efficiency of biological treatment for chronic pouchitis. Chronic pouchitis is inflammation in a reconstruction after removal of the colon, a pouch.
- Trial name
- ADAP (NCT01670240)
- Testing
- Adalimumab
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Odense University Hospital
Pouchitis
Stelara fOr ChRonic AntibioTic rEfractory pouchitiS
To evaluate the efficacy and safety of ustekinumab in the treatment of chronic antibiotic refractory and relapsing pouchitis.
- Trial name
- SOCRATES (NCT04089345)
- Testing
- Ustekinumab
- Where
- 3 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pouchitis
Treating Chronic Pouchitis With a Low FODMAP Diet
We aim to determine whether low FODMAP diet in patients with chronic pouchitis will improve symptoms and pouch inflammation.
- Trial name
- NCT04640155
- Testing
- Low FODMAP Diet, Regular Diet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Pouchitis
A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis
When some people have their large bowel removed, a surgeon can make a "pouch" from part of the small bowel to connect it to the back passage (anus). Pouchitis is when the pouch becomes inflamed (swollen) or infected.
- Trial name
- NCT06443502
- Testing
- Vedolizumab, Concomitant Antibiotic Therapy
- Where
- 14 sites in Belgium, Croatia and 6 more
- Volunteers
- 30 people
- Sponsor
- Takeda
Ulcerative Colitis, Pouchitis
Fecal Microbiota Transplantation for Chronic Pouchitis
Patients with chronic pouchitis are treated with fecal transplant from several unrelated, healthy donors. The treatment consists of enemas of 100 mL fecal suspension, applied for 14 consecutive days.
- Trial name
- NCT03538366
- Testing
- Donor FMT
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Aalborg University Hospital