Clinical trials: Chronic Post-surgical Pain
Hyperalgesia, Opioid Use
Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting
Randomized, double-blinded, three arm study in adult patients undergoing first time coronary artery bypass grafting (CABG) surgery with median sternotomy.
- Conditions
- Hyperalgesia, Opioid Use, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT03450161
- Testing
- Fentanyl dosing schemes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Postoperative Pain, Chronic Pain
Chronic Postoperative Pain After Laparoendoscopic Groin Hernia Repair
The study attempts to quantify the relative risks for chronic postoperative inguinal pain (CPIP) depending on different combinations of mesh and mesh fixation.
- Trial name
- NCT04838028
- Testing
- TEP, TAPP, Other or unspecified laparoendoscopic groin hernia repair
- Volunteers
- 15,360 people
- Sponsor
- Karolinska Institutet
Ilioinguinal Nerve Section, Pain Prevention
Prophylactic Ilioinguinal Neurectomy During Open Tension-Free Inguinal Hernia Repair
postoperative chronic inguinal pain is a common postoperative complication after open inguinal hernia repair. Chronic inguinal pain is a common complication following open inguinal hernia repair.
- Conditions
- Ilioinguinal Nerve Section, Pain Prevention, Hernioplasty
- Trial name
- NCT06327763
- Testing
- ilioinguinal nerve section
- Where
- Egypt
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Surgery, Breast Cancer
Chronic Pain and Minor Breast Cancer Surgery
Breast cancer is the most frequent in women. Early diagnosis and recent treatments have improved overall mortality. However, chronic pain (pain lasting more than 3 months after surgery) remains a public health problem with impact…
- Conditions
- Surgery, Breast Cancer, Pain, Postoperative, Pain, Chronic
- Trial name
- DCPO Sein (NCT03912948)
- Where
- France
- Volunteers
- 205 people
- Sponsor
- Institut Claudius Regaud
Postoperative Cognitive Dysfunction, Acute Postoperative Pain
Effect of TPVB on Postoperative Pain and Cognitive Function After VATS in Elderly Patients
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block on postoperative acute and chronic pain and cognitive function in elderly patients with thoracoscopic partial lung resection.
- Conditions
- Postoperative Cognitive Dysfunction, Acute Postoperative Pain, Chronic Postsurgical Pain
- Trial name
- NCT05364216
- Testing
- Measurement of cognitive function, Thoracic paravertebral block, The assessment of cognitive function
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Acute Post-operative Pain, Chronic Post Operative Pain
Duloxetine Impact on Postoperative Pain Control and Outcomes
1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2.
- Conditions
- Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use
- Trial name
- NCT05611749
- Testing
- Duloxetine 60 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Joint (Knee or Hip Replacement)
The Impact of Extending Sleep Before Joint-replacement Surgery on Post-surgical Pain
This study will evaluate the impact of sleep banking on joint replacement surgery recovery.
- Trial name
- NCT07383584
- Testing
- Sleep banking
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Scoliosis, Kyphosis
Postoperative and Chronic Pain Genetic Spine and Pectus Surgery Study
This will be an open label, prospective study to determine the association between specific genotypes, epigenetics and behavioral factors, with the phenotypes, defined by pain perception, postoperative pain, analgesic and side…
- Conditions
- Scoliosis, Kyphosis, Kyphoscoliosis, Pectus Excavatum
- Trial name
- NCT02998138
- Where
- 5 sites in United States
- Volunteers
- 880 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pain, Acute, Pain, Chronic
Ketamine With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain
Postoperative pain after thoracic surgery is associated with adverse outcomes. The current strategy to prevent postoperative pain is the use of regional anesthesia and analgesic agents.
- Conditions
- Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT03280017
- Testing
- Ketamine, Normal saline
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Mahidol University
Postoperative Pain, Acute, Postoperative Pain, Chronic
Postoperative Pain in Patients Undergoing Scheduled Laparoscopic Intestinal Resection Surgery
This observational prospective study aims to evaluate the postoperative analgesic effect of a regional anesthesia thechnique (TAP block) in patients undergoing scheduled laparoscopic intestinal resection for intestinal cancer.
- Trial name
- TAP (NCT05222789)
- Testing
- TAP
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Chronic Pain Post-Procedural
Block REducing Pain After Surgery Trial
This observational study evaluates difference in chronic pain after six months from surgery between patients who received PECS block and general anesthesia versus general anesthesia alone.
- Trial name
- BREAST (NCT03448913)
- Testing
- PECS block
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- University of Padova
Chronic Pain
Ketamine and Magnesium in Post-operative Pain Control in Patients Treated With Opioids
The goal of this research proposal is to determine if the intraoperative administrative of Ketamine and Magnesium during laparoscopic gynecologic surgery improves postoperative pain in patients on chronic opioid therapy for…
- Trial name
- NCT02940509
- Testing
- Ketamine plus Magnesium sulfate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Postoperative Pain, Chronic Postsurgical Pain
Perioperative Quantitative Sensory Testing and Incision Pain Mapping in Thoracic Surgery
Postoperative pain remains a common and clinically important burden after thoracic surgery and may progress to chronic postsurgical pain.
- Conditions
- Postoperative Pain, Chronic Postsurgical Pain, Thoracic Surgery, Lung Resection
- Trial name
- NCT07653932
- Testing
- Perioperative QST and incision pain mapping assessment
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Tongji Hospital
Juvenile; Scoliosis, Scoliosis Idiopathic
Studying Melatonin and Recovery in Teens
The goal of this feasibility clinical trial is to learn if melatonin can help teens having major musculoskeletal surgery by promoting healthy sleep.
- Conditions
- Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital
- Trial name
- SurgerySMART (NCT06093477)
- Testing
- Fast-Dissolve Melatonin Pill
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Inguinal Hernia, Chronic Pain
Trigger-point Blockade in Persistent Pain After Open Groin Hernia Repair
Groin hernia repair is a common procedure performed in approximately 2,000 patients per one million inhabitants. Severe chronic pain following groin hernia repair is seen in 2-5% of the patients indicating that a large number of…
- Trial name
- Trigger-open (NCT02065219)
- Testing
- Bupivacaine
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Total Knee Arthroplasty, Chronic Postoperative Pain
Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics
Chronic pain is an extremely disabling disease. It is a major public health problem due to the lack of effective therapy. Chronic postoperative pain (CPOP) is defined by a painful symptomatology in the operated area unrelated to…
- Trial name
- KNEE BDNF (NCT04604847)
- Testing
- blood test
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Chronic Post-thoracotomy Pain, Neuropathic Pain
SPS Block vs. Surgical Intercostal Block for Chronic Pain After Thoracoscopic Surgery
This study aims to evaluate the efficacy of ultrasound-guided Serratus Posterior Superior (SPS) block compared to surgeon-administered intercostal blockade in preventing chronic pain at 3, 6, and 12 months following…
- Conditions
- Chronic Post-thoracotomy Pain, Neuropathic Pain, Postoperative Pain, Acute
- Trial name
- NCT07436806
- Testing
- SPS block, Surgical Intercostal Blockade.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Chronic Postoperative Pain
A Comparative Effect of Echogenic Needle for Nerve Block on Acute and Chronic Postoperative Pain
Surgical pain is a common complication after surgery, affecting patient recovery and treatment quality. >20% of patients suffer from chronic postoperative pain. China has >70 million surgeries yearly.
- Trial name
- NCT06281431
- Testing
- Echogenic nerve block needle, Non-echogenic nerve block needle
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Osteoarthritis, Knee, Total Knee Arthroplasty
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent…
- Conditions
- Osteoarthritis, Knee, Total Knee Arthroplasty, Chronic Postsurgical Pain
- Trial name
- NCT06083480
- Testing
- GlyNAC (combination of glycine and n-acetylcysteine)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Vanderbilt University Medical Center
Apical Periodontitis, Postoperative Pain
Sealers in Chronic Apical Lesions
This clinical study evaluated whether different root canal sealers influence postoperative pain and early periapical healing in patients with apical periodontitis.
- Conditions
- Apical Periodontitis, Postoperative Pain, Periapical Healing
- Trial name
- NCT07339579
- Testing
- Root Canal Treatment With Sealapex, Root Canal Treatment With MTA Fillapex, Root Canal Treatment With AH Plus
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Kahramanmaras Sutcu Imam University