Clinical trials: Chronic Nociceptive Pain
Chronic Pain, Cancer Pain
Clinical Classification of Pain in Breast Cancer Survivors
Breast cancer is the most common malignancy in women worldwide according to International Agency for Research on Cancer. Unfortunately, cancer survivors often face long-term symptoms that occur or persist after completion of…
- Conditions
- Chronic Pain, Cancer Pain, Breast Cancer
- Trial name
- NCT04219072
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Kutahya Health Sciences University
Chronic Pain, Nociceptive Pain
Central Sensitisation in Nociceptive and Neuropathic Pain
This study aims to investigate differences in central sensitization among patients with chronic nociceptive pain, neuropathic pain, and mixed pain conditions.
- Conditions
- Chronic Pain, Nociceptive Pain, Neuropathic Pain, Mixed Pain (Nociceptive and Neuropathic)
- Trial name
- ALGOS (NCT07321080)
- Testing
- Neuropsychological assessment, Laser evoked potentials
- Where
- Italy
- Volunteers
- 185 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Chronic Pain, Nociceptive Pain
A Placebo-Controlled, Two-Part Study, Oral Dose to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of CNTX-6970 in Healthy Subjects
A Phase 1, placebo-controlled, two part study with either single dose or multiple increasing oral dose to evaluate the safety, pharmacokinetics, and pharmacodynamics of CNTX-6970 in healthy subjects.
- Trial name
- NCT03787004
- Testing
- CNTX-6970
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Low Back Pain, Healthy Volunteers
Locating Nociceptive Stimuli on Digital Body Chart
Digital body charts are used to assess the pain experience in people with pain. People are asked to report their pain by shading a human body template on a digital tablet.
- Trial name
- NCT03463109
- Testing
- Electrocutaneous stimulation, Assessment + Electrocutaneous stimulation
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Pain, Opioid Use
Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, physical function and quality of life when compared with placebo in women…
- Conditions
- Pain, Opioid Use, Androgen Deficiency, Back Pain
- Trial name
- NCT04895306
- Testing
- Testosterone Cypionate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Brigham and Women's Hospital
Pain, Neuropathic Pain
A Clinical Study in Healthy Women Which Aims to Explore the Intestinal Uptake of Two Different Tablets of GRTA9906 Into the Body and the Effect of Food on it
The aim of this clinical study in healthy women is to explore the intestinal uptake (bioavailability) of two different tablets of GRTA9906 (formulations) into the body and the effect of food on it.
- Conditions
- Pain, Neuropathic Pain, Chronic Pain, Visceral Pain
- Trial name
- NCT03765801
- Testing
- GRTA9906 60 mg PR tablet, GRTA9906 60 mg IR capsule
- Where
- Germany
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Neuropathic Pain, Nociceptive Pain
PET/MRI in the Diagnosis of Chronic Pain
Several studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain.
- Conditions
- Neuropathic Pain, Nociceptive Pain, Mixed Pain (Nociceptive and Neuropathic), Spinal Pain
- Trial name
- NCT03556137
- Testing
- [18F]FTC-146
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Stanford University
Gastroparesis, Chronic Abdominal Pain
Gastric Electrical Stimulation for Abdominal Pain in Patients With Gastroparesis
Gastroparesis is a disorder characterized by delayed gastric emptying and symptoms including nausea, vomiting, and abdominal pain.
- Trial name
- HEAL (NCT07556237)
- Testing
- Enterra™ neurostimulator
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Louisville
Chronic Nociceptive Pain, Neuropathic Pain
A Pilot Study of Ultra Rapid Opioid Rotation and Titration of Oxymorphone
This project will explore the safety and feasibility of performing a successful intravenous patient controlled analgesia (IV PCA) Oxymorphone titration and conversion to oral ER Oxymorphone (extended release or OPANA ER) in the…
- Conditions
- Chronic Nociceptive Pain, Neuropathic Pain, Non-cancer Pain
- Trial name
- NCT00945919
- Testing
- Oxymorphone ER
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Pain, Pediatric Disorder
PET/MRI in the Diagnosis of Pediatric Chronic Pain
[18F]FTC-146 is a sigma-1 receptor detector and is an experimental radiotracer. Several studies have implicated involvement of sigma-1 receptors in generation and perpetuation of chronic pain conditions, while others are…
- Conditions
- Chronic Pain, Pediatric Disorder, Neuropathic Pain, Nociceptive Pain
- Trial name
- NCT04435821
- Testing
- [18F]FTC-146
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
Low Back Pain, Neck Pain
Prediction of Outcome of Interventional Pain Management
Interventional pain management for back and neck pain is widely used, but the indications and relative merits of these techniques rest subject to discussion.
- Conditions
- Low Back Pain, Neck Pain, Chronic Pain
- Trial name
- POINTPM (NCT02774694)
- Testing
- nociceptive flexion reflex (NFR) threshold ("Paintracker", Dolosys GmbH, Berlin, Germany)
- Where
- Switzerland
- Volunteers
- 350 people
- Sponsor
- Benno Rehberg-Klug
Catastrophizing Pain, Pain, Somatic
The Association Between Conditioned Pain Modulation and Pain Catastrophizing in Chronic Low Back Pain
This study evaluates the potential association between pain catastrophizing thoughts and the ability to dampen pain via endogenous descending inhibition.
- Conditions
- Catastrophizing Pain, Pain, Somatic, Chronic Low Back Pain
- Trial name
- NCT03644810
- Testing
- PPT measurement, Pain catastrophizing scale, Cold Pressor Test
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Chronic Pain
"MecPain", a New Questionnaire to Assess Chronic Pain Mechanisms.
Validation of a new clinical questionnaire, called 'MecPain', including 12 questions, aimed at better defining the pathophysiological mechanisms of a chronic pain condition.
- Trial name
- MecPain (NCT05713604)
- Where
- 2 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Grenoble
Neuropathic Pain, Chronic Pain
Translation of the Self Completed-Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale
Neuropathic pain, described as 'pain arising as a direct consequence of a lesion or disease on the somatosensory system', affects up to 3-9.8% of the investigators' population, but is often underdiagnosed and undertreated.
- Conditions
- Neuropathic Pain, Chronic Pain, Nociceptive Pain
- Trial name
- NCT02450565
- Testing
- Questionnaire
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong