Clinical trials: Chronic Mental Disorder
Substance Use Disorders
Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers
In recent years ketamine abuse becomes prevalent in youth in some Asian countries. Chronic ketamine abuse may lead to uropathology and cognitive impairments.
- Trial name
- NCT03644719
- Testing
- Cognitive behavioral skills training
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- National Taiwan University
Alzheimer Disease, Late Onset, Stroke
Explore the Sharing Model Intervene to Improve the Knowledge, Attitudes, Service Intentions and Service Start-up Effects of the Eight Major Non-cancer Disease End-stage Caregivers on Well-being and Palliative Care
Since September 1st, 2009, Taiwan has begun to pay attention to the care of patients with organ failure, dementia and the elderly, and brought eight of non-cancer terminal patients into health insurance subsidies to implement the…
- Conditions
- Alzheimer Disease, Late Onset, Stroke, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT05407272
- Testing
- Health Education Manual, manual
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wen-Shiou Pan
Chronic Pain, Fatigue
Real-world Momentary Assessment of Kratom Use Accompanied by Product Assays: A Natural-history Study for Interdisciplinary Characterization of Kratom Use and Pharmacology
Background: Mitragyna speciosa, also called kratom, is a plant used in Southeast Asia for its psychoactive effects. Its use has increased in the US, and an estimated 10 million adults may take it at least semiregularly.
- Conditions
- Chronic Pain, Fatigue, Substance Use Disorders
- Trial name
- NCT05457803
- Where
- United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cannabis Dependence
Effects of Chronic Intake of Cannabis on Contrast Sensitivity
Rates of driving under the influence of cannabis have risen in recent years. Cannabis is involved in 1/3 of motor vehicle collisions.
- Trial name
- NCT01793961
- Testing
- electroretinogram, contrast sensitivity tests
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Long COVID, Long COVID Syndrome
Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19
At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue.
- Trial name
- NCT06864156
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Rehabilitacion
Trauma, Nervous System
Northwest Therapies Trauma Psilocybin Study Compassionate Use Study
The on-boarding of unregulatable trauma in the United States has reached 20%, which is 1/5 of the population. A population of this magnitude, by definition has now reached an epidemic classification.
- Trial name
- NWTTPS (NCT05042466)
- Testing
- Trauma
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NWTraumatherapies
Medication Adherence
Daily Delivery and Supervision of Psychotropic Medication for High-Risk Patients With Severe/Persistent Mental Illness
The main study intervention is the daily witnessing of participant self-administration of medications by trained pharmacy staff to ensure compliance.
- Trial name
- NCT03766503
- Testing
- Daily
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Renal Failure Chronic, Restless Legs Syndrome
Massage, Oxidative and Antioxidant Enzymes in Hemodialysis Patients With Restless Legs Syndrome(RLS)
This study; It will be done to evaluate the presence of oxidative stress and its effects on lipid peroxidation products and antioxidant parameters after massage application and the possible effects of the appropriate massage…
- Trial name
- RLS (NCT05787080)
- Testing
- Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Baskent University
Stroke, Chronic, Aging
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors.
- Conditions
- Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction
- Trial name
- AMPLIFI (NCT06950060)
- Testing
- High intensity cycling, Low-intensity cycling, Health education session
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Mood Disorders
ACUTE AND CHRONIC EFFECTS OF A BOTANICAL EXTRACT ON ANXIETY, PERCEIVED STRESS, MOOD AND CORTISOL IN HEALTHY ADULTS
Mood disorders, including depression and anxiety, are one of the main causes of the overall disease burden worldwide. In recent years, the efficacy of certain botanicals as an alternative solution for depression has been…
- Trial name
- NCT03639831
- Testing
- Proprietary, standardized botanical extract
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Activ'inside
Prostatic Hyperplasia, Urinary Bladder, Overactive
A Randomized, Double-Blinded, Placebo-Controlled, Two-Way Crossover Study to Investigate the Safety and Toleration of Single Dose Sildenafil in Subjects Receiving Chronic UK-369,0031
To investigate the safety and overall tolerability of co-administration two PDE5 inhibitors UK369,003 and sildenafil
- Conditions
- Prostatic Hyperplasia, Urinary Bladder, Overactive, Erectile Dysfunction
- Trial name
- NCT00814736
- Testing
- UK369,003, sildenafil
- Where
- Singapore
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Obstructive Pulmonary Disease (COPD)
Neuromuscular Fatigue in Chronic Obstructive Pulonary Disease
Fatigue is a prevalent symptom in Chronic Obstructive Pulmonary Disease (COPD) that limits patients in their daily living activities.
- Trial name
- NEUROTIGUE (NCT04028973)
- Testing
- Single then dual task situation, Dual then single task situation
- Where
- 2 sites in France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
HIV-1-infection, Hepatitis C, Chronic
Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy
The study hypothesis is to determine the feasibility of switching HIV-HCV co-infected patients receiving methadone or buprenorphine/naloxone as opioid substitution therapy with suppressed HIV RNA viral load on current…
- Conditions
- HIV-1-infection, Hepatitis C, Chronic, Methadone Dependence, Opioid Dependence
- Trial name
- NCT03549312
- Testing
- Genvoya, Epclusa, Biktarvy
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Opiate Addiction
Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients
The purpose of this study is to determine if buprenorphine or methadone is better for the treatment of chronic pain among patients who have become addicted to prescription narcotics.
- Trial name
- NCT00879996
- Testing
- Methadone, Buprenorphine/naloxone
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Family, Dementia
Evaluation of "My Tools 4 Care" for Family Caregivers of Persons With Dementia
With the number of Canadians with Alzheimer's disease and related dementias (ADRD) growing, supporting family care partners of persons with ADRD is critical.
- Trial name
- NCT02428387
- Testing
- My Tools 4 Care
- Where
- 2 sites in Canada
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Post-traumatic Stress Disorder, Post-Traumatic Stress Disorder, Chronic
PTSD Affect Labeling Study
The overall goal of this study is to use fMRI and psychophysiological measures to investigate a novel strategy involving "Affect Labeling" for improving emotion regulation in PTSD that could lead to a new treatment regimen for…
- Trial name
- NCT05924399
- Testing
- Affect Labeling Training
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Depression in Old Age, Chronic Pain
Development of a Healthcare Service Platform for Successful Aging
The goal of this living-lab clinical trial is to test the effectiveness of digital health monitoring and feedback platform for community dwelling older adults.
- Conditions
- Depression in Old Age, Chronic Pain, Sleep Disorder Insomnia Chronic
- Trial name
- NCT06270121
- Testing
- Living-lab digital intervention group
- Where
- South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sunmi Song
Sleep, Insomnia
Treatment of Insomnia and Glucose Metabolism
Available data suggest that obtaining adequate sleep is associated with a better ability of the body to use carbohydrates as a source of energy and a lower risk of developing diabetes.
- Conditions
- Sleep, Insomnia, Insulin Resistance
- Trial name
- NCT00724282
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Restless Legs Syndrome (RLS), End-Stage Renal Disease
Effect of Intra-Dialytic Muscle Energy Technique on Restless Leg Syndrome in Hemodialysis Patients
The goal of this clinical trial is to learn if intra-dialytic Muscle Energy Technique (MET) can reduce symptoms of restless legs syndrome (RLS) in people with end-stage renal disease (ESRD) receiving maintenance hemodialysis.
- Trial name
- MET-RLS (NCT07748065)
- Testing
- Muscle Energy Technique, Routine Medical Treatment and Hemodialysis
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Respiratory Insufficiency, Pulmonary Disease, Chronic Obstructive
The Effect of Aromatherapy Massage on Pain, Anxiety and Comfort
Patients in the intensive care unit (ICU) experience physical and psychological discomfort, including pain. Anxiety is a condition frequently encountered in the ICU.
- Conditions
- Respiratory Insufficiency, Pulmonary Disease, Chronic Obstructive, Diabetes Mellitus, Type 2, High Blood Pressure
- Trial name
- NCT06295874
- Testing
- Effect of aromatherapy massage on vital signs, pain, anxiety and comfort level
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Nilgün Erdoğan