Clinical trials: Chronic Low-back Pain (cLBP)
Chronic Low-back Pain (cLBP)
Therapeutic Exercise Plus Pain Neuroscience Education for Chronic Low Back Pain
### What is this study about? This study looked at whether adding pain neuroscience education (PNE) to standard therapeutic exercise helps people with chronic low back pain who are afraid of moving (a condition called…
- Trial name
- NCT07856992
- Testing
- Therapeutic exercise, Pain Neuroscience Education
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Qingdao Municipal Hospital
Chronic Pain, Chronic Back Pain
Virtual Reality Treatment for Adults With Chronic Back Pain (VRNT)
Participants with chronic back pain will complete an online Qualtrics eligibility survey. After signing a consent form, eligible participants enter a two-week baseline period ("Baseline Period"), during which they complete two…
- Conditions
- Chronic Pain, Chronic Back Pain, Chronic Lower Back Pain (CLBP)
- Trial name
- NCT07033195
- Testing
- Skills-based Virtual Reality Therapy, Distraction-based Virtual Reality Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- CognifiSense Inc.
Chronic Low Back Pain (CLBP)
Non Invasive Brain Stimulation Treatment for CLBP
This trial is designed to preliminary evaluate the efficacy and safety of NIBS system for treatment of chronic low back pain (CLBP) (over 6 months).
- Trial name
- NIBSTCLBP (NCT02615418)
- Testing
- NIBS system for evaluation and treatment utilizing non invasive brain stimulation
- Volunteers
- 60 people
- Sponsor
- NIBS NeuroScience Technologies
Chronic Low Back Pain (CLBP), Acute Low Back Pain
Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)
This prospective cohort study investigates the neurobiological, genetic, and psychosocial mechanisms underlying acute and chronic low back pain (LBP).
- Conditions
- Chronic Low Back Pain (CLBP), Acute Low Back Pain, Low Back Pain, Chronic Pain
- Trial name
- LBPB (NCT06967363)
- Testing
- Nerve Block, endoscopic spinal disecetomy, Medication
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Peking University Third Hospital
Obesity, Overweight
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.
- Conditions
- Obesity, Overweight, Chronic Low Back Pain (CLBP)
- Trial name
- TRIUMPH-7 (NCT07035093)
- Testing
- Retatrutide
- Where
- 40 sites in United States, Argentina and 2 more
- Volunteers
- 586 people
- Sponsor
- Eli Lilly and Company
Chronic Low-back Pain (cLBP), Myofacial Pain
Treatment Validation for Myofascial Pain
The goal of this clinical trial is to see if a body test called the NUN biomarker can track changes in chronic low back pain after dry needling and predict who will feel better.
- Trial name
- NCT07133139
- Testing
- Dry Needling, NUN Biomarker
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ajay Wasan, MD, Msc
Chronic Low Back Pain (CLBP)
Virtual Reality Programme Incorporating Psychology and Physiotherapy for Chronic Low Back Pain
The main objective of this randomized controlled pilot trial is to investigate the efficacy of a 4-week multidisciplinary intervention for patients with chronic non-specific low back pain, combining a therapeutic exercise program…
- Trial name
- CLEVER-BODY (NCT06757413)
- Testing
- Enhanced Virtual reality, Active Comparator: Treatment as usual
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Cardenal Herrera University
Chronic Low Back Pain (CLBP)
A Mediation Analysis Investigating Dry Needling Treatment Mechanisms in a Chronic Low Back Pain Population
Low back pain is a common problem that many adults experience at some point in their lives. One treatment being studied is dry needling, a technique where a small needle is inserted into a specific area of muscle to help relieve…
- Trial name
- NCT06940492
- Testing
- Dry needling
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Florida
Chronic Low-back Pain (cLBP)
Acceptance and Commitment Therapy Plus Exercise for Older People With Chronic Low-back Pain: A Pragmatic Cluster Randomised Controlled Trial
Low back pain (LBP) is the fifth-most common disorder among older adults 60 years or older. The prevalence of LBP increases with age, with the highest prevalence occurring at 85 years old.
- Trial name
- NCT07211464
- Testing
- Acceptance and commitment therapy (ACT), back exercise, back care education
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The Hong Kong Polytechnic University
Fibromyalgia (FM), Chronic Low Back Pain (CLBP)
Pain Neuroscience Education for Chronic Pain
Chronic pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, with a high prevalence in Spain (25.9%) and an average duration of 6.83 years, highlighting its significant health…
- Conditions
- Fibromyalgia (FM), Chronic Low Back Pain (CLBP), Chronic Pain
- Trial name
- PNE (NCT07693998)
- Testing
- Therapeutic Exercise and Education in Pain Neuroscience
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- University of Valencia
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Chronic Low-back Pain
The Feasibility, Potential Efficacy, and Experiences of Using a Group-based Acceptance and Commitment Therapy Among Older People With Chronic Low Back Pain
No study has investigated the effects of ACT on community-dwelling Chinese older adults. Given that clinical practice guidelines have recommended exercise therapy for treating people with CLBP, a combination of ACT and exercise…
- Trial name
- NCT05919446
- Testing
- Acceptance and commitment therapy (ACT), back exercise
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Chronic Low Back Pain (Non-specific, Uncomplicated), Chronic Low Back Pain (CLBP)
Chronic Low Back Pain Comorbidities: Unravelling Impaired Glucose Metabolism
Chronic low back pain (CLBP) is a global health problem. The first step for developing effective treatments is a better understanding of underlying mechanisms, including its comorbidities.
- Trial name
- GLOW (NCT07734714)
- Testing
- Glucose beverage, Isomaltulose beverage, Standardized breakfast
- Where
- Belgium
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Chronic Low Back Pain (CLBP)
Integrated Feldenkrais Method With and Without DNS for Chronic Low Back Pain in Females
Non-specific low back pain is defined as low back pain not attributable to an identifiable, known specific pathology. Non-specific low back pain accounts for over 90% of patients presenting to primary care and these are the majority…
- Trial name
- NCT07912060
- Testing
- Integrated Feldenkrais Method with Dynamic Neuromuscular Stabilization exercises DNS, Feldenkrais Method Alone
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Management and Technology Lahore
Chronic Low-back Pain (cLBP)
Pain Science Education and Graded Exposure for Chronic Low Back Pain
Chronic low back pain can affect daily activities and may be influenced by how people understand pain, their fear of movement, and their responses to stressful or uncertain physical activities.
- Trial name
- PSE-GEM (NCT07836946)
- Testing
- Pain Science Education Plus Graded Exposure, Usual Physical Therapy
- Volunteers
- 82 people
- Sponsor
- University of Chile
Chronic Low-back Pain (cLBP), Chronic Neck Pain
Investigation of Conservative Treatment Preferences of Patients With Chronic Low Back and Neck Pain
Objective: The aim of this study is to determine the preferences of individuals with chronic low back and neck pain regarding physiotherapy treatment methods and to examine the factors influencing these preferences.
- Trial name
- NCT06898502
- Testing
- Electrotherapy ( TENS, hot pack, and therapeutic ultrasound )
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Low-back Pain (cLBP)
Factors Associated With Quality of Life in Chronic Low Back Pain
The aim of this study was to identify and validate the factors that may affect quality of life in patients with chronic low back pain.
- Trial name
- NCT06694493
- Where
- Turkey (Türkiye)
- Volunteers
- 174 people
- Sponsor
- Kutahya Health Sciences University
Chronic Low-back Pain (cLBP)
Exercise-Based Strategies for Chronic Back Pain
This randomized, controlled, five-arm, parallel-group trial will evaluate the effects of 8 weeks of supervised resistance training and developmental position-based exercise, with or without real-time non-invasive intra-abdominal…
- Trial name
- BACK-FIT (NCT07475481)
- Testing
- Gym settings, Physio settings, Home - based settings: exercises based on developmental positions
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Charles University, Czech Republic
Pain Threshold, Low Back Pain
Relationship Between Pressure Pain Threshold and Pain Intensity, Affect and Disability in CLBP
The association between pressure pain threshold and different aspects of low back pain has garnered attention over the years. However, since most of such studies in the past employed cross sectional designs, a longitudinal study…
- Conditions
- Pain Threshold, Low Back Pain, Pain Measurement
- Trial name
- NCT04482075
- Testing
- segmental stability training
- Where
- Pakistan
- Volunteers
- 41 people
- Sponsor
- Dow University of Health Sciences
Chronic Low Back Pain (CLBP)
Comparison of Two Patient Education Methods in Women With Chronic Low Back Pain: Online Pain Education vs. AI-Driven Patient Education on Pain Beliefs, Catastrophizing, and Self-Efficacy
The goal of this study is to learn if ChatGPT-generated answers can improve pain beliefs, catastrophizing, and self-efficacy in women with chronic low back pain compared to supervised pain education.
- Trial name
- NCT07916597
- Testing
- Patient Education, ChatGPT
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Amasya University