Clinical trials: Chronic Low-back Pain (cLBP)
Chronic Low Back Pain (CLBP)
Comparison of the Immediate Effect of Passive vs. Passive-Active Hamstring Stretching on Flexibility in Patients With Chronic Low Back Pain
The goal of this clinical trial is to determine whether a combination of passive and active hamstring stretching (PAS) is more effective than passive stretching alone (PS) in improving flexibility in patients with chronic low…
- Trial name
- EFIM2 (NCT06888895)
- Testing
- Passive-active stretching (PAS), Passive hamstring stretching
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Low Back Pain (CLBP)
Virtual Reality Programme Incorporating Psychology and Physiotherapy for Chronic Low Back Pain
The main objective of this randomized controlled pilot trial is to investigate the efficacy of a 4-week multidisciplinary intervention for patients with chronic non-specific low back pain, combining a therapeutic exercise program…
- Trial name
- CLEVER-BODY (NCT06757413)
- Testing
- Enhanced Virtual reality, Active Comparator: Treatment as usual
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Cardenal Herrera University
Chronic Low Back Pain (Non-specific, Uncomplicated), Chronic Low Back Pain (CLBP)
Chronic Low Back Pain Comorbidities: Unravelling Impaired Glucose Metabolism
Chronic low back pain (CLBP) is a global health problem. The first step for developing effective treatments is a better understanding of underlying mechanisms, including its comorbidities.
- Trial name
- GLOW (NCT07734714)
- Testing
- Glucose beverage, Isomaltulose beverage, Standardized breakfast
- Where
- Belgium
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Chronic Low-back Pain (cLBP)
Combining Brain Stimulation and Physiotherapy for the Management of Chronic Low Back Pain
Chronic low back pain (CLBP) is a major health challenge in Canada, leading to substantial disability and socioeconomic burden, particularly among Veterans. In military Veterans, LBP is the most common chronic pain condition.
- Trial name
- NCT06999772
- Testing
- Active rTMS, Psychologically-informed physiotherapy (PiP), Usual physiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 96 people
- Sponsor
- Laval University
Low Back Pain
Effects of Manipulative Therapy and Pain Education in Individuals With CLBP
The burden of low back pain more than doubled in the last 20 years, probably caused by biopsychosocial factors. Some noninvasive treatments have been applied in individuals with chronic nonspecific low back pain as spinal…
- Trial name
- NCT02982382
- Testing
- Manipulative Therapy, Pain Education
- Where
- Brazil
- Volunteers
- 128 people
- Sponsor
- Santa Catarina Federal University
Chronic Low-back Pain (cLBP)
Yoga and Mindfulness for Chronic Low Back Pain: A Randomized Controlled Trial
Chronic low back pain (CLBP) is a leading cause of disability, significantly impacting quality of life and work productivity. Traditional treatments often provide limited relief, necessitating alternative approaches.
- Trial name
- NCT06910982
- Testing
- Sphinx Pose Yoga Therapy
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- University of Karachi
Chronic Low Back Pain (CLBP)
Pain Neurophysiology Education in Chronic Low Back Pain
The investigators conducted a randomized controlled study including 22 patients suffering from chronic common low back pain. Patients were randomized into 2 groups: Control group received conventional rehabilitation only (11…
- Trial name
- PNE-LBP (NCT06915532)
- Testing
- Pain Neurophysiology Education, conventional rehabilitation
- Where
- Tunisia
- Volunteers
- 22 people
- Sponsor
- Hopital Charles Nicolle
Chronic Lower Back Pain (CLBP), Lumbar Facet Joint Pain
Lumbar Facet Platelet-Rich Plasma Injection Versus Medial Branch Radiofrequency Ablation for Chronic Lumbar Facet-Mediated Pain
The first clinical research effort under this initiative is a pilot randomized controlled trial comparing intra-periarticular lumbar facet platelet-rich plasma (PRP) injection to standard-of-care medial branch radiofrequency…
- Trial name
- NCT07692737
- Testing
- Platelet Rich Plasma Joint Injection, Medial branch radiofrequency ablation
- Volunteers
- 30 people
- Sponsor
- The New England Baptist Hospital
Chronic Non-specific Low Back Pain
Prolotherapy in Acupoints in Chronic Non-specific Low Back Pain (cLBP)
Chronic non-specific low back pain (CNSLBP) is among the most prevalent causes of disability on the planet, which often proves to be refractory to conventional pharmacological, interventional, and rehabilitation approaches.
- Trial name
- NCT07296653
- Testing
- Dextrose 15% and lidocaine 1% infiltration, Lidocaine 1% infiltration
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Non-specific Chronic Low Back Pain, Chronic Low-back Pain (cLBP)
Mindfulness-Based Therapy for Chronic Low Back Pain in Office Workers
This study evaluated whether a mindfulness-based therapy program could reduce pain severity in office workers with non-specific chronic low back pain.
- Conditions
- Non-specific Chronic Low Back Pain, Chronic Low-back Pain (cLBP), Mindfulness Meditation
- Trial name
- NCT07621302
- Testing
- Mindfulness-Based Therapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Dokuz Eylul University
Chronic Low Back Pain (CLBP), Post Cesarean Section Patient
The Role of Therapeutic Ultrasound in Comparison With Electrical Dry Needling in Chronic Low Back Patients Post Cesarean Section
HYPOTHESIS Null Hypothesis (HO): There was a non-significant difference in the role of therapeutic ultrasound in comparison with electrical dry needling in chronic low back patients post cesarean-section.
- Trial name
- NCT07246369
- Testing
- Electrical Dry Needling, Ultrasound
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- University of Lahore
Overweight or Obesity, Chronic Low-back Pain
Lifestyle Intervention in Overweight/Obese Chronic Low Back Pain (CLBP) Patients: an International Multi-center RCT
Chronic low back pain (CLBP) is the most expensive cause of workrelated disability: it causes the highest number of years lived with disability.
- Trial name
- BO2WL (NCT05811624)
- Testing
- Physiotherapy intervention, including behavioral weight reduction program combined with pain neuroscience education and cognition-targeted exercise therapy., Physiotherapy intervention, including pain neuroscience education and cognition-targeted exercise therapy alone.
- Where
- 2 sites in Belgium, Switzerland
- Volunteers
- 252 people
- Sponsor
- Vrije Universiteit Brussel
Chronic Low Back Pain (CLBP), Insomnia
Resilience Enhancement Following Sleep Treatment
The primary objective of this study is to evaluate the efficacy of an adaptive intervention targeting both insomnia and positive affect in improving pain outcomes for adults with chronic low back pain (cLBP) and comorbid…
- Trial name
- REST (NCT07298941)
- Testing
- Cognitive-behavioral therapy for insomnia (CBTi), CBTi + Savoring Meditation, CBTi + Pain Education
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Virginia
Chronic Low Back Pain (CLBP), Chronic Neck Pain
Comparative Analysis of Heart Rate Variability in Patients with Cervical Pain, Lumbar Pain, and Healthy Controls
This is a cross-sectional study designed to evaluate potential differences in heart rate variability (HRV) indices based on the affected body region (cervical vs lumbar) in individuals with chronic pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Neck Pain, Heart Rate Variability, Autonomic Nervous System Dysfunction
- Trial name
- NCT06890793
- Where
- Spain
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Universidad de Extremadura
Low Back Pain, Mechanical
Short Terms Effects of Medial Branch Block vs Para-spinal Muscle Injection in Patients With Non-specific CLBP
This study compares the efficacy of medial branch block (MBB) vs. paravertebral deep intramuscular (PDI) injection for pain relief in chronic low back pain.
- Trial name
- NCT02521519
- Testing
- Medial branch block in one side, paravertebral deep intramuscular (PDI) injection
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Low-back Pain (cLBP)
Visual Feedback Manipulation in Virtual Reality Alters Extension-evoked Pain Perception in Chronic LBP
This study investigates the potential to modify movement-evoked pain in individuals with chronic low back pain (LBP) by manipulating visual proprioceptive feedback through virtual reality (VR).
- Trial name
- CLEVER BODY (NCT06750900)
- Testing
- NORMAL CONDITION, UNDERSTATED CONDITION, OVERSTATED CONDITION
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Cardenal Herrera University
MSK Conditions, Chronic Low Back Pain (CLBP)
Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial
The goal of this clinical trial is to learn if antibiotics (amoxicillin) work to treat chronic low back pain in adults. In some patients, this type of back pain may be caused by bacteria in the vertebrae, resulting in a condition…
- Conditions
- MSK Conditions, Chronic Low Back Pain (CLBP), Modic Changes
- Trial name
- ABBA (NCT06771492)
- Testing
- Amoxicillin
- Where
- Netherlands
- Volunteers
- 144 people
- Sponsor
- Bart Koes
Chronic Low Back Pain (CLBP)
Clinical Investigation to Assess the Clinical Effect of the LumbaCure® Intervention on Patients Suffering From Chronic Low Back Pain
Low Back Pain (LBP) is one of the common causes of morbidity worldwide, with a one-month prevalence of 23.3 %. Number of people with LBP reached 577 million people in 2020.
- Trial name
- LumbaCure2302 (NCT06662032)
- Testing
- LumbaCure®, Rehab program
- Where
- 2 sites in Belgium
- Volunteers
- 50 people
- Sponsor
- Odix
Chronic Low-back Pain (cLBP)
Combined and Aquatic Exercise in Chronic Low Back Pain
The goal of this randomized clinical trial is to evaluate the effects of a combined aquatic- and land-based exercise program, as well as an aquatic-exercise program, compared with a control group receiving home-based exercise, on…
- Trial name
- NCT07732595
- Testing
- Aquatic-exercise Program, Land-based Exercise Program, Home-based Exercise Program
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- University of Beira Interior
Sciatica, Lumbar Radiculopathy
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments.
- Conditions
- Sciatica, Lumbar Radiculopathy, Lower Back Pain, Degenerative Disc Disease
- Trial name
- NCT04982965
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego