Clinical trials: Chronic Illness
Chronic Illness
Virtual ACT for Adolescent Stress
This study aims to test the effectiveness of a 6-week long virtual Acceptance Commitment group therapy as a non-pharmaceutical intervention to improving other functional outcomes for adolescents with a chronic medical condition…
- Trial name
- NCT04978610
- Testing
- Virtual Acceptance Commitment Therapy
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Atrial Fibrillation (AF), Heart Failure
Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
People with severe mental illness have a substantially increased risk of undiagnosed and insufficiently treated somatic disease.
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Asthma (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- SomaScreen (NCT07518446)
- Testing
- Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
- Where
- Denmark
- Volunteers
- 2,800 people
- Sponsor
- Amager Hospital
Renal Failure , Chronic, Intradialytic Hypotension
Ultrasound-Based Prediction of Hemodynamic Instability During CVVHDF Initiation
This prospective observational study aims to evaluate the ability of transthoracic echocardiographic and bedside ultrasonographic parameters to predict intradialytic hypotension and hemodynamic instability at the initiation of…
- Conditions
- Renal Failure , Chronic, Intradialytic Hypotension, Critical Illness
- Trial name
- US-CVVHDF (NCT07397663)
- Volunteers
- 80 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Chronic Mental Illness, Major Depression
My Coach Connect: An Automated Telephone-based Reporting System for Patients With Mental Illness
This is a pilot study for a novel, automated telephone system called "My Coach Connect". The purpose of the study is to evaluate the feasibility and effectiveness of this telephone tool while engaging clients and providers in…
- Conditions
- Chronic Mental Illness, Major Depression, Schizophrenia, Bipolar Disorder
- Trial name
- MCC (NCT01749124)
- Testing
- My Coach Connect
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- RAND
Trauma Injury, Trauma
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery.
- Conditions
- Trauma Injury, Trauma, Critical Illness, Microbiome
- Trial name
- NCT06606119
- Testing
- Data and tissue collection
- Where
- 3 sites in United States
- Volunteers
- 275 people
- Sponsor
- University of Florida
Caregiver Stress in Chronic Mental Illness, Psychosocial Burden in Psychiatric Caregivers
Effect of a Mindfulness-Based Stress Reduction Program on Caregivers
This study is designed to investigate the effects of a Mindfulness-Based Stress Reduction (MBSR) program on cognitive control and flexibility, psychological well-being, and self-compassion among primary caregivers of individuals…
- Conditions
- Caregiver Stress in Chronic Mental Illness, Psychosocial Burden in Psychiatric Caregivers, Chronic Mental Illness Caregiving, Cognitive and Emotional Outcomes in Caregivers
- Trial name
- MBSR-CG (NCT07322081)
- Testing
- The Mindfulness-Based Stress Reduction program consists of structured mindfulness practices, psychoeducation, and experiential exercises delivered to caregivers., Usual Care Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Trauma Injury, Sepsis
Pathological Myeloid Activation After Sepsis and Trauma
The goal of this observational study is to better understand what happens to circulating blood after a patient experiences severe trauma injury.
- Conditions
- Trauma Injury, Sepsis, Immunosuppression, Chronic Critical Illness
- Trial name
- NCT05616130
- Testing
- Data Collection, Bone marrow collection and blood collection, Serial interviews to complete surveys and questionnaires
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of Florida
Primary Myelofibrosis (PMF), Post Polycythemia Myelofibrosis (PPV MF)
Managed Access Programs for INC424, Ruxolitinib
The purpose of this registration is to list Managed Access Programs (MAPs) related to INC424, Ruxolitinib
- Conditions
- Primary Myelofibrosis (PMF), Post Polycythemia Myelofibrosis (PPV MF), Thrombocythemia Myelofibrosis (PET-MF), Severe/Very Severe COVID-19 Illness
- Trial name
- NCT04745637
- Testing
- Ruxolitinib
- Sponsor
- Novartis Pharmaceuticals
Healthy, Chronic Stable Illness
COVID-19 Study to Assess Immunogenicity, Safety, and Tolerability of Moderna mRNA-1273 Vaccine Administered With Casirivimab+Imdevimab in Healthy Adult Volunteers
The primary objectives of the study are: To evaluate the extent of effect, if any, of REGN10933+REGN10987 administration on vaccine-induced neutralizing antibody responses to SARS-CoV-2 by Moderna mRNA-1273 To evaluate the time…
- Trial name
- NCT04852978
- Testing
- casirivimab+imdevimab, Moderna mRNA-1273 vaccine
- Where
- 6 sites in United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Healthy, Chronic Stable Illness
COVID-19 Study Assessing the Safety and Tolerability of Co-Formulated Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (Casirivimab+Imdevimab) in Adult Volunteers
The primary objective of the study is to assess the safety and tolerability of co-formulated subcutaneous (SC) and intravenous (IV) casirivimab+imdevimab The secondary objectives of the study are to: Explore variability in the…
- Trial name
- NCT05181683
- Testing
- Casirivimab+Imdevimab
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Chronic Illness, Caregivers
Effect of a Person-Centred Care Intervention for Families Providing Home-Based Care to a Person With Advanced Chronic Illness: A Pilot Randomised Controlled Trial
The goal of this clinical trial is to learn if a Person-Centred Care (PCC) intervention can improve the caregiving experience and wellbeing of families who provide home care for a loved one with advanced chronic illness.
- Trial name
- HELP-F (NCT07184216)
- Testing
- Person-centered care intervention
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
COPD, Dyspnea
Dyspnea and Psychosocial Effects of Hand Fan Application in COPD Patients
This randomized controlled trial aims to evaluate the effects of hand fan application on dyspnea, illness perception, anxiety, and depression in COPD patients.
- Conditions
- COPD, Dyspnea, Illness Perception, Anxiety
- Trial name
- COPD (NCT06857422)
- Testing
- Hand Fan Application, Standard Care for COPD Patients
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Ardahan University
Siblings of Children With Chronic Illness
SIBS-Intervention for Siblings and Parents of Children With Chronic Illness
SIBS-RCT is a randomized controlled trial comparing the effect of a 5-session group intervention for siblings and parents of children with chronic illness to 12-week waitlist.
- Trial name
- SIBS-RCT (NCT04056884)
- Testing
- SIBS intervention
- Where
- Norway
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Family, End of Life
Web-based Support for Family Caregivers of Patients With Advanced Cancer
For family caregivers of patients with advanced cancer, preparedness for caregiving is crucial for maintaining health and quality of life both during care and after the death of the patient.
- Conditions
- Family, End of Life, Cancer Metastatic, Chronic Illness
- Trial name
- NCT05785494
- Testing
- Narstaende.se
- Where
- Sweden
- Volunteers
- 204 people
- Sponsor
- Ersta Sköndal University College
Chronic Illness
"Sport on Prescription" in Primary Care for Patients With Long-term Illnesses
Adapted Physical Activity (APA) helps to prevent chronic diseases identified as major causes of mortality, particularly cardiovascular diseases and some cancers, according to the World Health Organization (WHO).
- Trial name
- PRIMAPA-VAR (NCT05437978)
- Testing
- "Cap Sport Santé 83" program
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Chronic Mental Illness, Schizophrenia
Exploring the Health Effects of Group Game-based Activities on Individuals With Chronic Mental Illness
This study aims to explore the health effects of group games for patients with chronic mental illness. The goal of this clinical intervention study is to compare the efficacy of group games in two ways (experimental group/ group…
- Conditions
- Chronic Mental Illness, Schizophrenia, Psychiatry
- Trial name
- NCT06440200
- Testing
- group gamed-based activity
- Where
- Taiwan
- Volunteers
- 109 people
- Sponsor
- National Taiwan University Hospital
Depression, Anxiety
The Mental Health Experiences of Sexual and Gender Minorities Living With Cancer and Their Care Partners
The purpose of this study is to examine relationships between contextual stressors and stress moderators, depression symptom experience, resilience, frailty, and quality of life among older sexual gender minorities cancer…
- Conditions
- Depression, Anxiety, Caregiver Burden, Stress
- Trial name
- SGMC (NCT05866705)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Respiratory Disease, Cardiovascular Diseases
Prospective Observational Study to Characterize Patients Treated at Internal Medicine Clinics
Patients referred to internal medicine wards are becoming increasingly complex and fragile. Despite deep knowledge of their specific disorders, steps are required to improve overall management of their acute and chronic…
- Conditions
- Respiratory Disease, Cardiovascular Diseases, Infectious Disease, Critical Illness
- Trial name
- MED-Cli (NCT05780099)
- Testing
- Inpatient or Outpatient visit
- Where
- 2 sites in Italy
- Volunteers
- 50,000 people
- Sponsor
- IRCCS San Raffaele
Pain, Pain Acute
The PainSMART Research Program: Evaluating a Pain Education Strategy for Patients Seeking Primary Care Physiotherapy
The goal of this clinical trial is to test the PainSMART-strategy in a population of patients seeking primary care physiotherapy for pain related to muscles, joints and bones, so called musculoskeletal pain.
- Conditions
- Pain, Pain Acute, Pain, Chronic, Self Efficacy
- Trial name
- PainSMART (NCT06187428)
- Testing
- PainSMART-strategy, Usual physiotherapy management
- Where
- 6 sites in Sweden
- Volunteers
- 494 people
- Sponsor
- Kajsa Johansson
Chronic Disease, Mental Illness
Tablet-Enabled Video Telehealth to Enhance Veterans' Access and Care
In order to enhance access to clinical and mental health services for Veterans who have geographic, clinical, or social barriers to in-person care, VA Offices of Connected Care and Rural Health began distributing 5,000 tablets to…
- Trial name
- NCT03089801
- Testing
- Tablet-Enabled Video Telehealth
- Where
- United States
- Volunteers
- 32,186 people
- Sponsor
- VA Palo Alto Health Care System