Clinical trials: Chronic Idiopathic Constipation
Chronic Idiopathic Constipation
The Plecanatide Chronic Idiopathic Constipation (CIC) Study
This is a randomized, double-blind, placebo controlled, 12 week repeat oral dose, dose ranging study to determine the efficacy and safety of 3 doses of plecanatide compared to placebo in patients with Chronic Idiopathic…
- Trial name
- NCT01429987
- Testing
- plecanatide
- Where
- 121 sites in United States
- Volunteers
- 951 people
- Sponsor
- Bausch Health Americas, Inc.
Chronic Idiopathic Constipation
A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults
The purpose of this study is to evaluate a daily dose of BLI400 Laxative for safety and efficacy versus lubiprostone in constipated adults.
- Trial name
- NCT02481947
- Testing
- BLI400 Laxative, Lubiprostone
- Where
- 50 sites in United States
- Volunteers
- 459 people
- Sponsor
- Braintree Laboratories
Constipation, Chronic Constipation
Study of Elobixibat (A3309) in Patients With Chronic Idiopathic Constipation
The purpose of this trial is to determine the efficacy and safety of A3309 administered to patients with chronic idiopathic constipation.
- Trial name
- ACCESS (NCT01007123)
- Testing
- A3309
- Where
- 44 sites in United States
- Volunteers
- 190 people
- Sponsor
- Albireo
Constipation, Chronic Idiopathic Constipation
BLI400-302: A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults
The objective of this study is to evaluate a daily dose of BLI400 Laxative for safety and efficacy versus placebo in constipated adults.
- Conditions
- Constipation, Chronic Idiopathic Constipation, CIC
- Trial name
- NCT02819297
- Testing
- BLI400 Laxative
- Where
- 51 sites in United States
- Volunteers
- 1,020 people
- Sponsor
- Braintree Laboratories
Constipation, Constipation Chronic Idiopathic
A Pilot Study to Explore the Role of Gut Flora in Chronic Constipation
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding chronic constipation
- Conditions
- Constipation, Constipation Chronic Idiopathic, Constipation - Functional, Constipation (Excl Faecal Impaction)
- Trial name
- NCT04148248
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Chronic Idiopathic Constipation
A Exploratory Study of KWA-0711 in Patients With Chronic Idiopathic Constipation (CIC)
The purpose of this study is to evaluate the efficacy and safety of KWA-0711 in Chronic Idiopathic Constipation (CIC) patients.
- Trial name
- NCT01600001
- Testing
- KWA-0711
- Where
- Japan
- Volunteers
- 75 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Constipation, Chronic Idiopathic Constipation
An Open Label Study of Chronic Use of BLI400 Laxative in Constipated Adults
The objective of this study is to evaluate the safety of chronic use of BLI400 laxative in constipated adults.
- Conditions
- Constipation, Chronic Idiopathic Constipation, CIC
- Trial name
- NCT02819310
- Testing
- BLI400 Laxative
- Where
- 24 sites in United States
- Volunteers
- 330 people
- Sponsor
- Braintree Laboratories
Constipation and Dyspepsia
The Effects of Tegaserod vs. Placebo on Whole Gut Transit Time in Patients With Chronic Constipation and Dyspepsia
To demonstrate the effects of tegaserod on gastrointestinal scintigraphic orocecal transit in female patients with CC and upper GI symptoms of dyspepsia
- Trial name
- NCT00277550
- Volunteers
- healthy volunteers welcome
- Sponsor
- Novartis
Chronic Idiopathic Constipation
Efficacy and Safety of Vibrant Capsule vs. Placebo for the Treatment of Chronic Idiopathic Constipation
The study is a prospective, randomized, multicenter, adaptive design, double blinded, placebo-controlled study, to evaluate the efficacy and safety of Vibrant Capsule vs.
- Trial name
- Vibrant (NCT03879239)
- Testing
- Vibrating capsule
- Where
- 8 sites in United States
- Volunteers
- 349 people
- Sponsor
- Vibrant Ltd.
Chronic Idiopathic Constipation
This Study Aims to Evaluate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties and Food Effect of IN-114199 in Healthy Participants
This study aims to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic properties and food effect of IN-114199 in healthy participants
- Trial name
- NCT06736912
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Chronic Idiopathic Constipation
Evaluation of Clinical Equivalence Between Two Linaclotide Products in the Treatment of Chronic Idiopathic Constipation
The objective of this study is to evaluate the clinical equivalence of the test formulation of Linaclotide compared to the marketed formulation LINZESS® in patients with Chronic Idiopathic Constipation, and to evaluate the…
- Trial name
- NCT04804267
- Testing
- Linaclotide, LINZESS®
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Chronic Idiopathic Constipation
Evaluation of Clinical Equivalence Between Two Lubiprostone Products
The objective of this study is to evaluate the clinical equivalence and safety of the Test formulation of lubiprostone 24 mcg capsules compared to the marketed formulation AMITIZA® (lubiprostone) 24 mcg capsules (Sucampo…
- Trial name
- NCT01372423
- Testing
- Lubiprostone
- Where
- 79 sites in United States
- Volunteers
- 808 people
- Sponsor
- Anchen Pharmaceuticals, Inc
Constipation Chronic Idiopathic
MowOot and Trans-anal Irrigation fOr coNstipation
This prospective, open-labelled, longitudinal, controlled study aims to evaluate the suitability of Intermittent Colonic Exoperistalsis (ICE) treatment for adults with refractory chronic constipation who are awaiting trans-anal…
- Trial name
- MOTION (NCT06833684)
- Testing
- ICE Treatment, TAI Standard-of-Care Treatment
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- usMIMA S.L.
Chronic Idiopathic Constipation, Functional Constipation
Botulinum Toxin Injection Versus Anal Myectomy in Management of Idiopathic Constipation
Chronic idiopathic constipation is most common cause of Constipation in childhood with numerous cases in Egypt. Numerous conservative measures were tried but many fail.
- Trial name
- NCT02361749
- Testing
- Botulinum Toxin, Anal Myectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Chronic Idiopathic Constipation
An Efficacy and Safety Study of Plecanatide in Adolescents 12 to <18 Years of Age With Chronic Idiopathic Constipation
This is a study of efficacy and safety of Plecanatide in pediatric subjects aged 12 to < 18 years diagnosed with Chronic Idiopathic Constipation.
- Trial name
- NCT03120520
- Testing
- Plecanatide
- Where
- 36 sites in United States
- Volunteers
- 124 people
- Sponsor
- Bausch Health Americas, Inc.
Chronic Idiopathic Constipation
Efficacy and Safety of Vibrant Capsule vs. Vibrant Placebo for the Treatment of Chronic Idiopathic Constipation (CIC)
The was performed to assess the safety and efficacy of the vibrant capsule vs. placebo for the treatment of subjects with functional Constipation.
- Trial name
- CIC (NCT04458675)
- Testing
- Vibrant capsule
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Vibrant Ltd.
Fecal Incontinence and Constipation
Sacral Nerve Stimulation for Anal Incontinence and Bowel Control
Multicenter European study to evaluate efficacy and safety of sacral nerve stimulation with InterStim Therapy to treat fecal incontinence or constipation
- Trial name
- MDT-301 (NCT00200005)
- Testing
- Type: Implantable neurostimulator; InterStim
- Where
- 9 sites in United States, Austria and 6 more
- Volunteers
- 140 people
- Sponsor
- MedtronicNeuro
Functional Constipation, Fecal Impaction
Comparison of Efficacy & Tolerability Of PEG 4000 Versus PEG 3350+ Electrolytes for Pediatric Fecal Disimpaction
Childhood constipation is a common but serious gastrointestinal disorder prevalent worldwide. In 90-95% of children, it is of functional origin.
- Conditions
- Functional Constipation, Fecal Impaction, Constipation - Functional, Constipation Chronic Idiopathic
- Trial name
- NCT06349031
- Testing
- Administration of Polyethylene Glycol (PEG) 4000 as per treatment allocation to participants, Administration of Polyethylene Glycol (PEG) 3350 + Electrolyte as per treatment allocation to participants
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Medical Sciences and SUM Hospital
Chronic Idiopathic Constipation
Pharmacodynamic, Pharmacokinetic, and Tolerability Study of a Liquid Form of Lubiprostone in Adult Subjects With Chronic Idiopathic Constipation
To evaluate the pharmacodynamics and tolerability of a liquid formulation of lubiprostone, as compared to matching placebo, when administered orally to subjects with chronic idiopathic constipation.
- Trial name
- NCT01993875
- Testing
- Lubiprostone
- Where
- 11 sites in United States
- Volunteers
- 164 people
- Sponsor
- Mallinckrodt
Gastroparesis, GERD
Domperidone for Relief of Gastrointestinal Disorders
The purpose of this study is to make Domperidone available to patients with gastrointestinal disorders who have failed standard therapy and who might benefit from it.
- Conditions
- Gastroparesis, GERD, Esophagitis, Dyspepsia
- Trial name
- NCT00761254
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Carle Physician Group