Clinical trials: Chronic Condition
Chronic Insomnia, Cancer-related Problem/Condition
The Association Between CBT-I Dose, Sleep Duration, and Fatigue in Breast Cancer Patients
Cancer-related fatigue (CRF) and insomnia are prevalent among cancer patients and have been linked to de-creases in quality of life and poorer overall survivorship.
- Conditions
- Chronic Insomnia, Cancer-related Problem/Condition, Cancer-Related Syndrome
- Trial name
- NCT05226078
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Multiple Chronic Conditions, Adverse Event
Real-time Symptom Monitoring Using ePROs to Prevent Adverse Events During Care Transitions
This study aims to predict and minimize post-discharge adverse events (AEs) during care transitions through early identification and escalation of patient-reported symptoms to inpatient and ambulatory clinicians by way of…
- Trial name
- NCT05282654
- Testing
- ePRO Application
- Where
- 2 sites in United States
- Volunteers
- 937 people
- Sponsor
- Brigham and Women's Hospital
Opioid Dependence, Substance Abuse Disorders
The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care
The goal of this pilot clinical trial is to learn if a community informed designed program of addiction counseling with coordinated community peer navigator for people with Opioid Use Disorder (OUD) and other medical conditions…
- Conditions
- Opioid Dependence, Substance Abuse Disorders, Complex Medical Patients, Primary Care Patients With Chronic Conditions
- Trial name
- MOUD+ (NCT06837662)
- Testing
- MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Oregon Health and Science University
Chronic Conditions, Multiple
ElderTree Via a Voice Activated Device for Managing Chronic Health Conditions (NHLBI)
Multiple chronic conditions (MCCs) are costly and pervasive among older adults. MCCs account for 90% of Medicare spending, and 65% of Medicare beneficiaries have 3 or more chronic conditions; 23% have 5 or more.
- Trial name
- NCT05240534
- Testing
- ET-Text (Laptop), ET-Voice (Smart System)
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- University of Wisconsin, Madison
Chronic Respiratory Conditions, Obstructive Sleep Apnea (OSA)
Evaluation of the F&P Mask, US, 2026
This clinical investigation is designed to validate and confirm the overall performance, safety, usability, reliability, and acceptability of the F\&P PAP mask in a home environment.
- Trial name
- NCT07826429
- Testing
- F&P Licorice Mask
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Implementation Science, Chronic Disease Self-management
Adapting and Implementing a Chronic Disease Self-Management Program for Primary Care Patients With Opioid Use Disorder and Serious Mental Illness
The purpose of this study is to evaluate a self-management education program designed to help people with opioid use disorder (OUD), serious mental illness (SMI), and other chronic health conditions better manage their health.
- Conditions
- Implementation Science, Chronic Disease Self-management, Mental Illness, Addiction
- Trial name
- NCT07865078
- Testing
- The Chronic Disease Self-Management Program (CDSMP), Treatment as Usual plus self-management information
- Volunteers
- 40 people
- Sponsor
- University of Utah
Hepatitis B, Chronic
Phase 2 Study of AHB-137 in HBeAg Negative Chronic Hepatitis B (CHB) Participants in Asia Pacific Region
This study is a randomized, open-label, multicenter phase 2 clinical trial to evaluate the efficacy and safety of AHB-137 injection in participants with HBeAg-negative CHB treated with Nucleos(t)ide Analogue (NAs).
- Trial name
- ASPIRE-201 (NCT07370207)
- Testing
- AHB-137
- Where
- 10 sites in Australia, China and 5 more
- Volunteers
- 84 people
- Sponsor
- AusperBio Therapeutics Inc.
Chronic Respiratory Conditions, Obstructive Sleep Apnea (OSA)
Evaluation of F&P Mask, US, 2026
This clinical investigation is designed to validate and confirm the overall performance, safety, usability, reliability, and acceptability of the F\&P mask in a home environment.
- Trial name
- NCT07847814
- Testing
- F&P Mask
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
Neurological Conditions, Musculoskeletal Diseases or Conditions
IAMABLE: Implementation and Evaluation of an App for Evidence-Based Self-Management Rehabilitation Strategies
Background: As the population gets older, a rise in chronic conditions has resulted in increased demand for rehabilitation. We developed a web-based app called IAMABLE (I am able), to share evidence-based rehabilitation…
- Conditions
- Neurological Conditions, Musculoskeletal Diseases or Conditions, Cardiovascular Diseases
- Trial name
- IAMABLE (NCT06773169)
- Testing
- IAMABLE web-based app, General health information
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Contraceptive Usage, Contraceptive Behavior
A Web-Based Tool to Help People With Health Conditions Make Contraceptive Decisions
Among people who do not want to get pregnant, some do not use any birth control. This is also called contraceptive nonuse. Common reasons for contraceptive nonuse include concerns about birth control safety or side effects.
- Conditions
- Contraceptive Usage, Contraceptive Behavior, Chronic Disease, Chronic Condition
- Trial name
- NCT07075536
- Testing
- My Health, My Choice Web-Based Contraceptive Decision Tool, Usual Contraceptive Care
- Where
- 19 sites in United States, Puerto Rico
- Volunteers
- 795 people
- Sponsor
- University of Michigan
Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome
The Precision Mito- Mito Map COMPASS Study
Mito Map is a research tool that produces an Energy Score from information provided by a participant. This remote observational study has an initial enrollment target of 400 adults across seven prespecified cohorts: healthy…
- Conditions
- Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome, Post-COVID-19 Condition, Postural Orthostatic Tachycardia Syndrome
- Trial name
- COMPASS (NCT07856121)
- Testing
- Mito Map Energy Score and Home Functional Assessments
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- AI Agent Vault, Inc. d/b/a Precision Mito
Chronic Conditions, Multiple
Psychometric Validation of the Flemish Version of the Transition Readiness Assessment Questionnaire (TRAQ 6.0) in Young People With Chronic Conditions
Healthcare transition, which involves preparing children and adolescents for the shift from pediatric to adult healthcare, received increased attention in recent years.
- Trial name
- NCT07852169
- Where
- Belgium
- Volunteers
- 128 people
- Sponsor
- Universiteit Antwerpen
Multimorbidity, Cancer
The LifeMeds Cohort
The goal of this observational study is to investigate lifestyle behaviours, their determinants, and their associations with health outcomes in adults with multimorbidity, defined as the presence of at least two lifestyle-related…
- Conditions
- Multimorbidity, Cancer, Cardio Vascular Disease, Chronic Respiratory Conditions
- Trial name
- LifeMeds (NCT07846800)
- Volunteers
- 2,000 people
- Sponsor
- Tilburg University
Multiple Chronic Conditions
Digitally Supported Person-centered Care Systems
The case history of patients with complex and long-term needs is often stored in fragments across many different care providers, each with a separate electronic health record.
- Trial name
- DignityCare (NCT07142616)
- Testing
- 03 - Summaries of and clinical notes from several providers, 01 - Clinical notes from one provider, 02 - Access to notes from primary and secondary care
- Where
- Norway
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Hepatitis B, Chronic
Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions
This study is a randomized, open-label, multicenter phase 2 clinical trial to evaluate the efficacy and safety of AHB-137 injection in participants with CHB treated with Nucleos(t)ide Analogue (NAs).
- Trial name
- ASPIRE-202 (NCT07654283)
- Testing
- AHB-137
- Where
- 10 sites in United States, Canada and 4 more
- Volunteers
- 70 people
- Sponsor
- AusperBio Therapeutics Inc.
Digital Health Intervention, Remote Consultation, Teleconsultation
Evaluation and Implementation of Digital Health Ecosystem in Academic Health Center
Mobile health technologies, such as smartwatches, wearable sensors, and digital applications, have the potential to support healthier lifestyles and improve the management of health conditions.
- Conditions
- Digital Health Intervention, Remote Consultation, Teleconsultation, Lifestyle Factors, Stress
- Trial name
- e-IDEA (NCT07831837)
- Testing
- Integrated Digital Health Ecosystem, Usual Primary Care
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Trauma Exposure, Trauma
Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress
The goal of this clinical trial is to compare the effectiveness of trauma-focused therapies for improving mental health symptoms and daily functioning in youth with chronic medical conditions who have experienced psychological…
- Conditions
- Trauma Exposure, Trauma, Trauma and Stressor Related Disorder, Mental Health Functioning
- Trial name
- NCT07483333
- Testing
- Structured Psychotherapy for Adolescents Responding to Chronic Stress - Group, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Group, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Individual
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Anthony Vesco
Multiple Chronic Conditions, Decision Making, Shared
Effect of Patient Priorities Care Implementation in Older Veterans With Multiple Chronic Conditions
The investigators will conduct a randomized control trial enrolling 420 older Veterans with multiple chronic conditions receiving primary care at the Michael E.
- Trial name
- PPC (NCT04922320)
- Testing
- Patient Priorities Care, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 437 people
- Sponsor
- VA Office of Research and Development
Multimorbidity
Telehealth-delivered Peer Support to Improve Quality of Life Among Veterans With Multimorbidity
The VetASSIST study is a randomized clinical trial testing whether receiving virtual health coaching from Veteran peers improves the physical and mental health-related quality of life of Veterans with multiple chronic health…
- Trial name
- VetASSIST (NCT05560451)
- Testing
- Peer health coach intervention
- Where
- United States
- Volunteers
- 298 people
- Sponsor
- VA Office of Research and Development