Clinical trials: Choroidal Nevus
Uveal Melanoma
Study of Adjuvant Darovasertib and Crizotinib in Participants With Primary Non-metastatic Uveal Melanoma
This is a randomized, multi-center, open-label study of adjuvant darovasertib in participants with non-metastatic uveal melanoma (OptimUM-11)
- Trial name
- NCT07804186
- Testing
- Darovasertib, Crizotinib (Xalkori)
- Where
- 13 sites in United States, Canada
- Volunteers
- 450 people
- Sponsor
- IDEAYA Biosciences
Choroidal Melanoma, Indeterminate Lesions
Choroidal Melanoma Patient-Reported Outcome Study (CM-PRO) in a Subset of AU-011-301 (CoMpass) Subjects
To assess subject-centric evidence of QoL outcomes in a subset of subjects enrolled in the global Phase 3 AU-011-301 clinical trial.
- Conditions
- Choroidal Melanoma, Indeterminate Lesions, Uveal Melanoma, Ocular Melanoma
- Trial name
- NCT07421739
- Testing
- Non-interventional, digital, patient-reported, study
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Aura Biosciences
Choroidal Melanoma, Indeterminate Lesions
A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma
The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melanoma (CM).
- Conditions
- Choroidal Melanoma, Indeterminate Lesions, Uveal Melanoma, Ocular Melanoma
- Trial name
- CoMpass (NCT06007690)
- Testing
- Bel-sar, Suprachoroidal Microinjector, Infrared Laser
- Where
- 53 sites in United States, Australia and 12 more
- Volunteers
- 108 people
- Sponsor
- Aura Biosciences
Choroidal Melanoma, Indeterminate Lesions of Eye
A Registry of Subjects With Primary Indeterminate Lesions or Choroidal Melanoma
The purpose of this observational research study is to follow participants who have been treated with bel-sar while participating in a previous Aura Biosciences clinical research study to assess the long-term safety and…
- Trial name
- NCT03941379
- Where
- 16 sites in United States
- Volunteers
- 63 people
- Sponsor
- Aura Biosciences
Uveal Neoplasms, Choroid Neoplasms
Validation of a Molecular Prognostic Test for Eye Melanoma
Up to half of patients with ocular melanoma (also called iris, choroidal or uveal melanoma) develop metastasis. We have found that certain molecular features of the eye tumor can be detected by gene expression profiling and…
- Conditions
- Uveal Neoplasms, Choroid Neoplasms, Iris Neoplasms
- Trial name
- NCT00406120
- Testing
- Fine needle aspiration biopsy
- Where
- United States
- Sponsor
- Washington University School of Medicine
Metastatic Melanoma
Taxoprexin Treatment for Advanced Skin Melanoma
To evaluate objective response rate and duration of response to weekly Taxoprexin®. To evaluate the safety profile of weekly Taxoprexin® in this patient population. To evaluate overall survival in the same patient population.
- Trial name
- NCT00249262
- Testing
- Taxoprexin
- Volunteers
- 30 people
- Sponsor
- American Regent, Inc.
Choroidal Melanoma, Indeterminate Lesions
Prospective Group-Matched Study With Belzupacap Sarotalocan (Bel-sar; AU-011) or Plaque Radiotherapy for Primary Indeterminate Lesions or Choroidal Melanoma (IL/ CM)
This is a prospective multicenter, group-matched study of patients with primary indeterminate lesions or choroidal melanoma who receive treatment with belzupacap sarotalocan (bel-sar; AU-011) and patients who are planned to…
- Trial name
- IL (NCT05266430)
- Testing
- Standard of Care, AU-011
- Where
- 7 sites in United States
- Volunteers
- 2 people
- Sponsor
- Aura Biosciences
Choroidal Nevus
Validation of a Virtual Model of Service Delivery for Choroidal Nevi
Choroidal nevomelanocytic lesions have a high prevalence affecting up to 7% of the entire population and are increasingly incidentally identified during routine eye check- ups in community optometry services.
- Trial name
- NCT02707133
- Testing
- No intervention
- Volunteers
- 199 people
- Sponsor
- Manchester University NHS Foundation Trust
Uveal Melanoma
Treatment Of Radiation Retinopathy Trial
The purpose of this study is to demonstrate a statistically significant improvement of visual acuity after treatment using either Lucentis® or Triamcinolone® compared to no treatment, in patients with radiation retinopathy.
- Trial name
- TORR (NCT00811200)
- Testing
- ranibizumab, triamcinolone acetonide
- Volunteers
- 220 people
- Sponsor
- Leiden University Medical Center
Metastatic Melanoma
Taxoprexin® Treatment for Advanced Eye Melanoma
To evaluate objective response rate and duration of response to weekly Taxoprexin®. To evaluate the safety profile of weekly Taxoprexin® in this patient population. To evaluate overall survival in the same patient population.
- Trial name
- NCT00244816
- Testing
- Taxoprexin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- American Regent, Inc.
Choroidal Melanoma
Long Term Results of Combined Transpupillary Thermotherapy (TTT) Indocyanine Green (ICG) Based Photodynamic Therapy (PDT) in Choroidal Melanoma
This is a report of 10 years results of combined Transpupillary thermotherapy (TTT) treatment with Indocyanine green (ICG) in controlling small and medium-sized choroidal melanomas.
- Trial name
- NCT01253759
- Testing
- TTT + ICG-based PDT
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- New England Retina Associates
Uveal Melanoma, Ocular Melanoma
Study in Subjects With Small Primary Choroidal Melanoma
The primary objective is to assess the safety, immunogenicity and efficacy of one of three dose levels and repeat dose regimens of Light-activated AU-011 and one or two laser applications for the treatment of subjects with…
- Conditions
- Uveal Melanoma, Ocular Melanoma, Choroidal Melanoma
- Trial name
- NCT03052127
- Testing
- Light-activated AU-011, Laser Activation
- Where
- 13 sites in United States
- Volunteers
- 57 people
- Sponsor
- Aura Biosciences
Choroidal Melanoma
Safety and Efficacy of Silicone Oil Tamponade for Surgical Attenuation of Radiation Damage in Choroidal Melanoma
A prospective, experimental, case series of 20 patients, with choroidal melanoma, in which pars plana vitrectomy and Silicone oil as vitreous substitute will be used as intraocular shielding for attenuating the deleterious…
- Trial name
- NCT01460810
- Testing
- 1000CsK Silicon Oil Tamponade
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Ocular Melanoma
Prevention of Neovascular Glaucoma by Intravitreal Injections of Anti-VEGF in Patients Treated with Proton Therapy for a Large Choroidal Melanoma
The reference treatment of ocular melanoma is a conservative treatment by proton therapy. Its goal is to treat the tumor while preserving the eyeball and visual acuity.
- Trial name
- PROTECT (NCT03172299)
- Testing
- Aflibercept Injection, False injection
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Ocular Melanoma, Choroidal Melanoma
Combined PET/CT Imaging for the Early Detection of Ocular Melanoma Metastasis Compared to CT Scanning Alone
Patients diagnosed with ocular melanoma consent to participate in the study. Combined PET/CT scans of the whole body are performed at baseline, three months later, and six months after that for a total of three combined scans in…
- Conditions
- Ocular Melanoma, Choroidal Melanoma, Uveal Melanoma
- Trial name
- NCT00351728
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Choroidal Nevi, Uveal Melanoma
BAP1 Testing in Instance Choroidal Nevi or Uveal Melanoma
The BAP1 trial will examine the blood of patients diagnosed with choroidal nevi or uveal melanoma for a germline BAP1 mutation and other genetic markers associated with developing malignancy as well as additional sequencing of…
- Trial name
- NCT01925599
- Where
- 3 sites in United States
- Volunteers
- 133 people
- Sponsor
- Amy C Schefler, MD
Ocular Melanoma
Optical Coherence Tomography of Retinal Abnormalities Associated With Choroidal Nevus, Choroidal Melanoma and Choroidal Melanoma Treated With Iodine-125 Brachytherapy
During regularly scheduled appointments, Optical Coherence Tomography (OCT) is performed on consented subjects. The OCT is a new type of camera that takes very detailed pictures inside of the eye and deeper into eye tissues.
- Trial name
- NCT00346372
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Metastatic Malignant Neoplasm in the Liver, Metastatic Uveal Melanoma
Transarterial Chemoembolization for the Treatment of Uveal Melanoma With Liver Metastases
This phase II trial studies the effect of transarterial chemoembolization in treating patients with uveal melanoma that has spread to the liver (liver metastases).
- Conditions
- Metastatic Malignant Neoplasm in the Liver, Metastatic Uveal Melanoma, Stage IV Choroidal and Ciliary Body Melanoma AJCC V8
- Trial name
- NCT04728633
- Testing
- Carmustine, Ethiodized Oil, Transarterial Chemoembolization
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Thomas Jefferson University
Nevus
Detection of Choroidal Nevus Cells in Vitrectomy Fluid
The purpose of this study is to determine if the investigators can detect the presence of choroidal nevi cells in the vitreous fluid of humans, as this may improve the diagnosis and classification of choroidal nevi and melanomas…
- Trial name
- NCT01324609
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Stanford University
Small Posterior Choroidal Tumors
Blood Vessel Patterns in Small Choroidal Tumors
The purpose of this study is to see if mapping blood vessel patterns with optical coherence tomography (OCT) will help identify life-threatening choroidal tumors in their early stages and improve overall patient survival through…
- Trial name
- NCT01955915
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- OHSU Knight Cancer Institute