Clinical trials: Chorioretinitis
Hearing Loss, Mental Retardation
Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes.
The aim of this study is to investigate short and long term consequences from early postnatal HCMV infection transmitted via human milk in very preterm infants (birth weight < 1500 g or gestational age < 32 weeks).
- Conditions
- Hearing Loss, Mental Retardation, Microcephaly, Chorioretinitis
- Trial name
- NCT01151462
- Where
- Norway
- Sponsor
- Oslo University Hospital
Birdshot Chorioretinopathy, Posterior Uveitis
Birdshot Chorioretinopathy : Prospective Follow-up and Immunogenetic Studies(CO-BIRD)
The purpose of this study is twofold: 1. To analyze the clinical features of a cohort of patients with birdshot chorioretinopathy (BCR), an inflammatory bilateral ocular disease, affecting the choroid and the retina.
- Trial name
- CO-BIRD (NCT05153057)
- Testing
- Observational study
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vitiligo, Chorioretinopathy
Ocular Changes in Vitiligo Patients on Therapy
Vitiligo patients on systemic and local therapy may have some ocular adverse effects associated with the disease and its therapy.
- Conditions
- Vitiligo, Chorioretinopathy, Chorioretinitis
- Trial name
- NCT05335746
- Testing
- Optical coherence tomography angiography (OCT-A)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Central Serous Chorioretinitis
Effect of Spironolactone in Treating Chronic Non-resolutive Central Serous Chorioretinitis
The objective of the study is to evaluate the effect of spironolactone on 16 patients presenting with chronic non-resolutive central serous chorioretinitis (CSCR) and to evaluate whether spironolactone can resolve sub retinal…
- Trial name
- NCT01552044
- Testing
- Spironolactone
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Birdshot Chorioretinopathy, Cystoid Macular Edema
Evaluation of Birdshot Retine Choroidopathy Treatment by Either Steroid or Interferon alpha2a
Birdshot Retine choroidopathy (BRC) is a sight threatening posterior uveitis. The long term visual outcome has recently be studied showing a legal blindness to 14% at 5 years.
- Conditions
- Birdshot Chorioretinopathy, Cystoid Macular Edema, Transient Partial Visual Loss
- Trial name
- BIRDFERON (NCT00508040)
- Testing
- interferon alpha 2a, prednisone
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-infectious Uveitis
Safety and Efficacy of AIN457 in Noninfectious Uveitis
This study was performed to evaluate the efficacy and safety of AIN457 for patients with active uveitis that requires systemic immunosuppression.
- Trial name
- NCT00685399
- Testing
- AIN457, AIN 457
- Where
- 23 sites in United States, Germany
- Volunteers
- 76 people
- Sponsor
- Novartis Pharmaceuticals
Chorioretinitis
Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Central Chorioretinitis
The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to central chorioretinitis.
- Trial name
- COAST_UAcCNV (NCT04245072)
- Testing
- Intravitreal injection, Fluorescent angiography, Visometry
- Where
- 3 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Autoimmune Diseases, Ulcerative Colitis
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation.
- Conditions
- Autoimmune Diseases, Ulcerative Colitis, Multiple Sclerosis, Scleroderma
- Trial name
- NCT06587828
- Testing
- Companion blood samples with procedure
- Where
- 11 sites in United States
- Volunteers
- 238 people
- Sponsor
- TScan Therapeutics, Inc.
Subjects Clinically Suspected an Active Source of Toxoplasmosis Chorioretinitis Infection
Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis
Toxoplasmosis affects one to two newborn each 10000 births. Among them, 1 to 2 % develop learning disabilities or die, and 4 to 27 % develop a chorioretinitis sometimes leading to an amblyopia responsible for visual impairment.
- Trial name
- BIOLUVE (NCT02843438)
- Testing
- Fluorescein angiography, Dilated fundus examination, Toxoplasmosis serology
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Grenoble
Fungal Retinitis
SD-OCT Guided Treatment of Fungal Chorioretinitis
Fungal Chorioretinitis is a vision threatening condition.The investigators evaluate the efficacy of SD-OCT role in the treatment
- Trial name
- NCT04947592
- Testing
- Fluconazole 150 mg
- Where
- United Arab Emirates
- Volunteers
- 10 people
- Sponsor
- Benha University
Anterior Uveitis (AU), Birdshot Chorioretinitis
Quantification & Classification of Inflammatory Cells in Uveitis Using OCT
The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of…
- Conditions
- Anterior Uveitis (AU), Birdshot Chorioretinitis, Behcet Disease, Herpes Simplex Virus
- Trial name
- NCT07065747
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Uveitis, Conjunctivitis
Ocular Manifestations in Rheumatic Diseases
This is a search strategy for determining the prevalence of ocular complications in inflammatory rheumatic diseases for the purposes of a meta analysis.
- Conditions
- Uveitis, Conjunctivitis, Keratoconjunctivitis Sicca, Xerophthalmia
- Trial name
- NCT03753893
- Testing
- No intervention used
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Congenital Toxoplasmosis, Retinochoroiditis
Pregnancy and Congenital Toxoplasmosis
The Toxoplasma gondii parasite causes toxoplasmosis. It is characterized by persistent cysts mostly localised in the brain and ocular areas. In the case of immunodeficiency, those cysts are likely to reactivate.
- Trial name
- GRETA (NCT05774496)
- Testing
- Estimation of the occurrence of retinochoroiditis in women with congenital toxoplasmosis and previous retinochoroiditis lesions (recurrence) during pregnancy and postpartum.
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Hospices Civils de Lyon
Ocular Toxoplasmosis
Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis
The investigators study aims to determine the effect of prophylactic therapy with Trimethoprim-sulfamethoxazole on the recurrences of toxoplasma retinochoroiditis gondii.
- Trial name
- ISROT (NCT01449877)
- Testing
- Trimethoprim-Sulfamethoxazole
- Where
- Brazil
- Volunteers
- 141 people
- Sponsor
- University of Campinas, Brazil
Chorioretinitis
To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis
Toxoplasmosis, an intra cellular parasite, is a very important cause of chorioretinitis. The goal of treatment is arresting multiplication of the parasite in its inflammatory active phase.
- Trial name
- NCT00372294
- Testing
- pyrimethamine-sulfadiazine + prednisolone, Clindamycin+Dexamethasone
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences