Clinical trials: Children Under 2 Years
Sickle Cell Disease
PASS of Xromi Comparing Safety and Effectiveness in Children Under 2 Years With Sickle Cell Disease [PRECISE PASS]
This post-authorisation safety and efficacy study (PRECISE PASS) evaluates the use of Xromi® (hydroxycarbamide 100 mg/mL oral solution) in children aged 9 months to under 2 years with sickle cell disease (SCD).
- Trial name
- PRECISE (NCT06923111)
- Testing
- Xromi
- Where
- 12 sites in Germany, United Kingdom
- Volunteers
- 180 people
- Sponsor
- Nova Laboratories Limited
Healthy
Efficacy of 3 Nutritional Supplements to Improve Diverse Outcomes in Children Under 2 Years of Age and Pregnant Women
The Mexican poverty alleviation program, Oportunidades provides a fortified food supplement to all beneficiary children under 2 years of age, and all pregnant and lactating women.
- Trial name
- NCT00531674
- Testing
- fortified milk-based beverage, Sprinkles, tablets
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mexican National Institute of Public Health
Malnutrition, Child
Community-based, Controlled, Open-label, Cluster-randomized Trial for the Reduction of Chronic Malnutrition in Children Under Two Years of Age, With Three Intervention Arms Grouped by Clusters, in Two Provinces in Southern Angola, Huíla and Cunene.
The severity of the stunting in the provinces of Huíla and Cunene, Angola, in children aged 6 to 59 months is considered to be very high, as defined by the World Health Organization (WHO) classification of 2018.
- Trial name
- NCT05571280
- Testing
- Nutritional Supplementation, Money transfers, Standard intervention
- Where
- 2 sites in Angola
- Volunteers
- 1,423 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Atopic Dermatitis (AD)
A Phase 3 Trial of OPA-15406 Foam in Children and Infants With Atopic Dermatitis
To investigate the superiority of 0.3% OPA-15406 foam to the vehicle in children with atopic dermatitis (AD)
- Trial name
- NCT07184645
- Testing
- OPA-15406, Vehicle
- Where
- Japan
- Volunteers
- 198 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
HIV Infections
Evaluation of Simplified Antiretroviral Treatment Strategies in HIV Infected Children Treated by Antiretroviral (ARV) Before One Year of Age
The MONOD trial aim to evaluate the implementation of early antiretroviral treatment strategies in HIV-infected infants and assess the feasibility and efficacy of simplifying the initial proposed regimen after a successful one…
- Trial name
- NCT01127204
- Testing
- AZT-3TC-LPV/r twice a day, ABC-3TC-EFV once a day
- Where
- 4 sites in Burkina Faso, Côte d’Ivoire
- Volunteers
- 161 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Child Malnutrition, Feeding Behavior
Nutrition Intervention Integrated With Food Voucher to Improve Child Growth and Feeding Practices
Brief Summary: Background: The period from birth to two years of age is the "critical window" for the promotion of optimal growth, health, and development.
- Conditions
- Child Malnutrition, Feeding Behavior, Growth; Stunting, Nutritional
- Trial name
- NCT03641001
- Testing
- Child feeding counselling, food voucher, micronutrient powder, WASH
- Where
- Bangladesh
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Epilepsy
Ketogenic Diet in Infants With Epilepsy (KIWE)
Epilepsy, a condition where individuals are prone to recurrent epileptic seizures, is the most common chronic neurological disorder in children.
- Trial name
- KIWE (NCT02205931)
- Testing
- Ketogenic diet, Antiepileptic drug therapy
- Where
- 11 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- University College, London
Venous Thromboembolism, Children Under 2 Years
A Study to Observe the Pattern of Use and Safety of Rivaroxaban in Children Under 2 Years Old With Venous Thromboembolism (VTE)
This is an observational study in which only data are collected from participants receiving their usual treatment. The study is done in children under 2 years old with venous thromboembolism (VTE).
- Trial name
- XAPAEDUS (NCT05900388)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Standard of care (SOC)
- Where
- 4 sites in Denmark, France and 2 more
- Volunteers
- 850 people
- Sponsor
- Bayer
Malnutrition
Preventing Malnutrition in Children Under Two Years of Age Approach
A study conducted by IFPRI in Haiti provided the first programmatic evidence, using a cluster randomized evaluation design, that preventing child undernutrition in children under two years of age (PM2A) through an integrated…
- Trial name
- NCT01072279
- Testing
- Tubaramure (Burundi), Procomida (Guatemala)
- Where
- 2 sites in Burundi, Guatemala
- Volunteers
- 16,895 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Rhinitis, Allergic, Perennial
Cetirizine Placebo Controlled Study For Perennial Allergic Rhinitis
Study objective is to verify the superiority of CTZ DS to the placebo groups in the change of total nasal symptom score (TNSS) over the total treatment period from the score of the baseline assessment period.
- Trial name
- NCT00490204
- Testing
- Cetirizine
- Where
- 28 sites in Japan
- Volunteers
- 239 people
- Sponsor
- GlaxoSmithKline
Vaccine Response Impaired
Immunogenicity of Co-administered Yellow Fever and Measles, Mumps, and Rubella (MMR) Vaccines
This study evaluates seroconversion against measles, mumps, rubella and yellow fever following vaccination. One-third of children will receive both yellow fever and measles, mumps, and rubella (MMR) vaccines on the same day; one…
- Trial name
- NCT03368495
- Testing
- Co-administration of MMR/YF, MMR followed by YF, YF followed by MMR
- Where
- 4 sites in Argentina
- Volunteers
- 851 people, healthy volunteers welcome
- Sponsor
- Alba Maria Ropero
Undernutrition, Stunting
The Effectiveness of HBM-based Education Program on Improve Knowledge and Behaviors
The randomized controlled trial design with one intervention arm (nutrition education and complementary feeding) and one control (usual care) arm (1:1 ratio).
- Conditions
- Undernutrition, Stunting, Wasting, Underweight
- Trial name
- NCT05517395
- Testing
- health nutrition education, usual care
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Cognitive Ability, General
Nutrigenomics, PUFA, Iron and Cognition Amongst Under-two-year-old Indonesian Children
Rationale: Review on the positive effect of long chain polyunsaturated fatty acids (LCPUFA), especially docosahexanoic acid (DHA), supplementation on cognitive function in human using randomized controlled trials (RCTs) showed…
- Trial name
- NUPICO (NCT01504633)
- Testing
- DHA/EPA and iron supplementation
- Where
- Indonesia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Neuromuscular Blockade
Sugammadex Dose Finding Under Two Years Old
This is a prospective dose-finding study of sugammadex for conventional reversal of rocuronium-induced neuromuscular blockade in children under two years of age.
- Trial name
- NCT06575036
- Testing
- Sugammadex
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Sang-Hwan Ji
Diarrhoea
Immunological and Clinical Responses to Zinc in Children With Diarrhoea
Zinc deficiency has been found to be widespread among children in developing countries.Clinical and field studies have consistently observed an association between zinc deficiency and higher rates of infectious diseases…
- Trial name
- NCT00408356
- Testing
- Zinc
- Where
- Bangladesh
- Volunteers
- 338 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Children Health Under Two Years Old, Health Professionals
Care of Child's Hygiene From Zero to Two Years Old
This study aimed to identify the perceptions of family caregivers and professionals of the Family Health Strategy (FHS) for health care for children from 0 to 2 years, and actions on this issue developed by the FHS.
- Trial name
- CCH (NCT01016535)
- Where
- Brazil
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Faculdade Santa Marcelina
Food Allergy in Children, Oral Immunotherapy for Food Allergy
A Randomized Controlled Trial of Oral Immunotherapy Versus Allergen Avoidance in Children Under 2 Years With Food Allergy
The goal of this clinical trial is to learn whether oral immunotherapy (OIT) is safe and effective for treating food allergy in children aged 0-2 years with peanut, tree nut, or sesame allergy.
- Trial name
- SAFARI (NCT07825662)
- Testing
- Oral immunotheraphy (OIT)
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen Studies on Asthma in Childhood
Post Operative Pain, Analgesia
Newborn Infant Parasympathetic Evaluation (NIPE) for Guiding Intraoperative Fentanyl in Children Under 2 Years
During general anesthesia, objective monitoring for analgesia is still lacking. The administration of opioids relies on the experience of the anesthesiologist.
- Conditions
- Post Operative Pain, Analgesia, Children, Only, Narcotic Use
- Trial name
- NCT05758090
- Testing
- NIPE monitor, Control
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Khon Kaen University
Malaria, Falciparum
Time to Become Negative of Three Rapid Diagnostic Tests for Malaria
Background: Antigen-detecting rapid diagnostic tests (RDTs) for malaria provide the possibility of a parasite-based diagnosis in areas where good quality microscopy can not be achieved. P.
- Trial name
- NCT01325974
- Where
- 2 sites in Uganda
- Volunteers
- 424 people
- Sponsor
- Epicentre
Emotional Neglect
How to Collect the Expression of Psychological Suffering of Children Under Two Years?
Emotional Neglect (NE) is a form of abuse to the child whose prevalence is high (WHO Europe). Experiencing NE, psycho-emotional development and brain child may be impacted generating psychic suffering signs may progress to severe…
- Trial name
- RESOPSYBB (NCT02774863)
- Testing
- Home passages
- Where
- 6 sites in France
- Volunteers
- 6 people
- Sponsor
- Nantes University Hospital