Clinical trials: Challenge Test
Hemodynamic Instability, General Anesthesia
End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)
The purpose of the study is to evaluate the influence of different durations of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients in the operating room.
- Conditions
- Hemodynamic Instability, General Anesthesia, Surgery, Protective Mechanical Ventilation
- Trial name
- EXPIRE (NCT04399278)
- Testing
- Diagnostic Test: end-expiratory occlusion (EEO) test
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Asthma
Use of Buventol Easyhaler and Bufomix Easyhaler in Methacoline Challenge Testing
The study compares Buventol® Easyhaler® and Bufomix® Easyhaler® to the current standard treatment during methacholine challenge test. The trial will also provide inspiratory flow profile data for Easyhaler inhaler.
- Trial name
- EASYRELIEF (NCT05084222)
- Testing
- Buventol® Easyhaler® 200 µg/inhalation dmDPI, Bufomix® Easyhaler® 160/4.5 µg/inhalation dmDPI, Ventoline® Evohaler® 100 µg/inhalation pMDI
- Where
- 2 sites in Finland
- Volunteers
- 180 people
- Sponsor
- Orion Corporation, Orion Pharma
Asthma, Bronchial Hyperresponsiveness
Bronchial Hyperreactivity During Histamine Passive Exposure
Bronchial hyperresponsiveness consists in excessive response to bronchial stimuli.Bronchial challenge test is used to confirm/exclude asthma (metacholine or histamine).Protection are used to avoid passive exposure of the…
- Trial name
- NCT01937494
- Testing
- histamine-benzylic alcohol (magistral preparation)
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Endometrium Cancer
Risk Evaluation and Screening to Tailor Prevention and Reduce the Incidence of Endometrial Cancer
This study proposes to assess feasibility and acceptability of screening and risk reducing interventions in individuals at increased for endometrial cancer (EC).
- Trial name
- RESToRE (NCT05651282)
- Testing
- Provera
- Where
- Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Asthma
Exercise Challenge Test in 3-6 Years Old Asthmatic Children
Vigorous exercise is known to cause transient bronchoconstriction in school children with asthma, many of whom initially have normal lung function at rest.
- Trial name
- NCT00442715
- Testing
- Exercise chalenge test
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Cardiac Surgery
End-expiratory and End-inspiratory Occlusion Tests to Predict Fluid Responsiveness
The purpose of the study is to verify the efficacy of using end-expiratory and end-inspiratory occlusion tests as an index of fluid responsiveness in mechanically ventilated patients with cardiac surgery.
- Trial name
- EEOFR (NCT03485833)
- Testing
- EEO and EIO test
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
History of IgE Dependent Reaction to a Penicillin Product
Evaluation of Skin Testing Reagents for Penicillin Allergy
A self- or parent-reported history of penicillin allergy excludes approximately 10% of the US population from receiving penicillin (Kerr 1994, Kagy, Blaiss 1998, Solensky et al. 2000, Neugut et al. 2001).
- Trial name
- NCT01818336
- Testing
- Penicillin skin test kit
- Where
- 13 sites in United States
- Volunteers
- 481 people, healthy volunteers welcome
- Sponsor
- AllerQuest LLC
Bronchial Hyperreactivity, Abnormal Respiratory Airway Resistance
Diagnostic Utility of Different Airway Resistance Assessment Techniques in the Methacholine Challenge Test
The aim of the study is to compare standard spirometric evaluation of methacholine challenge test with plethysmographic, interrupter technique and forced oscillation technique (FOT) evaluation of the airways resistance.
- Trial name
- NCT02343419
- Testing
- Methacholine Challenge Test
- Where
- Poland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Cardiometabolic Risk, Abdominal Obesity
Characterization of Gut Microbiota Composition and Activity After a Daily Supplementation of 4.5 g/Day of ChitinGlucan Fibre During 3 Weeks in At-cardiometabolic Risk Volunteers
The aim of this study is to demonstrate the beneficial effects on gut microbiota composition and activity of the diary intake of insoluble fiber (extract from Aspergillus Niger) for three weeks.
- Trial name
- FITACHITIN (NCT03773900)
- Testing
- Kiotransine (chitin-glucan from aspergillus niger)
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Food Hypersensitivity
Food Allergy Challenge Diagnostic Study
The objective of this study is to correlate various diagnostic measurements taken during an escalating dose oral food challenge to the subject's response.
- Trial name
- NCT02606721
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- ORA, Inc.
Sepsis, Shock
Assessment of Transcutaneous Oxygen Tension/Oxygen Challenge Test in Intensive Care Unit (ICU) Patients
The lack of subcutaneous partial pressure of oxygen (PO2) rise in response to high fraction of inspired oxygen (FiO2), called the "oxygen challenge test (OCT)", was associated with higher morbidity and mortality in human…
- Trial name
- ICUPtO2OCT (NCT01174966)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Allergy Penicillin
Interest of the Second Phase of the Oral Challenge Test in Patients With Suspected Long-standing Penicillin Allergy
The most common drug allergy reported is penicillin allergy, approximately 10% of the world's population. According to the latest studies, only 1-2% of them have a proven hypersensitivity to penicillins.
- Trial name
- PENI (NCT04513938)
- Where
- France
- Volunteers
- 195 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Healthy, Chronic Kidney Diseases
Exploring the Mechanisms of Indoxyl Sulfate Production by Oral Tryptophan Challenge Test
Cardiovascular disease (CVD) is prevalent in patients with chronic kidney disease (CKD) and is associated with extremely poor prognosis.
- Trial name
- NCT04117191
- Testing
- Doctor's Best L-Tryptophan
- Where
- Taiwan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Healthy, Healthy Volunteer
Avocado and Postprandial Responses
The purpose of this study is to see how adding avocado to a breakfast meal affects blood sugar control and signals of hunger and fullness after eating.
- Conditions
- Healthy, Healthy Volunteer, Healthy Volunteers, Healthy Adult
- Trial name
- NCT06818032
- Testing
- Negative control, Avocado, Fat and fiber addition
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Crohn's Disease
Bronchial Hyperreactivity in Children With Crohn Disease
Background: Latent pulmonary involvement is described in Crohn Disease(CD). Bronchial hyperreactivity measured by the Methacholine Challenge Test (MCT) has been evaluated in two studies involving mainly adults.Our aim was to…
- Trial name
- NCT01297907
- Testing
- Methacholine Challenge Test, Fractional Exhaled NO (FENO), Blood Test
- Where
- Israel
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Hypersensitivity
Study to Determine Skin Irritation and/or Sensitization Potential of an Antifungal Cream Containing Trolamine (Repeated Insult Patch Test)
In this study researcher want to learn more about possible skin reactions such after repeated application of an antifungal cream containing Trolamine. They are especially interested in skin irritations or allergic skin reactions.
- Trial name
- NCT04531540
- Testing
- Butenafine HCl 1% (BAY1896425)
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Bayer
Mouse Allergies, Mouse Sensitization
A Comparison of Skin Prick Tests, Clinical Symptoms, and Nasal Challenge Using a New Mouse Extract
The purpose of this study is to test a new mouse skin test extract on people who work with mice in a lab or through animal care.
- Trial name
- NCT01063985
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Food Hypersensitivity, Shellfish Allergy
Recombinant Tropomyosin- and Hemocyanin-Specific IgE in Children With Suspected Shrimp Allergy
This study will evaluate whether blood tests that measure IgE antibodies to two shrimp proteins, tropomyosin and hemocyanin, can help diagnose shrimp allergy in children.
- Trial name
- NCT07501325
- Testing
- Oral Food Challenge (OFC), Skin Prick Test, Recombinant Tropomyosin- and Hemocyanin-Specific IgE Measurement
- Where
- Vietnam
- Volunteers
- 129 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Bronchial Hyperreactivity
Methacholine Challenge Testing: Comparison of FEV1 and IOS Parameters in Adult Asthma Patients
A classic methacholine challenge test is considered positive when forced expiratory volumen after one second (FEV1) decrease 20%.
- Trial name
- NCT06034145
- Testing
- No intervention
- Volunteers
- 500 people
- Sponsor
- Allergi- og Lungeklinikken, Elsinore
Dietary Modification, Cardiovascular Diseases
Oral Carnitine Challenge Test Guides Personalized Nutrition for CV Patients
The investigators plan to use the recently developed oral carnitine challenge test (OCCT) as a tool to exam individual's trimethylamine N-oxide (TMAO) production capacity from their gut microbiota.
- Trial name
- NCT03781011
- Testing
- Vegetarian diet intervention
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital