Clinical trials: Chagas Disease
Chagas Disease With Heart Failure
Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS)
The main purpose of the study is to determine noninvasive markers of brain involvement in Chagas disease. In a subgroup of patients with high intensity transient signals (HITS) on transcranial Doppler monitorization, the…
- Trial name
- CLINICS (NCT01650792)
- Testing
- Aspirin
- Where
- Brazil
- Volunteers
- 500 people
- Sponsor
- Federal University of Bahia
HIV, Herpes Simplex 2
Improving Blood Safety and HIV Testing in Brazil
Conduct a randomized controlled trial (RCT) to test the hypothesis that offering client-centered HIV counseling and testing (HCT) to blood donor candidates will reduce the risk of HIV contamination in the blood supply and also…
- Conditions
- HIV, Herpes Simplex 2, Hepatitis C, Hepatitis B
- Trial name
- NCT01681420
- Testing
- HIV Counseling and Testing, Blood Donation
- Where
- Brazil
- Volunteers
- 11,900 people, healthy volunteers welcome
- Sponsor
- Vitalant Research Institute
Chagas Disease
Assessment of Speckle Tracking Strain Predictive Value for Myocardial Fibrosis in Chagas Disease
One of the most challenging issues of chronic Chagas disease is to provide earlier detection of heart involvement. Two-dimensional speckle tracking (2-D ST) echocardiography, a new imaging modality with useful applications in…
- Trial name
- NCT02327052
- Testing
- No intervention was performed.
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Hospital Sao Rafael
Chagas' Disease
Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits Study
This study evaluated the effect of food on the absorption of the drug as well as safety and tolerability in adults suffering from chronic Chagas' disease In addition pharmacokinetics of the drug following 120 and 240 mg single…
- Trial name
- NCT03334838
- Testing
- Nifurtimox (Lampit, BAYA2502)
- Where
- Argentina
- Volunteers
- 36 people
- Sponsor
- Bayer
Chagas Disease
Syndecan-4 as a Biomarker in Patients With Chagas Disease
The purpose of this study is to analyze the efficacy of syndecan-4 as a biomarker on the Chagas Disease prognosis. This analysis will be done through the correlation between the plasmatic levels of this molecule with functional…
- Trial name
- NCT01842867
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital Sao Rafael
Infectious Diseases
Specificity Study of Diagnostic for Chagas Disease
This study assesses the specificity of Chagas Detect™ Plus (CDP) rapid test versus standard reference tests (e.g. RIPA or IFA) for Chagas diagnosis in the US.
- Trial name
- NCT02544139
- Testing
- Chagas Detect Plus
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- InBios International, Inc.
Chagas Disease
CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY)
This randomized, blind, parallel-group trial will evaluate the efficacy and safety of Nifurtimox (NFX) and Benznidazole (BZN), the two usual interventions to treat the parasite Trypanosoma cruzi.
- Trial name
- CHICAMOCHA-3 (NCT02369978)
- Testing
- Nifurtimox, Benznidazole
- Where
- Colombia
- Volunteers
- 500 people
- Sponsor
- Universidad Autónoma de Bucaramanga
Chagas Heart Disease
Impact of the Pharmaceutical Care on the Quality of Life in Patients With Chagas Heart Disease
The investigators hypothesize that pharmaceutical care may constitute an important tool for the clinical management of these patients by improving their compliance to their treatment with consequent improvement in their quality…
- Trial name
- ChagasCare (NCT01566617)
- Testing
- Standard care and Pharmaceutical care, Standard care
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Evandro Chagas Institute of Clinical Research
Human Immunodeficiency Virus, Acquired Immune Deficiency Syndrome Virus
Prospective Evaluation of HIV Patients Using Non-invasive Methods for Estimation of Liver Fibrosis and Steatosis
Human immunodeficiency virus (HIV) infection is a major global health issue with up to 40 million people infected worldwide. Due to highly active antiretroviral therapy, mortality related to acquired immunodeficiency syndrome…
- Conditions
- Human Immunodeficiency Virus, Acquired Immune Deficiency Syndrome Virus, Liver Diseases, Liver Cirrhosis
- Trial name
- Prospec-HIV (NCT02542020)
- Where
- Brazil
- Volunteers
- 2,000 people
- Sponsor
- Oswaldo Cruz Foundation
Chagas' Disease
Population Pharmacokinetics Study of Benznidazole in Children With Chagas'Disease
The purpose of this study is to describe the population pharmacokinetics parameters of benznidazole in children with acute or early chronic indeterminate form of Chagas Disease.
- Trial name
- Pop PK Chagas (NCT01549236)
- Testing
- Benznidazole 12,5mg or 100mg
- Where
- 3 sites in Argentina
- Volunteers
- 80 people
- Sponsor
- Drugs for Neglected Diseases
Chagas Disease, Chagas Cardiomyopathy
Cardiac Rehabilitation in Chagas Heart Failure
Due to the lack of information in the literature about the role of cardiac rehabilitation on Chagas heart failure, the aim of the present study was to evaluate the effects of a cardiac exercise program on functional capacity…
- Trial name
- NCT02516293
- Testing
- Exercise, nutritional and pharmaceutical counseling
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Evandro Chagas National Institute of Infectious Disease
Chagas Cardiomyopathy, Ventricular Arrythmia
Sympathetic Denervation by Video-assisted Thoracoscopy in Control of Cardiac Arrhythmias in Patients With Chagas Disease
Ventricular tachycardia (VT) is the main cause of sudden death in patients with structural heart diseases. The use of ICD (implantable cardio-defibrillator) could prevent sudden death, however, the occurrence of repetitive shock…
- Trial name
- NCT04239144
- Testing
- Bilateral sympathectomy, Catheter ablation
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo General Hospital
Chagas' Disease
Study on Benefits of Therapy With Nifurtimox in Chagas Disease, a Parasitic Illness Mostly Transmitted to Humans by a Bug, Using Information From Patient Medical Records in Argentina
The researchers in this trial want to analyze prerecorded patient data which provide information on benefits of the drug nifurtimox in patients with a sudden (acute) and long lasting (chronic) Chagas´ disease an illness caused by…
- Trial name
- NCT03784391
- Testing
- Lampit (Nifurtimox, BAYA2502)
- Where
- Argentina
- Volunteers
- 3,000 people
- Sponsor
- Bayer
Chagas Disease, Heart Diseases
Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease
The study "Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients with Chagas Disease" is a prospective, multicenter, randomized study that is being conducted at several centers in Latin America with…
- Trial name
- NCT01539161
- Testing
- Implantable Cardiac Monitor, Standard of Care
- Where
- 4 sites in Argentina, Colombia
- Volunteers
- 12 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Chagas Disease
Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole
The investigators propose the evaluation of posaconazole and benznidazole in humans for the treatment of Chagas disease chronical infection. Exploratory trial of posaconazole antiparasitic activity against Trypanosoma cruzi.
- Trial name
- CHAGASAZOL (NCT01162967)
- Testing
- Benznidazole, Posaconazole
- Where
- 3 sites in Spain
- Volunteers
- 78 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Chagas
Prospective Evaluation of Rapid Diagnostic Tests for Trypanosoma Cruzi Infection
Chagas disease (CD) is the most significant endemic zoonosis in Argentina. Two-thirds of affected individuals live in urban areas but only 10% globally are aware of their infection.
- Trial name
- NCT07304349
- Where
- 4 sites in Argentina
- Volunteers
- 3,234 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben
Healthy Volunteers
First-in-Human Trial of Oral AN2-502998
First-in-Human Phase 1, Single-Center, Randomized, Blinded, Placebo-Controlled Trial in Healthy Adults to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Oral AN2-502998
- Trial name
- NCT07024589
- Testing
- AN2-502998
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AN2 Therapeutics, Inc
Chagas Disease
Longitudinal Study of Patients With Chronic Chagas Cardiomyopathy in Brazil (SaMi_Trop Project)
BACKGROUND: Chagas Disease (ChD) remains as one of the most neglected diseases in the world, with 8-10 million infected people and only one marginally effective therapeutic.
- Trial name
- SaMi-Trop (NCT02646943)
- Volunteers
- 1,959 people
- Sponsor
- University of Sao Paulo
Chagas Disease, Heart Failure
Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC
The purpose of this study was to evaluate the effect of sacubitril/valsartan 200 mg BID compared with enalapril 10 mg BID, in addition to conventional heart failure (HF) treatment, in improving a hierarchical composite of…
- Trial name
- PARACHUTE-HF (NCT04023227)
- Testing
- Sacubitril/valsartan, Enalapril
- Where
- 79 sites in Argentina, Brazil and 2 more
- Volunteers
- 922 people
- Sponsor
- Novartis Pharmaceuticals
Chagas Disease
A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Disease, an Inflammatory, Infectious Disease Caused by the Parasite Trypanosoma Cruzi
Researchers are looking for a better way to treat children who have an infectious disease caused by the parasite Trypanosoma cruzi (Chagas' disease).
- Trial name
- NCT02625974
- Testing
- Nifurtimox (Lampit, BAYA2502)
- Where
- 25 sites in Argentina, Bolivia and 1 more
- Volunteers
- 330 people
- Sponsor
- Bayer