Clinical trials: Chagas Disease
Q Fever, Leptospirosis
Assessment of the Risk of Zoonotic Infections in Prisons in French Guiana
The prison system in French Guiana is characterized by severe overcrowding, high levels of promiscuity, poor sanitary conditions, and the documented presence of potential reservoirs or vectors of zoonotic diseases, particularly…
- Conditions
- Q Fever, Leptospirosis, Chagas Disease, Histoplasmosis
- Trial name
- CARYANA (NCT07808775)
- Where
- French Guiana
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne
Chagas Disease
A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease.
This study is to investigate the ability of LXE408 to clear or reduce the level of parasites in the blood of people with chronic Chagas disease. Participants must have chronic Chagas disease without severe organ dysfunction.
- Trial name
- NCT06632600
- Testing
- LXE408, Benznidazole
- Where
- 22 sites in United States, Argentina and 2 more
- Volunteers
- 130 people
- Sponsor
- Novartis Pharmaceuticals
Visceral Leishmaniasis, Chagas Disease
A First-in-human, Safety, Tolerability, and Pharmacokinetics Study of LXE408 in Healthy Subjects
The purpose of this first-in-human study is to generate the necessary safety, tolerability, and pharmacokinetics (PK) information that will support further clinical development of LXE408 for the treatment of patients with…
- Trial name
- NCT07809919
- Testing
- LXE408, Iohexol
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Chagas Disease
An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's Health
This is an observational study in which data from women with Chagas disease who will take or have already taken nifurtimox during pregnancy and the impact on their babies are studied.
- Trial name
- NCT05477953
- Testing
- Nifurtimox (BAYA2502)
- Where
- 12 sites in United States, Argentina and 10 more
- Volunteers
- 50 people
- Sponsor
- Bayer
Chagas Disease, Trypanosoma Cruzi Infection
University-Based Chagas Testing in Salta Province, Argentina
The goal of this observational study is to improve access to diagnosis and treatment for chronic Trypanosoma cruzi infection among university students of all ages and genders at the National University of Salta (UNSa), Argentina.
- Conditions
- Chagas Disease, Trypanosoma Cruzi Infection, Chronic Chagas Disease
- Trial name
- NCT07033325
- Testing
- Rapid diagnostic test (RDT) for Trypanosoma cruzi infection.
- Where
- 2 sites in Argentina
- Volunteers
- 2,568 people, healthy volunteers welcome
- Sponsor
- Mundo Sano Foundation
Chagas Disease, Heart Failure
Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC
The purpose of this study was to evaluate the effect of sacubitril/valsartan 200 mg BID compared with enalapril 10 mg BID, in addition to conventional heart failure (HF) treatment, in improving a hierarchical composite of…
- Trial name
- PARACHUTE-HF (NCT04023227)
- Testing
- Sacubitril/valsartan, Enalapril
- Where
- 79 sites in Argentina, Brazil and 2 more
- Volunteers
- 922 people
- Sponsor
- Novartis Pharmaceuticals
Healthy Volunteers
First-in-Human Trial of Oral AN2-502998
First-in-Human Phase 1, Single-Center, Randomized, Blinded, Placebo-Controlled Trial in Healthy Adults to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Oral AN2-502998
- Trial name
- NCT07024589
- Testing
- AN2-502998
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AN2 Therapeutics, Inc
Chagas Disease
Prospective Study of Benznidazole for Chagas' Disease Children With Chronic Indeterminate Chagas Disease
This study evaluate the efficacy and safety of benznidazole in the treatment of chronic indeterminate Chagas disease in children.
- Trial name
- NCT04024163
- Testing
- Benznidazole
- Where
- 9 sites in Argentina, Bolivia and 1 more
- Volunteers
- 178 people
- Sponsor
- Insud Pharma
Chagas Disease
Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age
The investigators are proposing to perform a double-blinded, non-inferiority randomized controlled trial comparing a short 30-day treatment with BZN 150mg/day (30d/150mg) vs. a 60-day treatment with BZN 300 mg/day (60d/300mg).
- Trial name
- BETTY (NCT03672487)
- Testing
- Benznidazole
- Where
- 3 sites in United States, Argentina
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Tulane University School of Public Health and Tropical Medicine
Chagas Cardiomyopathy, Ventricular Arrythmia
Sympathetic Denervation by Video-assisted Thoracoscopy in Control of Cardiac Arrhythmias in Patients With Chagas Disease
Ventricular tachycardia (VT) is the main cause of sudden death in patients with structural heart diseases. The use of ICD (implantable cardio-defibrillator) could prevent sudden death, however, the occurrence of repetitive shock…
- Trial name
- NCT04239144
- Testing
- Bilateral sympathectomy, Catheter ablation
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo General Hospital
Chronic Chagas
Prospective Evaluation of Rapid Diagnostic Tests for Trypanosoma Cruzi Infection
Chagas disease (CD) is the most significant endemic zoonosis in Argentina. Two-thirds of affected individuals live in urban areas but only 10% globally are aware of their infection.
- Trial name
- NCT07304349
- Where
- 4 sites in Argentina
- Volunteers
- 3,234 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben
Hiv, Hepatitis B
Delivering a Multi-disease Screening Tool to Migrant Populations
Migrants' overall health status may be improved by increasing the detection of certain infectious diseases and other conditions for which effective care is available.
- Conditions
- Hiv, Hepatitis B, Hepatitis C, Tuberculosis
- Trial name
- ISMiHealth (NCT05868005)
- Testing
- Clinical decision support system for screening of migrants using the ISMiHealth software tool.
- Where
- 2 sites in Spain
- Volunteers
- 980 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Chronic Chagas Disease
Short Benznidazole Regimen for Chronic Phase Chagas Disease Patients
Multicentric study on Chagas disease that seeks to evaluate a new treatment regimen using the drug benznidazole. Currently, existing treatment regimens are long and have frequent side effects, which leads to a high dropout rate…
- Trial name
- Benlatino (NCT06339710)
- Testing
- benznidazole 300 mg daily 8 weeks
- Where
- 2 sites in Brazil
- Sponsor
- Evandro Chagas Institute of Clinical Research
Chagas Cardiomyopathy, Speckle Tracking Echocardiography
Cardiac Mechanics by Speckle Tracking as a Prognostic Predictor in Patients With Chagas Cardiomyopathy
This study aims to evaluate the prognostic value of myocardial mechanics parameters, including global longitudinal strain (GLS) and mechanical dispersion (MD), assessed through speckle tracking echocardiography, in patients with…
- Conditions
- Chagas Cardiomyopathy, Speckle Tracking Echocardiography, Arrythmias, Sudden Death
- Trial name
- ST-Chagas (NCT06806722)
- Where
- Brazil
- Volunteers
- 153 people
- Sponsor
- University of Sao Paulo
Chronic Chagas Disease
Atorvastatin on Inflammation and Cardiac Function in Chronic Chagas Disease
Chagas Disease, caused by the parasite Trypanosoma cruzi afflicts 7 million people in Latin America, and due to migration, abroad. The diagnosis lies in clinical suspicion and serologic detection of antibodies.
- Trial name
- ATOCHA (NCT04984616)
- Testing
- 40 mg Atorvastatin/day for 120 days P.O., Atorvastatin 80
- Where
- 4 sites in Chile
- Volunteers
- 300 people
- Sponsor
- Juan D. Maya
Chagas Disease
A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Disease, an Inflammatory, Infectious Disease Caused by the Parasite Trypanosoma Cruzi
Researchers are looking for a better way to treat children who have an infectious disease caused by the parasite Trypanosoma cruzi (Chagas' disease).
- Trial name
- NCT02625974
- Testing
- Nifurtimox (Lampit, BAYA2502)
- Where
- 25 sites in Argentina, Bolivia and 1 more
- Volunteers
- 330 people
- Sponsor
- Bayer
Trypanosoma Cruzi Infection, Chagas Disease
New Therapies and Biomarkers for Chagas Infection
Chagas disease (CD) is an endemic zoonotic disease with a significant global impact. Current approved treatments for CD (benznidazole (BZN) and nifurtimox (NFX)) were developed in the 1970s with regimens and dosing intervals…
- Trial name
- TESEO (NCT03981523)
- Testing
- Benznidazole, Nifurtimox
- Where
- 3 sites in Bolivia
- Volunteers
- 450 people
- Sponsor
- University of Texas, El Paso
Ventricular Tachycardia, Chagas Disease
SBRT in Chagas Disease Ventricular Tachycardia
This is an observational study of 10 Chagas Disease patients with Ventricular Tachycardia that have failed prior catheter ablation or have this procedure contraindicated due to clinical status.
- Conditions
- Ventricular Tachycardia, Chagas Disease, Cardiac Arrhythmia
- Trial name
- NCT04984265
- Testing
- Stereotactic Body Radiation Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Chagas Cardiomyopathy
Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF.
Chagas disease is considered by the World Health Organization (WHO) as one of the most neglected tropical diseases in the world, having relevance in many Latin America countries.
- Trial name
- ANSWER-HF (NCT04853758)
- Testing
- Sacubitril / Valsartan Oral Tablet [Entresto], Enalapril
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo General Hospital
Chagas Disease, Trypanosoma Cruzi Infection
Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease.
A phase 2 clinical trial to evaluate the the efficacy of different benznidazole regimens (300mg/day for 60 days, 150mg/day for 60 days, and 400mg/day for 15 days) for the treatment of chronic Chagas disease in adult patients.
- Trial name
- MULTIBENZ (NCT03191162)
- Testing
- Benznidazole
- Where
- 7 sites in Argentina, Brazil and 2 more
- Volunteers
- 238 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute