Clinical trials: Cesarean Delivery
Hypotension During Cesarean Delivery, Spinal Anesthesia
Ninvasive Cardiac Output Measurements During Cesarean Delivery Under Spinal Anesthesia.
The purpose of the study is to learn more about how the heart works during cesarean delivery under spinal anesthesia (medicines given in the spine that numb parts of your body to block pain) in women.
- Trial name
- NCT01928797
- Testing
- Cardiac output monitor data
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Endometritis, Wound Infection
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
The Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) study is a large pragmatic multi-center randomized clinical trial designed to evaluate the comparative effectiveness and safety of azithromycin-based extended-spectrum…
- Conditions
- Endometritis, Wound Infection, Abscess, Surgical Site Infection
- Trial name
- C/SOAP (NCT01235546)
- Testing
- Azithromycin and standard of care
- Where
- 9 sites in United States
- Volunteers
- 2,013 people
- Sponsor
- Alan Tita
Pregnancy, Cesarean Section
Gastric Volumes by US in Term Parturients Undergoing CS With and Without Metoclopramide
Our objective is to compare gastric volumes (mL) between women who receive metoclopramide versus placebo prior to scheduled cesarean delivery in appropriately fasted patients.
- Conditions
- Pregnancy, Cesarean Section, Aspiration
- Trial name
- NCT05033041
- Testing
- Study drug metoclopramide
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Northwestern University
Obesity, Complications; Caesarean Section, Wound
Silver Impregnated Dressings to Reduce Wound Complications in Obese Patients at Cesarean Section
Obese patients undergoing cesarean section are at high risk for wound complications, which occur in approximately 20% of patients.
- Trial name
- NCT01528696
- Testing
- Silverlon, Standard Dressing
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Skin to Skin Contact in Cesarean Deliveries
Impact of Skin to Skin Contact on Maternal Satisfaction, Pain Scores, and Narcotic Usage After Cesarean Delivery
Early skin to skin contact has beneficial effects and is part of the Healthy Birth Initiative. Positive effects on breast feeding, cardiorespiratory status, blood glucose control, and temperature has been demonstrated.
- Trial name
- NCT02533167
- Testing
- skin to skin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Wake Forest University Health Sciences
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain
Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section
This is a Phase 4, multicenter, open-label study evaluating EXPAREL infiltration into the transversus abdominis plane (TAP) after bupivacaine hydrochloride (HCl) spinal anesthesia in subjects undergoing elective Cesarean section…
- Trial name
- NCT02353754
- Testing
- Intrathecal morphine injection, EXPAREL
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Patient Satisfaction
Music vs. No Music During Cesarean Delivery on Patient Satisfaction
Several studies have demonstrated that music can improve various outcomes during labor and delivery. However, many of these studies didn't measure satisfaction rate accurately.
- Trial name
- NCT03412019
- Testing
- Music
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Uterine Scar, Cesarean Section Complications
Single or Double-layer Uterine Closure Techniques
There are different surgical techniques of uterine closure during cesarean. A growing data has suggested that the closure technique has an effect on uterine scar healing.
- Conditions
- Uterine Scar, Cesarean Section Complications, Cesarean Section; Dehiscence
- Trial name
- NCT03629028
- Testing
- Residual myometrium thickness, Niche Presence, Adjacent myometrium thickness
- Where
- Turkey (Türkiye)
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Safak Baran Yilmaz
Breast Feeding, Analgesia Obstetrical
Intravenous Dexmedetomidine for Cesarean Section
Nervous, anxiety, fear and other psychological reactions always appears in parturients during cesarean section. This study intends to investigate the effectiveness and safety of dexmedetomidine combined with butorphanol tartrate…
- Conditions
- Breast Feeding, Analgesia Obstetrical, Postoperative Pain
- Trial name
- NCT03065530
- Testing
- Normal Saline, Dexmedetomidine 0.03ug/kg/h, Dexmedetomidine 0.05ug/kg/h
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pain, Cesarean Section
Intrathecal Hydromorphone for Pain Control After Cesarean Section
The use of intrathecal opioids for analgesia in the setting of cesarean section has become standard obstetric anesthesia practice. Currently, two opioids are commonly used. These opioids are fentanyl and morphine (Duramorph).
- Trial name
- NCT02096003
- Testing
- Intrathecal morphine, Intrathecal hydromorphone
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Labor Pain, Complications; Cesarean Section
Outcomes of Neuraxial Anesthetic Technique on the Trial of Labor After Cesarean (TOLAC)
To compare the effects of epidural versus combined spinal and epidural (CSE) anesthesia on the success of Trial of Labor After Cesarean (TOLAC).
- Conditions
- Labor Pain, Complications; Cesarean Section, Pregnancy
- Trial name
- NCT02105558
- Testing
- Epidural anesthesia, Combined spinal and epidural anesthesia
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Effects of; Anesthesia, in Labor and Delivery
Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean Delivery
The purpose of the study is to determine if a medication called phenylephrine, which helps to control blood pressure, is more effective as a continuous intravenous (IV) infusion compared to continuous IV norepinephrine in…
- Trial name
- NCT02354833
- Testing
- Phenylephrine, Norepinephrine
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Pain Levels
Dural Puncture Epidural Versus Epidural Anesthesia for Cesarean Delivery
This study will compare two anesthetics techniques called Dural Puncture Epidural (DPE) and Standard Epidural as to which of the two can provide faster and potentially better at providing pain relief for cesarean sections.
- Trial name
- NCT03915574
- Testing
- 25G Dural Puncture Epidural, Standard Epidural
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Arkansas
Cesarean Section, Pain, Postoperative
RCT (Randomized Controlled Trial) of IV Acetaminophen for Post Cesarean Pain Relief
This study is being done to evaluate the scheduled use of intravenous (IV) acetaminophen among cesarean section patients. The study hopes to find out if patients who receive scheduled IV acetaminophen for 48 hours following…
- Trial name
- NCT02046382
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- TriHealth Inc.
Intrauterine Devices, Cesarean Section
Immediate Postplacental Insertion of IUDs at Time of Cesarean Delivery: A Randomized Clinical Trial
This is a randomized controlled trial among women who deliver by cesarean at UNC Women's Hospital and desire an Intrauterine Device (IUD) for contraception postpartum.
- Trial name
- IUD@CSD (NCT01539759)
- Testing
- Immediate Postplacental Placement of an IUD during cesarean delivery
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of North Carolina, Chapel Hill
Cardiac Arrythmias
Carbetocin on Myocardial Repolarization Dynamics in Obstetrics Study
Relationship between carbetocin dose on transmural dispersion of repolarization (TDR).
- Trial name
- CaRDIO (NCT03716076)
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Surgical Wound
A Clinical Trial of Subcuticular Staples Versus Subcuticular Suture for Cesarean Section Skin Closure
Currently, the way doctors close the skin during cesarean section is different between surgeons and there is little evidence to support the use of one kind of closure over the other.
- Trial name
- NCT01753518
- Testing
- Subcuticular suture, Subcuticular staple
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Margaret L. Dow, M.D.
Operative Time, Wound Heal
Subcuticular Absorbable Staples Versus Conventional Skin Closure in Women Undergoing Cesarean Delivery
Despite the high numbers of cesareans being performed, scientific evidence behind which surgical techniques are best remains uncertain.
- Trial name
- NCT05112640
- Testing
- INSORB: subcuticular stapling device, Subcuticular monocryl suture manufactured by Ethicon
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Post Partum Hemorrhage
Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section
Background Postpartum haemorrhage (PPH) is a major cause of maternal mortality worldwide accounting for 25% of maternal deaths. In Zimbabwe PPH is the second most common cause of death.
- Trial name
- NCT03463993
- Testing
- Tranexamic Acid, Oxytocin
- Where
- 2 sites in Zimbabwe
- Volunteers
- 506 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe