Clinical trials: Cervical Spondylotic Myelopathy
Cervical Spondylotic Myelopathy, Ossification of Posterior Longitudinal Ligament in Cervical Region
The Application of Enhanced Recovery After Surgery Clinical Pathway in Posterior Cervical Spine Surgery
This study intends to establish a multidisciplinary collaborative ERAS clinical pathway of cervical posterior surgery,and to verify its effectiveness, safety and value in health economics.
- Trial name
- NCT05149404
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Central Cord Syndrome
The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI
Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS).
- Trial name
- NCT00790361
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cervical Spondylotic Myelopathy
Gait in Adult Patients With Cervical Spondylotic Myelopathy
The purpose of this study is to evaluate the effect of cervical decompression surgery on the biomechanics of the lower extremities and spine during balance and gait in patients with cervical spondylotic myelopathy (CSM), before…
- Trial name
- NCT03513679
- Testing
- Surgical intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Texas Back Institute
Ossification of Posterior Longitudinal Ligament, Cervical Spondylosis With Myelopathy
Multi-centre Study to Evaluate ACAF Versus Laminoplasty in Treating Cervical Ossification of the Posterior Longitudinal Ligament
The purpose of this study is to compare the efficacy, safety and imaging outcomes between Anterior Controllable Antedisplacement and Fusion (ACAF) and Laminoplasty in the treatment of severe ossification of cervical posterior…
- Trial name
- NCT04968028
- Testing
- ACAF, Laminoplasty
- Where
- 12 sites in China
- Volunteers
- 167 people
- Sponsor
- Shanghai Changzheng Hospital
Degenerative Cervical Myelopathy (DCM)
Cervical Laminectomy With or Without Lateral Mass Fixation in Cervical Spondylotic Myelopathy
The cervical spine consists of seven cervical vertebrae joined by intervertebral disks and a complex network of ligaments. The cervical spine has a normal lordotic curve, and it is much more mobile than the thoracic or lumbar…
- Trial name
- NCT06045663
- Testing
- laminectomy without lateral mass fixation, laminectomy with lateral mass fixation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Cervical Spondylosis With Myelopathy
Cervical Spondylotic Myelopathy - Cost Observational Surgical Trial
The purpose of the study is to determine the cost-effectiveness of different surgical strategies to treat cervical spondylotic myelopathy. The study will use data generated from the CSM-S Trial (NCT02076113). 1.
- Trial name
- CSM-COST (NCT05994404)
- Testing
- ACDF, Posterior Cervical Fusion, Cervical Laminoplasty
- Where
- 2 sites in United States
- Volunteers
- 269 people
- Sponsor
- Lahey Clinic
Cervical Spondylotic Myelopathy
Surgical Treatment of Cervical Spondylotic Myelopathy
The primary purposes of this study are to compare anterior and posterior surgical approach in treatment of CSM ad to compare variations in treatment and outcomes of CSM worldwide.
- Trial name
- NCT00565734
- Where
- Canada
- Volunteers
- 479 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Cervical Disc Herniation, Cervical Degenerative Disc Disease
Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion
The purpose of this study is to determine what effect intraoperative topical steroids have on reducing swallowing difficulty following Anterior Cervical Discectomy and Fusion surgery.
- Conditions
- Cervical Disc Herniation, Cervical Degenerative Disc Disease, Cervical Spondylotic Myelopathy, Dysphagia
- Trial name
- NCT02539394
- Testing
- Methylprednisolone Acetate, Hemostatic Matrix Kit
- Volunteers
- 128 people
- Sponsor
- Hospital for Special Surgery, New York
Orthopedic Disorder of Spine, Neurologic Disorder
A fMRI Study of Compressive Spinal Cord
Cervical myelopathy (CM), a chronically compressive spinal cord lesion, is the most common cause of non-traumatic paraparesis/quadriparesis among the elderly.
- Trial name
- CSM Plasticity (NCT03504254)
- Testing
- MRI examination
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Cervical Spondylotic Myelopathy
Effectiveness of T2* MRI in Cervical Spondylotic Myelopathy
Utilization of T2* MRI in predicting prognosis in patients with cervical spondylotic myelopathy (CSM)
- Trial name
- NCT04955041
- Testing
- MRI
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Cervical Spondylotic Myelopathy
Fusion or no Fusion After Decompression of the Spinal Cord in Patients With Degenerative Cervical Myelopathy
Background: Degenerative cervical myelopathy (DCM) is characterized by neck pain, neck stiffness, weakness, paresthesia, sphincter disturbance and balance disorder.
- Trial name
- MyRanC (NCT04936074)
- Testing
- Muscle preserving selective laminectomy, Laminectomy with instrumented fusion
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Uppsala University Hospital
Cervical Spondylotic Myelopathy
Efficacy of Two Approaches in Cervical Single-door Laminoplasty for Spinal Canal Enlargement
The goal of this clinical trial is to learn if cervical single-door laminoplasty via the intermuscular space approach can better prevent axial symptom while reaching equal neurological outcome than the conventional approach in…
- Trial name
- NCT06941649
- Testing
- Expansive open-door laminoplasty via intermuscular space approach, cervical single-door laminoplasty via the conventional approach
- Volunteers
- 376 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cervical Spondylosis With Myelopathy
Predictors of Outcome and Natural History in Patients With Cervical Spondylotic Myelopathy
Cervical spondylotic myelopathy (CSM) is the most frequent cause of myelopathy in those over the age of 50. They claim that surgical treatment of myelopathy, especially of the mild and moderate forms, has not shown better results…
- Trial name
- NCT02936245
- Testing
- no specific intervention
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Cervical Spondylosis With Myelopathy
Cervical Spondylotic Myelopathy Surgical Trial
The purpose of the study is to determine the optimal surgical approach (ventral vs dorsal) for patients with multi-level cervical spondylotic myelopathy (CSM).
- Trial name
- NCT02076113
- Testing
- Ventral (Front) decompression with Fusion, Dorsal (Back) Decompression with Fusion, Dorsal (back) Laminoplasty
- Where
- 16 sites in United States, Canada
- Volunteers
- 269 people
- Sponsor
- Lahey Clinic
Cervical Spondylotic Myelopathy
Assessment of Surgical Techniques for Treating Cervical Spondylotic Myelopathy
The primary purpose of this study is to compare anterior and posterior surgical approach in treatment of CSM in terms of surgical complications and neurological, functional, disease-specific and quality of life outcomes measures.
- Trial name
- CSM (NCT00285337)
- Testing
- Laminectomy and Laminoplasty
- Where
- 13 sites in United States, Canada
- Volunteers
- 321 people, healthy volunteers welcome
- Sponsor
- AOSpine North America Research Network
10-second G&R Test
Evaluation of the Screening Effect of Artificial Intelligence Hand Activity Evaluation System for Cervical Spondylosis
The purpose of this study: 1. Build an artificial intelligence screening tool for cervical spondylosis based on hand function analysis; 2. Verify the accuracy of cervical spondylosis screening tools.
- Trial name
- NCT06041542
- Testing
- 10-second hand grip and release test
- Where
- China
- Volunteers
- 1,380 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Cervical Spondylotic Myelopathy
Biomarkers of Cervical Spondylotic Myelopathy
Investigators believe that patients with cervical spondylotic myelopathy (CSM) have measurable changes in certain molecules in their blood compared with people without CSM.
- Trial name
- NCT07772297
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lumbar Disk Herniation, Lumbar Spinal Stenosis
Screening and Prospective Cohort Study of Risk Factors for Enhanced Recovery After Spinal Fusion Surgery in Advanced Age Patient
To determine the high risk factors affecting accelerated recovery after spinal fusion surgery in advanced age patient.
- Conditions
- Lumbar Disk Herniation, Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Cervical Spondylotic Myelopathy
- Trial name
- NCT06591442
- Testing
- This is an observational study
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Cervical Spondylosis, Cervical Spondylotic Myelopathy
Pregabalin and Radicular Pain Study (PARPS)
This study is designed to investigate the effectiveness of pregabalin (Lyrica) on nerve pain caused by degenerative neck problems. Pregabalin is a new drug registered for use in nerve pain worldwide
- Conditions
- Cervical Spondylosis, Cervical Spondylotic Myelopathy, Cervical Spondylotic Radiculopathy
- Trial name
- PARPS (NCT01061697)
- Testing
- Pregabalin
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Cervical Spondylosis With Myelopathy
DTI of the Brain and Cervical Spine: Evaluation in Normal Subjects and Patients With Cervical Spondylotic Myelopathy
More than half of the middle-aged population has radiologic evidence of cervical spondylosis (Irvine 1965) and a subset of this population develops cervical spondylotic myelopathy (CSM), a condition in which the spinal cord is…
- Trial name
- NCT01868958
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Emory University