Clinical trials: Cervical Spine Disease
Degenerative Disc Disease, Degenerative Spondylolisthesis
Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion
The aim of this study is to evaluate the effectiveness and safety of Natural Matrix Protein™ (NMP™) fibers when used in cervical or lumbar interbody fusion in patients with degenerative disc disease (DDD), spinal stenosis…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT06000319
- Testing
- Natural Matrix Protein (NMP) Fibers, Lumbar interbody fusion, Cervical interbody fusion
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Induce Biologics USA Inc.
Cervical Vertebrae, Single
The Comparison Between the Stand-alone Cage and the Autologous Iliac Bone Graft/Anterior Plating in the Single-level Surgical Treatment of the Cervical Spine
The use of plate in addition to autologous bone is better then stand alone cage fusion regarding fusion rate and segmental lordosis.
- Conditions
- Cervical Vertebrae, Single, Degenerative Disease
- Trial name
- CAP_2014 (NCT02030899)
- Testing
- Cage fusion, Plate fusion
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Rheumatoid Arthritis
Effect of TNF-Inhibition Combined With Conventional DMARDs on Cervical Pannus in Patients With RA and Cervical Spine Involvement
Atlantoaxial subluxation (AAS) is a complication of rheumatoid arthritis (RA) due to pannus formation around the odontoid process of C2 of the cervical spine. It occurs frequently in 15-30% of all RA patients.
- Trial name
- NCT01292616
- Testing
- therapy with disease-modifying anti rheumatic drugs (DMARD)
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Cervical Spondylosis
Effectiveness of Pressure Biofeedback-Assisted Deep Cervical Flexor Training With and Without Scapular Stabilization Exercises on Pain, Range of Motion and Neck Disability in Cervical Spondylosis
This randomized controlled trial will evaluate the effectiveness of pressure biofeedback-assisted deep cervical flexor training with and without scapular stabilization exercises in patients with cervical spondylosis.
- Trial name
- NCT07814833
- Testing
- Pressure Biofeedback-Assisted Deep Cervical Flexor Training, Scapular Stabilization Exercises, Standard Physiotherapy
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Ibadat International University, Islamabad
Degenerative Disc Disease (DDD)
Kineflex|C Artificial Disc System to Treat Cervical Degenerative Disc Disease (DDD)
The purpose of this study is to show that the Kineflex|C Spinal System is no worse than conventional Anterior Cervical Diskectomy with Fusion (ACDF) in patients with single level degenerative disc disease at any cervical level…
- Trial name
- NCT00374413
- Testing
- Artificial disk, Artificial disc
- Where
- 21 sites in United States
- Volunteers
- 343 people
- Sponsor
- SpinalMotion
Low Back Pain, Cervical Pain
Prospective Study of Post Surgical Continued Spinal Pain Patients
Continued spinal pain following spine surgery is reported in up to 50% of patients. Disability and pain following spine surgery occurs.
- Conditions
- Low Back Pain, Cervical Pain, Neck Disorder, Low Back Disorder
- Trial name
- NCT05401682
- Testing
- Cox chiropractic care
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Keiser University College of Chiropractic Medicine
Dysphagia
Dysphagia Following Anterior Cervical Spine Surgery; Single Dose Steroid vs Saline (DysDexVSSal)
This prospective, randomized, double blind, controlled study evaluates the effect of a single dose of perioperative IV steroid versus saline on swallowing after anterior cervical spine surgery
- Trial name
- NCT03711474
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Neck Pain, Spondylosis
CEM-Plate and CEM-Cage First-In-Human Use Efficacy Study
The study is a prospective, first-in-human, multi-center, non-randomized, single-arm study to assess the safety and efficacy of the CEM-Cage used with the CEM-Plate in patients who are appropriate candidates for a 2-level…
- Conditions
- Neck Pain, Spondylosis, Spondylosis With Myelopathy, Spondylosis With Radiculopathy
- Trial name
- NCT04883411
- Testing
- CEM-Plate Anterior Cervical Plating System and CEM-Cage Cervical Interbody System
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- ReVivo Medical, Corp.
Cervical Disc Disease, Radiculopathy, Cervical
Physiotherapy After Anterior Cervical Spine Surgery
Background: Patients suffering residual disability after anterior decompression and fusion (ACDF) surgery for cervical disc disease may be prescribed physical activity (PPA) or neck-specific exercises (NSE).
- Trial name
- NCT03036007
- Testing
- Prescribed Physical Activity, Exercises with Internet support
- Where
- Sweden
- Volunteers
- 39 people
- Sponsor
- Linkoeping University
Neck Pain, Back Pain
The Prevalence of Neck and Low Back Pain in FMSTRC Staff At the UWI Mona
The purpose of this study is to determine the prevalence of neck and low back pain among full-time staff at the Faculty of Medical Sciences Teaching and Research Complex (FMSTRC), The University of the West Indies, Mona.
- Conditions
- Neck Pain, Back Pain, Musculoskeletal Pain, Low Back Pain
- Trial name
- NCT07194746
- Testing
- Clinical Control Group (Group A), Spine Exercise Program (Group B)
- Where
- Jamaica
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Cervical Disc Herniation
Effect of Neck vs. Combined Neck-Lumbar Mobilization on Pain and Motion in Cervical Disc Herniation
Background To assess the effectiveness of Kaltenborn-Evjenth Orthopedic Manual Therapy (KEOMT) applied to cervical-only mobilization versus both lumbar and cervical regions on pain intensity and range of motion (ROM) in…
- Trial name
- NCT06858605
- Testing
- Kaltenborn-Evjenth Orthopedic Manual Therapy (KEOMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Fenerbahce University
Posterior Cervical Decompression and Fusion
A Randomized Controlled Crossover Study Comparing Sugammadex and Placebo
Intraoperative monitoring of the motor evoked potentials has been shown to be both a sensitive and specific indicator for detecting intraoperative neurological injuries during spine surgery.(Fehlings, Brodke et al.
- Trial name
- NCT03087513
- Testing
- Sugammadex Injection [Bridion]
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Cervical Radiculopathy, Cervical Spondylosis
Effectiveness of Cervical Transforaminal Epidural Steroid Injection
Study Purpose: This study is intended to monitor outcomes for 1 year following cervical TFESI. Based on current clinic volume and enrollment rates into a current study of cervical epidural injections that is nearing completion…
- Conditions
- Cervical Radiculopathy, Cervical Spondylosis, Disk, Herniated
- Trial name
- NCT04544683
- Testing
- Cervical Transforaminal Epidural Injection with dexamethasone sodium phosphate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Utah
Disc Herniation, Cervical Radiculopathy
Mobilization With Movement vs. Neural Mobilization on Nerve Root Function in Patients With Cervical Radiculopathy
This study will be conducted to compare the effect of sustained natural apophyseal glides (SNAGS) versus neural mobilization on clinical outcomes such as 1- nerve root function in the form of: (A) peak to peak amplitude; (B)…
- Conditions
- Disc Herniation, Cervical Radiculopathy, Cervical Radiculopathy at C5 Nerve Root, Cervical Radiculopathy at C6 Nerve Root
- Trial name
- NCT05803954
- Testing
- Sustained natural apophyseal glides (SNAGS), Neural mobilization, Traditional physical therapy
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Intervertebral Disc Displacement
Comparison of Software-assisted Implantation of Elastic Spine Pad (TM) With Respect to Postoperative Change in Neck Disability Index (NDI) With the Conventional Disc Prosthesis Rotaio (TM) After Anterior Cervical Discectomy for Cervical Disc Prolapse
This is an investigator-initiated study. The primary goal is to evaluate the efficacy of two different cervical disc prosthetic devices with respect to postoperative change in neck disability index.
- Trial name
- NCT02936739
- Testing
- Anterior cervical discectomy with prosthetic disc replacement / ESP., Anterior cervical discectomy with prosthetic disc replacement / Rotaio.
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Technische Universität Dresden
Ossification of the Posterior Longitudinal Ligament
A Prospective Study Comparing the Efficacy of Laminoplasty and Laminectomy With Fusion for Ossification of the Posterior Longitudinal Ligament With High Occupation Rate in Cervical Spine
The efficacy of laminoplasty and laminectomy with fusion for ossification of the posterior longitudinal ligament with high occupation rate in the cervical spine is not clear in the literature report so far.
- Trial name
- NCT05019001
- Testing
- Laminoplasty, Laminectomy With Fusion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Low Back Pain, Mechanical, Spinal Stenosis
Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients
Observational study of axial spine pain and hyperflexibility. Patients will receive physical exam maneuvers (traditional straight leg raise, FABER, facet loading as well as Beighton's hypermobility score) and blood / urine /…
- Conditions
- Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical
- Trial name
- Hypermoble (NCT02761928)
- Testing
- Beighton score for hypermobility
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spine Fusion, Spine Disease
Erector Spinae Plane Block for Cervical Spine Surgery
The study aims to assess the interfacial plane blocks' effect on pain level, course of postoperative rehabilitation, and anti-inflammatory analgesic effect.
- Conditions
- Spine Fusion, Spine Disease, Spinal Disease
- Trial name
- NCT06393530
- Testing
- 0.9%sodium chloride, 0.2% ropivacaine
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Cervical Spondylosis
Effects of Breathing Exercises on Pain, Range of Motion and Neck Disability in Patients With Cervical Spondylosis
A randomized controlled trial was conducted on 72 diagnosed patients with cervical spondylosis at University of Lahore Teaching hospital. The study was completed within 9 months after the approval of synopsis.
- Trial name
- NCT05086367
- Testing
- Diaphragmatic and pursed lip breathing, Routine Physical Therapy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- University of Lahore
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal…
- Conditions
- Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine
- Trial name
- NCT02713269
- Testing
- Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center