Clinical trials: Cervical Cancer (Early Detection)
Endometrial Neoplasms, DNA Methylation
Cervical Cytology DNA Methylation for Endometrial Lesion Screening and Follow-up
The goal of this observational study is to evaluate the accuracy of a novel molecular test for screening and monitoring endometrial lesions in women at medium-to-high risk for endometrial cancer.
- Conditions
- Endometrial Neoplasms, DNA Methylation, Cervical Smears, Early Detection of Cancer
- Trial name
- EndoMethy-V (NCT07298707)
- Volunteers
- 3,500 people
- Sponsor
- Peking Union Medical College Hospital
Malignant Tumor of Cervix, Cervical Intraepithelial Neoplasia
Participation in Screening for Cervical Cancer: Interest of a Self-sampling Device Provided by the General Practitioner
This study evaluates the benefit in women aged from 30 to 65 years, who do not participate to the French opportunistic cervical cancer screening program, of an organized screening with the proposition by the family physician of a…
- Trial name
- PaCUDAHL-Gé (NCT02749110)
- Testing
- Vaginal self-sampling brush
- Where
- France
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
High Grade Serous Ovarian Cancer, Cervical Cancer Screening
Routine Shallow-coverage Whole Genome Sequencing Testing of Liquid-based Cervical Smears for the Early Diagnosis of Ovarian Cancer
High-grade serous ovarian carcinoma (HGSOC) is the deadliest gynaecological tumour. The 5-year overall survival rate for advanced-stage disease is less than 30 per cent, due to diagnosis at an advanced stage.
- Conditions
- High Grade Serous Ovarian Cancer, Cervical Cancer Screening, Whole Genome Sequencing, Genomic Instability
- Trial name
- SHALLOW ROUTE (NCT07821879)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut Claudius Regaud
Lung Cancers, Liver Cancer
AI-Assisted Non-Contrast CT for Multi-Cancer Screening
Cancer poses a major public health challenge in China. Early detection can improve treatment outcomes and survival rates. In this study, we will conduct a large-scale, prospective, multi-center cohort study to evaluate the…
- Conditions
- Lung Cancers, Liver Cancer, Gastric Cancers, Colorectal, Cancer
- Trial name
- NCT06632886
- Testing
- AI-Assisted Non-Contrast CT for Multi-Cancer Screening
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Guo ShiWei
Esophageal Squamous Cell Carcinoma, Esophageal Cancer
Esophageal cAncer Screening Trial
This multicenter study aims to include 15000 participants undergoing screening upper gastrointestinal endoscopy and establish a risk prediction model for esophageal squamous cell carcinoma and esophagogastric junctional (EGJ)…
- Conditions
- Esophageal Squamous Cell Carcinoma, Esophageal Cancer, Gastroesophageal Junction Adenocarcinoma
- Trial name
- EAST (NCT04609813)
- Testing
- Sponge cytological test
- Where
- China
- Volunteers
- 14,597 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Breast Cancer, Cervical Cancer
Community Clinic Model to Improve Early Detection of Breast and Cervical Cancers in Kenya
Kenya has a high incidence of breast and cervical cancers, and most women are diagnosed with late-stage disease. The investigators will conduct a study to assess the effectiveness and cost-effectiveness of strategies to increase…
- Trial name
- C3Link (NCT06572774)
- Testing
- C3Link Strategies
- Where
- Kenya
- Volunteers
- 5,400 people, healthy volunteers welcome
- Sponsor
- Implenomics
Esophagogastroduodenoscopy
AQCS for Detection of Early Cancer and Precancerous Lesions on Upper Gastrointestinal Tract
The purpose of our study was to assess the performance of esophagogastroduodenoscopy automatic quality-control system in real-time quality control of EGD.
- Trial name
- NCT04720924
- Testing
- Computer-aided Real-time Automatic Quality-control System
- Where
- 6 sites in China
- Volunteers
- 1,840 people
- Sponsor
- Shandong University
Cervical Dysplasia, Vulvar Dysplasia
OCT-AF Imaging of Pre-cancers of Vulva and Cervix
The multimodal imaging technology, OCT-AFI, will be used to image sites on the cervix, the endocervical canal and vulva. The imaging probe is small enough, it can be inserted into the endocervical canal for imaging.
- Conditions
- Cervical Dysplasia, Vulvar Dysplasia, Precancerous Lesions, Vulvar Cancer
- Trial name
- NCT03285841
- Testing
- OCT-AFI
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Breast Cancer, Cervical Cancer
Salud en Mis Manos - Breast and Cervical Cancer Prevention and Early Detection - Expansion 2
The purpose of this study is to increase early detection and prevention of breast and cervical cancer through education and navigation and to increase breast and cervical cancer screening and Human Papillomavirus (HPV)…
- Trial name
- SEMM2 (NCT06082882)
- Testing
- Education, Navigation to clinic
- Where
- United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Early Detection of Cancer
The Effect of Face-to-face and Online Health Education on Women's Cervical Cancer Knowledge, Health Beliefs and Screening
Aim: The aim of this study is to determine the effect of health education given by two different methods on women's knowledge about HPV, cervical cancer health belief and screening test.
- Trial name
- NCT06021496
- Testing
- face to face health education, online health education
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Endometrial Cancer, Endometrial Neoplasms
Real-time Lymphatic Channel Visualization Improves Bilateral Sentinel Lymph Node Detection in Endometrial Cancer
Endometrial cancer is the most common malignancy of the female genital tract. Standard treatment for early-stage disease includes hysterectomy, bilateral salpingo-oophorectomy, and lymph node assessment.
- Conditions
- Endometrial Cancer, Endometrial Neoplasms, Sentinel Lymph Node Biopsy (SLNB)
- Trial name
- NCT05191212
- Testing
- indocyanine green
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Esophageal Cancer, Head and Neck Cancer
Early Detection of Esophageal Squamous Cancer With the Capsule Sponge Device
Esophageal squamous cell carcinoma accounts for ~90% of the nearly half-million annual incident cases of esophageal cancer worldwide.
- Conditions
- Esophageal Cancer, Head and Neck Cancer, Squamous Cell Carcinoma
- Trial name
- ANGELA (NCT06418516)
- Testing
- Capsule-sponge
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Esophagus Cancer, Gastric Cancer
Predictive Model to Early Diagnosis of Anastomotic Leak After Esophagectomy and Gastrectomy.
The PROFUGO study (PRedictive Model for the early diagnosis of anastomotic leak after esophagectomy and gastrectomy) is proposed as a prospective and multicenter study at spanish national level that aims to develop, with the help…
- Conditions
- Esophagus Cancer, Gastric Cancer, Leak, Anastomotic, Complication
- Trial name
- PROFUGO (NCT05390684)
- Testing
- audit of complications, prospective data collection
- Where
- Spain
- Volunteers
- 800 people
- Sponsor
- Hospital Universitario La Fe
Nasopharyngeal Carcinoma, Early Diagnosis of Cancer
Methylation-specific PCR Test for Early Screening and Early Diagnosis of Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma is one of the most common malignant tumors in China, with the progress of radiochemical comprehensive treatment, early stage The 5-year survival rate of nasopharyngeal cancer is more than 95%.
- Trial name
- NCT06367049
- Testing
- Methylation-specific PCR
- Where
- China
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cervical Cancer, Cervical Dysplasia
Role of Liquid Biopsies in HPV-associated Cancer Treatment Monitoring
This trial will evaluate the possible benefits and the performance of liquid biopsies in HPV-associated cancer treatment monitoring.
- Conditions
- Cervical Cancer, Cervical Dysplasia, Oropharyngeal Cancer, Human Papillomavirus Infection
- Trial name
- NCT05774561
- Testing
- Arm A - Diagnostic test: HPV detection in liquid biopsies, Arm B - Diagnostic test: HPV detection in liquid biopsies
- Where
- Czechia
- Volunteers
- 480 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Nasopharyngeal Carcinoma (NPC)
Comparison of Multi-omics Models for Early Nasopharyngeal Carcinoma Screening: cfDNA Methylation, EBV DNA, and Serological Double-antibodies Detection
This study focus on nasopharyngeal carcinoma, a cancer type with Chinese characteristics, analyze the early screening detection performance of nasopharyngeal carcinoma in the multi-cancer early screening model, and compare the…
- Trial name
- PROFOUND-NPC (NCT06763289)
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Esophageal Cancer
Non-endoscopic EC Screening Program in Northern Iran
The aim of this study is to assess the effects of implementation of a non-endoscopic esophageal cancer-screening program on outcomes of interest in an asymptomatic high-risk population in Golestan Province, Iran.
- Trial name
- NESP (NCT02311712)
- Testing
- Capsule sponge
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Oesophageal Squamous Cell Carcinoma, Oesophageal Adenocarcinoma
Breath Research Narrow Validation for Gastrointestinal Cancer Detection
The investigators of this study are developing a simple breath test to help detect gastrointestinal (gut) cancers earlier, including cancers of the oesophagus (food pipe), stomach, pancreas, liver and bowel.
- Conditions
- Oesophageal Squamous Cell Carcinoma, Oesophageal Adenocarcinoma, Gastric Adenocarcinoma, Pancreatic Ductal Adenocarcinoma (PDAC)
- Trial name
- BRAVE (NCT07714538)
- Where
- 6 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Barretts Esophagus, High Grade Dysplasia
Endoscopic Tri-Modal Imaging in Patients With Barrett's Esophagus
This study is being done to determine if a new endoscope will help doctors identify pre-cancer or early cancer lesions in patients who have Barrett's esophagus.
- Conditions
- Barretts Esophagus, High Grade Dysplasia, Early Esophageal Adenocarcinoma
- Trial name
- ETMI (NCT00586989)
- Testing
- Upper endoscopy with biopsy
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cervical Cancer
The Effect of Motivational Interviewing Based on the COM-B Model
This research will be conducted to determine the effect of motivational interviewing based on the COM-B model on women's cervical cancer health beliefs and participation in screening.
- Trial name
- NCT06509529
- Testing
- Motivational Interviewing Based on the COM-B Model
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ordu University