Clinical trials: Cerebral Hemodynamics
Acute Subdural Hematoma
Comparison of Total Intravenous Anesthesia vs. Inhalational Anesthesia in Acute Subdural Hematoma Patients
Consent will be taken from the relatives and the patient will be taken to the operating room. Inside the operation theatre patient will be shifted to operating table and standard monitors will be attached.
- Trial name
- NCT03146104
- Testing
- Propofol, Isoflurane
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Cerebral Injuries, Acute Respiratory Distress Syndrome (ARDS)
Alveolar Recruitment Maneuvers, Intracerebral Hemodynamic and Oxygenation
This study aims to compare 2 alveolar recruitment maneuvers (ARM) in patients with cerebral injuries and acute respiratory distress syndrome (ARDS) in term of efficacy and tolerance.
- Trial name
- M'RHICO (NCT02574169)
- Testing
- alveolar recruitment maneuvers group 1, alveolar recruitment maneuvers group 2
- Where
- 5 sites in France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Stroke
Short- and Long-Term Hemodynamic Effects of Carotid Endarterectomy and Carotid Artery Stenting
Carotid artery stenting(CAS) and endarterectomy(CEA) are both important treatment strategy for patients with ICA (internal carotid artery) stenosis.
- Trial name
- NCT03216369
- Testing
- MRI
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
Post-operative Cognitive Dysfunction
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
BACKGROUND: Post-operative cognitive dysfunction (POCD) is a potentially irreversible loss of brain functions observed in elderly patients after surgical operations under general anaesthesia.
- Trial name
- THE BRIDGE (NCT02428062)
- Testing
- Hemodynamic target, Phenylephrine, Intravenous fluids
- Where
- Italy
- Volunteers
- 1,812 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Intracranial Hypertension, Cerebral Circulatory Failure
Cerebral Compliance Impairment in COVID-19
Several recent studies point to the possibility of the new coronavirus (SARS-Cov2), which currently causes pandemic COVID-19, to infiltrate the central nervous system (CNS) and cause primary damage to neural tissues, increasing…
- Trial name
- NCT04429477
- Testing
- Cerebral compliance and hemodynamics monitoring
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Functional Magnetic Resonance Imaging
A Study of Two Methodologies for Measuring Blood Flow in the Brain in Response to Non-Drug Stimuli (P08085/MK-0000-180)
This study will identify a dose of ferumoxytol that can reliably detect changes in blood flow/volume in response to non-drug stimuli.
- Trial name
- NCT01244282
- Testing
- fMRI with sensory stimulation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Out-of-hospital Cardiac Arrest (OHCA), Post-Cardiac Arrest Syndrome
Pulse Pressure and Outcomes After Out-of-Hospital Cardiac Arrest
STEP-PRESS is a predefined exploratory observational substudy nested within the STEPCARE trial. The study will evaluate whether early low pulse-pressure burden after out-of-hospital cardiac arrest is associated with early…
- Trial name
- STEP-PRESS (NCT07586878)
- Where
- Sweden
- Volunteers
- 3,500 people
- Sponsor
- Region Skane
Hypovolemia, Hyperoxia
Supplemental Oxygen in Hypovolemia
Supplemental oxygen is frequently administered in acutely and critically ill patients, specifically, it is often administered in trauma patients to avoid arterial hypoxemia and tissue hypoxia.
- Trial name
- NCT05150418
- Testing
- Oxygen gas, Air
- Where
- Norway
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Sickle Cell Disease
Study of the Effect of Etavopivat on Cerebral Hemodynamic Response in Children With Sickle Cell Disease
An open-label, single arm study in patients 12 to 21 years of age with SCD to evaluate the effects of etavopivat on cerebral and muscle hemodynamics.
- Trial name
- NCT05725902
- Testing
- Etavopivat
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Novo Nordisk A/S
Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke
Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)
Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor…
- Conditions
- Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke, Acute Ischemic Stroke, Cardioembolic Stroke
- Trial name
- NCT07013396
- Testing
- Transcranial Doppler (TCD) examination
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Thoracic Aortic Aneurysm, Thoracic Aortic Dissection
Cerebral Hemodynamics and Microemboli During Placement of Relay®Branch Thoracic Stent-Graft System
This is an observational cohort study addressing the incidence of cerebral microemboli and alterations of cerebral hemodynamic physiology of the Relay®Branch thoracic stent-graft system.
- Conditions
- Thoracic Aortic Aneurysm, Thoracic Aortic Dissection, Microemboli
- Trial name
- CHaMP (NCT05155956)
- Testing
- transcranial Doppler ultrasonography (TCD)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Migraine, Headache
The Hemodynamic Effects of PACAP38 After Glibenclamide Administration in Healthy Volunteers
To investigate the hemodynamic effects of PACAP38 after glibenclamide administration.
- Conditions
- Migraine, Headache, Pain
- Trial name
- NCT04960657
- Testing
- glibenclamide, PACAP38
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Headache, Migraine
The Effects of Maxipost (BMS 204352) on Cerebral Hemodynamic and Headache in Healthy Volunteers and Migraine Patients
It is not previously investigated whether, there is a correlation between potassium channels and migraine, so it is unclear whether, this signaling pathway through potassium channels has an impact on migraine pathophysiology.
- Trial name
- NCT03887325
- Testing
- Maxipost, Saline
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Supratentorial Neoplasms
Remifentanil Infusion Alone During the Closure Period for Early Emergence Following Craniotomy
Total intravenous anaesthesia using propofol and remifentanil are routinely used drugs for this purpose. The hemodynamic stability and at the same time early emergency are the main goals following neurosurgery.
- Trial name
- NCT02593942
- Testing
- Remifentanil, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yeditepe University Hospital
Cognitive Decline
Volume Optimisation and Cognitive Function in Major Abdominal Surgery
In the last 25 years, there has been a lot of attention directed on reducing perioperative morbidity and mortality by improving intraoperative monitoring and hemodynamic optimisation of patients.
- Trial name
- NCT03186846
- Testing
- multimodal monitoring
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Intrauterine Growth Restriction, Small-for-gestational Age
Ultrasound Evaluation of Fetal Hemodynamics and Perinatal Complications
In case of fetal weight below the 10th centile for gestational age, it is important to distinguish SGA and IUGR. SGA is defined as a fetal weight below the 10th centile.
- Trial name
- PTI'DOP (NCT03865628)
- Volunteers
- 1,200 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Supratentorial Brain Tumor
Magnesium Sulphate for Attenuation of Hemodynamic Pressor Response After Myfield's Clamp Application
Use of Mayfield skull clamp during craniotomies; results in a sharp and intense noxious stimulus which results in a severe hemodynamic pressor response. Many strategies have been reported to blunt this undesirable pressor effect.
- Trial name
- NCT03318471
- Testing
- MgSo4, 0.9% NaCl
- Volunteers
- 60 people
- Sponsor
- El-Sahel Teaching Hospital
Acute Ischemic Stroke, Intracranial Hemorrhage
Hemodynamic in Postreperfusion Period and Functional Recovery in Acute Ischemic Stroke Patients
The investigators are suggtesting that lower goals of systolic blood pressure after intravenous thrombolysis may reduce the risk of hemorrhagic complications and improve functional outcomes after acute ischemic stroke.
- Trial name
- NCT05517109
- Testing
- Hemodynamic goal including lower goal of systolic blood pressure
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Northern State Medical University
Cerebral Hemodynamics, Cognitive Change
Effects of Pulsed Electromagnetic Fields (PEMFS) On Cerebral Haemodynamics
The investigators are looking to determine the effects of PEMFs device on cerebral blood flow and cognition in healthy volunteers.
- Trial name
- EPOCH (NCT03944993)
- Testing
- Pulsed Electromagnetic Fields Therapy (Dominant leg), Pulsed Electromagnetic Fields Therapy (Non-dominant leg)
- Where
- Singapore
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore