Clinical trials: Cerebral Blood Flow Regulation
Infant, Very Low Birth Weight, Infant, Premature, Diseases
Regulation of Cerebral Blood Flow in Very Low Birth Weight Infants
Advances in newborn intensive care have lead to dramatic improvements in survival for the most premature infants-often weighing 1 pound at birth.
- Conditions
- Infant, Very Low Birth Weight, Infant, Premature, Diseases, Cerebral Hemorrhage
- Trial name
- NCT00579943
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Arkansas
Brain Concussion, Post-Concussion Syndrome
Cerebral Blood Flow Regulation and Concussions
The purpose of this study is to understand how biochemical markers in blood, balance disturbances, and cognitive performance are related to brain blood flow changes after a concussion.
- Trial name
- NCT02754206
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Inactivity/Low Levels of Exercise
Handgrip Training and Brain Blood Flow Regulation
This study aims to investigate the effect of isometric handgrip training on brain blood vessel function in physically inactive adults.
- Trial name
- NCT07223645
- Testing
- Handgrip Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Florida State University
Cerebral Arterial Diseases
Human Cerebral Blood Flow Regulation
To determine cerebrovascular control mechanisms in humans and provide mechanistic knowledge to offer new sex-specific therapeutic options for cerebrovascular diseases.
- Trial name
- Gas Challenge (NCT04265053)
- Testing
- Indomethacin 25 MG/50 MG
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy, Hypercapnia
Role of Prostaglandins in the Regulation of Brain Blood Flow
This study will use magnetic resonance imaging (MRI) to examine the role of prostaglandins-a type of fatty acid with hormone-like actions-in the regulation of brain blood flow.
- Trial name
- NCT00006318
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hypoxia, Hypercapnia
Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation
Elucidating cerebrovascular control mechanisms during physiologic stress may help identify novel therapeutic targets aimed at preventing or reducing the impact of cerebrovascular disease.
- Trial name
- NCT03066115
- Testing
- L-NMMA, Ketorolac, Ascorbic Acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Concussion
Vascular Assessment of Regulation Index Arrays Registry
The objective of this patient registry is to collect and analyze physiological data associated with baseline and brain injury identified in standard clinical practice (Normal Values, Recovery Curves, Correlation between Symptoms…
- Trial name
- VARIA (NCT02435082)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- NeuroChaos Solutions, Inc.
Cerebrovascular Disorders
HYPEROXIA Responses and ROS
30 participants (15 males and 15 females) who are ≥18 - ≤ 40 years old and considered healthy will be enrolled into this study to test the role of reactive oxygen species (ROS) in regulating cerebral blood flow (CBF).
- Trial name
- NCT05958303
- Testing
- Antioxidant Cocktail
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy
Evaluating Q-Collar Effects on Brain Blood Flow Control During Exercise
The goal of this clinical trial is to learn how the FDA-cleared Q-Collar device affects brain blood flow regulation during rest and exercise in healthy adults. The main questions this study aims to answer are: 1.
- Trial name
- NCT06826781
- Testing
- Q30 Q-Collar, Not wearing Q-Collar
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Cerebrovascular Disorders
Brain Blood Flow Responses to Stress: Sex Differences
Twenty-six otherwise healthy adults between 18-40 years of age composed of 13 males and 13 females will be enrolled in this study to determine how sex and sex hormones influence cerebral blood flow (CBF) control in healthy young…
- Trial name
- NCT06253702
- Testing
- Indomethacin, Orilissa, Testosterone gel
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cerebrovascular Regulation
Brain Blood Flow Responses at Rest and During Exercise
Tight regulation of brain blood flow is integral for delivery of oxygen and energy for survival. During childhood, the brain has a twofold higher metabolic requirement, thus requires greater blood flow to match this.
- Trial name
- NCT06142045
- Testing
- RespirACT RA-MR System
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Brain Blood Flow, Neurovascular Control
Cardiovascular and Neurovascular Regulation in GWI
Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.
- Trial name
- NCT04586049
- Testing
- MRI, Transcranial Doppler Ultrasound, Sympathetic Nerve Activity
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Essential Hypertension, Older Adults
Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults With Hypertension.
High blood pressure (BP) is a public health problem worldwide. Nearly three-quarters of older adults (age ~60 years) in the United States have high BP. High BP links to many health problems, like stroke.
- Trial name
- NCT06287580
- Testing
- chlorthalidone
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Texas Southwestern Medical Center
Brain Blood Flow, Healthy
Blood Vessel Anatomy and Blood Flow Regulation
Brain blood flow regulation will be measured in response to environmental changes using MRI.
- Trial name
- NCT05396287
- Testing
- MRI
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Wisconsin, Madison
Chronic Heart Failure, Aging
Comparing the Effects of Combining Cognitive and Physical Exercise Training on Cognition, and Cerebral Blood Flow Regulation in Men and Women With Chronic Heart Failure
The objective of this project is to assess the effects of combined physical exercise and cognitive training interventions on cognitive and brain health in patients with heart failure (HF).
- Trial name
- ReCARDIO (NCT04970888)
- Testing
- Cognitive training, Exercise training, Usual care
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Montreal Heart Institute
Stroke
Blood Flow Regulation and Neuromuscular Function Post-Stroke
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking.
- Trial name
- NCT06027294
- Testing
- Ischemic Conditioning
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Orthostatic Intolerance
Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury
This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury.
- Trial name
- NCT01498809
- Testing
- Midodrine
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of British Columbia
Cerebrovascular Disorders
Identification of microRNAs Involved in Cerebral Collateral Regulation
Patients >18 years of age presenting to Ohio State Wexner Medical Center Emergency department with stroke symptoms, within 6 hours of last know well and found to have acute anterior circulation large vessel occlusion (LVO) will…
- Trial name
- microRNA (NCT03905434)
- Testing
- miRNA sampling
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Healthy
Endothelial Derived Hyperpolarization Factor and Vascular Control
Most cardiometabolic diseases are characterized by increased muscle sympathetic nerve activity (MSNA) during rest and exercise which contributes to poor health outcomes.
- Trial name
- NCT05176379
- Testing
- Fluconazole 150 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
At Risk for AD-dementia, With Subjective Cognitive Decline, At Risk for Cognitive Decline
High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults ages 60 to 79 who are at higher risk for Alzheimer's disease and…
- Trial name
- NCT07444554
- Testing
- High-Velocity Resistance Training
- Volunteers
- 60 people
- Sponsor
- University of Illinois at Chicago