Clinical trials: Centella
Skin Quality, Skin Wrinkles
Evaluation of Effects on Skin Quality of a Centella Asiatica Extracellular Vesicle-based Skin Care Formulation.
The study evaluates the effects of a skin care formulation containing Centella asiatica extracellular vesicles as the main active ingredient on facial appearance and skin quality in healthy participants.
- Conditions
- Skin Quality, Skin Wrinkles, Melanin Hyperpigmentation, Skin Hydration
- Trial name
- NCT06850935
- Testing
- Centella asiatica extracellular vesicle formulation
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hungkuang University
Scalp Health, Alopecia
Evaluation of the Scalp Skin Care Effects of Premium Revitalizing Elixir and Topical 5% Minoxidil
The study aims to evaluate the efficacy of two formulations on human scalp skin against established standard treatment of 5% minoxidil and base formula (placebo).
- Conditions
- Scalp Health, Alopecia, Hair Condition, Hair Loss
- Trial name
- NCT07901426
- Testing
- Base formula only, Base formula plus Centella asiatica extracellular vesicles, IGF-1 & FGF-7, Base formula plus Centella asiatica and ginger extracellular vesicles, IGF-1 & FGF-7
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hungkuang University
Hemorrhoids
Irritation and Anal Bleeding in Patients Affected by Hemorrhoids.
Haemorrhoidal disease is an increasingly frequent benign condition, able to negatively affect the quality of working and relationship life in affected individuals.The primary objective of the study is the comparative assessment…
- Trial name
- IR-AN-BLEED (NCT03569930)
- Testing
- flavonoid-based supplements, Centella Complex, standard of care
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- University of Roma La Sapienza
Scalp Health, Hair Condition
Scalp Care Efficacy Evaluation for Premium Revitalizing Elixir
The study aims to evaluate the efficacy of the Premium Revitalizing Elixir on human scalp skin. A total of 60 healthy adults, aged 18 to 60 with alopecia, baldness, or self-identified with symptoms of hair thinning will be…
- Conditions
- Scalp Health, Hair Condition, Hair Loss, Alopecia
- Trial name
- NCT07271212
- Testing
- Base formula only, Base formula plus IGF-1 and FGF-7, Base formula plus Centella asiatica and ginger extracellular vesicles
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hungkuang University
Gingivitis, Dental Plaque
The Effect of Mouthrinses Containing Bamboo Salt, Magnolia Bark and Centella Asiatica on Reducing Plaque and Gingivitis
This study aims to evaluate the effect of novel mouthrinse formulations containing bamboo salt, magnolia bark and centella asiatica extracts on gingivitis and dental plaque.
- Trial name
- NCT03047798
- Testing
- Mouthrinse
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Periodontal Diseases, Periodontal Bone Loss
Adjunctive Antioxidant Effect of Centella Asiatica Nanoemulsion Gel in Management of Periodontitis
The aims of the current study are: 1. Evaluation of the clinical efficacy of local delivery of nanoemulsion gel containing Centella asiatica extract as an adjunct to conventional non-surgical periodontal therapy in periodontitis…
- Trial name
- NCT07697209
- Testing
- Centella asiatica nanoemulsion gel, Scaling and Root Planing (SRP)
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Scalp Health, Hair Condition
Scalp Care Efficacy Evaluation for Premium Scalp Revitalizing Essence
The study aims to evaluate the efficacy of the Premium Scalp Revitalizing Essence on human scalp skin. A total of 60 healthy adults, aged 18 to 60, will be recruited and randomly assigned into five groups receiving different…
- Conditions
- Scalp Health, Hair Condition, Hair Loss, Sebum Production
- Trial name
- NCT06985121
- Testing
- Base formula only, Base formula plus IGF-1 and FGF-7, Base formula plus Centella asiatica extracellular vesicles
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hungkuang University
Temporomandibular Disorder
Efficacy of a Standardized Centella Asiatica Extract in Patients With Temporomandibular Disorder
The goal of this clinical trial is to test analgesic effect of ECa 233 in subjects with TMD. The main questions it aims to answer are: Can ECa 233 reduce pain intensity score in subjects with acute TMD? Can ECa 233 increase jaw…
- Trial name
- TMD ECa233 (NCT06231212)
- Testing
- ECa 233, Ibuprofen
- Where
- Thailand
- Volunteers
- 23 people
- Sponsor
- Chulalongkorn University
Cognitive Impairment, Elderly
Pharmacokinetics Centella Asiatica Product (CAP) in Mild Cognitive Impairment
This study will measure the oral bioavailability and pharmacokinetics of known bioactive compounds from a standardized Centella asiatica water extract product (CAP) in mildly demented elders on cholinesterase inhibitor therapy.
- Trial name
- NCT03937908
- Testing
- 2g Centella asiatica water extract product, 4g Centella asiatica water extract product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Stretch Marks, Striae Distensae
Topical Centella Asiatica and the Cosmetic Appearance of Stretch Marks
The purpose of this study is to clinically evaluate the efficacy, safety as well as patient satisfaction in the use of topical Centella asiatica (CA) on the cosmetic appearance of stretch marks.
- Conditions
- Stretch Marks, Striae Distensae, Cosmetic Appearance of Stretch Marks
- Trial name
- NCT02601105
- Testing
- Centella Asiatica Cream
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Rosacea, Acne
Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic Dermatosis
The purpose of this study was to investigate the efficacy and safety of repairing facial mask containing Asiaticum asiatica in treating disjunctive skin diseases.
- Conditions
- Rosacea, Acne, Centella, Melasma
- Trial name
- NCT06763367
- Testing
- Face mask containing Centella sinensis
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Endothelial Dysfunction
Centella Asiatica in Older Adults
The purpose of this study is to determine the effects of a dietary supplement containing centella asiatica on on vascular endothelial function in older adults.
- Trial name
- NCT06472791
- Testing
- Centella Asiatica
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Labor Trial Refused
The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis
This study aims to evaluate the effect of dentifrice formulations containing Centella asiatica and bamboo salt on gingivitis and dental plaque.
- Trial name
- NCT02616042
- Testing
- Centella asiatica and bamboo salt, Centella asiatica
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- LG Household & Health Care Ltd.
Xerosis Cutis, Diabetes Mellitus, Type 2
Effect of Centella Asiatica on Xerotic Skin in Diabetes Mellitus Type 2
The objective of this study is to evaluate the effect of Centella asiatica on hydration status of lower leg skin of DM type 2 patients by measuring SRRC and Skin Capacitance in correlation with AGEs CML, inflammation marker…
- Trial name
- NCT03815305
- Testing
- Centella Asiatica Extract, Topical CA, Petroleum jelly
- Where
- Indonesia
- Volunteers
- 159 people
- Sponsor
- Universitas Indonesia
Mild Cognitive Impairment, Alzheimer's Disease
Safety and Target Engagement of Centella Asiatica in Cognitive Impairment
This clinical trial is focused on determining whether biological signatures of target engagement by a Centella asiatica water extract product administered orally for 6 weeks can be measured in comparison to placebo.
- Trial name
- NCT05591027
- Testing
- Centella asiatica product
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Oregon Health and Science University
Iron Deficiency Anemia
Hibiscus Sabdariffa and Centella Asiatica in the Treatment of Anemia by Iron Deficiency
The study aims to investigate the prevalence of genetic polymorphisms in adults with iron deficiency and anemia, and the responses to two different treatments: iron sulphate and a composite herbal medicine (Hibiscus sabdariffa…
- Trial name
- NCT01414374
- Testing
- Herbal medicine, Iron
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Casa Espirita Terra de Ismael
Breast Cancer Female, Pain, Postoperative
Effects of Bromelain and Boswellia Serrata Casperome With Centella Asiatica and Vitamins on Edema, Paresthesia and Postoperative Pain After Quadrantectomy With or Without Sentinel Lymph Node Biopsy.
Aim: to investigate the effects of dietary supplements on postoperative edema and pain in patients undergoing quadrantectomy for breast cancer.
- Trial name
- NCT04669119
- Testing
- Bromelain/Boswellia Serrata Casperome, Centella Asiatica/Vitamins
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Bari Aldo Moro
Diabetic Neuropathy
Centella Asiatica Selected Triterpenes (CAST) for Diabetic Neuropathy
The purpose of this protocol is to investigate the safety, tolerability and effectiveness of CAST as a treatment for diabetic neuropathy. The primary outcome measure will be Total Neuropathic Symptom Score.
- Trial name
- CAST (NCT00608439)
- Testing
- Centella asiatica selected triterpenes (CAST)
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Oregon Health and Science University
To Prevent Scar Formation for Patients Underwent Surgery
The Effect of Centella Asiatica Cream on Scar Tenderness Who Underwent Open Carpal Tunnel Release Surgery
The centella asiatica cream applied to the wrist after the CTR surgery was found to be beneficial in preventing the scar tenderness in the thenar and hypothenar regions of the hand.
- Trial name
- NCT05017467
- Testing
- undefinedCentella Asiatica Extract
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Mustafa Balevi,MD
Gingival Diseases
Centella Asiatica (Gotukola) Mouthwash as an Adjunct to Mechanical Plaque Control
This study evaluates the adjunctive use of Centella Asiatica (gotukola) to scaling in the reduction of plaque and gingival inflammation.
- Trial name
- NCT02827305
- Testing
- Gotukola, Scaling
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sri Hasanamba Dental College and Hospital