Clinical trials: Cefazolin
Pharmacokinetics, Amoxicillin-clavulanate
Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)
Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Trial name
- PADECMO (NCT06426836)
- Testing
- Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Where
- 3 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- University Hospital, Ghent
Paracetamol, Cefazolin
Paracetamol and Cefazolin Pharmacokinetics in Normal Weight and Overweight Children
Pharmacokinetic evaluations will be conducted to characterize the cefazolin plasma concentration-time profile, cefazolin penetration into subcutaneous adipose tissue, and paracetamol metabolization as assessed through blood…
- Trial name
- TISSUE (NCT07585487)
- Testing
- Cefazolin, Paracetamol (drug)
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- University Hospital, Ghent
Bariatric Sleeve Gastrectomy, Cefazolin
Plasma and Tissue Concentration of Cefazolin in Preoperative Prophylaxis in Patients Undergoing Bariatric Surgery
This study investigates whether current cefazolin dosing guidelines for obese patients-2 g IV for those <120 kg and 3 g IV for those ≥120 kg-achieve adequate plasma and tissue concentrations (≥8 mg/L) for effective surgical…
- Trial name
- NCT07253805
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Laval University
Preterm Birth, Obstetric Labor, Premature
Azithromycin to Improve Latency in Exam Indicated Cerclage Control Trial
Azithromycin is an antibiotic that is effective against bacteria that been associated with preterm birth (PTB). The purpose of this study is to evaluate if the addition of azithromycin prior to exam indicated cerclage prolongs…
- Conditions
- Preterm Birth, Obstetric Labor, Premature, Obstetric Labor Complications, Pregnancy Complications
- Trial name
- ALEC (NCT05132829)
- Testing
- Azithromycin 1 gram IV, Cefazolin and indomethacin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Obese, Atracurium
Peri -and Postoperative Drug Therapy Schedules for Morbidly Obese Patients
Rationale: Obesity is an increasing health risk worldwide, with the USA recording prevalence in adults of around 20%. The mean body weight of obese patients is also increasing.
- Conditions
- Obese, Atracurium, Cefazolin, Morphine
- Trial name
- POP-II (NCT01097148)
- Testing
- Atracurium, TBW
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- St. Antonius Hospital