Clinical trials: Cathartics
Constipation
Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant Pain
The primary purpose of the protocol is to evaluate the safety, efficacy, and tolerability of MOA-728 in subjects with Opioid-Induced Bowel Dysfunction (OIBD) with associated chronic non-malignant pain.
- Trial name
- NCT00366431
- Testing
- MOA-728
- Where
- 67 sites in United States
- Volunteers
- 420 people
- Sponsor
- Bausch Health Americas, Inc.
Constipation
A Safety and Efficacy Evaluation of BLI801 Laxative in Constipated Adults
A pilot study to evaluate the safety and efficacy of multiple BLI801 doses in constipated adults.
- Trial name
- NCT01687985
- Testing
- BLI801 laxative - low dose, BLI801 laxative - high dose
- Where
- 4 sites in United States
- Volunteers
- 81 people
- Sponsor
- Braintree Laboratories
Constipation
A Safety and Efficacy Evaluation of BLI801 Laxative in Adults Experiencing Non-Idiopathic Constipation
The objective of this study is to evaluate multiple doses of BLI801 Laxative for safety and efficacy versus placebo in adults experiencing non-idiopathic constipation.
- Trial name
- NCT02822508
- Testing
- BLI801 Laxative
- Where
- 73 sites in United States
- Volunteers
- 434 people
- Sponsor
- Braintree Laboratories
Constipation
Extended Use of Polyethyleneglycol3350 Laxative in Constipated Patients
To evaluate the safety and efficacy of extended use of polyethyleneglycol3350 laxative as compared to placebo in constipated patients.
- Trial name
- NCT00153153
- Testing
- polyethyleneglycol3350
- Where
- 45 sites in United States
- Volunteers
- 300 people
- Sponsor
- Braintree Laboratories
Constipation
A Preference Study Comparing Kristalose® and Liquid Lactulose
This study will evaluate whether patients have an overall preference for Kristalose® or liquid lactulose based on taste, consistency, and portability.
- Trial name
- NCT00712543
- Testing
- lactulose (Kristalose®), liquid lactulose
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Cumberland Pharmaceuticals
Colorectal Cancer
Pharmacodynamic Evaluation of Stool Output Following Oral Administration of Various Low Volume PEG3350-based Gut Cleansing Solutions Using the Split Dose Intake in Healthy Subjects
This study is to investigate the effect of various modified low volume polyethylene glycol (PEG) 3350 and ascorbic acid/ascorbate (PEG+ASC)-based gut cleansing solutions on stool output in healthy subjects.
- Trial name
- OUT (NCT01834742)
- Testing
- NER1006, Moviprep
- Where
- 2 sites in Romania
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Norgine
Constipation
Comparison of PolyethyleneGlycol and Placebo for Relief of Constipation From Constipating Medications
The purpose of this study is to assess treatment responses comparing a newly FDA-approved PEG laxative versus placebo.
- Trial name
- NCT00153127
- Testing
- polyethyleneglycol3350
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Braintree Laboratories
Constipation
BLI801 Laxative in Constipated Adults
A pilot study to evaluate the safety and efficacy of BLI801 vs. placebo in constipated adults.
- Trial name
- NCT01301781
- Testing
- BLI801
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Braintree Laboratories
Constipation
Comparator Study of PEG 3350 Versus Prucalopride in Females With Chronic Constipation
This study is to compare the efficacy and safety of polyethylene glycol (PEG) 3350 with that of prucalopride in the treatment of chronic constipation in females.
- Trial name
- NCT01251822
- Testing
- PEG 3350 plus electrolytes, Prucalopride
- Where
- Romania
- Volunteers
- 240 people
- Sponsor
- Norgine
Constipation
Dose-Finding Trial of Polyethylene Glycol 3350 Laxative Plus Electrolytes for the Treatment of Constipation (Protocol P07515)
The primary objective of the study was to evaluate the proportion of subjects with a bowel movement (BM) without straining or without hard and/or lumpy stool within the first 24 h of treatment for subjects taking 1 of 3 single…
- Trial name
- NCT01212445
- Testing
- PEG 3350 laxative plus electrolytes (PEG + E)/Macrogol (Movicol®, BAY81-8430)
- Where
- Ireland
- Volunteers
- 154 people
- Sponsor
- Bayer
Opioid Induced Constipation
To Evaluate Patient Preference of Movantik and Polyethylene Glycol 3350 for Opioid Induced Constipation
The purpose of this study is to determine whether patients with opioid induced constipation prefer treatment with naloxegol (Movantik) or with Polyethylene Glycol 3350.
- Trial name
- NCT03060512
- Testing
- Polyethylene Glycol 3350, Movantik
- Where
- 53 sites in United States
- Volunteers
- 276 people
- Sponsor
- AstraZeneca
Constipation, Chronic Idiopathic Constipation
BLI400-302: A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults
The objective of this study is to evaluate a daily dose of BLI400 Laxative for safety and efficacy versus placebo in constipated adults.
- Conditions
- Constipation, Chronic Idiopathic Constipation, CIC
- Trial name
- NCT02819297
- Testing
- BLI400 Laxative
- Where
- 51 sites in United States
- Volunteers
- 1,020 people
- Sponsor
- Braintree Laboratories
Constipation
A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adolescent Subjects
The objective of this study is to evaluate the safety and efficacy of BLI400 laxative in constipated adolescent subjects.
- Trial name
- NCT02665728
- Testing
- BLI400 Laxative
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Braintree Laboratories
Chronic Constipation
To Determine the Effect of Forlax® Treatment in Children With Chronic Constipation Who May Also Suffer From Soiling/ Faecal Incontinence.
The purpose of this study is to determine whether Forlax® is more effective than placebo in relieving chronic constipation in children who may also suffer from soiling or faecal incontinence.
- Trial name
- NCT00255372
- Testing
- PEG 4000 (Forlax®)
- Where
- 2 sites in Thailand
- Volunteers
- 88 people
- Sponsor
- Ipsen
Constipation, Chronic Idiopathic Constipation
An Open Label Study of Chronic Use of BLI400 Laxative in Constipated Adults
The objective of this study is to evaluate the safety of chronic use of BLI400 laxative in constipated adults.
- Conditions
- Constipation, Chronic Idiopathic Constipation, CIC
- Trial name
- NCT02819310
- Testing
- BLI400 Laxative
- Where
- 24 sites in United States
- Volunteers
- 330 people
- Sponsor
- Braintree Laboratories
Constipation
Study Comparing PEG 3350 Laxative to Placebo in the Treatment of Occasional Constipation (Study CL2007-12)(P08216)
Randomized, placebo-controlled, double blind study. 203 subjects entered the study to compare the effect on occasional constipation of polyethylene glycol 3350 to placebo. Subjects took one of study treatments up to 7 days.
- Trial name
- NCT00770432
- Testing
- Polyethylene glycol 3350
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Bayer
Constipation
A Pilot Efficacy Evaluation of BLI-801 as a Laxative in Constipated Adults
To compare the safety and efficacy of BLI-801 administered at 4 dose levels in constipated adults.
- Trial name
- NCT00583154
- Testing
- BLI-801
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Braintree Laboratories
Opioid Induced Constipation
A Single-arm, Study to Assess the Effect and Tolerability of Standardised Laxative Therapy (SLT) for the Reversal of Opioid-induced Constipation (OIC).
The main purpose of this study is to assess how effective and tolerable the country specific clinical practice guidelines of SLTs are for UK, France and Sweden are.
- Trial name
- NCT01957046
- Testing
- Laxative
- Where
- Sweden
- Volunteers
- 117 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Constipation
PolyethyleneGlycol3350 Laxative vs Placebo in Constipated Children
Assess the safety and efficacy of polyethyleneglycol3350 laxative as compared to placebo therapy in pediatric patients with a history of constipation.
- Trial name
- NCT00153114
- Testing
- polyethyleneglycol3350
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Braintree Laboratories
Pain, Opioid Induced Constipation
Non-interventional Study Comparing Targiniq and Oxycodone/Laxatives
The objective of the non-interventional study is to compare the quality of life, health care resource use and costs between the use of a combination of oxycodone and naloxone (Targiniq) versus oxycodone and laxatives for patients…
- Trial name
- NCT01812733
- Where
- Sweden
- Volunteers
- 37 people
- Sponsor
- Mundipharma AB