Clinical trials: Cathartics
Cathartic Colon
Comparing Bowel Preparation Regimens for Flexible Sigmoidoscopy
Objective and Hypothesis: The investigators objective is to help determine the efficacy of oral and rectal bowel preparation regimens for sigmoidoscopy.
- Trial name
- NCT01554111
- Testing
- Picosulfate sodium,, phosphosoda rectal enema, Pico-Salax and Sodium phosphate enema
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Queen's University
Colorectal Cancer
Pharmacodynamic Evaluation of Stool Output Following Oral Administration of Various Low Volume PEG3350-based Gut Cleansing Solutions Using the Split Dose Intake in Healthy Subjects
This study is to investigate the effect of various modified low volume polyethylene glycol (PEG) 3350 and ascorbic acid/ascorbate (PEG+ASC)-based gut cleansing solutions on stool output in healthy subjects.
- Trial name
- OUT (NCT01834742)
- Testing
- NER1006, Moviprep
- Where
- 2 sites in Romania
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Norgine
Intestinal Recovery After Cesarean Section
The Efficacy of Chewing Gums Versus Laxative in Early Return of Bowel Function After CS
540 consented women for being enrolled in this clinical trial and candidates for elective cesarean section will be divided into 3 groups: Group A, 180 women will receive sugarless gum after their operating room discharge by 3…
- Trial name
- NCT02765971
- Testing
- gums, picolax drops, normal saline
- Where
- Egypt
- Volunteers
- 540 people
- Sponsor
- Ahmed M Maged, MD
Colorectal Liver Metastases
Optimised Recovery With Accelerated Nutrition and GI Enhancement
Factors which delay recovery following uncomplicated abdominal surgery include uncontrolled pain, intolerance of diet and poor mobility.
- Trial name
- ORANGE (NCT00538954)
- Testing
- Post operative laxation (Magnesium Oxide), Preoperative metabolic conditioning postoperative nutritional supplementation, Standard ERAS group
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 64 people
- Sponsor
- University of Edinburgh
Constipation
A Pilot Efficacy Evaluation of BLI-801 as a Laxative in Constipated Adults
To compare the safety and efficacy of BLI-801 administered at 4 dose levels in constipated adults.
- Trial name
- NCT00583154
- Testing
- BLI-801
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Braintree Laboratories
Constipation
A Pilot Study of BLI801 Laxative in Adults Experiencing Non-Idiopathic Constipation
The objective of this study is to evaluate BLI801 laxative in adults experiencing non-idiopathic constipation.
- Trial name
- NCT02820714
- Testing
- BLI801 Laxative
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Braintree Laboratories
Constipation
Comparison of PolyethyleneGlycol and Placebo for Relief of Constipation From Constipating Medications
The purpose of this study is to assess treatment responses comparing a newly FDA-approved PEG laxative versus placebo.
- Trial name
- NCT00153127
- Testing
- polyethyleneglycol3350
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Braintree Laboratories
Colonoscopy
Effect of Lactulose and/or Polyethylene Glycol Solution for Bowel Preparation for Colonscopy Procedures
Colonoscopy is the most useful exam used to evaluate colorectal diseases, like colorectal polyps and cancer. The appropriate bowel preparation is indispensable for colonoscopy procedures.
- Trial name
- NCT05076799
- Testing
- 100 ml lactulose combined with 1 L PEG, 100 ml lactulose combined with 2 L PEG, 200 ml lactulose
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sichuan University
Constipation
Randomized, Double-Blinded, Placebo-Controlled Trial of Laxatives for Children With Urge Syndrome
HYPOTHESIS: Is MiraLAX an effective treatment of pediatric urinary urge syndrome? OBJECTIVE: Polyethylene glycol (PEG) is common first-line therapy for urinary symptoms despite minimal evidence-based support.
- Trial name
- NCT00765557
- Testing
- MiraLAX
- Volunteers
- 138 people
- Sponsor
- University of Texas Southwestern Medical Center
Colorectal Cleansing Prior Operation
Moviprep® Versus Fleet Phospho-Soda® (Golden Standard): A Study That Compared Two Laxatives on Patients Undergoing Colo-Rectal Cleansing Prior to an Abdominal Operation
The patients are assigned by randomisation on one of the two laxatives. After cleansing they have to fill in an evaluation form to report their findings and difficulties.
- Trial name
- NCT00618930
- Testing
- Moviprep®, Fleet
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Adenomatous Polyp, Colorectal Carcinoma
Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal Cancer
This randomized phase II trial studies how well macrogol 3350-based oral osmotic laxative (polyethylene glycol 3350) works in preventing cancer in patients at risk of colorectal cancer.
- Trial name
- NCT00828984
- Testing
- macrogol 3350-based oral osmotic laxative, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Volunteers
- 87 people
- Sponsor
- National Cancer Institute (NCI)
Constipation
BLI801 Laxative in Constipated Adults
A pilot study to evaluate the safety and efficacy of BLI801 vs. placebo in constipated adults.
- Trial name
- NCT01301781
- Testing
- BLI801
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Braintree Laboratories
Colonoscopy Preparation
PEG Versus PEG+Bisacodyl Versus Sennosides for Colon Cleansing Before Colonoscopy
Background: Polyethylene glycol (PEG) solution has been proven to be effective for large bowel cleansing prior to colonoscopy in children.
- Trial name
- NCT01531140
- Testing
- polyethylene glycol +Bisacodyl, Polyethylene glycol, Sennosides
- Where
- 2 sites in Poland
- Volunteers
- 240 people
- Sponsor
- Medical University of Warsaw
Bowel Preparation for Colonoscopy
Split Dose Pico-Salax + Bisacodyl vs. PEG Split Dose
The objective of this study is to compare the efficacy, safety and tolerability of two bowel preparations for colonoscopy - split dose Polyethylene Glycol-Based Lavage and Pico-Salax plus Bisacodyl - with a specific emphasis on…
- Trial name
- BP (NCT01415687)
- Testing
- Polyethylene Glycol-Based Lavage, Pico-Salax (Magnesium Citrate) plus Bisacodyl
- Where
- 2 sites in Canada
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Chronic Severe Pain
A Non-interventional, Observational Study for Targinact® Treatment in Patients With Chronic Severe Pain
This non-interventional, observational study is set up on request of the Belgian reimbursement authorities and evaluates the efficacy of Targinact with regard to pain relief and constipation in daily clinical practice in Belgium…
- Trial name
- NCT01710904
- Testing
- Targinact® (oxycodone/naloxone)
- Where
- Belgium
- Volunteers
- 68 people
- Sponsor
- Mundipharma CVA
Cathartic Colon, Colonic Neoplasms
Different Bowel Preparations in CT Colonography: is Diet Necessary? A Randomized Controlled Trial
The aim of this study is to compare a new regimen of reduced bowel preparation that does not include low fiber diet with another reduced bowel preparation including low-fiber diet.
- Trial name
- DIETSAN (NCT02371655)
- Testing
- Diet, Faecal Tagging, Bowel cleansing
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Colorectal Diseases, Mechanical Bowel Preparation
Effect of Oral Laxative Use Before Colorectal Surgery on Intraoperative Surgical Difficulty
This prospective randomized pilot study will evaluate whether the use of an oral laxative before elective laparoscopic colorectal surgery affects small-bowel diameter and intraoperative surgical difficulty.
- Trial name
- OLAX-CRC (NCT07820696)
- Testing
- Oral Laxative, Rectal Enema
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Van Training and Research Hospital
Colonic Polyps
Cathartic-Free DECT Colonography for Detection of Colonic Polyps
Asses the clinical performance of dual-energy CTC for the detection of larger polyps 1 cm or larger without cathartic preparation.
- Trial name
- NCT00587028
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Postoperative Ileus
Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery
Postoperative bowel dysmotility is a frequent condition after colorectal surgery. The influence of colon stimulating laxatives have not been studied.
- Trial name
- NCT00509327
- Testing
- bisacodyl, glucosemonohydricum
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Bowel Evacuant Prior to Colonoscopy
Kristalose as Bowel Evacuant Prior to Colonoscopy
To determine whether Kristalose causes a significant increase in hydrogen and/or methane gas levels in patients requiring bowel evacuation, and also to determine the safety, efficacy, and patient preference of Kristalose as a…
- Trial name
- NCT01256541
- Testing
- Kristalose
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Benaroya Research Institute