Clinical trials: Cardiovascular Disease Risk Factor
Cardiovascular Disease, Coronary Disease
Effects of Cardiac Rehabilitation (CR) on Functional Capacity and Cardiovascular Risk Factors
The purpose of this trial are to pragmatically investigate whether participation in a comprehensive CR (i.e., exercise with education) program in a Latin American MIC results in better functional capacity, cardiovascular risk…
- Trial name
- NCT02575976
- Testing
- comprehensive CR, exercise-based CR, wait list control
- Where
- Brazil
- Volunteers
- 115 people
- Sponsor
- Federal University of Minas Gerais
Cardiovascular Risk Factors
Beneficial Impact of Orange Juice Consumption on Risk Factors Associated With Cardiovascular Diseases
The primary aim is to examine both the acute and chronic effects of hesperidin consumption from 100% Florida orange juice in various doses on functional and systemic markers associated with cardiovascular disease (CVD) risks.
- Trial name
- CITRUS (NCT02479568)
- Testing
- Control, 100% Florida OJ, 100% Florida OJ-enriched
- Where
- Spain
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Type 1 Diabetes Mellitus
Exercise Training Intervention in Children With Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) is associated with multiple co-morbidities, such as hypertension, dyslipidemia, coronary heart disease and osteoporosis. The foundation of these conditions lays in childhood.
- Trial name
- Diabex (NCT01220479)
- Testing
- Exercise training program
- Where
- Switzerland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Blood Pressure, High, Cardiovascular Risk Factor
Efficacy of a Brief Intervention on Reduction of Systolic Blood Pressure
This study examines the efficacy of individualized counseling letters to reduce systolic blood pressure level of ≥ 130 mmHg in individuals aged between 40 and 65 years.
- Trial name
- NCT03077373
- Testing
- Counseling letter
- Where
- Germany
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Aortic Regurgitation
Mild and Moderate Aortic Regurgitation: Risk Factors for Progress and Outcome
This observational study aims to evaluate risk factors of progress and adverse outcome of aortic regurgitation
- Trial name
- NCT07104968
- Where
- Sweden
- Volunteers
- 35,000 people
- Sponsor
- Uppsala University
Healthy People
The Effects of Freeze-Dried Whole Grape Powder on Chronic Disease and Cardiovascular Risk Factors-a Pilot Study
Cardiovascular disease (CVD) is responsible for 1 out of every 5 deaths, is the number one killer of Americans, killing about 700K US adults per year (1).
- Trial name
- NCT06006182
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- California State Polytechnic University, Pomona
Pre-diabetes, Cardiovascular Risk Factor
Effectiveness of Nurse-coordinated Follow-up Program in Primary Care for People at Risk for T2DM
Previous Icelandic studies regarding prevalence of diabetes have mostly used data from the capital area. Information on the proportion of people at risk at developing T2DM or having undiagnosed T2DM among people living in rural…
- Conditions
- Pre-diabetes, Cardiovascular Risk Factor, T2DM (Type 2 Diabetes Mellitus), Primary Health Care
- Trial name
- NCT04688359
- Testing
- Guided Self Determination
- Where
- Iceland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Akureyri
Intracerebral Hemorrhage
Etiology and Prognostic Risk Factors of Intracerebral Hemorrhage in Beijing
There were lack of data and analysis about medical management, etiology, and long-term outcome of Intracerebral Hemorrhage (ICH) in Beijing.
- Trial name
- NCT02350010
- Testing
- CT Angiography
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Neurosurgical Institute
Hyperlipidemia, Hypertension
Medication Adherence Clinical Decision Support
More than 50% of adults treated for diabetes, hypertension, or lipid disorders have suboptimal medication adherence, a prominent barrier to continued improvement in chronic disease care in the United States.
- Conditions
- Hyperlipidemia, Hypertension, Diabetes, Medication Nonadherence
- Trial name
- ADH-Wizard (NCT03748420)
- Testing
- Adherence Intervention
- Where
- United States
- Volunteers
- 5,421 people
- Sponsor
- HealthPartners Institute
Graft Failure, Death
European Transplant Registry of Senior Renal Transplant Recipients on Advagraf
SENIOR transplant Registry European transplant registry of senior renal transplant recipients (above the age of 65 years) receiving initial immunosuppression with tacrolimus once daily, mycophenolate and steroids to investigate…
- Conditions
- Graft Failure, Death, Acute Rejection of Renal Transplant, Infections
- Trial name
- SENIOR (NCT02558452)
- Testing
- Tacrolimus once daily (Advagraf)
- Volunteers
- 1,000 people
- Sponsor
- Klemens Budde
Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Disease Risk Factor
Early Add-On Combination of GLP-1 Receptor Agonist and SGLT2 Inhibitor in People With Cardiovascular-Kidney-Metabolic Stage 2-3
This retrospective observational target-trial emulation uses electronic health record data from the TriNetX US Collaborative Network to compare early treatment intensification strategies in adults with obesity, type 2 diabetes…
- Conditions
- Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Disease Risk Factor, Kidney Disease, Type 2 Diabetes
- Trial name
- GLP1-SGLT2-CKM (NCT07465926)
- Testing
- GLP-1 receptor agonist, SGLT2 inhibitor
- Volunteers
- 451,036 people
- Sponsor
- Chung Shan Medical University
Racial Disparities, Blood Pressure
The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood…
- Conditions
- Racial Disparities, Blood Pressure, Cardiovascular Risk Factor, Renal Function
- Trial name
- MAVHS (NCT04334135)
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Auburn University
T2D
Peanut Consumption and Cardiovascular Disease Risk in a Chinese Population
This is a 2 parallel-arm randomized controlled study with free-living subjects on self-selected diets. The objective of this study is to compare the effects of two servings of peanuts with an isocaloric matched refined…
- Trial name
- NCT03194152
- Testing
- Peanut, Control
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Harvard School of Public Health (HSPH)
Diabetes Type 1, Endothelial Dysfunction
Cardiovascular Risk Factors After Single Pancreas Transplantation
Patients accepted for the waiting list for single pancreas transplantation suffer from severe glucose instability with hyperglycemia due to diabetes type 1, but do not have significant diabetes-related complications.
- Trial name
- Diamant (NCT02066350)
- Testing
- Single pancreas transplantation
- Where
- Norway
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Coronary Artery Disease
Cross-over Study of Coronary Risk Factors With a Polypill
Open-label, randomized, cross-over study conducted in a single center, applied to patients receiving a polypill with 100 mg of acetyl salicylic acid and different doses of ramipril and atorvastatin for indication of secondary…
- Trial name
- POLICROSS (NCT05030818)
- Testing
- Polypill of acetylsalicylic acid, ramipril and atorvastatin, Drugs taken separately: acetylsalicylic acid, ramipril and atorvastatin
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Fundación EPIC
Diabetes Mellitus, Foot Ulcer
Becaplermin Use and Cancer Risk in a Patient Population of U.S. Veterans With Diabetes
The purpose of this study is to evaluate risk of cancer incidence and mortality associated with the use of REGRANEX (becaplermin) in patients with diabetes who are members of a U.S. Veterans Health Administration.
- Conditions
- Diabetes Mellitus, Foot Ulcer, Diabetic Foot, Diabetic Neuropathies
- Trial name
- NCT01235260
- Testing
- Becaplermin nonusers, Becaplermin users
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Obesity and Overweight, Obese Adolescents
Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity
The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3).
- Conditions
- Obesity and Overweight, Obese Adolescents, Weight Management, Weight Loss
- Trial name
- MODERN (NCT06967389)
- Testing
- Ozempic®
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Bauer
Cognitive Decline, Stroke
Identification of Epigenetic Risk Factors for Ischemic Complication During the TAVR Procedure in the Elderly
Over the past ten years, the number of endovascular procedures has increased by 5% per year in Europe with the development of interventional cardiology, such as percutaneous coronary angioplasty, aortic valve replacements (TAVR)…
- Trial name
- METHYSTROKE (NCT02972008)
- Where
- France
- Volunteers
- 542 people
- Sponsor
- University Hospital, Lille
Osteoarthritis, Knee, Endocrine System Diseases
Influence of Adipocytokines in Osteoarthritis
Adipocytokines play an important role in joint inflammation in patients with knee osteoarthritis as measured by ultrasound and high sensitivity protein-C reactive.
- Conditions
- Osteoarthritis, Knee, Endocrine System Diseases, Cardiovascular Risk Factors
- Trial name
- NCT01906281
- Testing
- Blood analyse, arthrocentesis, ultrasound examination
- Where
- 2 sites in Spain
- Volunteers
- 105 people
- Sponsor
- Parc Taulí Hospital Universitari
Metabolic Syndrome, Cardiovascular Diseases
Effects of Coenzyme Q10 Supplement on Cardiovascular Risk Factors in Subjects at High Risk of Metabolic Syndrome
This study aims to evaluate the ameliorating effect of coenzyme Q10 supplementation on cardiovascular risk factors in high risk population for metabolic syndrome, including blood lipid metabolism, insulin resistance, blood…
- Trial name
- NCT06506630
- Testing
- coenzyme Q10
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tian Zezhong
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