Clinical trials: Cardioplegia
Cardiac Perfusion
Del Nido Cardioplegia Randomized Trial
The use of a modified depolarizing cardioplegia solution in adult cardiac surgery would allow for prolonged re-dosing intervals while providing equivalent myocardial protection.
- Trial name
- NCT02442050
- Testing
- del Nido solution, Blood-based cardioplegia
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Inova Health Care Services
C.Surgical Procedure; Cardiac
HELIox CardiOPlegia Trial During Cardiac surgERy
The HELICOPTER-1 Trial is a single centre pilot study to determine the feasibility of administering Heliox in cardioplegia during cardiac surgery and whether it has the potential to reduce the incidence and severity of myocardial…
- Trial name
- HELICOPTER-1 (NCT02745951)
- Testing
- Heliox, Standard of care
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Myocardial Protection
Effect of the Addition of Adenosine on Myocardial Protection During Cardiopulmonary Bypass
The goal of this clinical trial is to evaluate whether the addition of adenosine to standard cardioplegia improves myocardial protection in adult patients undergoing on-pump cardiac surgery.
- Trial name
- ADENOCARDIO (NCT07426237)
- Testing
- Adenoseine
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Congenital Heart Malformations
Study of Cardioplegia in Cardiac Surgery Due to Congenital Heart Malformation in Children
The objective of this investigation is to compare the safety and cardioprotective effects of Custodiol and Custodiol-N in children undergoing cardiac surgery with cardiopulmonary bypass (CPB) due to congenital heart malformation.
- Trial name
- NCT07381530
- Testing
- heart will be treated with Custodiol-N, heart will be treated with Custodiol
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Dr. F. Köhler Chemie GmbH
Cardiac Surgery
The Levels of Anaesthetics in Heart Muscle During Heart Surgery
In the last few years, anaesthetic agents, Isoflurane used in heart surgery have shown some benefits to reduce the risk of heart muscle damage.
- Trial name
- TLAHMHS (NCT02471001)
- Testing
- Blood samples
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University of Edinburgh
Aortic Valve Disease, Coronary Artery Disease
Intermittent Cold Blood vs Crystalloid Cardioplegia in Aortic Valve Surgery
Controversies still exists concerning the overall clinical effects of blood-based vs. crystalloid- based cardioplegic solution for myocardial protection during cardiac arrest. Both techniques are used world-wide.
- Trial name
- NCT00257777
- Testing
- Myocardial protection techniques
- Where
- Norway
- Volunteers
- 350 people
- Sponsor
- Oslo University Hospital
Myocardial Stunning
Safety and Efficacy of IV Diazoxide as an Additive to Hyperkalemic Cardioplegia in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
This study aims to confirm the safety and efficacy of diazoxide as an additive to hyperkalemic cardioplegia in patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT04830982
- Testing
- IV Diazoxide
- Where
- United States
- Sponsor
- Johns Hopkins University
Cardiac Surgery, Cardioplegia
Evaluation of Clinical Impact of the Type of Cardioplegia Used in the Patient Undergoing Major Cardiac Surgery.
Phase IV clinical trial of a single-blind, prospective and longitudinal randomized intervention comparing patients undergoing major cardiac surgery with extracorporeal circulation who are administered Custodiol crystalloid…
- Conditions
- Cardiac Surgery, Cardioplegia, Heart Arrest
- Trial name
- NCT06530641
- Testing
- Custodiol Htk Soln, Buckberg Cardi-Braun
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Lourdes Montero Cruces
Cardiac Ischemia
Ringer Acetate Based Modified Del Nido Cardioplegia Solution Versus HTK Solution Cardioplegia Solution in Cardiac Surgery
Low chloride solutions were proved to be better in resuscitation of emergency cases and decrease the resulting hyperchloremic metabolic acidosis in the last decade.
- Trial name
- HTK (NCT06414330)
- Testing
- Ringer acetate based Del Nido cardioplegia, HTK
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Assiut University
CAD, Arrhythmia Ventricular
Adding Lidocaine to Custodiol Mixture
The Bretschneider solution, also known as Custodiol, has been widely used in open-heart surgery requiring cardiopulmonary bypass (CPB) since its introduction in 1970.
- Trial name
- NCT07205757
- Testing
- Lidocaine Hydrochloride, Custodiol Solution
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Bypass Complication, Cardioplegia Solution Adverse Reaction
Investigation of Myocardial Protection Level With Specific Cardioplegia Methods in Cardiac Surgery
Investigating the myocardial effects of cold blood cardioplegia and del nido cardioplegia solution, which are routinely used in clinical practice, will contribute to the studies in the literature on the safety and efficacy of…
- Conditions
- Bypass Complication, Cardioplegia Solution Adverse Reaction, Endothelial Degeneration, Oxidative Stress
- Trial name
- NCT05603429
- Testing
- Endocan, E-Selectin, TNF-alpha, Total Oxidant and Antioxidant Status
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Cardiovascular Diseases, Myocardial Reperfusion Injury
Investigation of Myocardial Protection Efficacy of Cardioplegia Solutions Used in Open Heart Surgery
Cardioplegias are different pharmacokinetic solutions routinely used in cardiac surgery to protect the heart from ischemia and induce arrest.
- Trial name
- NCT06373549
- Testing
- Patients with coronary artery bypass surgery routine procedural administration of cardioplegia solutions, Patients who underwent heart valve surgery without coronary artery disease routine procedural administration of cardioplegia solutions
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Tamer cebe
Cardiopulmonary Bypass Surgery
Post-Market Clinical Follow-up Study on the Performance and Safety of the Aortic Root Cannula Used in Cardiopulmonary Bypass Surgery
Prior to the implementation of the Medical Device Regulation (MDR), the clinical evaluation of existing devices was conducted by Notified Bodies (NBs) based on clinical data from equivalent devices, and CE marking was granted to…
- Trial name
- NCT07628907
- Testing
- aortic root cannula
- Volunteers
- 20 people
- Sponsor
- Bıçakcılar Tıbbi Cihazlar Sanayi ve Ticaret A.Ş.
Coronary Artery Disease, Valvular Heart Disease
The ABC Trial Does All-Blood Cardioplegia Prevent Blood Transfusion in Cardiac Surgery? A Single Centre Pilot Study
This study is a single centre pilot for a randomized trial comparing all-blood cardioplegia to more dilute 4:1 blood cardioplegia during cardiac surgery.
- Trial name
- ABC (NCT01623193)
- Testing
- All-blood cardioplegia, Standard cardioplegia
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Pam Trenholm
Myocardial Injury
Comparison of the Effects of Crystalloid Cardioplegia and HTK Solution for Postoperative Troponin-I and CK-MB Levels After Pediatric Cardiac Surgery
The purpose of this study is to compare two different cardioplegia solutions effect on postoperative Troponin-I and CK-MB levels after pediatric cardiac surgery.
- Trial name
- NCT01548872
- Testing
- HTK solution, crystalloid cardioplegia solution
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Baskent University
Congenital Heart Disease
Role of Terminal Warm Blood Cardioplegia as Myocardial Protection in the Use of Histidine-Tryptophan-Ketoglutarate Cardioplegia in Complex Congenital Heart Surgery
Terminal warm blood cardioplegia (TWBC) has been shown to enhance myocardial protection in adult patients. Even in pediatric patients, the use of cold blood cardioplegia followed by administration of TWBC will provide…
- Trial name
- NCT02618824
- Testing
- Histidine Tryptophan Ketoglutarate Solution, Terminal Warm Blood Cardioplegia
- Where
- Indonesia
- Volunteers
- 110 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Mitral Valve Surgery
Comparative Study Between Conventional Crystalloid Cardioplegic Solution With Modified Del Nido Cardioplegia
Mitral valvuloplasty for correction of chronic mitral regurgitation carries a lower operative mortality and morbidity and improved long-term survival than does mitral valve replacement.
- Trial name
- NCT05797090
- Testing
- Crystalloid Cardioplegic solution
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- mohamed
Congenital Heart Disease
Custodiol Versus Blood Cardioplegaia in Paediatric Cardiac Surgery
Cardioplegic arrest is an essential part of cardiac surgery which aims to allow myocardial preservation and minimise myocardial swelling ,while providing a motionless and bloodless field ,.Blood cardioplegia has proven its…
- Trial name
- NCT03082716
- Testing
- Custodiol Solution, Blood cardioplegia
- Where
- Saudi Arabia
- Volunteers
- 49 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
CABG Surgery, Cold Blood Cardioplegia, Coagulation Profile and Platelet Function
Hypothermic Versus Normothermic Cardiac Bypass in Patients Undergoing CABG Surgery, Effect on Coagulation; Randomized Controlled Trial
On-pump CABG surgery deleteriously affects hematological and coagulation profiles of patients and this effect was accentuated by the use of cold bypass.
- Trial name
- NCT04148404
- Testing
- Normothermic group
- Where
- Egypt
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Cairo University
Del Nido Cardioplegia
Magnesium Administration After Cardioplegic Arrest With Del Nido Cardioplegia
The cardioplegia solution of choice in many pediatric cardiac congenital programs is the del Nido solution. While many cardioplegia solutions provide diastolic arrest, del Nido provides a longer period of time between doses of…
- Trial name
- MGSO (NCT05298618)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati