Clinical trials: Cardiogenic Shock
Cardiogenic Shock Post Myocardial Infarction
Rapid Microaxial Flow Pump Support and Escalation in Patients With Myocardial Infarction Associated Cardiogenic Shock and Persistent Need of Hemodynamic Support
The aim of this trial is to evaluate whether a structured and time-optimized escalation strategy from a transfemoral microaxial flow-pump (Impella CP™) to the Impella 5.5™ microaxial flow-pump is associated with improved clinical…
- Trial name
- RISE (NCT07655479)
- Testing
- Escalation to more capable microaxial flow-pump (Impella 5.5)
- Where
- 3 sites in Germany
- Volunteers
- 115 people
- Sponsor
- University Hospital of Cologne
Myocardial Infarction, Cardiogenic Shock
Efferon CT Hemoadsorption for Cardiogenic Shock in Acute Myocardial Infarction
Cardiogenic shock is the most severe manifestation of acute heart failure and remains the leading cause of death in patients hospitalised with acute myocardial infarction.
- Trial name
- NCT06955936
- Testing
- Efferon CT
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Efferon JSC
Cardiogenic Shock, Acute Myocardial Infarction (AMI)
Routine Microaxial Heart Pump Support and Protocolized Pulmonary Artery Catheter Monitoring Versus Standard Care in Heart Attack-Related Cardiogenic Shock
The goal of this clinical trial is to learn which treatment strategies improve survival in adult patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS).
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction (AMI), Heart Failure, Acute
- Trial name
- DOUBLE-SHOCK (NCT07762560)
- Testing
- Microaxial flow pump (left ventricular assist device), Pulmonary artery catheter, Conventional hemodynamic monitoring
- Where
- Germany
- Volunteers
- 780 people
- Sponsor
- Leipzig Heart Science gGmbH
Acute Coronary Syndrome, Cardiogenic Shock
Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock
A Clinical Events Committee (CEC) will include Cardiac Surgery Professor and chief of cardiac surgery Rose Kelly MD, Professor of Medicine Ganesh Raveendran MD at the University of Minnesota who is the direction of Interventional…
- Trial name
- NCT05426083
- Testing
- Physiological Assessment
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Cardiogenic Shock
Empagliflozin's Microcirculatory Effects in Cardiogenic Shock: an Ancillary Pilot Study of the EMPASHOCK Trial
Despite advancements in treatment, the mortality rate for cardiogenic shock (CS) remains high at around 50%. The EMPULSE-HF trial showed that early introduction of empagliflozin in stabilized patients with acute heart failure led…
- Trial name
- EMPAmicroSHOCK (NCT07141355)
- Testing
- microcirculation using the video microscopy tool.
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Strasbourg, France
Heart Failure, Cardiomyopathy
Impella Reverse Remodeling in End-Stage Heart Failure
This observational study is being done to learn more about heart attack recovery in patients supported with the Impella 5.5 left ventricular assist device (LVAD) as part of their standard of care.
- Trial name
- NCT06800716
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cardiogenic Shock
Prognostic Value Enhancement Of Sequential Organ Failure Assessment )SOFA( Score by Neutrophil-Lymphocyte Ratio and Red Cell Distribution Width in Cardiogenic Shock Patients.
Prognostic Value Enhancement Of Sequential Organ Failure Assessment )SOFA( Score by Neutrophil-Lymphocyte Ratio and Red Cell Distribution Width in Cardiogenic Shock Patients.
- Trial name
- NCT07773597
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Cardiogenic Shock
Safety and Efficacy of the Extracorporeal Ventricular Assist System in Car Diogenic Shock: A Prospective, Multicenter , Single-Arm Study
Study Title: Safety and Efficacy of Extracorporeal Ventricular Assist System for Cardiogenic Shock: A Prospective, Multicenter, Single-Arm Clinical Study Objective: To evaluate the safety and efficacy of temporary mechanical…
- Trial name
- NCT07769528
- Testing
- EVAS Treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiogenic Shock, Heart Failure
CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock
This pilot study investigates whether giving a short course of intravenous corticosteroids (methylprednisolone) alongside standard medical care can help patients recovering from heart failure-related cardiogenic shock.
- Conditions
- Cardiogenic Shock, Heart Failure, Inflammation
- Trial name
- CORTISHOCK-P (NCT07461961)
- Testing
- Methylprednisone, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure, Cardiogenic Shock
Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
There are two primary goals of this multicenter clinical trial that combines an FDA device trial and a phase II drug trial in the same study cohort. These two goals are to: 1.
- Conditions
- Heart Failure, Cardiogenic Shock, Congenital Heart Disease, Cardiomyopathies
- Trial name
- TROLLEY (NCT06080074)
- Testing
- Cardiohelp device (VA-ECMO), Heparin, Bivalirudin
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Respiration Failure, Cardio Vascular Disease
COMPARE-VENT Feasibility Pilot Study
Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20%…
- Conditions
- Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness
- Trial name
- NCT07656259
- Testing
- Volume Controlled Mode, Pressure Controlled Mode
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Heart Failure, Cardiogenic Shock
Cardiac Power Output in Cardiogenic Shock Patients
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
- Trial name
- NCT05700617
- Testing
- 1:1 Randomization to receive milrinone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Chicago
Cardiogenic Shock
Acute Impact of the Impella CP Assist Device in Pts. With Cardiogenic Shock on the Patients Hemodynamic
Prospective, monocentric open-label observational study for the assessment of acute hemodynamic effects following implantation of the IMPELLA CP cardiac support device
- Trial name
- JenaMACS (NCT04451798)
- Testing
- Impella CP microaxial pump
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Leipzig
Cardiogenic Shock, Acute Heart Failure (AHF)
Multimodal Phenotyping In Patients Referred With Acute Cardiac faiLurE
The goal of this observational study is to learn whether information collected during routine hospital care, together with blood and urine samples, can help doctors better identify different types of cardiogenic shock and better…
- Trial name
- MIRACLE (NCT07515508)
- Where
- 4 sites in Germany
- Volunteers
- 600 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Cardiogenic Shock Post Myocardial Infarction
Ivabradine in the Acute Management of Cardiogenic Shock
Brief Summary: The IVASHOCK trial investigates whether ivabradine can achieve at least one-class improvement in SCAI cardiogenic shock classification compared to placebo, and evaluates its safety profile in patients with…
- Trial name
- IVASHOCK (NCT07714746)
- Testing
- Ivabradine 5mg Tab
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Cardiogenic Shock
Evaluation of Oxiris Membrane as a Treatment for Ischemia-reperfusion Syndrome in Cardiogenic Shock Treated With Extracorporeal Life Support (ECMO/ECLS): A Randomized Pilot Study ECMORIX
The Oxiris membrane is an AN-69 membrane whose surface is treated with polyethyleneimine (PEI) grafted with heparin. This property allows the removal of lipopolysaccharide and cytokines from the blood.
- Trial name
- ECMORIX (NCT04886180)
- Testing
- Oxiris membrane, Prismaflex membrane, Blood tests
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cardiogenic Shock, Heart Failure
Magenta Elevate™ Clinical Feasibility Study in Cardiogenic Shock
The Elevate™ CS Clinical Feasibility Study is designed to evaluate the initial safety, effectiveness, and device performance of the Magenta Elevate™ System in patients with cardiogenic shock due to isolated or predominant left…
- Conditions
- Cardiogenic Shock, Heart Failure, Acute Myocardial Infarction (AMI)
- Trial name
- NCT07293923
- Testing
- Elevate™ System
- Where
- 8 sites in Georgia, Israel
- Volunteers
- 10 people
- Sponsor
- Magenta Medical Ltd.
Cardiogenic Shock, Acute Myocardial Infarction (AMI)
CRP Apheresis in Infarct-Related Cardiogenic Shock
Cardiogenic shock complicating acute myocardial infarction remains associated with high short-term mortality despite guideline-directed therapy.
- Trial name
- CRP-SHOCK (NCT07687017)
- Testing
- Selective C-reactive protein apheresis (PentraSorb®-CRP), Standard of care
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Leipzig Heart Science gGmbH
AMI Cardiogenic Shock
Assessment of Support With Impella® Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
The observational study titled "Observational Assessment of Support with Impella Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock (OASIS-AMICS)" aims to evaluate the safety outcomes of patients with…
- Trial name
- OASIS-AMICS (NCT06964685)
- Testing
- Impella
- Where
- 18 sites in United States
- Volunteers
- 350 people
- Sponsor
- Abiomed Inc.
Cardiogenic Shock
Abiomed Impella RT-DAQ - Observational Study
Abiomed IMPELLA-RT-DAQ - Impella Real Time Data AcQuisition
- Trial name
- NCT06308055
- Testing
- Data Acquisition
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 125 people
- Sponsor
- Abiomed Inc.