Clinical trials: Cardiac Surgery With Sternotomy
Post-operative Pain, Post-operative Delirium
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
The goal of this clinical trial is to assess whether the use of intermittent superficial parasternal intercostal plane blocks reduces opioid usage in patients undergoing cardiac surgery with median sternotomy.
- Conditions
- Post-operative Pain, Post-operative Delirium, Post-cardiac Surgery, Chronic Pain
- Trial name
- EPOCH (NCT06028126)
- Testing
- Intermittent Superficial Parasternal Intercostal Plane Block - Experimental
- Where
- 4 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
Cardiac Disease, Surgery
Parasternal Block Combined With Rectus Sheath Block for Cardiac Surgery Under Sternotomy
The aim of this randomized controlled trial is to examine the effect of ultrasound guided bilateral Parasternal Nerve Block combined with rectus sheath block on preoperative analgesia, opioid consumption and respiratory function…
- Conditions
- Cardiac Disease, Surgery, Analgesia, Acute Pain
- Trial name
- PARARECTUS (NCT05764616)
- Testing
- PARASTERNAL BLOCK, LOCAL INFILTRATION OF DRAINAGE EXIT SITES, RECTUS SHEATH BLOCK
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Campus Bio-Medico University
Cardiac Surgery Requiring Cardiopulmonary Bypass and Median Sternotomy, Cardiopulmonary Bypass
Safety and Hemostatic Efficacy of Fibrin Sealant Vapor Heated, Solvent/Detergent Treated (FS VH S/D) Compared With Currently Licensed TISSEEL VH Fibrin Sealant in Subjects Undergoing Cardiac Surgery
The objective of this study is to demonstrate equivalent hemostatic efficacy and safety between FS VH S/D and TISSEEL VH fibrin sealant in subjects undergoing cardiac surgery requiring cardiopulmonary bypass.
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass and Median Sternotomy, Cardiopulmonary Bypass, Sternotomy
- Trial name
- NCT00161733
- Testing
- Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D), TISSEEL VH fibrin sealant
- Where
- 22 sites in United States
- Sponsor
- Baxter Healthcare Corporation
Heart Valve Surgery
Effect Of Bioelectric Therapy On Sternal Instability In Patients With Median Sternotomy After Heart Valve Surgery
The aim of this study is to investigate the effect of bioelectric therapy on sternal instability in patients with median sternotomy after heart valve surgery.
- Trial name
- SI (NCT04949581)
- Testing
- bioelectric therapy, cardiac rehabilitation program
- Volunteers
- 40 people
- Sponsor
- Cairo University
Coronary Artery Bypass Grafting or Heart Valve Surgery Via Median Sternotomy
Transversus Thoracis Muscle Plane Block Plus Rectus Sheath Block in the Perioperative Pain Management of Cardiac Surgery
An emerging regional block technique, transverse thoracic muscle block covers the T2-T6 intercostal nerves and can effectively relieve perioperative pain during median sternotomy.
- Trial name
- NCT04838132
- Testing
- Bilateral transversus thoracis muscle plane and rectus sheath block with ropivacaine, Bilateral transversus thoracis muscle plane and rectus sheath puncture with saline
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guangzhou First People's Hospital
Bariatric Surgery, Cardiac Surgery With Sternotomy
Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery
This is prospective, randomized study. The purpose of this study is to evaluate whether the addition of Suzetrigine to well established multimodal pain regimen for participants undergoing bariatric patients undergoing weight-loss…
- Conditions
- Bariatric Surgery, Cardiac Surgery With Sternotomy, Post-operative Pain
- Trial name
- SMOOTH-SURG (NCT07539623)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cardiac Septal Defects With Coarctation of the Aorta, Mitral Regurgitation
Comparison of Erector Spinae Block and Pecto-Intercostal Facial Block For Enhanced Recovery in Adult Cardiac Surgery
The current study is designed to compare the perioperative analgesic efficacy of Erector spinae plane block (ESPB) and Pecto-intercostal-fascial plane block (PIFB) in adults undergoing cardiac surgery via median sternotomy.
- Trial name
- NCT05475561
- Testing
- Ultrasound guided Pecto-intercostal- fascial plane block, Ultrasound guided erector spinae plane block, Bupivacain
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Pneumonia, Cardiac Surgery
Catheter Outcomes With Sternotomy Cardiac Operated
Pneumonia occurs frequently in patients undergoing cardiac surgery and allows to increase their mortality. While chest physical therapy plays a crucial role to prevent postoperative pneumoniae, painful mobilization of the sternum…
- Conditions
- Pneumonia, Cardiac Surgery, Multiperforated Catheter, Analgesia
- Trial name
- STERNOCAT (NCT01648777)
- Testing
- L bupivacaine
- Where
- France
- Volunteers
- 1,502 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Postoperative
Gabapentin for Postoperative Pain Management After Cardiac Surgery With Median Sternotomy
In this study we will focus on the postoperative recovery. A successful postoperative recovery should bring the patient to at least to the pre-surgical level.
- Trial name
- NCT00572208
- Testing
- Gabapentin group
- Where
- 2 sites in Denmark
- Volunteers
- 64 people
- Sponsor
- Aarhus University Hospital
Fluid Therapy, Coronary Artery Bypass Surgery Patients
Evaluation of Fluid Responsiveness With Recruitment Maneuver After Sternotomy in Coronary Artery Bypass Surgery
Assuming that the basic reliability of dynamic indices will increase with the application of functional hemodynamic tests after sternotomy and protective lung ventilation in patients undergoing elective coronary artery bypass…
- Conditions
- Fluid Therapy, Coronary Artery Bypass Surgery Patients, Lung Recruitment Maneuver
- Trial name
- fluidresponse (NCT06249568)
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Sternotomy Pain
Erector Spinae Plane Block With Two Different Volume for Open Heart Surgery
The erector spine plane block is currently used in many surgeries to provide postoperative analgesia. It has also been used successfully in open-heart surgery for postoperative sternotomy pain.
- Trial name
- ESP (NCT04989933)
- Testing
- Ultrasound-guided erector spinae plane block
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Congenital Heart Disease
Bilateral Two Levels Serratus Anterior Plane Block in Pediatric Cardiac Surgery With Median Sternotomy
The serratus anterior plane block (SAPB) is an anterolateral thoracic wall block that was described in 2013 by Blanco et al. who presented it as an alternative to other regional anesthetic techniques.
- Trial name
- NCT06221150
- Testing
- Bilateral two level serratus anterior block
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Surgical Site Infection (SSI), Mediastinitis
Use of Platelet-Rich Plasma to Reduce Sternal Wound Complications After CABG With Median Sternotomy
The goal of this clinical trial is to learn whether applying autologous platelet-rich plasma (PRP) to the sternal wound during heart surgery improves wound healing and reduces complications after surgery.
- Conditions
- Surgical Site Infection (SSI), Mediastinitis, Delayed Wound Healing
- Trial name
- NCT07352020
- Testing
- Autologous Platelet-Rich Plasma (PRP) Application, Standard Sternal Wound Closure
- Where
- Pakistan
- Volunteers
- 98 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Cardiac Surgery, Sternotomy
Pecto-Intercostal Fascial Plane Block Catheter Trial for Reduction of Sternal Pain
One of the most painful aspects of open heart surgery is the incision made through the skin and the sternum to access the heart (a "sternotomy").
- Conditions
- Cardiac Surgery, Sternotomy, Acute Pain
- Trial name
- NCT05054179
- Testing
- Ropivacaine 0.2% Injectable Solution Bolus, Normal Saline Infusion, Ropivacaine 0.2% Injectable Solution Infusion
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Surgical Incision, Surgical Site Infection
Comparison of the Classical Median Sternotomy Skin Incision with the Paramedian Flap Skin Incision
The goal of this observational study is to determine the effects of a flap-shaped paramedian skin incision on protection from mediastinal infections, wound healing, and scar formation in open heart surgery performed through the…
- Conditions
- Surgical Incision, Surgical Site Infection, Keloid Scar Following Surgery
- Trial name
- NCT06725472
- Testing
- Open Heart Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ataturk University
Sternotomy, Postoperative Pain
Erector Spinae Plane Block in Post-operative Recovery in Cardiac Surgery With Median Sternotomy.
This study aim is to measure the time of extubation in patients receiving ultrasound guided bilateral Erector Spinae Plane (ESP) block after cardiac surgery .
- Trial name
- NCT05356715
- Testing
- Ultrasound guided bilateral ESBP
- Where
- 2 sites in Egypt
- Volunteers
- 239 people
- Sponsor
- Kasr El Aini Hospital
Postoperative Pain, Sternotomy Pain
Comparison of Erector Spinae Plane Block (ESPB) With the Combination of Superficial Parasternal Intercostal Plane Block (SPIPB) and Serratus Anterior Plane Block (SAPB) in the Management of Postoperative Sternotomy Pain in Patients Undergoing Cardiac Surgery Via Sternotomy
This study aims to compare the effectiveness of two regional anesthesia techniques in managing pain for participants undergoing cardiac surgery via sternotomy.
- Conditions
- Postoperative Pain, Sternotomy Pain, Acute Pain, Cardiac Surgery
- Trial name
- NCT07472296
- Testing
- Erector spinae plane block (ESPB), Superficial Parasternal Intercostal Plane Block (SPIPB), Serratus Anterior Plane Block (SAPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uludag University
Cadiac Surgery, Median Sternotomy
Analgesic Effect of Bilateral Erector Spinae Plane Block With Ropivacaine After Sternotomy for Cardiac Surgery
The sternotomy site is the most painful area after cardiac surgery. Erector spinae plane block is effective in thoracic and abdominal surgery, but literature is lacking in cardiac surgery.
- Conditions
- Cadiac Surgery, Median Sternotomy, Regional Anesthesia, Postoperative Pain
- Trial name
- ESB-Sterno (NCT05160298)
- Testing
- Ropivacaine 0,2% Injectable Solution, Control group
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiac Valve Disease, Coronary Heart Disease
Superficial Parasternal Block Combined With Rectus Sheath Block for Open Cardiac Surgery
The investigators will examine whether the combination of a superficial parasternal block and rectus sheath block with multimodal analgesia can enhance postoperative pain control and reduce opioid administration when compared to…
- Trial name
- NCT07890857
- Testing
- Parasternal and rectus sheath block, ropivacaine 0.25 %
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Hôpital du Valais
Coronary Bypass Graft Stenosis
The Benefit of Local Anesthesia at the Sternum in Patients With Coronary Surgery
Patients undergoing coronary artery bypass grafting are at risk for perioperative myocardial ischemia. Episodes of tachycardia and hypertension, which are associated with an increase in myocardial oxygen consumption, are…
- Trial name
- PARA (NCT03734159)
- Testing
- Ropivacaine, sodium chloride 0.9%
- Where
- France
- Volunteers
- 35 people
- Sponsor
- CMC Ambroise Paré