Clinical trials: Cardiac Sarcoidosis
Infective Endocarditis, Cardiac Sarcoidosis
Evaluation of the Impact of a Patient Education Protocol on the Quality of 18F-FDG PET Imaging Indicated for Investigation of Cardiac Inflammation
The aim of this study is to assess the impact of implementing a patient education and preparation protocol for FDG PET (18F-FDG PET) imaging on the quality of imaging results.
- Trial name
- CARTEP (NCT07029295)
- Testing
- Sending a link to the video, Compliance questionnaire, Determination of beta-hydroxybutyrate (BHB) in capillary blood
- Where
- 2 sites in France
- Volunteers
- 138 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Sarcoidosis
A Trial of Baricitinib in Patients With Cardiac Sarcoidosis
The goal of this clinical trial is to learn if baricitinib in combination with a background steroid-sparing medication can treat active cardiac sarcoidosis in adults.
- Trial name
- NCT06868381
- Testing
- Baricitinib (LY3009104) 4 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Heart Transplantation, Dilated Cardiomyopathy (DCM)
Multimodal Analysis of Endomyocardial Biopsies
The goal of this observational study is to pursue a multimodal approach to identify the molecular signatures and immune signalling molecules of various myocardial diseases and thereby contribute to improving diagnosis and…
- Conditions
- Heart Transplantation, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Myocarditis, Pericarditis
- Trial name
- NCT07359690
- Where
- Germany
- Volunteers
- 216 people
- Sponsor
- University Hospital, Essen
Cardiac Sarcoidosis
Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis
Sarcoidosis is a heterogeneous disorder of unknown etiology whose signature lesions are granulomatous inflammatory infiltrates in involved tissues. Tissue commonly affected are lungs, skin, eyes, lymph nodes and the heart.
- Trial name
- MAGiC-ART (NCT04017936)
- Testing
- Anakinra
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Virginia Commonwealth University
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
The purpose of this research study is to learn about the safety of transplanting lungs obtained from non-heart-beating donors (NHBDs) that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01615484
- Testing
- Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™, STEEN Solution™
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Sarcoidosis, Cardiomyopathies
Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis
The aim of the study is to find better and more specific non-invasive methods to diagnose and stage cardiac sarcoidosis with the use of advanced imaging modalities, simultaneous 3T MRI and PET.
- Trial name
- NCT03561025
- Testing
- 18F-FDG-PET/MRI, 18F-GE180-PET/MRI
- Where
- Norway
- Volunteers
- 33 people
- Sponsor
- St. Olavs Hospital
Cardiac Sarcoidosis
Somatostatin Receptor Imaging in Cardiac Sarcoidosis
The purpose of the trial is to determine the accuracy of Cu-64 labelled DOTATATE for diagnosing cardiac sarcoidosis using PET/CT or PET/MRI.
- Trial name
- NCT02812849
- Testing
- Cu-64 DOTATATE
- Where
- Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sarcoidosis
Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82
In this this investigation, 15 subjects with a high probability of cardiac sarcoidosis based on clinical criteria and abnormal cardiac FDG uptake on initial, clinically indicted FDG PET study will be considered for this study.
- Trial name
- NCT03048097
- Testing
- Fluorodeoxyglucose, Rubidium, FDG-PET/CT with Rb82 Myocardial Perfusion Imaging
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Sarcoidosis of the Heart, Cardiomyopathy
Implantable Cardiac Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis
The purpose of this study is to identify patients with cardiac sarcoidosis who may be at risk for sudden death.
- Trial name
- NCT01013311
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Sarcoidosis
Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis
The purpose of this research study to find out if a drug called OctreoScan or DOTATATE can help doctors diagnose people with cardiac sarcoidosis better. OctreoScan and DOTATATE are both approved by the U.S.
- Trial name
- NCT02546388
- Testing
- Indium-111 Pentreotide, Gallium-68 DOTATATE
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Marcelo F. Di Carli, MD, FACC
Danon Disease, Fabry Disease
Precision Diagnosis and Risk Stratification of Rare Cardiomyopathies Based on Novel Cardiac Magnetic Resonance Techniques
What is this study about? This research is focused on improving the care for people with rare heart muscle diseases, known as rare cardiomyopathies.
- Conditions
- Danon Disease, Fabry Disease, Cardiac Amyloidosis, Noonan Syndrome
- Trial name
- NCT07336394
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Cardiac Sarcoidosis
Biomaterial Collection - and Analysis in Cardiac Sarcoidosis
Cardiac sarcoidosis (CS) is a complex disease that is characterized by the formation of inflammatory granulomas in the myocardium.
- Trial name
- NCT05793398
- Volunteers
- 100 people
- Sponsor
- Heart Center Leipzig - University Hospital
Cardiac Sarcoidosis, Infective Endocarditis
A Prospective Diagnostic Trial of Al[¹⁸F]F-NOTA-folate PET in Patients With Suspected Cardiac Sarcoidosis and Infective Endocarditis
The goal of this prospective diagnostic study is to evaluate the imaging characteristics, diagnostic performance, radiation dosimetry, and safety of Al[¹⁸F]F-NOTA-folate PET imaging in patients with suspected cardiac sarcoidosis…
- Trial name
- FOL-CARD (NCT07814222)
- Testing
- Al[¹⁸F]F-NOTA-folate PET imaging, [15O]water PET imaging, Echocardiography
- Where
- Finland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cardiac Sarcoidosis
d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis
The Researchers are trying to determine if 68Ga-DOTATATE PET/CT imaging will have a similar accuracy as 18FDG PET/CT in diagnosing cardiac sarcoidosis and if it will be able to do so without the need for complex patient dietary…
- Trial name
- NCT03549598
- Testing
- 68Ga-DOTATATE PET/CT, 18FDG PET/CT scan, 13NH3 PET/CT scan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Interstitial Lung Disease, Pulmonary Sarcoidosis
CASPA: CArdiac Sarcoidosis in PApworth
Sarcoidosis is a disease of unknown cause which affects adults of all ethnic backgrounds. Clumps of tissue called granulomas develop primarily in the lungs, but can damage other organs, especially the heart.
- Conditions
- Interstitial Lung Disease, Pulmonary Sarcoidosis, Cardiac Sarcoidosis
- Trial name
- CASPA (NCT03599414)
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
Heart scarring, also known as fibrosis, plays a major role in a lot of heart muscle abnormalities. These abnormalities of the heart muscle can lead to major issues such as symptoms of heart failure, dangerous heart rhythm…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy, Cardiac Sarcoidosis, Hypertensive Heart Disease
- Trial name
- CHIEFTain (NCT06409585)
- Testing
- 68Ga-FAPI or 18F-AlF-FAPI cardiac PET-MR, Echocardiogram, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Sarcoidosis
Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis
The study aims at assessing diagnostic and therapeutic impact of Rubidium-82 PET in cardiac sarcoidosis.
- Trial name
- PARCS (NCT01648933)
- Testing
- Rubidium PET
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Solid Malignancy Located in the Head and Neck, Cancer
Study of 68GaNOTA-Anti-MMR-VHH2 in Oncological Lesions, Cardiovascular Atherosclerosis, Syndrome With Abnormal Immune Activation and sarcoïdosis
Phase II study to evaluate the clinical potential of 68GaNOTA-anti-MMR-VHH2 for in vivo imaging of Macrophage Mannose Receptor (MMR)-expressing Macrophages by means of Positron Emission Tomography (PET) in patients with…
- Conditions
- Solid Malignancy Located in the Head and Neck, Cancer, Carotid Stenosis, Atherosclerosis of Artery
- Trial name
- MITRAS (NCT04758650)
- Testing
- 68GaNOTA-Anti-MMR-VHH2
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cardiac Sarcoidosis
Evaluation of the Prognostic Value of PET/MRI in Cardiac Sarcoidosis
Cardiac damage is the second leading cause of death in patients with sarcoidosis, after lung damage. Today's challenge is to diagnose the disease as effectively as possible, and to develop tools for better risk stratification…
- Trial name
- SARCASTIM (NCT05954507)
- Testing
- PET/MRI
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Sarcoidosis
Macrophage PET/CT Imaging Using 64Cu-DOTATATE for the Diagnosis of Cardiac Sarcoidosis
The purpose of the CuDOSIS study is to examine the diagnostic value of activated macrophage imaging in patients with or under evaluation for cardiac sarcoidosis.
- Trial name
- CuDOSIS (NCT06131112)
- Testing
- 64Cu-DOTATATE PET/CT scan
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet