Clinical trials: Cardiac MRI
Takotsubo Cardiomyopathy, Machine Learning
Prognotic Role of CMR in Takotsubo Syndrome
The primary objective of this observational registry is to develop a comprehensive clinical and imaging score (incorporating echocardiography and cardiac magnetic resonance data) that enhances risk stratification for patients…
- Conditions
- Takotsubo Cardiomyopathy, Machine Learning, Magnetic Resonance Imaging
- Trial name
- EVOLUTION (NCT06277297)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- University of Cagliari
Heart Failure With Normal Ejection Fraction
Validation of CMR Against Invasive Haemodynamics in Patients With HFpEF
Heart failure (HF) currently affects app. 2% of the western population and app. 10% of people >75 years. In about 50% of patients with symptomatic HF ejection fraction (EF) is preserved (HF-PEF).
- Trial name
- DECIPHER-HFpEF (NCT03251183)
- Testing
- Comprehensive Cardiovascular magnetic resonance (CMR), Blood sampling, TTE (EchoErgo)
- Where
- 7 sites in Germany
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Goethe University
Atrial Fibrillation
Consistency of LGE-MRI Fibrosis and EAM Low-voltage Area
This study aims to: 1. Assess the consistency of LGE-MRI bi-atrial fibrosis and electroanatomical mapping of bi-atrial low voltage region 2.
- Trial name
- NCT06552845
- Testing
- LGE-MRI Scan
- Where
- China
- Volunteers
- 50 people
- Sponsor
- China National Center for Cardiovascular Diseases
Aortic Coarctation, Arterial Stiffness
Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment
Background: Coarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty or stent implantation. Although short-term results are excellent with all three treatment modalities, long term cardiovascular (CV)…
- Conditions
- Aortic Coarctation, Arterial Stiffness, PULSE WAVE VELOCITY, Functional Magnetic Resonance Imaging
- Trial name
- LOVE-COARCT (NCT03262753)
- Testing
- Surgery, Balloon dilation, Stent
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Cardiac Disease
Accelerated Contrast-Enhanced High Resolution Whole Heart Cardiac MRI
Coronary artery disease (CAD) is the leading cause of death in the United States. Cardiac MRI is a non-invasive non-ionizing technique for a comprehensive cardiac exam, which can be used in the diagnosis of CAD.
- Trial name
- NCT02550366
- Testing
- MRI Contrast
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Heart Failure
Establishing a Non-invasive Method to Measure Your Heart's Performance
The purpose of the study is to evaluate a new way to examine cardiac function, using software developed at Caltech. The experimental device is software loaded on an iPhone.
- Trial name
- NCT02240979
- Testing
- cardiac MRI
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Marie Csete MD, PhD
ST-elevation Myocardial Infarction
Early Mineralocorticoid Receptor Antagonist Treatment to Reduce Myocardial Infarct Size
Heart attacks, or myocardial infarcts, are a major cause of death and disability in the UK. Immediate unblocking of the obstructed heart vessel with a balloon catheter and implantation of a mesh scaffold (stent) in heart centers…
- Trial name
- MINIMISE-STEMI (NCT01882179)
- Testing
- Mineralocorticoid receptor antagonist potassium-canrenoate
- Where
- 4 sites in United Kingdom
- Volunteers
- 61 people
- Sponsor
- University College, London
Cardiovascular Disease
Defining Late Onset Occult Asymptomatic Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy
The main hypothesis being tested is that magnetic resonance imaging and serologic biomarkers of apoptosis and extracellular matrix remodeling will precede echocardiographic indices of systolic and diastolic function among…
- Trial name
- NCT01671696
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Connecticut Children's Medical Center
Pulmonary Hypertension
PH-DyPred: A Multimodal Dynamic Risk Prediction Study in Pulmonary Hypertension
Pulmonary hypertension (PH) is a progressive cardiopulmonary disease characterized by elevated pulmonary artery pressure and vascular remodeling, which leads to right heart failure and increased mortality.
- Trial name
- PH-DyPred (NCT07131241)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Congenital Heart Disease, Pulmonary Hypertension
MRI and Computational Simulation Cardiology Study
The purpose of this study is to (1) quantify cardiovascular anatomy and physiology using magnetic resonance imaging under both resting and exercise conditions in patients who have congenital heart disease and in age-matched…
- Trial name
- NCT03149341
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Stanford University
Fabry Disease
Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI
This study will evaluate whether cardiac MRI T1 and T2 mapping improves our ability to detect early abnormalities in the heart in patients with Fabry disease and identify patients at increase risk of adverse events.
- Trial name
- FIESTA-MRI (NCT04856059)
- Testing
- Cardiac MRI, ECG/Holter and Blood Biomarkers
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Atrial Fibrillation
Does the Merged 3D Imaging Improve Contact Force and Long Term Procedure Outcome in Atrial Fibrillation?
The purpose of the study is to investigate whether or not there are the differences in acute procedure and long-term clinical outcome of radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) using the 3D map…
- Trial name
- MICRO-AF (NCT03350581)
- Testing
- FAM 3D map group, FAM-CT 3D map group
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Guro Hospital
Aortic Stenosis
Assessment of Myocardial Tissue Damage in Aortic Stenosis
Aortic stenosis (AS) is the most common valve disease in the United States and most common indication for valve replacement surgery. Anatomical and hemodynamic severity of AS is insufficient for elucidating patients' prognosis.
- Trial name
- NCT02101619
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Mayo Clinic
Chagas Disease, Colchicine Resistance
Colchicine for Patients With Chagas´ Disease( B1 Stage)
This study evaluate the addition of colchicine in the treatment of patients with Chagas´disease. Forty patients will receive colchicine while twenty patients will receive placebo
- Trial name
- COACH (NCT03704181)
- Testing
- Colchicine 0.5 MG twice day for one year
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Obesity & Overweight
Cardiac Function and Biomarkers in Patients With Obesity and Overweight
Obesity is a major public health problem worldwide and an established risk factor for cardiovascular disease. In individuals with obesity or overweight, systemic inflammation and endothelial dysfunction contribute to myocardial…
- Trial name
- BEYOND (NCT07455630)
- Testing
- Weight loss with pharmacotherapy, Weight loss without pharmacotherapy
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- TecSalud Investigación Clínica
Lymphoma
Cardiac Fibrosis by CMR in Patients With Cancer
A study to test the effectiveness of an investigational imaging technique for detecting cardiac injury after the administration of certain chemotherapies, such as doxorubicin.
- Trial name
- NCT01906437
- Testing
- Cardiac Magnetic Resonance Scan
- Where
- 3 sites in United States
- Sponsor
- Massachusetts General Hospital
Myocardial Infarction, Percutaneous Coronary Intervention
China-Administration of Nicorandil Group（CHANGE）
We compared the infarct size in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) treated by nicorandil before and after the reperfusion with those standard…
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention, Nicorandil
- Trial name
- NCT03445728
- Testing
- Nicorandil
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Chinese PLA General Hospital
Metabolic Syndrome, Lipotoxicity
Regression of Fatty Heart by Valsartan Therapy
Traditionally, obesity is considered an indirect cause of heart disease. Obese individuals typically present with a number of traditional Framingham risk factors (hypertension, dyslipidemia, and type 2 diabetes), predisposing…
- Trial name
- NCT00745953
- Testing
- Valsartan, Hydrochlorothiazide
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Anesthesia; Hypothermia, Congenital Heart Disease
Evaluation of a Novel Patient Warming System During MRI
Patients under deep sedation and general anesthesia lose heat to their surrounding environment. Hypothermia after anesthesia is associated with worse patient outcomes, including increased number of infections and cardiovascular…
- Trial name
- NCT03150953
- Testing
- MRI-safe bore covering
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Andrew Matisoff
Metabolic Syndrome, Coronary Microvascular Dysfunction
Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction
Coronary vascular dysfunction is one of the "final common pathways" for the impact of multiple cardiovascular risk factors. The investigators will conduct a randomized, double-blind placebo-controlled study in individuals with…
- Trial name
- NCT05711719
- Testing
- Vericiguat
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Johns Hopkins University