Clinical trials: Cardiac Electrophysiology, open to volunteers
Left Bundle-Branch Block, Aortic Valve Stenosis
Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI
The primary hypothesis of the proposed study is that an electrophysiology-based algorithmic approach is superior to standard clinical follow-up with 30-day monitoring in reducing the combined endpoint of syncope, hospitalization…
- Trial name
- COME-TAVI (NCT03303612)
- Testing
- Pacemaker implant, Transcutaneous cardiac monitor
- Where
- 10 sites in Canada, France
- Volunteers
- 250 people
- Sponsor
- Montreal Heart Institute
Atrial Fibrillation, Atrial Flutter
Anatomical Navigation for Guided Electrophysiology in AFL and AFib
The objective of the study is to collect data on the use of the VERAFEYE Anatomical Guidance System in adult patients indicated to undergo a catheter ablation procedure for the treatment of Atrial Flutter (AFL), paroxysmal AF…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Atrial Arrhythmia
- Trial name
- ANGEL-AF (NCT07210151)
- Testing
- VERAFEYE Anatomic Guidance System
- Where
- 4 sites in Croatia, Czechia and 1 more
- Volunteers
- 50 people
- Sponsor
- LUMA Vision Ltd.
Atrial Fibrillation
Evaluation of 4D Intracardiac Echocardiography (ICE) During Structural Heart and Electrophysiology Procedures
The purpose of this study is to evaluate the imaging performance and procedural safety of a prototype 4D ICE catheter during real-time intracardiac imaging and to optimize device imaging parameters, compared with current standard…
- Trial name
- 4D-ICE (NCT07806890)
- Testing
- 4D ICE Adjunct Imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Cerebrovascular Circulation, Physiology
Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate
The investigators will seek to determine the relationship between heart rate and middle cerebral artery (MCA) cerebral blood flow (CBF), as well as better understand the hemodynamic determinants of MCA CBF velocity.
- Trial name
- NCT04391465
- Testing
- Electrophysiological Pacing
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Cardiac Arrhythmia, Atrial Fibrillation
The Role of Right Atrial Ectopy Triggering Ganglionated Plexuses in AF
Atrial fibrillation (AF) is the most common rhythm disturbance of the heart. It can affect people of any age but usually happens as we get older. It can cause palpitations, breathlessness, lethargy, and fainting attacks.
- Trial name
- RGanglia-AF (NCT05539040)
- Testing
- Right Atrial ganglionated plexus ablation, Holter Monitor, Pulmonary vein isolation
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- Imperial College London
Atypical Atrial Flutter, Atrial Flutter
Pulsed-Field Ablation for Recurrent Atypical Atrial Flutter
Recurrent atypical atrial flutter (AFL) after prior atrial fibrillation or flutter ablation remains challenging to treat, and conventional radiofrequency ablation may be limited by incomplete lesion formation and risk of…
- Trial name
- NCT07362134
- Testing
- Point-by-point pulsed-field catheter ablation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
PVC - Premature Ventricular Complex, Ablation
Virtual Reality in Electrophysiology Laboratory (EP)
The purpose of this study is to evaluate the use of virtual reality (VR) technology as adjunct to routine anesthesia care for patients undergoing electrophysiology (EP) procedures.
- Trial name
- NCT04893278
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Cardiac Arrhythmias
ViewFlex X ICE First-in-Human Study
This prospective, acute, first-in-human, non-significant risk study is intended to evaluate a modified version of the ViewFlex X ICE Catheter, Sensor Enabled (ViewFlex X SE) and ViewMate Multi Ultrasound Console (VMM) ICE data…
- Trial name
- ViewFlex X FIH (NCT06772493)
- Testing
- ViewFlex X ICE System
- Where
- 8 sites in United States
- Volunteers
- 500 people
- Sponsor
- Abbott Medical Devices
Hemodynamic, Remimazolam
RCT Comparing Remimazolam With Propofol Under EEG DSA Guidance During Cardiac Electrophysiology Studies and Ablation
Brief Summary: The goal of this RCT is to compare the Safety and efficacy of remimazolam compared with propofol under EEG DSA guiding during cardiac electrophysiology studies and ablation.
- Conditions
- Hemodynamic, Remimazolam, Propofol, Cardiac Electrophysiology
- Trial name
- NCT06700681
- Testing
- Propofol, Remimazolam, With intubation and controlled ventilation to maintain airway
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Pain, Acute
Impact of Virtual Reality in Cardiac Electrophysiology
Pain during pacemaker or defibrillator implantation can increase patient discomfort, anxiety, and the need for deeper sedation. Using virtual reality (VR) as a non-pharmacological distraction tool may help reduce perceived pain…
- Trial name
- NCT07009951
- Testing
- Virtual reality
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Calabria
Persistent Atrial Fibrillation
Endocardial Mapping With the CoreMap EP Mapping System
This is a global, multi-site, prospective, feasibility study.
- Trial name
- INvENI (NCT06529978)
- Testing
- CoreMap EP Mapping System Mapping, CoreMap EP Mapping System Map-Guided Ablation
- Where
- 4 sites in United States, Czechia
- Volunteers
- 245 people
- Sponsor
- CoreMap Inc.
Atrial Fibrillation (AF)
Catheter Ablation for Atrial Fibrillation in Non-Fluoroscopic Lab
This randomized controlled trial investigates the efficacy and safety of atrial fibrillation (AF) catheter ablation performed in non-fluoroscopic electrophysiology (EP) labs compared to conventional fluoroscopic digital…
- Trial name
- NON-FLUORO-LAB (NCT06719921)
- Testing
- AF ablation, AF ablation in a non-fluoroscopic EP lab, AF ablation in a fluoroscopic lab
- Where
- China
- Volunteers
- 724 people
- Sponsor
- Sir Run Run Shaw Hospital
Atrial Fibrillation (AF), Persistent Atrial Fibrillation
Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)
Conquer-AF is a prospective, multi-center, interventional, non-randomized clinical study that will enroll up to 400 subjects at up to 30 sites across the United States, Europe, and Australia.
- Conditions
- Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- Conquer-AF (NCT07298473)
- Testing
- Sphere-9 Catheter Ablation
- Where
- 30 sites in United States, Australia and 4 more
- Volunteers
- 400 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation (AF), Pacemaker Therapy
Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF
This prospective, randomized controlled trial aims to evaluate the effect of left bundle branch pacing (LBBP) compared with conventional right ventricular (RV) pacing on the cumulative duration (total time) of atrial high-rate…
- Conditions
- Atrial Fibrillation (AF), Pacemaker Therapy, Atrioventricular Block, Preserved Ejection Fraction
- Trial name
- LBBP-AHRE (NCT07250529)
- Testing
- Right Ventricular Pacing, Left Bundle Branch Pacing
- Where
- Greece
- Volunteers
- 244 people
- Sponsor
- University Hospital of Patras
Ventricular Arrhythmias
Evaluation of Electrocardiographic Measurements by High Density Electrode ECG
Cardiac electrical activity is detected on the body surface with conventional electrocardiography involving 12 leads (ECG 12). A limitation of the current ECG technique is that recordings are obtained from only 6 independent…
- Trial name
- ECG-HD (NCT04921501)
- Testing
- HD ECG, Conventional 12-lead ECG
- Where
- 11 sites in France, Monaco
- Volunteers
- 1,800 people
- Sponsor
- University Hospital, Bordeaux
Heart Failure
Optimization of Cardiac Resynchronization Therapy by Non-Invasive Imaging of Cardiac Electrophysiology
The principal aim is to analyze total left and right ventricular activation time in different CRT device programming algorithms (SyncAV) measured by non-invasive electrophysiology
- Trial name
- NICE CRT (NCT04662970)
- Testing
- Device programming
- Where
- Austria
- Volunteers
- 25 people
- Sponsor
- Medical University Innsbruck
Cardiovascular Diseases, Arrhythmias, Cardiac
Intracardiac Echocardiography Catheter Supply-Chain Reliability and Clinical Access Study
The ICE-ACCESS study is a prospective observational study designed to evaluate how procurement reliability, distribution restrictions, supply-chain interruptions, and device availability affect access to intracardiac…
- Conditions
- Cardiovascular Diseases, Arrhythmias, Cardiac, Atrial Fibrillation
- Trial name
- ICE-ACCESS (NCT07788040)
- Testing
- Intracardiac Echocardiography Catheter
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Truway Health, Inc.