Clinical trials: Cardiac Arrest Circulatory
Heart Arrest, Out-Of-Hospital, Cognitive Impairment
Brain Outcome After Cardiac Arrest - Intervention
People who suffered a cardiac arrest are often have cognitive impairments. In this study the investigators test the effectiveness of an intervention, combining direct training and metacognitive training, in a single case…
- Trial name
- BROCA-i (NCT05133869)
- Testing
- Metacognitive training + direct training
- Where
- 3 sites in Netherlands
- Volunteers
- 4 people
- Sponsor
- Maastricht University
Cardiac Arrest, Extracorporeal Circulation
Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resuscitation
Almost all patients with refractory cardiac arrest, who are primarily stabilized under ongoing cardiopulmonary resuscitation by transcutaneous implantation of a venoarterial extracorporeal membrane oxygenation system (va-ECMO for…
- Conditions
- Cardiac Arrest, Extracorporeal Circulation, Extracorporeal Membrane Oxygenation, Cytokine Storm
- Trial name
- CYTER (NCT03685383)
- Testing
- Cytosorb removal column in eCPR, standard eCPR (va-ECMO)
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- University Hospital Freiburg
Cardiorespiratory Arrest
Predictive Electrophysiological Score of the Neurological Prognosis Post Cardiac Arrest
Cardiac arrest (CA) is a major public health problem (1) because of its frequency (30000 to 50000 new cases of CA per year in France), a high mortality 80-90% and a relevant morbidity : 50% of survivors have cerebral sequela.
- Trial name
- CA-EEG (NCT02886039)
- Testing
- Electroencephalogram
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Montpellier
Out-Of-Hospital Cardiac Arrest
Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest
Patients admitted to intensive care unit (ICU) following an out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality rate, primarily due to ischemia-reperfusion (I/R) syndrome leading to anoxic-ischemic brain…
- Trial name
- RIPOST-CA (NCT06473207)
- Testing
- Remote ischemic post conditioning sessions
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Cardiac Arrest
Care After Resuscitation
The purpose of this study is to investigate whether simple psychological interventions can be implemented at the Essex Cardiothoracic Centre (CTC) with a view to supporting the psychological wellbeing of survivors of cardiac…
- Trial name
- CARE (NCT02275234)
- Testing
- Psychological intervention
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Cerebral Hypoxic Injury, Cardiac Arrest
Monitoring of Cerebral Oxygenation Using Jugular Oximetry in Comatose Patients After Cardiac Arrest
The use of protective ventilation (to maintain normoxia and normocapnia), optimise haemodynamics, diagnose/treat seizures, therapeutic hypotermia etc is recommended for ICU management of patients who have had cardiac arrest and…
- Trial name
- NCT02806778
- Testing
- BIS Monitor-guided sedation, Jugular bulb catheter
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Ostrava
Myocardial Infarction
Continuous Rhythm Monitoring in Patients After Acute Myocardial infaRction andpREServed Lef venTricle Ejection Fraction (ARREST)
The trial will inform whether detection of ventricular arrhythmias by means of implantable loop recorder (ILR) can help to predict SCD in the large population of survivors of a myocardial infarction with preserved left…
- Trial name
- NCT02492243
- Testing
- PCI, ILR implantation
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Chronic Stress, Cardiac Arrest (CA)
The Role of Stress in Cardiac Arrest (Cortizol CPR)
The aim of this study is to assess long-term stress in patients after an out-of-hospital cardiac arrest. To do this, we will measure levels of the stress hormone cortisol in hair samples.
- Conditions
- Chronic Stress, Cardiac Arrest (CA), Post-Resuscitation Syndrome, Heart Attack
- Trial name
- Cortizol (NCT07285915)
- Testing
- Sample of hair
- Where
- Czechia
- Volunteers
- 136 people
- Sponsor
- University Hospital Pilsen
Congestive Heart Failure, Sudden Cardiac Death
Study of the Implantable Cardioverter Defibrillator (ICD) Intracardiac Electrograms
The purpose of this study is to determine whether waveforms of the intracardiac electrograms, acquired through an ICD, can be used: to predict malignant ventricular arrhythmias, requiring appropriate ICD therapies, and to predict…
- Conditions
- Congestive Heart Failure, Sudden Cardiac Death, Arrhythmia, Cardiomyopathies
- Trial name
- ICD-EGMs (NCT00916435)
- Where
- 2 sites in United States
- Volunteers
- 630 people
- Sponsor
- Johns Hopkins University
Acute Coronary Syndrome
Effects and Plasma Concentration of Ticagrelor, After Crushed and Non-crushed Intake, After Acute Coronary Syndrome
The first aim of the study is to prove that after starting the therapy with crushed tablets, the platelet inhibition will be as expected after starting therapy with intact tablets. Gurbel et al.
- Trial name
- ticagrelor (NCT02341729)
- Testing
- ticagrelor
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Cardiac Arrest
Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest
The purpose of this study is to assess the feasibility of hemofiltration in patients resuscitated from cardiac arrest. Cardiac arrest is the loss of mechanical activity of the heart including the loss of detectable pulse, or…
- Trial name
- NCT01509040
- Testing
- Standard Care, Low Volume Hemofiltration, High Volume Hemofiltration
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Washington
Cardiac Arrest (CA)
The Impact of First Responder Intervention on Survival in Out-of-Hospital Cardiac Arrest in Emilia-Romagna Region
Out-of-hospital cardiac arrest (OHCA) is a life-threatening emergency and one of the leading causes of death worldwide. Survival depends critically on how quickly help arrives and whether cardiopulmonary resuscitation (CPR) and…
- Trial name
- FIRSST-RER (NCT07589504)
- Where
- Italy
- Volunteers
- 5,200 people
- Sponsor
- Azienda Usl di Bologna
Heart Arrest, Out-of-hospital Cardiac Arrest
Cognitive Impairment Following Cardiac Arrest and Target Temperature Management
This is a steering group approved substudy to the Target Temperature Management trial (TTM, ClinicalTrials.gov Identifier: NCT01020916).
- Conditions
- Heart Arrest, Out-of-hospital Cardiac Arrest, Cognition Disorders, Brain Injury
- Trial name
- NCT01946932
- Testing
- Temperature treatment
- Where
- 20 sites in Denmark, Italy and 3 more
- Volunteers
- 287 people
- Sponsor
- Region Skane
Cardiac Arrest
Assessing CPR Quality During In-Hospital Cardiac Arrest
Using an investigational monitor/defibrillator that passively records CPR quality parameters, including chest compression rate and depth and ventilation rate and volume, we are prospectively recording CPR quality during…
- Trial name
- NCT00228293
- Testing
- investigational monitor/defibrillator with CPR feedback
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Ischemia, Reperfusion Injury
Goal-directed CPR Using Cerebral Oximetry
The proposed study is a single-center, randomized controlled pilot trial of adults who suffer in-hospital cardiac arrests. Using cerebral oxygenation and end-tidal carbon dioxide physiological targets to predict survival and…
- Trial name
- NCT04924985
- Testing
- Non-Physiological Feedback CPR, Physiological Feedback CPR
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- NYU Langone Health
Implantable Cardioverter Defibrillator (ICD)
Patient and Partner Intervention After an Implantable Cardioverter Defibrillator (ICD)
The goal of this study is to compare a patient only to a patient+partner intervention on recovery outcomes of patients and partners after Implantable Cardioverter Defibrillator (ICD) implantation.
- Trial name
- P+P (NCT01252615)
- Testing
- patient only, patient and partner intervention
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- University of Washington
Cardiac Arrest, Cardiopulmonary Arrest
Quality of Pediatric Resuscitation in a Multicenter Collaborative
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression…
- Trial name
- pediRES-Q (NCT02708134)
- Where
- 63 sites in United States, Australia and 13 more
- Volunteers
- 7,000 people
- Sponsor
- Children's Hospital of Philadelphia
Cardiac Arrest
Arterial Blood Pressure and Cardiac Arrest
To describe and measure diastolic and systolic femoral arterial pressure during medical cardiac arrest. To define baseline measures. To describe and measure arterial blood pressure after placement of an ITD device.
- Trial name
- ABaCAS (NCT06443567)
- Testing
- impedance threshold device
- Sponsor
- Manchester University NHS Foundation Trust
Cardiac Arrest
Ischemic Conditioning in STEMI Patients
The purposes of the study are to 1) study alterations in the metabolomic profile of patients exposed to post-ischemic conditions and 2) study alterations in myocardial infarction size of patients exposed to post-ischemic…
- Trial name
- EDICT (NCT03097419)
- Testing
- Remote post-ischemic conditioning
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Beth Israel Deaconess Medical Center
Heart Failure, Arrhythmias, Cardiac
Heart Failure and Sudden Cardiac Death Japan Registry
The purpose of this observational registry is to collect clinical events and outcome data in 4 different study populations (cohorts), with a majority of Japanese subjects, that are at risk of sudden cardiac death (SCD) and heart…
- Conditions
- Heart Failure, Arrhythmias, Cardiac, Sudden Cardiac Death
- Trial name
- HINODE (NCT03185832)
- Testing
- CRT-D, ICD, PM / CRT-P
- Where
- 34 sites in Japan
- Volunteers
- 354 people
- Sponsor
- Boston Scientific Corporation
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