Cardiac ArrestABaCASNCT06443567
Arterial Blood Pressure and Cardiac Arrest
An observational study of Cardiac Arrest, run by Manchester University NHS Foundation Trust.
Trial summary
To describe and measure diastolic and systolic femoral arterial pressure during medical cardiac arrest. To define baseline measures. To describe and measure arterial blood pressure after placement of an ITD device. To observe the diastolic pressure immediately prior to return of spontaneous circulation. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest
- What is being tested?
- impedance threshold device
- Type of treatment
- Medical device
- How many people
- 0 participants
- Where
- No sites listed yet
- Study dates
- Sep 2024to Jun 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients (18+) suffering an out of hospital cardiac arrest (OHCA) by a presumed medical cause that have been deemed suitable to attempt resuscitation of. All individuals will be considered for inclusion in this study regardless of age, disability, gender reassignment, marriage, and civil partnership, pregnancy and maternity, race, religion and belief, sex, and sexual orientation except where the study inclusion and exclusion criteria EXPLICITLY state otherwise.
Who may be able to join
- Adult patients (≥18years) in medical cardiac arrest
- Deemed suitable to attempt resuscitation.
Who cannot join
- Prisoners
- <18years
- Pregnancy
- Traumatic cardiac arrest
- Arrest caused by hypovolaemia, tension or tamponade as determined by the clinical team on scene
- Inability to secure a patent airway.
About this study
To describe and measure diastolic and systolic femoral arterial pressure during medical cardiac arrest.
To define baseline measures. To describe and measure arterial blood pressure after placement of an ITD device.
To observe the diastolic pressure immediately prior to return of spontaneous circulation.
To quantify and describe the effects of intravenous adrenaline on arterial blood pressure in cardiac arrest.
Read the detailed description
Cardiac arrest is a complex disorder whose outcome is reliant on a huge number of factors. Moreover, many interventions are time critical, therefore an intervention that may be lifesaving if given early, may have no benefit if instigated further in the disease course. For these reasons' studies involving cardiac arrest are incredibly difficult to carry out and interpret. Many of the interventions carried out during cardiac arrest are aimed at improving blood pressure and thereby increasing the amount of blood and oxygen delivered to the myocardium in the hopes of achieving a return of spontaneous circulation (ROSC). However current data on what a 'normal' blood pressure, based largely upon non-invasive measurement, during cardiac arrest is severely limited, making comparison and evaluation of interventions extremely difficult. This provides the basis for this study in order to prospectively collate and describe data from invasive blood pressure monitoring during adult, medical cardiac arrest in the pre-hospital environment.
- Research Question/Aim(s) To measure and describe femoral arterial pressure during cardiac arrest with mechanical CPR by a LUCAS device. 3.1 Objectives Primary objective To quantify and describe baseline arterial systolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting. This will be defined as a line of best fit for systolic blood pressure superimposed on the arterial trace during a 3 minute period.
Secondary Objectives
- To quantify and describe baseline arterial diastolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting. This will be defined as a line of best fit for diastolic blood pressure superimposed on the arterial trace during a 3 minute period.
- To quantify and describe arterial blood pressure after the placement of an ITD device over a 3 minute period.
- To quantify and describe the effect of intravenous adrenaline on blood pressure as administered in line with ALS guidelines (every 3-5 mins) in adult patients in cardiac arrest.
- To document the diastolic blood pressure of those patients that achieve return of spontaneous circulation (ROSC) following out of hospital cardiac arrest.
- Conditions
- Cardiac Arrest
- Being tested
- impedance threshold device
- Keywords
- impedance threshold device, blood pressure, cardiac arrest
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
impedance threshold deviceDevice
impedance threshold device (ResQPOD, Zoll) applied to airway
| Study group | Role | What they receive |
|---|---|---|
| adult cardiac arrest | blood pressure measurement pre and post impedance threshold device placement Receives: Device: impedance threshold device |
What is being measured
The primary outcome is the main question the study is designed to answer.
systolic femoral invasive blood pressure
Measured: 3 mins average with CPR by LUCAS device
Secondary outcomes (2)
femoral diastolic pressure
Measured: 3 mins average with CPR by LUCAS device
femoral arterial pressure, both systolic and diastolic
Measured: 3 mins average post placement of ICD device
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Jun 2024
- Study startSep 2024 (estimated)
- Primary completionDec 2024 (estimated)
- Study completionJun 2025 (estimated)
Why it stopped: Not feasible
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac ArrestStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- Manchester University NHS Foundation Trust
- Sponsor type
- Other government
- Collaborators
- North West Ambulance Service nhs foundation trust
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06443567
- Sponsor's protocol ID
- B01830
- Acronym
- ABaCAS
- Status last verified
- Sep 2025
- First submitted
- 30 May 2024
- Last updated
- 25 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Arterial Blood Pressure and Cardiac Arrest
- ClinicalTrials.gov ID
- NCT06443567
- Acronym / sponsor ID
- ABaCAS / B01830
- Conditions
- Cardiac Arrest
- Keywords
- impedance threshold device, blood pressure, cardiac arrest
- Study type
- Observational
- Recruitment status
- WithdrawnReason stopped: Not feasible
- Enrolment
- 0 participants (actual)
- Lead sponsor
- Manchester University NHS Foundation TrustOther government
- Collaborators
- North West Ambulance Service nhs foundation trust
- Study start
- Sep 2024 (estimated)
- Primary completion
- Dec 2024 (estimated)
- Study completion
- Jun 2025 (estimated)
- First posted
- 5 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To describe and measure diastolic and systolic femoral arterial pressure during medical cardiac arrest.
To define baseline measures. To describe and measure arterial blood pressure after placement of an ITD device.
To observe the diastolic pressure immediately prior to return of spontaneous circulation.
To quantify and describe the effects of intravenous adrenaline on arterial blood pressure in cardiac arrest.
Detailed description
Cardiac arrest is a complex disorder whose outcome is reliant on a huge number of factors. Moreover, many interventions are time critical, therefore an intervention that may be lifesaving if given early, may have no benefit if instigated further in the disease course. For these reasons' studies involving cardiac arrest are incredibly difficult to carry out and interpret. Many of the interventions carried out during cardiac arrest are aimed at improving blood pressure and thereby increasing the amount of blood and oxygen delivered to the myocardium in the hopes of achieving a return of spontaneous circulation (ROSC). However current data on what a 'normal' blood pressure, based largely upon non-invasive measurement, during cardiac arrest is severely limited, making comparison and evaluation of interventions extremely difficult. This provides the basis for this study in order to prospectively collate and describe data from invasive blood pressure monitoring during adult, medical cardiac arrest in the pre-hospital environment.
- Research Question/Aim(s) To measure and describe femoral arterial pressure during cardiac arrest with mechanical CPR by a LUCAS device. 3.1 Objectives Primary objective To quantify and describe baseline arterial systolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting. This will be defined as a line of best fit for systolic blood pressure superimposed on the arterial trace during a 3 minute period.
Secondary Objectives
- To quantify and describe baseline arterial diastolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting. This will be defined as a line of best fit for diastolic blood pressure superimposed on the arterial trace during a 3 minute period.
- To quantify and describe arterial blood pressure after the placement of an ITD device over a 3 minute period.
- To quantify and describe the effect of intravenous adrenaline on blood pressure as administered in line with ALS guidelines (every 3-5 mins) in adult patients in cardiac arrest.
- To document the diastolic blood pressure of those patients that achieve return of spontaneous circulation (ROSC) following out of hospital cardiac arrest.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| adult cardiac arrest | – | Device: impedance threshold deviceblood pressure measurement pre and post impedance threshold device placement |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients (18+) suffering an out of hospital cardiac arrest (OHCA) by a presumed medical cause that have been deemed suitable to attempt resuscitation of. All individuals will be considered for inclusion in this study regardless of age, disability, gender reassignment, marriage, and civil partnership, pregnancy and maternity, race, religion and belief, sex, and sexual orientation except where the study inclusion and exclusion criteria EXPLICITLY state otherwise.
Key inclusion criteria (2 listed)
- Adult patients (≥18years) in medical cardiac arrest
- Deemed suitable to attempt resuscitation.
Key exclusion criteria (6 listed)
- Prisoners
- <18years
- Pregnancy
- Traumatic cardiac arrest
- Arrest caused by hypovolaemia, tension or tamponade as determined by the clinical team on scene
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| impedance threshold deviceimpedance threshold device (ResQPOD, Zoll) applied to airway | Device | adult cardiac arrest |
Primary outcome
systolic femoral invasive blood pressure
Time frame: 3 mins average with CPR by LUCAS device
2 secondary outcomes
femoral diastolic pressure
Time frame: 3 mins average with CPR by LUCAS device
femoral arterial pressure, both systolic and diastolic
Time frame: 3 mins average post placement of ICD device
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiac Arrest, run by Manchester University NHS Foundation Trust.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 25 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
systolic femoral invasive blood pressure (time frame: 3 mins average with CPR by LUCAS device). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2025.