Clinical trials: Cardiac
Microvascular Dysfunction, Hypertrophic Obstructive Cardiomyopathy
Association Between Microvascular Resistance and Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy
About 60% of patients with hypertrophic cardiomyopathy have microvascular dysfunction. Microvascular dysfunction is directly related to prognosis in hypertrophic cardiomyopathy.
- Conditions
- Microvascular Dysfunction, Hypertrophic Obstructive Cardiomyopathy, Microcirculation Resistance
- Trial name
- NCT05671367
- Where
- China
- Volunteers
- 340 people
- Sponsor
- China National Center for Cardiovascular Diseases
Frailty, Thoracic Surgery
A Frailty-specific Prehabilitation Program for Mild to Moderately Frail Patients Undergoing Cardiac Surgeries/Procedures
The purpose of this study is to investigate the effects of the frailty-specific prehabilitation program on functional capacity, frailty, cardiac-specific functional status, serum albumin level, high-sensitivity C-reactive protein…
- Trial name
- NCT07824700
- Testing
- Frailty-specific prehabilitation program
- Where
- Hong Kong
- Volunteers
- 144 people
- Sponsor
- The University of Hong Kong
Heart Failure
Role of Natriuretic Peptides in the Treatment of Acutely Decompensated Heart Failure Patient With Obstructive Airways Disease
Brain natriuretic peptide (BNP) is a useful therapy when treating patients with heart failure. As many of these patients also have airways disease it is important to determine if BNP also has a positive effect on their…
- Trial name
- BNP in OAD (NCT00562692)
- Testing
- Nesiritide
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- The Alfred
Congenital Heart Disease
Multi-micronutrient Supplementation During Peri-conception and Congenital Heart Disease
The purpose of this study is to determine whether daily oral supplements of vitamin B complex along with folic acid or supplements of iron plus folic acid given to women during peri-conception can reduce the risk of congenital…
- Trial name
- NCT02537392
- Testing
- Vitamin B Complex and Folic Acid, Iron and Folic Acid, Folic Acid
- Where
- China
- Volunteers
- 7,315 people
- Sponsor
- Xi'an Jiaotong University
Heart Transplantation
Magnetocardiography as a Non-Invasive Tool for Detecting Tissue Rejection in Heart Transplant Patients
Heart transplantation is a great procedure for selected patients with end-stage heart failure, but graft rejection remains a major factor limiting long-term survival despite continued advancement in the scientific skill of…
- Trial name
- NCT00169936
- Testing
- Magnetocardiograph
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Persistent Atrial Fibrillation
Optimized Ablation of the Posterior Wall in Persistent Atrial Fibrillation
The design of this study is an intervention, randomized, controlled study and contains three randomized groups：（1）PVI group；（2）PVI+PWI group;（3）PVI+PWI+EGM group.
- Trial name
- NCT07122336
- Testing
- PVI, PWI, EGM
- Where
- China
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Chronic Coronary Syndrome, Coronary Artery Disease
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
The primary objective of this study is to assess the accuracy in terms of sensitivity, specificity, negative and positive predicted values of the DL-based algorithm with respect to correct identification of the plaque and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- FOCUS DL (NCT06186336)
- Testing
- Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- GE Healthcare
Type 2 Diabetes
Impact of Empaglifozine on Cardiac Ectopic Fat
There is substantial evidence supporting the fact that ectopic fat accumulation is an important contributor to type 2 diabetes complications and cardiovascular risk [1].
- Trial name
- EMPACEF (NCT03118336)
- Testing
- Empagliflozin 10Mg Tab
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Noninvasive Cardiac Monitoring
Monitoring Blood Flow and Breathing Using a New Device (RFII) Compared to the Gold Standard Device in Post Operative Cardiac Patients
The purpose of this study will be to compare standard of care invasive methods to an FDA approved non-invasive device and a novel wireless non-invasive device, both manufactured by Non-Invasive Medical Technologies Inc., with the…
- Trial name
- NCT01434771
- Sponsor
- University of Florida
Coronary Artery Bypass
TELEsurveillance of Patients in PostopErative Bridge surgeryAge CoronairE
More than 20,000 patients benefit from coronary bypass surgery in France each year. Median discharge without complication is eight days postoperatively, whereas by day four after surgery, hospitalization is only necessary for…
- Trial name
- TELE-PEACE (NCT04236271)
- Testing
- connected objects
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Patient Depression, Anxiety, Stress and Pain
The Effect of Listening to Holy Quran Recital on Depression, Anxiety and Stress Post CABG
Coronary artery bypass graft (CABG) is one of the most common surgical treatments for coronary artery disease. CABG has many beneficial outcomes for patients.
- Trial name
- NCT05419544
- Testing
- Holy Quran Recital effect
- Where
- 2 sites in Jordan
- Volunteers
- 128 people
- Sponsor
- Applied Science Private University
Intraoperative Hypotension
Advanced Cardiovascular Management in Major Non-cardiac Surgery.
This is a single center, randomised and controlled clinical triaI whose aim is to predict and treat in advance, intraoperative hypotension episodes.
- Trial name
- NCT07134530
- Testing
- HPI-driven intraoperative hemodynamic management strategy, GDT strategy
- Where
- Italy
- Volunteers
- 534 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Aortic Valve Insufficiency, Aortic Stenosis
Three Dimensional Imaging and Wireless Technologies to Enhance Medical Care in Space
NASA has outlined the most urgent threats to life and health in manned spaceflight. One of the threats is the risk of trauma and acute medical problems.
- Trial name
- NCT00598767
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The Cleveland Clinic
Dyslipidemias
Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance
Aerobic training is essential for maintaining and improving physical performance and has a positive effect on physiological functions as well as anthropometric characteristics.
- Trial name
- NCT04164771
- Testing
- Aerobic training and Moringa Oleifera
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Diabetes Mellitus, Type 2, Myocardial Infarction
GLP-1RAs) and SGLT2is Combination Therapy and MACEs in Patients with Type 2 Diabetes.
Management of type 2 diabetes mellitus (T2DM) has evolved from a glucocentric to a cardiometabolic approach. Both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) reduce…
- Trial name
- NCT06017544
- Testing
- PCI
- Where
- Italy
- Volunteers
- 257 people
- Sponsor
- University of Campania Luigi Vanvitelli
Persistent Atrial Fibrillation
Cryoballon Versus Radiofrequency Ablation for Persistent Atrial Fibrillation
A randomized trial has recently demonstrated non-inferiority of cryoballoon vs. radiofrequency (RF) catheter ablation in patients with drug-refractory paroxysmal atrial fibrillation (AF).
- Trial name
- IRON-ICE (NCT03365700)
- Testing
- Radiofrequency Ablation, Cryoballoon ablation
- Where
- 3 sites in Italy
- Volunteers
- 303 people
- Sponsor
- Luigi Sacco University Hospital
Thrombosis
STRATAGEM: Strategy for Managing Antiplatelet Therapy in the Perioperative Period of Non Coronary Surgery
The STRATAGEM trial is an investigator-driven French nationwide multicenter, randomized, double-blind, placebo-controlled trial comparing perioperative low-dose aspirin therapy versus placebo in the perioperative period in…
- Trial name
- STRATAGEM (NCT00190307)
- Testing
- aspirin 75 mg/day
- Where
- France
- Volunteers
- 293 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Disease
Prospective Randomized Trial On RadiaTion Dose Estimates Of CT AngIOgraphy In PatieNts Scanned With A Sequential Scan Protocol
The objective of this study is to compare radiation dose of a standard spiral scan with the a new sequential scan protocol. We hypothesize that the sequential scan protocol is associated with a reduction in dose estimates of at…
- Trial name
- PROTECTION-III (NCT00612092)
- Testing
- Spiral image acquisition, sequential image acquisition
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Long QT Syndrome
Low Cost QTc Meter for Long QT Syndrome Screening in Primary Care
The purpose of this study is to further develop and evaluate a diagnostic procedure suitable for use in an inexpensive diagnostic instrument suitable for screening for Long QT Syndrome (LQTS) in the primary care environment.
- Trial name
- NCT04441892
- Testing
- QTc Meter
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Mayo Clinic
Dilated Cardiomyopathy
Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy
A randomised, double-blind, placebo-controlled trial to evaluate the role of intracoronary injection of progenitor cells compared to placebo injection in patients with Dilated Cardiomyopathy who have been pre-treated with G-CSF…
- Trial name
- REGEN-DCM (NCT01302171)
- Testing
- granulocyte colony stimulating factor (GCSF), bone marrow mononuclear cells
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Barts & The London NHS Trust
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