Clinical trials: Cannabis Use
Cannabis Abuse
Drug-Drug Interaction Between THC and AEF0117
This trial is a single center, double blind, placebo-controlled trial in healthy male and female recreational cannabis users with placebo and AEF0117 dosed in a fixed sequence.
- Trial name
- DDI (NCT06395688)
- Testing
- 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aelis Farma
Cannabis Use
Behavioral Pharmacology of THC and Beta-Myrcene
This study will evaluate the pharmacokinetics and pharmacodynamics of vaporized b-myrcene and THC administered via inhalation.
- Trial name
- NCT05432284
- Testing
- THC, Beta-Myrcene
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use, Depression
Cannabis, Linked Emotions, and Adolescent Risk Study
The goal of this study is to disentangle relationships between acute cannabis use and withdrawal on proximal depression and suicide risk and recovery in adolescents ages 12-18 years by incorporating time-varying patterns of…
- Conditions
- Cannabis Use, Depression, Suicidal Ideation, Adolescent Behavior
- Trial name
- CLEAR (NCT06576076)
- Testing
- Contingency management for cannabis abstinence
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Marijuana Use
Effects of a Range of Naltrexone Doses in Combination With Smoked Marijuana
The purpose of this study is to determine if the subjective effects of marijuana will be decreased by low-doses (< 25 mg) of naltrexone and increased by high-doses (> 50 mg) of naltrexone.
- Trial name
- NCT00403117
- Testing
- Naltrexone 12 Mg+ Active Marijuana (3.27% THC), Naltrexone 25 Mg + Active Marijuana (3.27% THC), Naltrexone 50 Mg+ Active Marijuana (3.27% THC)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cannabis
Internet-Based Treatment for Individuals With Regular Cannabis Use: A Randomized Controlled Trial
The aim of this randomized controlled trial is to investigate the effects of a Swedish Internet-based treatment program for individuals from the general population with a regular cannabis use.
- Trial name
- NCT02408640
- Testing
- Cannabishjalpen.se
- Where
- Sweden
- Volunteers
- 303 people
- Sponsor
- Karolinska Institutet
Osteo Arthritis Knee
The Relationship Between Cannabis Use, Biomarkers, Tissue Cannabinoid Levels and Clinical Outcomes in Patients With OA
Osteoarthritis (OA), the most common form of arthritis, is a leading cause of disability, affecting the quality of life, pain, and physical functioning of 4.6 million Canadians.
- Trial name
- NCT04971629
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- University Health Network, Toronto
Cannabis Use
Effects of Cannabis Species Labeling and Marketing on Perceptual, Subjective and Objective Use Outcomes (Aim 2 Study)
This study looks at how cannabis product label and marketing claims affect product perceptions, use expectancies, and use intentions among inexperienced and experienced cannabis users.
- Trial name
- NCT07513337
- Testing
- Strain label, Claim
- Where
- United States
- Volunteers
- 3,035 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Opioid-use Disorder, Cocaine Use Disorder
Feasibility and Validation of a Standard Phenotyping Assessment Battery
The overall goal of this project is to collect preliminary data on psychosocial measures and behavioral performance comparing individuals with Opioid Use Disorder, Cocaine Use Disorder, dual diagnosis of Opioid and Cocaine Use…
- Conditions
- Opioid-use Disorder, Cocaine Use Disorder, Marijuana Use Disorder, Healthy Controls
- Trial name
- PhAB (NCT03495869)
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- Virginia Commonwealth University
Relapse, Opioid Use
Evaluation of a Motion-Activated Refusal-Skills Training Video Game for Prevention of Substance Use Disorder Relapse
The project proposes to continue the development of an intervention for relapse prevention in the form of a professional quality video game which rewards drug-rejecting physical motions and spoken refusal phrases.
- Conditions
- Relapse, Opioid Use, Marijuana Usage
- Trial name
- NCT03957798
- Testing
- RecoveryWarrior 2.0
- Volunteers
- 80 people
- Sponsor
- George Washington University
Cannabis, Cannabis Use
Impact of Reduced Cannabis Use on Functional Outcomes (R33 Phase)
Nearly 20 million Americans report use of cannabis in the past month, and heavy cannabis use has increased by nearly 60% in the U.S. since 2007.
- Trial name
- FOCUS (NCT04567238)
- Testing
- Mobile contingency management
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Cannabis Use, Cancer
Cannabis Use Registry to Improve Overall Understanding of Symptoms (CURIOUS)
Through partnership with Ontracka, the HealthPartners Institute Cancer Research Center created a secure and compliant app-based technology with the ability to seamlessly collect patient-level data on symptoms, cannabis use…
- Trial name
- CURIOUS (NCT07227324)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Driving Under the Influence, Marijuana Intoxication
Cannabis Impairment Detection Application (CIDA)
Subjects will participate in a 4-visit study protocol in which they will be asked to complete a set of computerized tasks and a 45-minute simulated drive in a driving simulator.
- Conditions
- Driving Under the Influence, Marijuana Intoxication, Alcohol Intoxication
- Trial name
- CIDA (NCT04230460)
- Testing
- Cannabis (High% THC) (Inhaled), Cannabis (Very High% THC) (Inhaled), Alcohol (oral)
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Advanced Brain Monitoring, Inc.
Cannabis Use Disorder
Effects of THC on Alcohol Consumption and Neural Correlates of Reward
Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use.
- Trial name
- NCT06446479
- Testing
- Dronabinol Pill
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cannabis Use Disorder, Major Depressive Disorder (MDD)
Pregnenolone for Cannabis Use Disorder and Depression
This is UG3 phase of a multi-site, milestone-driven UG3/UH3 research program evaluating pregnenolone for individuals with co-occurring cannabis use disorder (CUD) and major depressive disorder (MDD).
- Trial name
- PREG-CUD-MDD (NCT07685964)
- Testing
- Pregnenolone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Knowledge
Good Shepherd: Back to Reality Series
The purpose of this pilot study is to explore whether the Back to Reality series of video games - Harry's Journey, Harry's Journal, and Pathways to care map - increase knowledge of the emotional, social, and psychiatric sequelae…
- Trial name
- NCT02710019
- Testing
- Back to Reality Series Video Games, Control Video Game
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cannabis Use Disorder, PREG1
The Influence of in Utero Cannabis Exposure on Neonatal Brain Morphology and Structural Connectivity
Cannabis is the most commonly used drug by women during pregnancy with an estimated prevalence of use in Colorado of 5.7%. THC and its metabolites freely cross the placenta and blood-brain barrier to bind with cannabinoid…
- Conditions
- Cannabis Use Disorder, PREG1, Drug Use, Fetal Exposure During Pregnancy
- Trial name
- NCT03718520
- Testing
- no intervention, this is a purely observational study
- Where
- 2 sites in United States
- Volunteers
- 168 people
- Sponsor
- University of Colorado, Denver
PTSD, Post Traumatic Stress Disorder
Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery
The overall strategy is to recruit veterans with PTSD who report minimal current cannabis use but are interested in or considering therapeutic cannabis to manage mental health symptoms (anxiety, depression, PTSD and/or…
- Conditions
- PTSD, Post Traumatic Stress Disorder, Suicide, Cannabis Use
- Trial name
- CAPER (NCT06222268)
- Testing
- Cannabidiol (CBD) only, Delta-9-tetrahydrocannabinol (THC) only, THC:CBD 1:1
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Leslie Lundahl
Musculoskeletal Pain, Cannabis Use
Medical Cannabis Against Chronic Musculoskeletal Pain: a Mixed Methods Study.
Despite many pharmaceutical options, there are no optimal treatments for Chronic musculoskeletal pain (CMP). Although many Canadians use medical cannabis (MC; legally authorized) to relieve their pain, there are no firm…
- Trial name
- NCT05210660
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- CHU de Quebec-Universite Laval
Cannabis Use
Cannabis Use Patterns Among Young Adults and Associations With Social and Health Outcomes.
The purpose of this study is to identify and characterize patterns of non-therapeutic cannabis consumption and their variation in time in regular/daily users aged 18-24 years using a multi-factor approach (frequency of use…
- Trial name
- TRICCHOME (NCT07063589)
- Testing
- Mobile application
- Where
- Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Opioid Use Disorder, Cannabis Use
Cannabis Effects on Opioid Self-Administration
The study will enroll participants with opioid use disorder and participants will reside at the University of Kentucky Hospital for this 6-week inpatient trial.
- Trial name
- NCT07668635
- Testing
- Cannabis, Intranasal Opioid Agonist, Oral Opioid Agonist
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shanna Babalonis, PhD