Clinical trials: Cancer in the Lung
Brachytherapy, Non-small Cell Lung Cancer
I-125 Seeds Implantation in the Treatment of Recurrent Lung Cancer After Radiotherapy
Patients with recurrence after radiotherapy are often encountered in clinical practice.Patients with recurrence after radiotherapy are less likely to undergo surgery or secondary radiotherapy, and the guidelines recommend only…
- Trial name
- RISIRLC (NCT04071418)
- Testing
- 3D-printing Template-assisted CT-guided I-125 Seeds Implantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Hematopoietic and Lymphatic System Neoplasm, Histiocytic Sarcoma
Q702 for the Treatment of Patients With Hematologic Malignancies
This phase I trial tests the safety, side effects, and best dose of Q702 in treating patients with hematologic malignancies. Q702 is in a class of medications called immunomodulatory agents.
- Conditions
- Hematopoietic and Lymphatic System Neoplasm, Histiocytic Sarcoma, Malignant Histiocytosis, Peripheral T-Cell Lymphoma, Not Otherwise Specified
- Trial name
- NCT06712810
- Testing
- Axl/Mer/CSF1R Inhibitor Q702, Biospecimen Collection, Bone Marrow Aspiration
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Mayo Clinic
Multiple Sclerosis, Lung Cancer
An Exploratory Study to Evaluate Attention Biases in Adults With Multiple Sclerosis, Breast Cancer, and Lung Cancer
CT-100 is a platform that provides interactive, software based therapeutic components that may be used as part of a treatment in future software-based prescription digital therapeutics.
- Conditions
- Multiple Sclerosis, Lung Cancer, Breast Cancer
- Trial name
- NCT06136923
- Testing
- CT-100-D-004-A, CT-100-D-004-B
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- Click Therapeutics, Inc.
Small Cell Lung Cancer
Cabazitaxel Compared to Topotecan for the Treatment of Small Cell Lung Cancer
Primary Objective: To demonstrate progression free survival (PFS) improvement for cabazitaxel compared to topotecan in participants with sensitive or resistant/refractory small cell lung cancer following a first line platinum…
- Trial name
- NCT01500720
- Testing
- Cabazitaxel, Topotecan
- Where
- 58 sites in United States, Brazil and 14 more
- Volunteers
- 179 people
- Sponsor
- Sanofi
Lung Cancer, Non-Small Cell
Efficacy Comparison of Dostarlimab Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Participants With Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC)
NSCLC comprises of approximately 84 percent (%) of all lung cancers and is often diagnosed at advanced stage due to poor prognosis.
- Trial name
- NCT04581824
- Testing
- Dostarlimab, Pembrolizumab, Chemotherapy
- Where
- 58 sites in United States, Argentina and 10 more
- Volunteers
- 243 people
- Sponsor
- GlaxoSmithKline
Non-small-cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck
Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors
This is a first-in-human, Phase 1, open label, multicenter, multiple dose, dose escalation and dose expansion study intended to evaluate the safety, pharmacokinetic, pharmacodynamic, and potential clinical benefit of PF-07209960…
- Conditions
- Non-small-cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck, Renal Cell Carcinoma, Urothelial Carcinoma
- Trial name
- NCT04628780
- Testing
- PF-07209960
- Where
- 13 sites in United States
- Volunteers
- 37 people
- Sponsor
- Pfizer
NSCLC (Advanced Non-small Cell Lung Cancer), VTE (Venous Thromboembolism)
A Clinical Trial on the Outcomes of Comprehensive Enhanced Prophylaxis Management (CEPM) in Chinese Patients With EGFR-Mutated Advanced NSCLC Receiving Amivantamab-Based Regimens
This study aims to explore the clinical outcomes of Comprehensive Enhanced Preventive Management (CEPM) combined with an amivantamab-containing treatment regimen in Chinese patients with EGFR-mutated advanced NSCLC.
- Conditions
- NSCLC (Advanced Non-small Cell Lung Cancer), VTE (Venous Thromboembolism), Rash Due to Epidermal Growth Factor Receptor Inhibitors, Infusion Reaction
- Trial name
- AmiCARE (NCT07469488)
- Testing
- Enhanced dermatologic management, Enhanced IRR Prophylaxis, Enhanced VTE Prophylaxis (Cohort 1 only)
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Radiation Pneumonitis
Hyperbaric Oxygen in the Prevention of Radiation Pneumonitis
Radiotherapy is one of the important treatments to improve the survival rate of breast cancer patients, but also has the risk of radiation lung injury, which can develop into pulmonary fibrosis.
- Trial name
- NCT05189496
- Testing
- hyperbaric oxygen therapy
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Guangdong Provincial People's Hospital
Lung Cancer Screening
Lung Cancer Screening for Early Detection of Suspicious Lung Nodules in Latin America(LUCAS-LATAM)
Prospective study to assess lung cancer screening with low dose CT scan (LDCT) in Latin America (LATAM) and prospectively evaluate chest-XRay analyzed with artificial intelligence (AI) using qXRin (QURE ai) at the initial visit…
- Trial name
- LUCAS-LATAM (NCT07524803)
- Testing
- Chest X-Ray, Low Dose CT scan
- Where
- 2 sites in Colombia, Costa Rica
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Latin American Consortium for the Lung Cancer Research
Non-small Cell Lung Cancer
Safety, Tolerability and Pharmacokinetics of SH-1028 in Patients With Advanced NSCLC
This is a Phase 1, open-label study of SH-1028 with dose escalation and dose expansion cohorts in locally advanced or metastatic non-small-cell lung cancer (NSCLC) patients who have progressed following prior therapy with an…
- Trial name
- NCT03603262
- Testing
- SH-1028
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Nanjing Sanhome Pharmaceutical, Co., Ltd.
Covid19, Hematologic Malignancy
Efficacy and Safety of the Anti- COVID-19 Vaccin in Clinical Hematology Patients
Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in December 2019 in Wuhan, China. Infection with this new coronavirus called SARS-CoV-2 can lead to fatal pneumonia associated with…
- Conditions
- Covid19, Hematologic Malignancy, Vaccine Response Impaired
- Trial name
- HEMVACO (NCT04852796)
- Testing
- Patients with hemopathy
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier de Cornouaille
Melanoma, Non-Small Cell Lung Cancer
A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors
This is a Phase 1a/1b, open-label, multicenter, global, dose-escalation study designed to evaluate the safety, tolerability, immune response, and pharmacokinetics of autogene cevumeran (RO7198457) as a single agent and in…
- Conditions
- Melanoma, Non-Small Cell Lung Cancer, Bladder Cancer, Colorectal Cancer
- Trial name
- NCT03289962
- Testing
- Autogene cevumeran, Atezolizumab
- Where
- 33 sites in United States, Belgium and 6 more
- Volunteers
- 273 people
- Sponsor
- Genentech, Inc.
Non-Small Cell Lung Cancer
A Study of Chidamide Combined With Ivonescimab in the Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) With Acquired Resistance to Immunotherapy and High Yes-associated Protein (YAP) Expression
This is a prospective, single-arm, multi-center, phase II clinical trial to evaluate the efficacy and safety of Chidamide in combination with Ivonescimab in the treatment of advanced non-small cell lung cancer with secondary…
- Trial name
- NSCLC， YAP (NCT07412262)
- Testing
- Chidamide in combination with Ivonescimab
- Where
- 2 sites in China
- Volunteers
- 32 people
- Sponsor
- Guangdong Association of Clinical Trials
Breast Cancer
Acupuncture Chemotherapy-Induced Peripheral Neuropathy (CIPN) IRG
The goal of this clinical research study is to compare the level of effectiveness for 2 acupuncture treatment schedules for chronic CIPN in breast cancer survivors.
- Trial name
- NCT01815346
- Testing
- Acupuncture, Questionnaires, Hand Function and Balance Tests
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Small Cell Lung Cancer Limited Stage
A Clinical Study of TQB2450 Combined With Anlotinib in Limited-Stage Small Cell Lung Cancer Patients
This study is a randomized, double-blind, placebo-controlled phase III clinical study to evaluate the efficacy and safety of TQB2450 in combination with anlotinib as maintenance therapy in patients with limited-stage small cell…
- Trial name
- NCT06469879
- Testing
- TQB2450+Anlotinib
- Where
- 16 sites in China
- Volunteers
- 358 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Lung Neoplasms, Non-Small Cell Lung Cancer, Postoperative Complications
Smartphone-based Remote Symptom Monitoring to Improve Postoperative Rehabilitation Exercise Adherence After Video-assisted Thoracic Surgery (VATS) for Lung Cancer
Brief Summary: This randomized controlled trial aims to evaluate whether active remote symptom monitoring and management via a smartphone app utilizing electronic patient-reported outcomes (ePRO) can improve adherence to…
- Conditions
- Lung Neoplasms, Non-Small Cell Lung Cancer, Postoperative Complications, Patient Reported Outcome Measures, Telerehabilitation
- Trial name
- NCT05990946
- Testing
- ePRO based Remote Symptom Management provide by a mobile phone app
- Where
- China
- Volunteers
- 736 people
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Small Cell Lung Cancer Extensive Stage
Antineoplaston Therapy in Treating Patients With Recurrent or Extensive-Stage Small Cell Lung Cancer
Current therapies for Recurrent or Extensive-Stage Small Cell Lung Cancer provide very limited benefit to the patient. The anti-cancer properties of Antineoplaston therapy suggest that it may prove beneficial in the treatment of…
- Trial name
- NCT00003496
- Testing
- Antineoplaston therapy (Atengenal + Astugenal)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Burzynski Research Institute
Gynecological Cancer
The Safety of Chemotherapy for Patients With Gynecological Malignancy in High-risk Region of COVID-19
A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) emerged at December 2019 in Wuhan, China, and soon caused a large global outbreak.
- Trial name
- NCT04341480
- Testing
- Chemotherapy
- Where
- China
- Volunteers
- 305 people
- Sponsor
- Tongji Hospital
Endometrial Cancer, Ovarian Cancer
Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors
HWK-007-101 is a multicenter, open-label, first-in-human (FIH) Phase 1 study evaluating HWK-007, a protein tyrosine kinase 7 (PTK7)-targeted antibody drug conjugate (ADC), in adult participants with advanced or metastatic solid…
- Conditions
- Endometrial Cancer, Ovarian Cancer, Ovarian Cancer Metastatic, Ovarian Cancer Metastatic Recurrent
- Trial name
- NCT07444814
- Testing
- HWK-007
- Where
- 12 sites in United States
- Volunteers
- 226 people
- Sponsor
- Whitehawk Therapeutics, Inc.
Lung Injury, Bleb Lung
Polypropylene vs Polyglactin in Suturing of the Lung
Comparative study comparing polypropylene and Polyglactin in suturing of the lung
- Conditions
- Lung Injury, Bleb Lung, Lung Cancer
- Trial name
- NCT06115447
- Testing
- lung suturing with polyglactin, ung suturing with polypropylene
- Volunteers
- 100 people
- Sponsor
- Assiut University
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